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Jaclyn Frances Hechtman

  1. "Alison Schram"
Formats
  1. Journal Article (9)
  2. Meeting Abstract (4)
  3. Research Letter (1)
Groups
  1. Department of Medicine (14)
  2. Early Drug Development Service (14)
  3. Gynecologic Medicine Service (14)
  4. Solid Tumor Oncology Division (14)
  5. Thoracic Oncology (14)
  6. GSK Faculty (13)

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People
  1. Alison Schram (14)
  2. David Hyman (14)
  3. Alexander Drilon (13)
  4. Maurizio Scaltriti (10)
  5. Ryma Benayed (8)
  6. Emiliano Cocco (7)

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Years
  1. 2021 (1)
  2. 2020 (5)
  3. 2019 (5)
  4. 2018 (1)
  5. 2017 (2)
Publications
  1. Cancer Research (4)
  2. JCO Precision Oncology (3)
  3. Cancer Discovery (2)
  4. Clinical Cancer Research (2)
  5. Nature Medicine (2)
  6. Annals of Oncology (1)
Publishers
  1. American Association for Cancer Research (8)
  2. American Society of Clinical Oncology (3)
  3. Nature Publishing Group (2)
  4. Oxford University Press (1)

Results (14)

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  • TRK XDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
    Journal Article

    Cocco, E.; Lee, J. E.; Kannan, S.; Schram, A. M.; Won, H. H.; Shifman, S.; Kulick, A.; Baldino, L.; Toska, E.; Arruabarrena-Aristorena, A.; more...
    Cancer Discovery (2021)

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  • Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer
    Meeting Abstract

    Liu, B.; Ross, D. S.; Schram, A. M.; Razavi, P.; Lagana, S. M.; Zhang, Y.; Scaltriti, M.; Bromberg, J. F.; Ladanyi, M.; Hyman, D. M.; more...
    Cancer Research (2020)

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  • TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
    Meeting Abstract

    Cocco, E.; Lee, J. E.; Kannan, S.; Schram, A. M.; Won, H. H.; Shifman, S.; Kulick, A.; Baldino, L.; Toska, E.; Arena, S.; more...
    Cancer Research (2020)

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  • Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients
    Journal Article

    Ross, D. S.; Liu, B.; Schram, A. M.; Razavi, P.; Lagana, S. M.; Zhang, Y.; Scaltriti, M.; Bromberg, J. F.; Ladanyi, M.; Hyman, D. M.; more...
    Annals of Oncology (2020)

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  • Landscape and outcome of TRK fusion-positive cancers
    Meeting Abstract

    Rosen, E. Y.; Goldman, D. A.; Hechtman, J. F.; Benayed, R.; Schram, A. M.; Cocco, E.; Shifman, S.; Gong, Y.; Kundra, R.; Solomon, J. P.; more...
    Clinical Cancer Research (2020)

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  • TRK fusions are enriched in cancers with uncommon histologies and the absence of canonical driver mutations
    Journal Article

    Rosen, E. Y.; Goldman, D. A.; Hechtman, J. F.; Benayed, R.; Schram, A. M.; Cocco, E.; Shifman, S.; Gong, Y.; Kundra, R.; Solomon, J. P.; more...
    Clinical Cancer Research (2020)

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  • Real-world outcomes of an automated physician support system for genome-driven oncology
    Journal Article

    Tao, J. J.; Eubank, M. H.; Schram, A. M.; Cangemi, N.; Pamer, E.; Rosen, E. Y.; Schultz, N.; Chakravarty, D.; Philip, J.; Hechtman, J. F.; more...
    JCO Precision Oncology (2019)

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  • Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
    Meeting Abstract

    Cocco, E.; Kulick, A.; Misale, S.; Yaeger, R.; Razavi, P.; Won, H. H.; Ptashkin, R.; Hechtman, J. F.; Toska, E.; Cownie, J.; more...
    Cancer Research (2019)

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  • Resistance to TRK inhibition mediated by convergent MAPK pathway activation
    Research Letter

    Cocco, E.; Schram, A. M.; Kulick, A.; Misale, S.; Won, H. H.; Yaeger, R.; Razavi, P.; Ptashkin, R.; Hechtman, J. F.; Toska, E.; more...
    Nature Medicine (2019)

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  • Larotrectinib demonstrates CNS efficacy in TRK fusion-positive solid tumors
    Journal Article

    Rosen, E. Y.; Schram, A. M.; Young, R. J.; Schreyer, M. W.; Hechtman, J. F.; Shu, C. A.; Ku, N. C.; Hyman, D. M.; Drilon, A.
    JCO Precision Oncology (2019)

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