Synapse - Jaclyn Hechtman

Results (34)

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing

Journal Article

Ziegler, J.; Hechtman, J. F.; Rana, S.; Ptashkin, R. N.; Jayakumaran, G.; Middha, S.; Chavan, S. S.; Vanderbilt, C.; DeLair, D.; Casanova, J.; more...
Nature Communications (2025)

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Microsatellite instability and mismatch repair deficiency define a distinct subset of lung cancers characterized by smoking exposure, high tumor mutational burden, and recurrent somatic MLH1 inactivation

Journal Article

Yang, S. R.; Gedvilaite, E.; Ptashkin, R.; Chang, J.; Ziegler, J.; Mata, D. A.; Villafania, L. B.; Nafa, K.; Hechtman, J. F.; Benayed, R.; more...
Journal of Thoracic Oncology (2024)

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Microsatellite instability defines a subset of lung cancers with smoking exposure, high tumor mutational burden and MLH1 inactivation

Meeting Abstract

Yang, S. R.; Gedvilaite, E.; Ptashkin, R.; Chang, J.; Ziegler, J.; Mata, D.; Villafania, L. B.; Nafa, K.; Hechtman, J. F.; Benhamida, J.; more...
Journal of Thoracic Oncology (2023)

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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Journal Article

Brannon, A. R.; Jayakumaran, G.; Diosdado, M.; Patel, J.; Razumova, A.; Hu, Y.; Meng, F.; Haque, M.; Sadowska, J.; Murphy, B. J.; more...
Nature Communications (2021)

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A performance comparison of commonly used assays to detect RET fusions

Journal Article

Yang, S. R.; Aypar, U.; Rosen, E. Y.; Mata, D. A.; Benayed, R.; Mullaney, K.; Jayakumaran, G.; Zhang, Y.; Frosina, D.; Drilon, A.; more...
Clinical Cancer Research (2021)

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Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer

Meeting Abstract

Liu, B.; Ross, D. S.; Schram, A. M.; Razavi, P.; Lagana, S. M.; Zhang, Y.; Scaltriti, M.; Bromberg, J. F.; Ladanyi, M.; Hyman, D. M.; more...
Cancer Research (2020)

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Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients

Journal Article

Ross, D. S.; Liu, B.; Schram, A. M.; Razavi, P.; Lagana, S. M.; Zhang, Y.; Scaltriti, M.; Bromberg, J. F.; Ladanyi, M.; Hyman, D. M.; more...
Annals of Oncology (2020)

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Landscape and outcome of TRK fusion-positive cancers

Meeting Abstract

Rosen, E. Y.; Goldman, D. A.; Hechtman, J. F.; Benayed, R.; Schram, A. M.; Cocco, E.; Shifman, S.; Gong, Y.; Kundra, R.; Solomon, J. P.; more...
Clinical Cancer Research (2020)

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Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes