Synapse - Population Sciences Research Program

Results (22)

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers

Journal Article

Chatila, W. K.; Walch, H.; Hechtman, J. F.; Moyer, S. M.; Sgambati, V.; Faleck, D. M.; Srivastava, A.; Tang, L.; Benhamida, J.; Ismailgeci, D.; more...
Nature Communications (2023)

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Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: Frequency, patterns, and molecular etiologies

Journal Article

Vyas, M.; Firat, C.; Hechtman, J. F.; Weiser, M. R.; Yaeger, R.; Vanderbilt, C.; Benhamida, J. K.; Keshinro, A.; Zhang, L.; Ntiamoah, P.; more...
Familial Cancer (2021)

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Characterization and clinical outcomes of DNA mismatch repair-deficient small bowel adenocarcinoma

Journal Article

Latham, A.; Shia, J.; Patel, Z.; Reidy-Lagunes, D. L.; Segal, N. H.; Yaeger, R.; Ganesh, K.; Connell, L.; Kemeny, N. E.; Kelsen, D. P.; more...
Clinical Cancer Research (2021)

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Tumor microbiome in colorectal carcinoma: Bacterial enrichment is associated with oncogenic variants within specific signaling pathways

Meeting Abstract

Beech, C.; Vanderbilt, C.; Keshinro, A.; Chen, C.; Kim, J.; Hechtman, J.; Zehir, A.; Bowman, A.; Arcila, M.; Ladanyi, M.; more...
Journal of Molecular Diagnostics (2020)

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Colorectal carcinoma with double somatic mismatch repair gene inactivation: Clinical and pathological characteristics and response to immune checkpoint blockade

Journal Article

Wang, T.; Lee, L. H.; Vyas, M.; Zhang, L.; Ganesh, K.; Firat, C.; Segal, N. H.; Desai, A.; Hechtman, J. F.; Ntiamoah, P.; more...
Modern Pathology (2019)

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Microsatellite instability is associated with the presence of Lynch syndrome pan-cancer

Journal Article

Latham, A.; Srinivasan, P.; Kemel, Y.; Shia, J.; Bandlamudi, C.; Mandelker, D.; Middha, S.; Hechtman, J.; Zehir, A.; Dubard-Gault, M.; more...
Journal of Clinical Oncology (2019)

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Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas

Journal Article

Liu, S.; Gӧnen, M.; Stadler, Z. K.; Weiser, M. R.; Hechtman, J. F.; Vakiani, E.; Wang, T.; Vyas, M.; Joneja, U.; Al-Bayati, M.; more...
Modern Pathology (2019)

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In colorectal carcinoma (CRC), true tumor cell staining for PD-L1 is uncommon and occurs in sporadic microsatellite-instable tumors with loss of MHC-I

Meeting Abstract

Liu, S.; Vyas, M.; Stadler, Z.; Weiser, M.; King, S.; Hechtman, J.; Vakiani, E.; Klimstra, D.; Shia, J.
Modern Pathology (2018)

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Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations

Journal Article

Wang, T.; Stadler, Z. K.; Zhang, L.; Weiser, M. R.; Basturk, O.; Hechtman, J. F.; Vakiani, E.; Saltz, L. B.; Klimstra, D. S.; Shia, J.
Familial Cancer (2018)

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Universal screening for microsatellite instability in colorectal cancer in the clinical genomics era: New recommendations, methods, and considerations

Journal Article

Hechtman, J. F.; Middha, S.; Stadler, Z. K.; Zehir, A.; Berger, M. F.; Vakiani, E.; Weiser, M. R.; Ladanyi, M.; Saltz, L. B.; Klimstra, D. S.; more...
Familial Cancer (2017)

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