A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition Journal Article


Authors: Mathias, M. D.; Ortiz, M. V.; Magnan, H.; Ambati, S. R.; Slotkin, E. K.; Chou, A. J.; Walsh, M. F.; Offit, K.; Moskowitz, C.; Kentsis, A.; Wexler, L. H.
Article Title: A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition
Abstract: Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.
Keywords: case report; neoplasms; risk; molecular analysis; rhabdomyosarcoma; children; susceptibility; diffuse large b cell lymphoma
Journal Title: Biomarker Research
Volume: 5
ISSN: 2050-7771
Publisher: Biomed Central Ltd  
Date Published: 2017-02-08
Start Page: 7
Language: English
ACCESSION: WOS:000414225000001
DOI: 10.1186/s40364-017-0086-7
PROVIDER: wos
PMCID: PMC5299656
PUBMED: 28194276
Notes: Article -- Source: Wos
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MSK Authors
  1. Kenneth Offit
    507 Offit
  2. Craig Moskowitz
    368 Moskowitz
  3. Leonard H Wexler
    130 Wexler
  4. Alexander Ja-Ho Chou
    55 Chou
  5. Srikanth Reddy Ambati
    24 Ambati
  6. Heather Magnan
    25 Magnan
  7. Emily Kanaya Slotkin
    12 Slotkin
  8. Alex   Kentsis
    47 Kentsis
  9. Melissa Divya Mathias
    14 Mathias
  10. Michael Francis Walsh
    46 Walsh
  11. Michael Vincent Ortiz
    8 Ortiz