Cellular and genetic programs underlying cerebellum development Book Section


Authors: Joyner, A. L.; Willett, R.; Lawton, A.
Editor: Marzban, H.
Article/Chapter Title: Cellular and genetic programs underlying cerebellum development
Title Series: Contemporary Clinical Neuroscience
Abstract: The cerebellum is a late developing structure compared to the rest of the central nervous system (CNS) and houses more cells than the entire rest of the brain in a complex set of folds. To accommodate production of the large number of cells, the cerebellum has not only a ventricular progenitor zone that produces all the glia and inhibitory neurons but also a unique progenitor zone, the rhombic lip, dedicated to excitatory neuron production. In this chapter we discuss how the inhibitory Purkinje cells, which integrate the incoming information and moderate the output neurons of the cerebellar nuclei, play a key role during development in ensuring appropriate production of the other neurons/astrocytes of the cerebellar cortex. Key transcription factors that regulate development of the two progenitor populations and the lineage relationships of the neurons and astrocytes produced by each are described, followed by a discussion of cerebellar foliation.
Keywords: purkinje cells; transcription factor; interneurons; sonic hedgehog; astrocytes; cerebellar nuclei; stem-cells; cells; granule cells; mouse cerebellum; isthmic organizer; purkinje-cells; rat cerebellum; rhombic lip; foliation; neural stem; rhombic-lip; ventricular zone; bergmann glia; climbing fibers; olivocerebellar relationships
Book Title: Development of the Cerebellum from Molecular Aspects to Diseases
Volume: 21
ISBN: 978-3-319-59749-2
Publisher: Springer International Publishing Ag  
Publication Place: Cham, Switzerland
Date Published: 2017-01-01
Start Page: 45
End Page: 65
Language: English
ACCESSION: WOS:000449416200004
PROVIDER: wos
DOI: 10.1007/978-3-319-59749-2_3
Notes: Book Chapter -- Source: Wos
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MSK Authors
  1. Alexandra L Joyner
    65 Joyner
  2. Andrew Kenneth Lawton
    3 Lawton