Synapse - Sjoukje van der Stegen

Results (26)

FT819: Translation of off-the-shelf TCR-less TRAC-1XX CAR-T cells in support of first-of-kind phase I clinical trial

Meeting Abstract

Chang, C.; Van Der Stegen, S.; Mili, M.; Clarke, R.; Lai, Y. S.; Witty, A.; Lindenbergh, P.; Yang, B. H.; Husain, M.; Shaked, H.; more...
Blood (2019)

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Generation of novel single cell-derived engineered master pluripotent cell line as a renewable source for off-the-shelf TCR-less CAR T cells in support of first-of-kind clinical trial

Meeting Abstract

Abujarour, R.; Lai, Y. S.; Pribadi, M.; Lee, T.; Robinson, M.; Ruller, C.; Van der Stegen, S.; Wang, X.; Stefanski, J.; Zhen, J.; more...
Cancer Research (2019)

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CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Journal Article

Hamieh, M.; Dobrin, A.; Cabriolu, A.; van der Stegen, S. J. C.; Giavridis, T.; Mansilla-Soto, J.; Eyquem, J.; Zhao, Z.; Whitlock, B. M.; Miele, M. M.; more...
Nature (2019)

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Novel therapeutic interventions to alleviate CAR T cell-induced cytokine release syndrome

Meeting Abstract

Giavridis, T.; van der Stegen, S. J.; Eyquem, J.; Hamieh, M.; Sadelain, M.
Cancer Research (2018)

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Generation of off-the-shelf TCR-less CAR-targeted cytotoxic T cells from renewable pluripotent cells for cancer immunotherapy

Meeting Abstract

Clarke, R. L.; van der Stegen, S.; Lee, T.; Mansilla-Soto, J.; Chang, C. W.; Sasaki, J.; Husain, M.; Peralta, E.; Hardy, I.; Ortiz, E.; more...
Cancer Research (2018)

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Pluripotent cell-derived off-the-shelf TCR-less CAR-targeted cytotoxic T cell therapeutic for the allogeneic treatment of B cell malignancies

Meeting Abstract

Clarke, R.; Van Der Stegen, S.; Chang, C. W.; Husain, M.; Lai, Y. S.; Peralta, E.; Stokely, L.; Abujarour, R.; Dinella, J.; Lee, T.; more...
Blood (2018)

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Restraining macrophages alleviates CAR T cell-induced cytokine release syndrome and informs novel therapeutic interventions

Meeting Abstract

Giavridis, T.; van der Stegen, S. J. C.; Eyquem, J.; Hamieh, M.; Sadelain, M.
Molecular Therapy (2018)

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CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Journal Article

Giavridis, T.; van der Stegen, S. J. C.; Eyquem, J.; Hamieh, M.; Piersigilli, A.; Sadelain, M.
Nature Medicine (2018)

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Generation of clonal antigen specific CD8αβ(+) cytotoxic T lymphocytes from renewable pluripotent stem cells for off-the-shelf T cell therapeutics