Synapse - Population Sciences Research Program

Results (25)

Discrepant MMR protein status between intestinal adenoma and carcinoma: Biological significance and practical implication

Meeting Abstract

Song, W.; Wang, C.; Firat, C.; Khandakar, B.; Weiser, M.; Vakiani, E.; Stadler, Z.; Shia, J.
Modern Pathology (2022)

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Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes

Journal Article

Moukarzel, L. A.; Da Cruz Paula, A.; Ferrando, L.; Hoang, T.; Sebastiao, A. P. M.; Pareja, F.; Park, K. J.; Jungbluth, A. A.; Capella, G.; Pineda, M.; more...
Modern Pathology (2021)

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Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes

Journal Article

Hechtman, J. F.; Rana, S.; Middha, S.; Stadler, Z. K.; Latham, A.; Benayed, R.; Soslow, R.; Ladanyi, M.; Yaeger, R.; Zehir, A.; more...
Modern Pathology (2020)

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Mismatch repair deficiency in squamous cell carcinoma of the gastrointestinal tract: Frequency and clinical implication

Meeting Abstract

Imam, R.; Gullo, I.; Dahoud, W.; Nourbakhsh, M.; Firat, C.; Patel, Z.; Vakiani, E.; Hechtman, J.; Tang, L.; Klimstra, D.; more...
Modern Pathology (2020)

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Colorectal carcinoma with double somatic mismatch repair gene inactivation: Clinical and pathological characteristics and response to immune checkpoint blockade

Journal Article

Wang, T.; Lee, L. H.; Vyas, M.; Zhang, L.; Ganesh, K.; Firat, C.; Segal, N. H.; Desai, A.; Hechtman, J. F.; Ntiamoah, P.; more...
Modern Pathology (2019)

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Inter-tumoral discordance in mismatch repair protein expression in synchronous or metachronous gastrointestinal tumors: Biological significance and clinical implications

Meeting Abstract

Vyas, M.; Stadler, Z.; Hechtman, J.; Vakiani, E.; Klimstra, D.; Shia, J.
Modern Pathology (2019)

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Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas

Journal Article

Liu, S.; Gӧnen, M.; Stadler, Z. K.; Weiser, M. R.; Hechtman, J. F.; Vakiani, E.; Wang, T.; Vyas, M.; Joneja, U.; Al-Bayati, M.; more...
Modern Pathology (2019)

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In colorectal carcinoma (CRC), true tumor cell staining for PD-L1 is uncommon and occurs in sporadic microsatellite-instable tumors with loss of MHC-I

Meeting Abstract

Liu, S.; Vyas, M.; Stadler, Z.; Weiser, M.; King, S.; Hechtman, J.; Vakiani, E.; Klimstra, D.; Shia, J.
Modern Pathology (2018)

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Expression of PD-L1 in colorectal carcinoma (CRC) primarily occurs in stromal/immune cells at tumor-stroma interface (TSI), and is associated with high tumor-infiltrating lymphocytes (TILs) irrespective of the microsatellite instability (MSI) status or the molecular mechanism of MSI

Meeting Abstract

Liu, S.; Hechtman, J.; Segal, N.; Smith, J.; Rao, D.; Markowitz, A.; Weiser, M.; Vakiani, E.; Klimstra, D. S.; Stadler, Z.; more...
Modern Pathology (2017)

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Morphological characterization of colorectal cancers in the Cancer Genome Atlas reveals distinct morphology-molecular associations: Clinical and biological implications

Journal Article

Shia, J.; Schultz, N.; Kuk, D.; Vakiani, E.; Middha, S.; Segal, N. H.; Hechtman, J. F.; Berger, M. F.; Stadler, Z. K.; Weiser, M. R.; more...
Modern Pathology (2017)

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