Synapse - Population Sciences Research Program

Results (20)

Genomic profiling reveals germline predisposition and homologous recombination deficiency in pancreatic acinar cell carcinoma

Journal Article

Mandelker, D.; Marra, A.; Zheng-Lin, B.; Selenica, P.; Blanco-Heredia, J.; Zhu, Y.; Gazzo, A.; Wong, D.; Yelskaya, Z.; Rai, V.; more...
Journal of Clinical Oncology (2023)

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Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade

Journal Article

Harrold, E. C.; Foote, M. B.; Rousseau, B.; Walch, H.; Kemel, Y.; Richards, A. L.; Keane, F.; Cercek, A.; Yaeger, R.; Rathkopf, D.; more...
Nature Medicine (2023)

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Methylation analyses reveal promoter hypermethylation as a rare cause of “second hit” in germline BRCA1-associated pancreatic ductal adenocarcinoma

Journal Article

Zheng-Lin, B.; Rainone, M.; Varghese, A. M.; Yu, K. H.; Park, W.; Berger, M.; Mehine, M.; Chou, J.; Capanu, M.; Mandelker, D.; more...
Molecular Diagnosis and Therapy (2022)

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Comprehensive assessment of germline pathogenic variant detection in tumor-only sequencing

Journal Article

Terraf, P.; Pareja, F.; Brown, D. N.; Ceyhan-Birsoy, O.; Misyura, M.; Rana, S.; O'Reilly, E.; Carlo, M. I.; Aghajanian, C.; Liu, Y.; more...
Annals of Oncology (2022)

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Early-onset pancreas cancer: Clinical descriptors, genomics, and outcomes

Journal Article

Varghese, A. M.; Singh, I.; Singh, R.; Kunte, S.; Chou, J. F.; Capanu, M.; Wong, W.; Lowery, M. A.; Stadler, Z. K.; Salo-Mullen, E.; more...
JNCI: Journal of the National Cancer Institute (2021)

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Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes

Journal Article

Momtaz, P.; O'Connor, C. A.; Chou, J. F.; Capanu, M.; Park, W.; Bandlamudi, C.; Berger, M. F.; Kelsen, D. P.; Suehnholz, S. P.; Chakravarty, D.; more...
Cancer (2021)

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Therapeutic implications of germline testing in patients with advanced cancers

Journal Article

Stadler, Z. K.; Maio, A.; Chakravarty, D.; Kemel, Y.; Sheehan, M.; Salo-Mullen, E.; Tkachuk, K.; Fong, C. J.; Nguyen, B.; Erakky, A.; more...
Journal of Clinical Oncology (2021)

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Randomized, multicenter, phase II trial of gemcitabine and cisplatin with or without veliparib in patients with pancreas adenocarcinoma and a germline BRCA/PALB2 mutation

Journal Article

O'Reilly, E. M.; Lee, J. W.; Zalupski, M.; Capanu, M.; Park, J.; Golan, T.; Tahover, E.; Lowery, M. A.; Chou, J. F.; Sahai, V.; more...
Journal of Clinical Oncology (2020)

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Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings

Journal Article

Maynard, H.; Stadler, Z. K.; Berger, M. F.; Solit, D. B.; Ly, M.; Lowery, M. A.; Mandelker, D.; Zhang, L.; Jordan, E.; El Dika, I.; more...
Cancer (2020)

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Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes

Journal Article

Wong, W.; Lowery, M. A.; Berger, M. F.; Kemel, Y.; Taylor, B.; Zehir, A.; Srinivasan, P.; Bandlamudi, C.; Chou, J.; Capanu, M.; more...
Cancer (2019)

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