Synapse - Terence Purdon

Results (61)

Engineered tumor-targeted T cells mediate enhanced anti-tumor efficacy both directly and through activation of the endogenous immune system

Journal Article

Avanzi, M. P.; Yeku, O.; Li, X.; Wijewarnasuriya, D. P.; van Leeuwen, D. G.; Cheung, K.; Park, H.; Purdon, T. J.; Daniyan, A. F.; Spitzer, M. H.; more...
Cell Reports (2018)

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Chimeric antigen receptor (CAR) T cells genetically engineered to deliver IL-12 to the tumor microenvironment in ovarian cancer

Meeting Abstract

Yeku, O. O.; Purdon, T.; Spriggs, D. R.; Brentjens, R. J.
Journal of Clinical Oncology (2017)

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Biomarkers associated with neurotoxicity in adult patients with relapsed or refractory B-ALL (R/R B-ALL) treated with CD19 CAR T cells

Meeting Abstract

Santomasso, B.; Park, J. H.; Riviere, I.; Mead, E.; Halton, E.; Diamonte, C.; Purdon, T.; Senechal, B.; Li, D.; Sadelain, M.; more...
Journal of Clinical Oncology (2017)

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Baseline and early post-treatment clinical and laboratory factors associated with severe neurotoxicity following 19-28z CAR T cells in adult patients with relapsed B-ALL

Meeting Abstract

Park, J. H.; Santomasso, B.; Riviere, I.; Senechal, B.; Wang, X.; Purdon, T.; Wang, Y.; Halton, E.; Diamonte, C.; Li, D.; more...
Journal of Clinical Oncology (2017)

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Development and evaluation of a human single chain variable fragment (scFv) derived BCMA targeted CAR T Cell vector leads to a high objective response rate in patients with advanced MM

Meeting Abstract

Smith, E. L.; Mailankody, S.; Ghosh, A.; Masakayan, R.; Staehr, M.; Purdon, T. J.; Halton, E.; Diamonte, C.; Anant, P.; Bernal, Y.; more...
Blood (2017)

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Enhancing CAR T cell anti-tumor efficacy through secreted single chain variable fragment (scFv) immune checkpoint blockade

Meeting Abstract

Rafiq, S.; Jackson, H. J.; Yeku, O.; Purdon, T. J.; van Leeuwen, D. G.; Curran, K. J.; Ahmed, R. N.; Cullen, G. D.; Yan, S.; Wang, P.; more...
Blood (2017)

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Development of JCARH125: Optimization of a fully human anti-BCMA CAR for use in the treatment of multiple myeloma

Meeting Abstract

Harrington, K.; Wu, R.; Hauskins, C.; Amin, R.; Long, T.; Chen, A.; Rahardjo, A.; Thayer, C.; Navvaro, G.; Myers, M.; more...
Blood (2017)

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Armored CAR T cells genetically modified to secrete IL-12 show enhanced efficacy and overcome a hostile tumor microenvironment in mouse ovarian peritoneal carcinomatosis