COVID-19
This COVID-19 page was actively updated between April 2020-December 31, 2022. It will remain visible here until March 31, 2023 and permanently archived in an upcoming publications report.
We continue to add new MSK-authored publications to Synapse each month and you can check here for newly added COVID-19-related publications.
MSK-authored COVID-19 publications listed by most recent. MSK authors are in bold and linked to
their Synapse profiles.
Works: Last updated: 2022-12-29
The impact of telehealth on nursing care in the radiation oncology setting during the COVID-19 pandemic. [Article]
Adames A (Nursing), Briody P (Nursing), Brown S (Nursing), Ford J (Nursing), Tolda C (Nursing), Barton-Burke M (Nursing).
Asia Pac J Oncol Nurs. 2022 Dec 28;100182. doi: 10.1016/j.apjon.2022.100182. Online ahead of print.
Summary: Results of two virtual focus groups to examine the impact of telehealth on radiation oncology nursing care at a comprehensive cancer care center during the COVID-19 pandemic, specifically between March and August 2020.
Fit for Duty: Lessons learned from outpatient and homebound HCT to prepare family caregivers for home-based care. [Article]
Applebaum AJ (Psychiatry Service), Sannes T, Mitchell HR, McAndrew NS, Wiener L, Knight JM, Nelson AJ, Gray TF, Frank PM, Lahijani SC, Pozo-Kaderman C, Rueda-Lara M, Miran DM, Landau H (Medicine), Amonoo HL.
Transplant Cell Ther. 2022 Dec 23;S2666-6367(22)01841-3. doi: 10.1016/j.jtct.2022.12.014. Online ahead of print.
Summary: Background and recommendations for supporting and preparing caregivers delivering home-based care to hematopoietic cell transplantation (HCT) patients, informed by the COVID-19 pandemic.
Differences in urban and suburban/rural settings regarding care provision and barriers of cancer care for older adults during COVID-19. [Research Article]
Pisegna JL, BrintzenhofeSzoc K, Shahrokni A (Medicine), Canin B, Plotkin E, Boehmer LM, Chien L, Malone MV, MacKenzie AR, Krok-Schoen JL.
Support Care Cancer. 2022 Dec 23;31(1):78. doi: 10.1007/s00520-022-07544-y.
Summary: Results of a survey of 271 multidisciplinary healthcare providers to examine the differences in cancer care for older adults between urban and suburban/rural settings during COVID-19.
COVID-19 vaccination response and its practical application in patients with chronic lymphocytic leukemia. [Review]
Shadman M, Liu C, Eakle K, Hiew HJ, Biondo JML, Ghia P, Mato AR (Medicine).
Hemasphere. 2022 Dec 20;7(1):e811. doi: 10.1097/HS9.0000000000000811. eCollection 2023 Jan.
Summary: A prospective review of 27 studies of patients with chronic lymphocytic leukemia, with each study including serology results for 20 or more patients, to evaluate COVID-19 vaccination response in this population.
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children. [Research Article]
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T (Immunology), Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X; CoV-Contact Cohort, Covid HGE, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard C, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL.
Science. 2022 Dec 20;eabo3627. doi: 10.1126/science.abo3627. Online ahead of print.
Summary: A study of 558 patients with multisystem inflammatory syndrome in children (MIS-C) from the international COVID Human Genetic Effort (CHGE) cohort, as this is a rare and severe condition that can follow benign COVID-19 infection.
A retrospective review of the characteristics and outcomes of patients through an Integrated Palliative Care Model during the First Wave of the SARS-COV-2 Pandemic. [Review]
Liu K, Hwang J (Graduate Medical Education), Chesteen K, Huth H, Zhu Y, Mixon A, Tillman S, Misra S, Karlekar M.
J Palliat Med. 2022 Dec;25(12):1844-1849. doi: 10.1089/jpm.2022.0006. Epub 2022 Sep 14.
Summary: Results of an observational retrospective study of 123 adult patients with confirmed COVID-19 who received a palliative care consultation and were hospitalized between April 6, 2020 and August 26, 2020.
International recommendations for plasma Epstein-Barr virus DNA measurement in nasopharyngeal carcinoma in resource-constrained settings: lessons from the COVID-19 pandemic. [Review]
Lee VH, Adham M, Ben Kridis W, Bossi P, Chen MY, Chitapanarux I, Gregoire V, Hao SP, Ho C, Ho GF, Kannarunimit D, Kwong DL, Lam KO, Lam WKJ, Le QT, Lee AW, Lee NY (Radiation Oncology), Leung TW, Licitra L, Lim DW, Lin JC, Loh KS, Lou PJ, Machiels JP, Mai HQ, Mesia R, Ng WT, Ngan RK, Tay JK, Tsang RK, Tong CC, Wang HM, Wee JT.
Lancet Oncol. 2022 Dec;23(12):e544-e551. doi: 10.1016/S1470-2045(22)00505-8.
Summary: Consensus recommendations from 33 international experts on nasopharyngeal carcinoma in the context of COVID-19 or similar future pandemics or settings.
Predictors of COVID-19 hospitalization after sotrovimab in hematologic malignancy patients during the BA.1 Omicron surge. [Article]
Yan J (Infection Control), Steiger SN (Pharmacy), Kodama R (Infectious Disease Service), Fender J (Infection Control), Tan C (Pharmacy), Laracy J (Medicine), Cohen N (Pharmacy), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Seo SK (Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 Nov 29;ciac916. doi: 10.1093/cid/ciac916. Online ahead of print.
Summary: Results of an observational study of 156 patients who received sotrovimab at Memorial Sloan Kettering Cancer Center in New York City during the BA.1 Omicron surge of the pandemic.
Outcomes of early versus late tracheostomy in patients with COVID-19: A multinational cohort study. [Article]
Harrell Shreckengost CS, Foianini JE, Moron Encinas KM, Tola Guarachi H, Abril K, Amin D, Berkowitz D, Castater CA, Douglas JM, Grant AA, Khullar OV, Lane AN, Lin A, Niroula A, Nizam A, Rashied A, Reitz AW, Roser SM, Spychalski J, Arap SS, Bento RF, Ciaralo PPD, Imamura R, Kowalski LP, Mahmoud A, Mariani AW, Menegozzo CAM, Minamoto H, Montenegro FLM, Pêgo-Fernandes PM, Santos J Jr, Utiyama EM, Sreedharan JK, Kalchiem-Dekel O (Medicine), Nguyen J, Dhamsania RK, Allen K, Modzik A, Pathak V, White C, Blas J, Talal El-Abur I, Tirado G, Yánez Benítez C, Weiser TG, Barry M, Boeck M, Farrell M, Greenberg A, Miller P, Park P, Camazine M, Dillon D, Smith RN.
Crit Care Explor. 2022 Nov 21;4(11):e0796. doi: 10.1097/CCE.0000000000000796. eCollection 2022 Nov.
Summary: Results of an international multi-institute retrospective cohort study of 549 hospitalized COVID-19 patients to compare outcomes in those who underwent tracheostomy within 14 days of intubation versus more than 14 days after intubation.
Worldview orientations and personal and social risk perceptions for COVID-19 in a U.S. population-based sample. [Article]
Lewicka M (Psychiatry & Behavioral Sciences), Hay JL (Psychiatry and Behavioral Sciences), Waters EA, Schofield E (Psychiatry & Behavioral Sciences), Orom H, Kiviniemi MT.
J Prev (2022). 2022 Nov 17. doi: 10.1007/s10935-022-00715-x. Online ahead of print.
Summary: Results of a study of 410 adults in the United States to examine associations between worldview orientations and six facets of risk for COVID-19.
The demand for change: How nurse leaders reframed the nurse orientation process during the COVID 'Great Resignation Era.' [Article]
Romano K (Nursing), Rodrigue D (Nursing).
Nurse Leader. 2022 Nov 16. doi: 10.1016/j.mnl.2022.10.002. Epub ahead of print.
Summary: A description of how nurse leaders modified traditional orientation methods in response to the COVID pandemic and staff turnover, with examples of quotes from preceptees and preceptors.
Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiops COVID-19 model. [Case Report]
Gonzalez AA, Olsen EL, Killeen SZ, Blair RV, Seshan SV, Jaimes EA (Medicine), Roy CJ, Prieto MC.
J Med Primatol. 2022 Nov 15. doi: 10.1111/jmp.12626. Online ahead of print.
Summary: A case report that describes the measurements of soluble urokinase plasminogen activator receptor in an African green monkey infected with SARS-CoV-2, with authors noting findings suggest elevated levels of this receptor may be associated with renal dysfunction and pathology in the context of COVID-19.
DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome. [Article]
Bradic M (Collaborative Research Centers), Taleb S, Thomas B, Chidiac O, Robay A, Hassan N, Malek J, Ait Hssain A, Abi Khalil C.
J Transl Med. 2022 Nov 12;20(1):526. doi: 10.1186/s12967-022-03737-5.
Summary: A study of 133 patients with acute respiratory distress syndrome (100 COVID-19 patients and 33 non-COVID-19 controls) to assess if COVID-19 infection could be complicated by this syndrome.
Prognostic value of procalcitonin in cancer patients with coronavirus disease 2019. [Article]
Tiutan T (Medicine), Wallins JS (Medicine), Brown S (Biostat/Epidemiology), Gonen M (Biostat/Epidemiology), Korenstein D (Medicine).
Clin Chem Lab Med. 2022 Nov 11;61(2):339-348. doi: 10.1515/cclm-2022-0366. Print 2023 Jan 27..
Summary: A retrospective study of 209 cancer patients hospitalized with COVID-19 who had procalcitonin recorded on admission in order to evaluate the utility of procalcitonin in predicting disease severity and death from COVID-19 in this population.
Factors associated with COVID 19 vaccine uptake among adolescents and young adults recently diagnosed with cancer. [Article]
Kwok G, Reese S, Dugad S (SKI Psychiatry/Counseling), Donovan KA, Tsui J, Sahler OJZ, Levonyan-Radloff K, Barnett ME (Psychiatry Service), Manne S, Ohman-Strickland P, Devine KA.
J Adolesc Young Adult Oncol. 2022 Nov 11. doi: 10.1089/jayao.2022.0113. Online ahead of print.
Summary: Results of a survey of 144 patients aged 18-39 who were recently diagnosed with and being treated for cancer, with responses evaluated to understand factors associated with COVID-19 vaccine uptake and intention.
The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variants. [Article]
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Robilotti EV (Medicine), Kamboj M (Medicine), Babady NE (Laboratory Medicine).
Sci Rep. 2022 Nov 8;12(1):18968. doi: 10.1038/s41598-022-21564-y.
Summary: Results of a study to investigate the detection accuracy of the spike gene target failure genomic signature for Alpha and Omicron variants by analyzing positive SARS-CoV-2 samples tested on a widely used, commercial test between December 2020 and July 2022.
Associations between social COVID-19 exposure and psychological functioning. [Article]
Lewicka M (Psychiatry Service), Hamilton JG (Psychiatry Service), Waters EA, Orom H, Schofield E, Kiviniemi MT, Kanetsky PA, Hay JL (Psychiatry Service).
J Behav Med. 2022 Nov 5;1-11. doi: 10.1007/s10865-022-00374-7. Online ahead of print.
Summary: Results of a survey of 343 participants who were enrolled in skin cancer prevention intervention studies to examine associations between social COVID-19 exposure and psychological functioning.
Interplay of immunosuppression and immunotherapy among patients with cancer and COVID-19. [Brief Report]
Bakouny Z, Labaki C, Grover P, Awosika J, Gulati S, Hsu CY, Alimohamed SI, Bashir B, Berg S, Bilen MA, Bowles D, Castellano C, Desai A, Elkrief A, Eton OE, Fecher LA, Flora D, Galsky MD, Gatti-Mays ME, Gesenhues A, Glover MJ, Gopalakrishnan D, Gupta S, Halfdanarson TR, Hayes-Lattin B, Hendawi M, Hsu E, Hwang C, Jandarov R, Jani C, Johnson DB, Joshi M, Khan H, Khan SA, Knox N, Koshkin VS, Kulkarni AA, Kwon DH, Matar S, McKay RR, Mishra S, Moria FA, Nizam A, Nock NL, Nonato TK, Panasci J, Pomerantz L, Portuguese AJ, Provenzano D, Puc M, Rao YJ, Rhodes TD, Riely GJ (Medicine), Ripp JJ, Rivera AV, Ruiz-Garcia E, Schmidt AL, Schoenfeld AJ, Schwartz GK, Shah SA, Shaya J, Subbiah S, Tachiki LM, Tucker MD, Valdez-Reyes M, Weissmann LB, Wotman MT, Wulff-Burchfield EM, Xie Z, Yang YJ, Thompson MA, Shah DP, Warner JL, Shyr Y, Choueiri TK, Wise-Draper TM; COVID-19 and Cancer Consortium.
JAMA Oncol. 2022 Nov 3. doi: 10.1001/jamaoncol.2022.5357. Online ahead of print.
Summary: A cohort study of 12,046 patients with cancer and COVID-19, with authors noting that findings suggest patients with baseline immunosuppression as well may experience worse outcomes when treated with immunotherapy or non-immunotherapy systemic anticancer therapy.
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells. [Article]
Nguyenla X, Wehri E, Van Dis E, Biering SB, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang X, Jockusch S, Tao C, Chien M, Xie W, Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Russo JJ, Ju J, Näär AM, Stanley S, Schaletzky J.
Sci Rep. 2022 Nov 2;12(1):18506. doi: 10.1038/s41598-022-21034-5.
Summary: Results of a study to identify compounds that act synergistically with remdesivir, which the authors note is the only FDA-approved therapeutic for COVID-19, in preventing SARS-CoV-2 replication.
Integrating palliative care into nursing care. [Editorial]
Parekh de Campos A, Levoy K, Pandey S (Ld-Advanced Practice Providers), Wisniewski R (Ld-Advanced Practive Providers), DiMauro P, Ferrell BR, Rosa WE (Psychiatry Service).
Am J Nurs. 2022 Nov 1;122(11):40-45. doi: 10.1097/01.NAJ.0000897124.77291.7d.
Summary: An editorial that explores how the COVID-19 pandemic has shown the need for palliative care education and training, especially amongst nurses.
Reexamining social determinants of health data collection in the COVID-19 era. [Viewpoint]
Mullangi S (Graduate Staff), Aviki EM (Surgery), Hershman DL.
JAMA Oncol. 2022 Dec 1;8(12):1736-1738. doi: 10.1001/jamaoncol.2022.4543. Epub 2022 Oct 27.
Summary: This is a viewpoint that uses data from the American Society of Clinical Oncology’s COVID-19 in Oncology Registry to study the association of various factors with cancer treatment delays among a cohort of patients who tested positive for SARS-CoV-2.
Frequently asked questions on coronavirus disease 2019 vaccination for hematopoietic cell transplant and chimeric antigen receptor T-cell recipients from the American Society for Transplantation and Cellular Therapy and the American Society of Hematology. [Guidelines]
Khawaja F, Papanicolaou G (Medicine), Dadwal S, Pergam SA, Wingard JR, Boghdadly ZE, Abidi MZ, Waghmare A, Shahid Z, Michaels L, Hill JA, Kamboj M (Medicine), Boeckh M, Auletta JJ, Chemaly RF.
Transplant Cell Ther. 2022 Oct 20;S2666-6367(22)01705-5. doi: 10.1016/j.jtct.2022.10.010. Online ahead of print.
Summary: A guidance document in the form of frequently asked questions that is based on current knowledge about COVID-19 vaccination in hematopoietic cell transplantation and chimeric antigen receptor T-cell recipients.
Wasserstein-based texture analysis in radiomic studies. [Article]
Belkhatir Z, Estépar RSJ, Tannenbaum AR (Medical Physics).
Comput Med Imaging Graph. 2022 Dec;102:102129. doi: 10.1016/j.compmedimag.2022.102129. Epub 2022 Oct 19.
Summary: A guidance document in the form of frequently asked questions that is based on current knowledge about COVID-19 vaccination in hematopoietic cell transplantation and chimeric antigen receptor T-cell recipients.
Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant. [Article]
Yang N (SKI Medicine), Garcia A, Meyer C, Tuschl T, Merghoub T (Human Oncology and Pathogenesis Program), Wolchok JD (Human Oncology and Pathogenesis Program), Deng L (Medicine).
NPJ Vaccines. 2022 Oct 19;7(1):120. doi: 10.1038/s41541-022-00542-5.
Summary: Results of a study to explore the potential of a virus as a cancer or SARS-CoV-2 vaccine adjuvant to create a stronger immune response in those being vaccinated.
Impact and recovery from COVID-19-related disruptions in colorectal cancer screening and care in the US: A scenario analysis. [Article]
van den Puttelaar R, Lansdorp-Vogelaar I, Hahn AI (Biostat/Epidemiology), Rutter CM, Levin TR, Zauber AG (Biostat/Epidemiology), Meester RGS.
Cancer Epidemiol Biomarkers Prev. 2022 Oct 10;EPI-22-0544. doi: 10.1158/1055-9965.EPI-22-0544. Online ahead of print.
Summary: Results of a study to predict the impact of COVID-19 pandemic-related delays in screening and diagnosis on colorectal cancer–related outcomes.
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. [Article]
Han Y, Tan L, Zhou T (Research Facilities), Yang L, Carrau L, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A (Research Facilities), Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S.
Cell Stem Cell. 2022 Oct 6;29(10):1475-1490.e6. doi: 10.1016/j.stem.2022.09.008.
Summary: A description of a screening strategy to link human genetics with viral infectivity using human-induced pluripotent stem cells (hiPSC), with SARS-CoV-2 infection discussed.
Immune-related adverse events among COVID-19-vaccinated patients with cancer receiving immune checkpoint blockade. [Article]
Widman AJ (Medicine), Cohen B, Park V (Pharmacy), McClure T (Infection Control), Wolchok J (HOPP), Kamboj M (Medicine).
J Natl Compr Canc Netw. 2022 Oct;20(10):1134-1138. doi: 10.6004/jnccn.2022.7048.
Summary: Results of an electronic health record analysis of 408 cancer patients receiving immune checkpoint inhibition therapy who were vaccinated for COVID-19 between January 16 and March 27, 2021 to see whether this vaccination increases susceptibility to immune-related adverse events.
The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems. [Article]
Fiore MC, Smith SS, Adsit RT, Bolt DM, Conner KL, Bernstein SL, Eng OD, Lazuk D, Gonzalez A, Jorenby DE, D'Angelo H, Kirsch JA, Williams B, Nolan MB, Hayes-Birchler T, Kent S, Kim H, Piasecki TM, Slutske WS, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew JP, McMahan G, Rolland B, Tindle HA, Warren GW, An LC, Boyd AD, Brunzell DH, Carrillo V, Chen LS, Davis JM, Dilip D (SKI Medicine), Ellerbeck EF, Iturrate E, Jose T, Khanna N, King A, Klass E, Newman M, Shoenbill KA, Tong E, Tsoh JY, Wilson KM, Theobald WE, Baker TB.
PLoS One. 2022 Sep 28;17(9):e0274571. doi: 10.1371/journal.pone.0274571. eCollection 2022.
Summary: Results of a study of 104,590 hospitalized adult COVID-19 patients to characterize changes in mortality, intubation, and intensive care unit admission rates during the first 20 months of the pandemic.
Novel technology deployed for remote ventilator management by respiratory therapists during the COVID-19 pandemic: Lessons learned. [Article]
Rausen MS (Anesthesiology), Nahass TA (Graduate Staff), Halpern NA (Anesthesiology).
J Intensive Care Med. 2022 Dec;37(12):1662-1666. doi: 10.1177/08850666221126648. Epub 2022 Sep 21.
Summary: A description of the experience of deploying Omnitool, a novel remote ventilator management control technology, for use with intensive care unit patients in the latter half of 2020 during the COVID-19 pandemic.
Editorial: Impact of COVID-19 on the clinical microbiology laboratory: Preparing for the next pandemic. [Editorial]
Dunbar S, Babady E (Laboratory Medicine), Das S, Moore C.
Front Cell Infect Microbiol. 2022 Sep 20;12:1031436. doi: 10.3389/fcimb.2022.1031436. eCollection 2022.
Summary: An editorial of the experiences of various diagnostic laboratories and manufacturers during the COVID-19 pandemic.
Building a resilient scientific network for COVID-19 and beyond. [Opinion]
Babady NE (Laboratory Medicine), Burckhardt RM, Krammer F, Moore PL, Enquist LW.
mBio. 2022 Oct 26;13(5):e0222322. doi: 10.1128/mbio.02223-22. Epub 2022 Sep 20.
Summary: An opinion piece on COVID-19 that looks at designing networks to systematically assess variants, connecting laboratory and clinical data, global data sharing, and becoming more proactive in responding to pathogens.
Self-supervised 3D anatomy segmentation using self-distilled masked image transformer (SMIT). [Book Chapter]
Jiang J (Medical Physics), Tyagi N (Medical Physics), Tringale K (Graduate Staff), Crane C (Radiation Oncology), Veeraraghavan H (Medical Physics).
Med Image Comput Comput Assist Interv. 2022 Sep;13434:556-566. doi: 10.1007/978-3-031-16440-8_53. Epub 2022 Sep 16.
Summary: This conference paper describes an image modeling method developed with 3,643 computed tomography scans arising from head and neck, lung, and kidney cancers as well as COVID-19.
SARS-CoV-2 can infect human embryos. [Article]
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Developmental Biology), Hadjantonakis AK (Developmental Biology), Coates A, Barnes FL, Zouves CG, Greene WC, Viotti M.
Sci Rep. 2022 Sep 14;12(1):15451. doi: 10.1038/s41598-022-18906-1.
Summary: A study of human embryos preimplantation to explore the factors required for SARS-CoV-2 entry into cells, with findings confirming that these embryos at the blastocyst stage are susceptible to SARS-CoV-2 infection.
SARS-CoV-2 in immunocompromised individuals. [Review]
DeWolf S (Medicine), Laracy JC (Medicine), Perales MA (Medicine), Kamboj M (Medicine), van den Brink MRM (Medicine), Vardhana S (Medicine).
Immunity. 2022 Oct 11;55(10):1779-1798. doi: 10.1016/j.immuni.2022.09.006. Epub 2022 Sep 13.
Summary: A review of SARS-CoV-2 immunologic vulnerability and how understanding the natural history of viral infections in these high-risk populations can improve prevention and treatment strategies.
The clinical utility of molecular imaging in COVID-19: An update. [Review]
Elsakka A (Graduate Staff), Yeh R (Radiology), Das J (Radiology).
Semin Nucl Med. 2023 Jan;53(1):98-106. doi: 10.1053/j.semnuclmed.2022.09.002. Epub 2022 Sep 22.
Summary: A review of the role of molecular imaging techniques in evaluating thoracic and extra-thoracic manifestations of COVID-19 and assessing post-acute COVID-19 syndrome.
Revised guidelines for coronavirus disease 19 management in hematopoietic cell transplantation and cellular therapy recipients (August 2022). [Guidelines]
Dioverti V, Boghdadly ZE, Shahid Z, Waghmare A, Abidi M, Pergam S, Boeckh M, Dadwal S, Kamboj M (Medicine), Seo S (Medicine), Chemaly RF, Papanicolaou GA (Medicine).
Transplant Cell Ther. 2022 Dec;28(12):810-821. doi: 10.1016/j.jtct.2022.09.002. Epub 2022 Sep 11.
Summary: An update to the 2020 guidelines for the diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplantation and cellular therapy recipients, produced using available data and the expert opinion of the American Society for Transplantation and Cellular Therapy (ASTCT) Infectious Diseases Special Interest Group members.
Demographics, outcomes, and risk factors for patients with sarcoma and COVID-19: A CCC19-registry based retrospective cohort study. [Article]
Wagner MJ, Hennessy C, Beeghly A, French B, Shah DP, Croessmann S, Vilar-Compte D, Ruiz-Garcia E, Ingham M, Schwartz GK, Painter CA, Chugh R, Fecher L, Park C, Zamulko O, Trent JC, Subbiah V, Khaki AR, Tachiki L, Nakasone ES, Loggers ET, Labaki C, Saliby RM, McKay RR, Ajmera A, Griffiths EA, Puzanov I, Tap WD (Medicine), Hwang C, Tejwani S, Jhawar SR, Hayes-Lattin B, Wulff-Burchfield E, Kasi A, Reuben DY, Nagaraj G, Joshi M, Polimera H, Kulkarni AA, Esfahani K, Kwon DH, Paoluzzi L, Bilen MA, Durbin EB, Grivas P, Warner JL, Davis EJ.
Cancers (Basel). 2022 Sep 5;14(17):4334. doi: 10.3390/cancers14174334.
Summary: A retrospective cohort study of 281 patients with sarcoma and COVID-19 reported to the COVID-19 and Cancer Consortium (CCC19) registry between March 17, 2020 and September 30, 2021.
Confronting anti-asian racism and health disparities in the era of COVID-19. [Viewpoint]
Santos PMG (Graduate Staff), Dee EC (Graduate Staff), Deville C Jr.
JAMA Health Forum. 2021 Sep 3;2(9):e212579. doi: 10.1001/jamahealthforum.2021.2579.
Summary: With the inequities exposed by the COVID-19 pandemic as a backdrop, this is a viewpoint of three areas that are needed to confront the harms of anti-Asian sentiment on Asian American health: disaggregation and genetic ancestry in medical research, cultural humility in clinical practice, and workforce diversity.
Updated International Society of Geriatric Oncology COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer. [Perspective]
Soto-Perez-de-Celis E, Mislang AR, Hernández-Favela CG, Russo C, Colloca G, Williams GR, O'Hanlon S, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Gironés-Sarrió R, Stauder R, Jaklitsch M, Cairo C, Gil LA Jr, Alam M, Sattar S, Kantilal K, Loh KP, Lichtman SM (Medicine), Brain E, Wildiers H, Kanesvaran R, Battisti NML.
J Geriatr Oncol. 2022 Sep;13(7):1054-1057. doi: 10.1016/j.jgo.2022.07.005. Epub 2022 Jul 15.
Summary: Updated recommendations from the International Society of Geriatric Oncology (SIOG) building on their initial set from 2021 regarding COVID-19 vaccinations among older adults with cancer.
Breast medical oncologists' perspectives of telemedicine for breast cancer care: A survey study. [Article]
Stavrou E, Qiu J, Zafar A, Tramontano AC, Isakoff S, Winer E, Schrag D (Medicine), Manz C.
JCO Oncol Pract. 2022 Sep;18(9):e1447-e1453. doi: 10.1200/OP.22.00072. Epub 2022 Jun 7.
Summary: Results of an electronically administered survey of 51 breast medical oncology clinicians to evaluate their perspectives on the use of telemedicine for outpatient breast cancer care, given its rise during the COVID-19 pandemic.
Premortem skin biopsy assessing microthrombi, interferon type I antiviral and regulatory proteins, and complement deposition correlates with coronavirus disease 2019 clinical stage. [Article]
Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ (Graduate Staff), Harp J, Ahamed J, Magro C.
Am J Pathol. 2022 Sep;192(9):1282-1294. doi: 10.1016/j.ajpath.2022.05.006. Epub 2022 May 28.
Summary: An investigator-initiated, prospective case series of 21 patients (15 with severe/critical COVID-19 and six with mild/moderate COVID-19) who had cutaneous punch biopsy specimens collected between April 1, 2020 and December 31, 2020 at a single institution.
PAN-cODE: COVID-19 forecasting using conditional latent ODEs. [Article]
Shi R, Zhang H, Morris Q (Computational and Systems Biology Program).
J Am Med Inform Assoc. 2022 Sep 1;ocac160. doi: 10.1093/jamia/ocac160. Online ahead of print.
Summary: Using COVID-19 as an example, the authors present PAN-cODE, an artificial intelligence method to forecast daily increases in pandemic infections and mortality. Such forecasting facilitates informed policy decisions on the introduction of non-pharmaceutical interventions to reduce infection spread.
Palliative care delivery changes during COVID-19 and enduring implications in oncology nursing: a rapid review. [Review]
Levoy K, Foxwell A, Rosa WE (Psychiatry Service).
Curr Opin Support Palliat Care. 2022 Sep 1;16(3):94-101.
Summary: This review article synthesizes evidence from individual studies on changes to palliative care delivery during the COVID-19 pandemic, and the implications of these changes in Oncology Nursing practice going forward.
Examining the impact of COVID-19 on upper Manhattan community-based organizations: A qualitative analysis of employee focus groups. [Article]
Wang JM, Henry C, Lynch KA (Psychiatry Service), Nisa NA, Basabe NC, Hernández R (Psychiatry Service), Lubetkin EI.
Int J Community Wellbeing. 2022 Aug 23;1-19. doi: 10.1007/s42413-022-00180-8.
Summary: The researchers examined community-based organizations (CBO) and employee perceptions of COVID-19’s impact on CBO health-related services. The CBOs participating in this study were located in Upper Manhattan, New York City (serving East Harlem, Central Harlem, Morningside Heights and Hamilton Heights, and Washington Heights and Inwood).
Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals. [Article]
Lambert B, Stopard IJ, Boroujeni A (Pathology), Mendoza R, Zuretti A.
PLoS One. 2022 Aug 18;17(8):e0272442. doi: 10.1371/journal.pone.0272442. eCollection 2022.
Summary: The authors used a mathematical model to quantify the mortality risk in patients hospitalized for COVID-19. The study was conducted across two hospitals in New York: State University of New York (SUNY) Downstate Health Sciences University and Maimonides Medical Center.
Relations of current and past cancer with severe outcomes among 104,590 hospitalized COVID-19 patients: The COVID EHR Cohort at the University of Wisconsin. [Article]
Nolan MB, Piasecki TM, Smith SS, Baker TB, Fiore MC, Adsit RT, Bolt DM, Conner KL, Bernstein SL, Eng OD, Lazuk D, Gonzalez A, Hayes-Birchler T, Jorenby DE, D'Angelo H, Kirsch JA, Williams BS, Kent S, Kim H, Lubanski SA, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle HA, Warren GW, Abu-El-Rub N, An LC, Boyd AD, Brunzell DH, Carrillo VA, Chen LS, Davis JM, Deshmukh VG, Dilip D (SKI Medicine), Goldstein A, Ha PK, Iturrate E, Jose T, Khanna N, King A, Klass E, Lui M, Mermelstein RJ, Poon C (DigITs), Tong E, Wilson KM, Theobald WE, Slutske WS.
Cancer Epidemiol Biomarkers Prev. 2022 Aug 15;EPI-22-0500. doi: 10.1158/1055-9965.EPI-22-0500. Online ahead of print.
Summary: This article reports on a study that uses the electronic health record data of over 100,000 adult hospitalized patients with COVID-19, obtained from 21 United States health systems from February 2020 through September 2021. The findings demonstrate that cancer patients with COVID-19 were at risk of severe COVID-19 outcomes (mitigated to a degree by prior COVID-19 vaccination), while past history of cancer was not associated with such risk.
Crystal structure of SARS-CoV-2 nsp10–nsp16 in complex with small molecule inhibitors, SS148 and WZ16. [Article]
Klima M, Yazdi AK, Li F, Chau I, Hajian T, Bolotokova A, Kaniskan HU, YHan Y, Wang K (Chemical Biology), Li D (Chemical Biology), Luo M (Chemical Biology), Jin J, Boura E, Vedadi M.
Protein Science. 2022; 31( 9):e4395. https://doi.org/10.1002/pro.4395.
Summary: This article presents research on the crystal struture of SARS-CoV-2 that may help in the development of more potent antiviral therapeutics against coronaviruses.
Discordant SARS-CoV-2 spike protein receptor binding domain IgG and neutralization after B cell depletion. [Case Report]
Noy A (Medicine), Vardhana SA (Medicine).
Haematologica. 2022 Dec 1;107(12):2988-2989. doi: 10.3324/haematol.2022.281484. Epub Aug 11.
Summary: This case study reports on the immune response and efficacy of vaccination in a cancer patient with a history of chemotherapy treatment. The patient contracted COVID-19 shortly after beginning chemotherapy, and received several rounds of vaccination with SARS-CoV-2 mRNA vaccine six months following treatment.
Impact of severe acute respiratory syndrome coronavirus-2 infection on the outcome of primary central nervous system lymphoma treatment: A study of the International PCNSL Collaborative Group. [Article]
Steffanoni S, Calimeri T, Laurenge A, Fox CP, Soussain C, Grommes C (Neurology), Tisi MC, Boot J, Crosbie N, Visco C, Arcaini L, Chaganti S, Sassone MC, Alencar A, Armiento D, Romano I, Dietrich J, Itchaki G, Bruna R, Fracchiolla NS, Arletti L, Venditti A, Booth S, Musto P, Hoang Xuan K, Batchelor TT, Cwynarski K, Ferreri AJM.
Br J Haematol. 2022 Nov;199(4):507-519. doi: 10.1111/bjh.18396. Epub 2022 Aug 9.
Summary: The authors studied the presentation, management, and outcomes in patients with primary central nervous system lymphoma and SARS-CoV-2 infection.
Predictors of chronic COVID-19 symptoms in a community-based cohort of adults. [Article]
Silverberg JI, Zyskind I, Naiditch H, Zimmerman J, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Rosenberg AZ.
PLoS One. 2022 Aug 4;17(8):e0271310. doi: 10.1371/journal.pone.0271310. eCollection 2022.
Summary: In this longitudinal observational study conducted before Covid-19 vaccines' availability, the authors studied chronic COVID-19 symptoms among 390 adults from 5 U.S. states.
Effectiveness of mRNA booster vaccine among health Care workers in New York City during the omicron surge, December 2021- January 2022. [Article]
Robilotti EV (Medicine), Whiting K (Biostat/Epidemiology), Lucca A (Employee Health), Poon C (DigITs), Jani K (Laboratory Medicine), McMillen T (Laboratory Medicine), Freeswick S (Pharmacy), Babady NE (Laboratory Medicine), Seshan VE (Biostat/Epidemiology), Kamboj M (Medicine).
Clin Microbiol Infect. 2022 Dec;28(12):1624-1628. doi: 10.1016/j.cmi.2022.07.017. Epub 2022 Aug 3.
Summary: In this retrospective study, the authors compared the effectiveness of receiving two doses of mRNA vaccines versus three doses in 21,557 healthcare workers employed at MSKCC. The study looked at the data from December 15, 2020 to January 15, 2022.
Beyond COVID-19 and lessons learned in the United States. [Review]
Gammon R, Katz LM, Strauss D, Rowe K, Menitove J, Benjamin RJ, Goel R, Borge D (Laboratory Medicine), Reichenberg S, Smith R.
Transfus Med. 2022 Aug 2. doi: 10.1111/tme.12896. Online ahead of print.
Summary: This article describes challenges in blood donation and banking during the COVID-19 pandemic in the United States, the ways the blood community addressed those challenges, and lessons learned for the future.
Long and persistent COVID-19 in patients with hematologic malignancies: from bench to bedside. [Review]
Laracy JC (Medicine), Kamboj M (Medicine), Vardhana SA (Medicine).
Curr Opin Infect Dis. 2022 Aug 1;35(4):271-279. doi: 10.1097/QCO.0000000000000841. Epub 2022 Jul 5.
Summary: The article describes the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 infection in patients with blood cancers.
COVID19 in hematological patients and telemedicine: lessons learned across Europe and the US. [Review]
Mussetti A, Peric Z, Figueroa C (Medicine).
Curr Opin Infect Dis. 2022 Aug 1;35(4):295-301. doi: 10.1097/QCO.0000000000000843. Epub 2022 Jul 5.
Summary: A review of how telemedicine is being used in hematology via studies published before and during the COVID-19 pandemic.
Risk factors associated with development of coinfection in critically Ill patients with COVID-19. [Article]
Orsini EM, Sacha GL, Han X, Wang X, Duggal A, Rajendram P (Anesthesiology).
Acute Crit Care. 2022 Aug;37(3):312-321. doi: 10.4266/acc.2022.00136. Epub 2022 Aug 29.
Summary: A retrospective, observational case-control study of 900 adult patients critically ill with COVID-19 admitted to the intensive care units of the Cleveland Clinic Health System between March 15, 2020 and August 31, 2020.
Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination. [Article]
Horvat JV (Radiology), Sevilimedu V (Biostat/Epidemiology), Becker AS (Radiology), Perez-Johnston R (Radiology), Yeh R (Radiology), Feigin KN (Radiology).
Eur Radiol. 2022 Aug;32(8):5752-5758. doi: 10.1007/s00330-022-08655-0. Epub 2022 Mar 5.
Summary: A retrospective cohort study of 357 patients who underwent breast magnetic resonance imaging (MRI) following COVID-19 vaccination between January 22, 2021 and March 21, 2021.
Behind the scenes: Moral distress among psychosocial oncology clinical research staff during the COVID-19 pandemic. [Editorial]
Gebert RR (SKI Psychiatry/Counseling), Behrens MR (SKI Psychiatry/Counseling), Loschiavo MJ (SKI Psychiatry/Counseling).
Palliat Support Care. 2022 Jul 28;1-2. doi: 10.1017/S1478951522000943. Online ahead of print.
Summary: An editorial that describes the moral distress and challenges faced by psychosocial oncology clinical research staff within the COVID-19 pandemic.
The COVID-19 pandemic and transition to digital health in clinical oncology care. [Review]
Baldwin-Medsker A (Health Informatics), Skwira-Brown A.
Clin J Oncol Nurs. 2022 Jul 25;26(4):374-382. doi: 10.1188/22.CJON.374-382.
Summary: A review of how the COVID-19 pandemic changed clinical oncology practice and impacted digital health technologies in oncology care.
COVID-19 vaccines and immunosuppressed patients with cancer: Critical considerations. [Review]
Cazeau N (Advanced Practice Providers), Palazzo M (Advanced Practice Providers), Savani M, Shroff RT.
Clin J Oncol Nurs. 2022 Jul 25;26(4):367-373. doi: 10.1188/22.CJON.367-373.
Summary: A review of current knowledge via research studies that looked to the COVID-19 vaccine immune response of immunosuppressed patients with hematologic and solid tumor malignancies.
A phase II study of N-acetylcysteine in cancer patients with severe COVID-19: clinical outcomes and biological correlates. [Preprint]
Johnson W (Medicine), Kalvin H (Biostat/Epidemiology), Panageas K (Biostat/Epidemiology), Nicodemus J (Medicine), Cathcart E (Medicine), Lin YH (HOPP), Hosszu K (Pediatrics), Lee C, Hamlin P (Medicine), Horwitz S (Medicine), Intlekofer A (Medicine), Joffe E (SKI Medicine), Kumar A (Medicine), Batlevi C (Medicine), Matasar M (Medicine), Moskowitz A (Medicine), Noy A (Medicine), Palomba M (Medicine), Salles G (Medicine), Straus D (Medicine), von Keudell G (Human Resources), Zelenetz A (Medicine), Boelens JJ (Pediatrics), Babady NE (Laboratory Medicine), Maslak P (Laboratory Medicine), Wolchok JD (HOPP), Vardhana S (Medicine).
Research Square. 2022 Jul 18; doi: https://doi.org/10.21203/rs.3.rs-1836295/v1.
Summary: A preprint of a two-arm, single-institution phase II study of N-acetylcysteine in 42 patients with severe COVID-19 admitted to Memorial Sloan Kettering Cancer Center between May 2020 and April 2021.
Clinical and imaging experience with COVID-19 in nonvaccinated children with cancer. [Article]
Behr GG (Radiology), Raphael JP, Price AP (Radiology), Pandit-Taskar N (Radiology).
Clin Imaging. Clin Imaging. 2022 Oct;90:1-4. doi: 10.1016/j.clinimag.2022.07.002. Epub 2022 Jul 11.
Summary: A retrospective review of 48 pediatric patients with documented COVID-19 who had undergone one or more imaging studies between March 2020 and December 2020 at Memorial Sloan Kettering Cancer Center.
A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase. [Review]
García-Gutiérrez V, Breccia M, Jabbour E, Mauro M (Medicine), Cortes JE.
J Hematol Oncol. 2022 Jul 11;15(1):90. doi: 10.1186/s13045-022-01309-0.
Summary: This review, written by international experts, uses clinically relevant case studies to discuss three major scenarios often seen in the treatment of chronic myeloid leukemia (CML) in the chronic phase, and also "addresses global challenges commonly faced by hematologists treating patients with CML during the COVID-19 pandemic."
Developing and validating multi-modal models for mortality prediction in COVID-19 patients: A multi-center retrospective study [Article]
Wu JTY, de la Hoz MAA, Kuo PC, Paguio JA, Yao JS, Dee EC (Graduate Staff), Yeung W, Jurado J, Moulick A, Milazzo C, Peinado P, Villares P, Cubillo A, Varona JF, Lee HC, Estirado A, Castellano JM, Celi LA.
J Digit Imaging. 2022 Dec;35(6):1514-1529. doi: 10.1007/s10278-022-00674-z. Epub 2022 Jul 5.
Summary: This study reports on an international, multi-center effort that originated at MIT. Retrospective data was used to develop COVID-19 mortality prediction models using the "best machine learning practices for clinical model development." These models were then tested but found to perform differently across different institutions, clinical settings, and populations.
Translating telemedicine to thoracic surgical oncological care: Performance analysis and patient perceptions during the COVID-19 pandemic. [Article]
Harrington CA (SKI Surgery), Hsu M (Epidemiology & Biostatistics), Tan KS (Epidemiology & Biostatistics), Medina B (Graduate Staff), Boerner T (SKI Surgery), Adusumilli PS (Surgery), Bains MS (Surgery), Bott MJ (Surgery), Isbell JM (Surgery), Park BJ (Surgery), Sihag S (Surgery), Rusch VW (Surgery), Jones DR (Surgery), Rocco G (Surgery), Molena D (Surgery). Ann Surg. 2022 Jul 4. doi: 10.1097/SLA.0000000000005525. Online ahead of print.
Summary: This single-institution study used patient characteristics and outcomes data from a 4-month period (March-June) in 2019 compared to data from that period in 2020, as well as survey data, to examine how the COVID-19 pandemic affected care for patients undergoing thoracic surgery for cancer, particularly with respect to the adoption of telemedicine.
The Impact of the COVID-19 pandemic on tobacco treatment program implementation at NCI-Designated cancer centers. [Article]
Hohl SD, Shoenbill KA, Taylor KL, Minion M, Bates-Pappas GE (SKI Psychiatry/Counseling), Hayes RB, Nolan MB, Simmons VN, Steinberg MB, Park ER, Ashing K, Beneventi D, Cox LS, Goldstein AO, King A, Kotsen C (Psychiatry Service), Presant CA, Sherman SE, Sheffer CE, Warren GW, Adsit RT, Bird JE, D'Angelo H, Fiore MC, Nguyen CVT, Pauk D, Rolland B, Rigotti NA.
Nicotine Tob Res. 2022 Jul 2;ntac160. doi: 10.1093/ntr/ntac160. Online ahead of print.
Summary: This article reports how 34 centers participating in tobacco cessation treatments adapted to the changes needed because of COVID-19. As a result, they had to shift to telehealth services rapidly. The centers are National Cancer Institute (NCI)-designated cancer centers participating in NCI's Cancer Center Cessation Initiative.
Factors associated with cancer treatment delay among patients diagnosed with COVID-19. [Article]
Mullangi S (Graduate Staff), Aviki EM (Surgery), Chen Y (Biostatistics & Epidemiology), Robson M (Medicine), Hershman DL.
JAMA Netw Open. 2022 Jul 1;5(7):e2224296. doi: 10.1001/jamanetworkopen.2022.24296.
Summary: A cohort study of 3,028 patients within the American Society of Clinical Oncology COVID-19 Oncology Data Registry, with authors noting that findings suggest some health disparities may have been exacerbated during the COVID-19 pandemic as an effect of cancer treatment delay.
Association between the COVID-19 pandemic and insurance-based disparities in mortality after major surgery among US adults. [Article]
Glance LG, Dick AW, Shippey E, McCormick PJ (Anesthesiology), Dutton R, Stone PW, Shang J, Lustik SJ, Lander HL, Gosev I, Joynt Maddox KE.
JAMA Netw Open. 2022 Jul 1;5(7):e2222360. doi: 10.1001/jamanetworkopen.2022.22360.
Summary: A cross-sectional study of 2,950,147 adults undergoing major surgery to compare changes in mortality in this population across insurance types, with authors noting that findings suggest the early phase of the COVID-19 pandemic was not associated with increases in insurance-based disparities.
Comparative performance of the Luminex NxTAG Respiratory Pathogen Panel, GenMark eSensor Respiratory Viral Panel, and BioFire FilmArray Respiratory Panel. [Article]
Popowitch EB, Kaplan S (Laboratory Medicine), Wu Z (Laboratory Medicine), Tang YW (Laboratory Medicine), Miller MB.
Microbiol Spectr. 2022 Jun 29;e0124822. doi: 10.1128/spectrum.01248-22. Online ahead of print.
Summary: In this article, the authors compare the accuracy of 3 tests for detecting non-COVID-19 respiratory pathogens such as rhinovirus/enterovirus or influenza.
Outcomes of gynecological cancer surgery during the COVID-19 pandemic: An international, multicenter, prospective CovidSurg-GO Cancer study. [Article]
Fotopoulou C, Khan T, Bracinik J, Glasbey J, Abu-Rustum N (Surgery), Chiva L, Fagotti A, Fujiwara K, Ghebre R, Gutelkin M, Konney TO, Ng J, Pareja R, Seenivasagam RK, Sehouli J, Surappa S, Bhangu A, Leung E, Sundar S; CovidSurg Gynecological cancer collaborators.
Am J Obstet Gynecol. 2022 Nov;227(5):735.e1-735.e25. doi: 10.1016/j.ajog.2022.06.052. Epub 2022 Jun 30.
Summary: The CovidSurg-Cancer Consortium studied the impact of COVID-19 on delaying surgeries for gynecologic cancer. The prospective cohort study was conducted internationally in 227 centers.
Barotrauma in COVID 19: Incidence, pathophysiology, and effect on prognosis. [Article]
Steinberger S, Finkelstein M, Pagano A (Radiology), Manna S, Toussie D, Chung M, Bernheim A, Concepcion J, Gupta S, Eber C, Dua S, Jacobi AH.
Clin Imaging. 2022 Oct;90:71-77. doi: 10.1016/j.clinimag.2022.06.014. Epub 2022 Jun 28.
Summary: A retrospective study of 363 patients with COVID-19 between March 1, 2020 and April 8, 2020, with authors noting barotrauma is a frequent complication of mechanically ventilated COVID-19 patients and those with barotrauma have a higher rate of pneumothorax and an increased risk of death.
Use of asynchronous interprofessional e-Consults in cancer patients during the COVID-19 pandemic: Current and future role.
Gordon A (Medicine), Rotemberg V (Medicine), Love D (Medicine), Kurtansky NR (Medicine), Pagel D (Medicine), Mones J (Medicine).
Telemed J E Health. 2022 Jun 28. doi: 10.1089/tmj.2021.0531. Online ahead of print.
Summary: This article analyzed the use of asynchronous provider-to-provider communications at Memorial Sloan Kettering Cancer Center during the COVID-19 pandemic from January to December 2020. Asynchronous communications are conducted via portal messages or interprofessional e-consults.
The critical need for a meaning-centered team-level intervention to address healthcare provider distress now. [Essay]
Rosa WE (Psychiatry Service), Roberts KE, Schlak AE, Applebaum AJ (Psychiatry Service), Breitbart WS (Psychiatry Service), Kantoff EH (Psychiatry Service), Pessin H (Psychiatry Service), Lichtenthal WG (Psychiatry Service).
Int J Environ Res Public Health. 2022 Jun 25;19(13):7801. doi: 10.3390/ijerph19137801.
Summary: This article discusses how Meaning-Centered Psychotherapy, an intervention developed initially to help cancer patients, could be adapted to assist with healthcare providers' burnout and distress.
“Doing palliative care with my hands tied behind my back”: telepalliative care delivery for oncology inpatients during a COVID-19 surge. [Article]
Rosa WE (Psychiatry Service), Lynch KA (Psychiatry Service), Hadler RA, Mahoney C (Human Resources), Parker PA (Psychiatry Service).
Transl Behav Med. 2022 Jun 18;ibac044. doi: 10.1093/tbm/ibac044. Online ahead of print.
Summary: In this study, the authors interviewed 11 palliative specialists from diverse roles, such as "social workers, pharmacists, chaplaincy services, physicians, and advanced practice providers," providing telehealth care. The participants shared their experience with telepalliative care, reporting on challenges and facilitators.
99mTc-Vitamin C SPECT/CT imaging in SARS-CoV-2 associated pneumonia. [Clinical Vignette]
Sayman HB, Toplutas KN, Tunick J, Aras O (Radiology).
Nucl Med Rev Cent East Eur. 2022;25(2):127-128. doi: 10.5603/NMR.a2022.0026. Epub 2022 Jun 14.
Summary: The authors present imaging using lung 99mTc-Vitamin C SPECT/CT from two patients. Those images may help identify lung damage and its potential progression.
The Doctor will FaceTime you now: Commentary on telehealth in cancer care. [Commentary]
Feinberg J (Graduate Staff), Sonoda Y (Surgery).
Oncologist. 2022 Jun 8;27(6):428-429. doi: 10.1093/oncolo/oyac044.
Summary: This is a commentary on telehealth specific to the oncologic field. It discusses its impact on patient outcomes, quality of patient care, cost, access, and future role.
Delirium in critically ill cancer patients with COVID-19. [Article]
Bjerre Real C (Graduate Staff), Dhawan V (Anesthesiology), Sharma M (Psychiatry Service), Seier K (Biostatistics/Epidemiology), Tan KS (Biostatistics/Epidemiology), Matsoukas K (Medical Library), Maloy M (Health Informatics), Voigt L (Anesthesiology), Alici Y (Psychiatry Service), Chawla S (Anesthesiology).
J Acad Consult Liaison Psychiatry. 2022 Nov-Dec;63(6):539-547. doi: 10.1016/j.jaclp.2022.05.005. Epub 2022 Jun 2.
Summary: This retrospective cohort single-center study looked at 70 critically ill cancer patients with a confirmed COVID-19 diagnosis over a ~4 month period early in the pandemic (3/1/2020-7/10/2020) to evaluate their delirium frequency and outcomes. Results showed this study population had a high incidence of delirium and patients with delirium had higher hospital and ICU stays and ventilation days, however, no statistically significant difference in hospital mortality. Also, patients being administered cancer-directed therapies were less likely to be positive for delirium.
Acute cardiac side effects after COVID-19 mRNA vaccination: a case series. [Article]
Freise NF, Kivel M, Grebe O, Meyer C, Wafaisade B, Peiper M, Zeus T, Schmidt J, Neuwahl J, Jazmati D, Luedde T, Bölke E, Feldt T, Jensen BEO, Bode J, Keitel V, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Knoefel WT, Schneider M, Gerber PA, Pedoto A (Anesthesiology), Häussinger D, van Griensven M, Rezazadeh A, Flaig Y, Kirchner J, Antoch G, Schelzig H, Matuschek C.
Eur J Med Res. 2022 Jun 2;27(1):80. doi: 10.1186/s40001-022-00695-y.
Summary: This paper reports on "a case series of eight consecutive patients with cardiac side effects after inoculation of either the first or the second dose of a mRNA vaccine against SARS-CoV-2." Study participants were young and healthy with no pre-vaccination cardiac history, however, study results suggested that "cardiac adverse events such as myocarditis or pericarditis shortly after SARS-CoV-2 mRNA vaccination are rare but possible and occur particularly in male patients."
The successes and challenges of SARS-CoV-2 molecular testing in the United States. [Review]
Dien Bard J, Babady NE (Laboratory Medicine).
Clin Lab Med. 2022 Jun;42(2):147-160. doi: 10.1016/j.cll.2022.02.007. Epub 2022 Mar 8.
Summary: This review paper describes the important role that molecular testing methods have played in the COVID-19 pandemic and discusses the challenges encountered and how these can be avoided in the future.
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses. [Article]
Lyudovyk O (SKI Epidemiology), Kim JY, Qualls D (Graduate Staff), Hwee MA (HOPP), Lin YH (HOPP), Boutemine SR (Medicine), Elhanati Y (SKI Epidemiology/Biostatistics), Solovyov A (SKI Epidemiology/Biostatistics), Douglas M (Ld-Advanced Practice Providers), Chen E, Babady NE (Laboratory Medicine), Ramanathan L (Laboratory Medicine), Vedantam P (Research Facilities), Bandlamudi C (Collaborative Research Centers), Gouma S, Wong P (Research Facilities), Hensley SE, Greenbaum B (Biostatistics/Epidemiology), Huang AC, Vardhana SA (Medicine).
Cancer Cell. 2022 Jul 11;40(7):738-753.e5. doi: 10.1016/j.ccell.2022.05.013. Epub 2022 May 30.
Summary: This important study analyzed cellular and humoral immune responses in 103 cancer patients with prior COVID-19 infection (based on SARS-CoV-2 positive PCR test, between March 1, 2020 and January 20, 2021) to establish whether B and CD4+ T cell immunity are key factors associated with delayed viral infection clearance and incidence of prolonged COVID-19 disease.
Pre-mortem skin biopsy assessing microthrombi, interferon-I antiviral and regulatory proteins, and complement deposition correlates with COVID-19 clinical stage. [Article]
Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ (Graduate Staff), Harp J, Ahamed J, Magro C.
Am J Pathol. 2022 May 28;S0002-9440(22)00149-3. doi: 10.1016/j.ajpath.2022.05.006. Online ahead of print.
Summary: This paper reports on an investigator-initiated, single institution prospective case series that included COVID-19 patient cohorts (between April 1, 2020 and December 31, 2020). The finding supports “the hypothesis that these microvascular changes may be a unique characteristic of COVID-19 ARDS versus other forms of ARDS” and may “refine the approach to predicting COVID-19 progression and intervening in its advance.”
Bacterial Infections and Antibiotic Utilization Varies by Coronavirus Disease 19 (COVID-19) Severity in Hospitalized Cancer Patients: Analysis from the First Phase of the Pandemic. [Article]
Maki KR (Pharmacy), Steiger SN (Pharmacy), Su Y (SKI Medicine), Boumiza A (Medicine), Tan CA (Pharmacy), Kerpelev M (Information Systems), Seo SK (Medicine), Cohen N (Pharmacy).
Infect Control Hosp Epidemiol. 2022 May 26;1-25. doi: 10.1017/ice.2022.129. Online ahead of print.
Summary: This observational study looked at hospitalized cancer patients with COVID-19 and bacterial co-infections. The results of this study can inform antibiotics use in this patient population.
COVID-19 double jeopardy: The overwhelming impact of the social determinants of health. [Review]
Badalov E, Blackler L (Ethics), Scharf AE (Ethics), Matsoukas K (Medical Library), Chawla S (Anesthesiology), Voigt LP (Anesthesiology), Kuflik A.
Int J Equity Health. 2022 May 24;21(1):76. doi: 10.1186/s12939-022-01629-0.
Summary: The article focuses on the effects of socioeconomic disparities on COVID-19 pandemic outcomes among vulnerable populations.
Plastic surgeons and their financial relationships with the industry in the era of COVID: Insights from the Physician Payments Sunshine Act. [Commentary]
Siotos C, Ferraro J, Horen SR, Siotou K, Lopez J (Graduate Staff), Dorafshar AH.
Aesthetic Plast Surg. 2022 Dec;46(6):3111-3116. doi: 10.1007/s00266-022-02944-1. Epub 2022 May 20.
Summary: The study compared industry payments to plastic surgeons before and during the COVID-19 pandemic and found that the pandemic had a significant impact on such payments.
Partial ORF1ab gene target failure with Omicron BA.2.12.1. [Research Article]
Rodino KG, Peaper DR, Kelly BJ, Bushman F, Marques A, Adhikari H, Tu ZJ, Marrero Rolon R, Westblade LF, Green DA, Berry GJ, Wu F, Annavajhala MK, Uhlemann AC, Parikh BA, McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Babady NE (Laboratory Medicine), Hahn AM, Koch RT, Grubaugh ND; Yale SARS-CoV-2 Genomic Surveillance Initiative, Rhoads DD.
J Clin Microbiol. 2022 Jun 15;60(6):e0060022. doi: 10.1128/jcm.00600-22. Epub 2022 May 18.
Summary: This article describes a particular indicator of a SARS-CoV-2 variant (Omicron BA.2.12.1) with both high diagnostic sensitiviy and specificity, that may provide a method for rapid detection of the variant.
Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies. [Letter]
Stuver R (Graduate Staff), Shah GL (Medicine), Roeker LE (Medicine), Mato AR (Medicine), Batlevi CL (Medicine), Chung DJ (Medicine), Doddi S (Laboratory Medicine), Falchi L (Medicine), Gyurkocza B (Medicine), Hamilton A (Medicine), Lin YH (Medicine), Jakubowski AA (Medicine), Joffe E (Medicine), Landau HL (Medicine), Lin RJ (Medicine), Mailankody S (Medicine), Palomba ML (Medicine), Park JH (Medicine), Perales MA (Medicine), Ponce DM (Medicine), Ramanathan LV (Laboratory Medicine), Salles GA (Medicine), Scordo M (Medicine), Seo SK (Medicine), Shah UA (Medicine), Stein EM (Medicine), Straus D (Medicine), Usmani SZ (Medicine), Young JW (Medicine), Zelenetz AD (Medicine), Noy A (Medicine), Vardhana SA (Medicine).
Cancer Cell. 2022 2022 Jun 13;40(6):590-591. doi: 10.1016/j.ccell.2022.05.007. Epub 2022 May 16.
Summary: This letter reports on a randomized clinical trial involving patients with hematological malignancies, a population especially vulnerable to COVID-19. The experimental group was treated with AZD7442, the combined monoclonal product AZD7442/Evusheld (tixagevimab-cilgavimab) that has been granted emergency use authorization (EUA). The drug was developed and studied before emergence of the Omicron variant. The trial showed reduced activity of the substance against the Omicron strain. The trial results, however, support the 300 mg dose of AZD7442 pre-exposure prophylaxis.
Reflectance confocal microscopy examinations of COVID-19 vaccination sites: A prospective observational study. [Research Letter]
Manci R (Graduate Staff), Nazir ZH (Graduate Staff), Marghoob AA (Medicine), Cordova M (Medicine).
JAAD Int. 2022 May 16. doi: 10.1016/j.jdin.2022.05.009. Online ahead of print.
Summary: In this study an imaging optical techique called Reflectance Confocal Microscopy (RCM) was used to track skin changes following COVID-19 vaccination with mRNA vaccines (Pfizer and Moderna). The study was conducted in a small sample of subjects and the findings should be viewed as secondary to local immune response to the vaccine. The methodology used may pave a way to identify potential vaccine non-responders.
"It took away and stripped a part of myself": Clinician distress and recommendations for future telepalliative care delivery in the cancer context. [Article]
Rosa WE (SKI Psychiatry), Lynch KA (Psychiatry), Hadler RA, Mahoney C (Psychiatry), Parker PA (Psychiatry).
Am J Hosp Palliat Care. 2022 May 15;10499091221101883. doi: 10.1177/10499091221101883.
Summary: This study explored the experiences of a multidisciplinary palliative care team delivering telepalliative care for oncology inpatients during the peak of the COVID-19 pandemic in New York City. The interviews conducted in the course of the study identified clinician distress as a primary experience stemming from the challenges of the situation. Participants provided detailed recommendations to improve telepalliative care delivery for hospitalized oncology patients in the future.
COVID-19 After Lung Resection in Northern Italy. [Article]
Scarci M, Raveglia F, Bortolotti L, Benvenuti M, Merlo L, Petrella L, Cardillo G, Rocco G (Surgery).
Semin Thorac Cardiovasc Surg. Summer 2022;34(2):726-732. doi: 10.1053/j.semtcvs.2021.03.038. Epub 2021 May 11.
Summary: This multicenter study (4 northern Italian medical centers) looked at the impact of COVID-19 on thoracic surgical patients, exploring the postoperative and recovery time (~ 90 days) outcomes of 107 patients who underwent lung resection from December 2019 to March 2020, twelve of which developed COVID-19 disease. Patients who developed COVID disease symptoms were at a possible higher risk of death, and factors such as BMI, smoking history, DLCO/VA%, number of resected segments and duration of surgery possibly put thoracic surgical patients at greater risk to develop COVID.
2019 (COVID-19) symptoms at diagnosis among healthcare personnel before and after the emergence of the omicron variant. [Concise Communication]
Laracy JC (Medicine), Robilotti EV (Medicine), Yan J (Infection Control), Lucca A (Employee Health & Wellness), Aslam A (Infection Control), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Infect Control Hosp Epidemiol. 2022 May 4;1-3. doi: 10.1017/ice.2022.105. Online ahead of print.
Summary: During the omicron surge of COVID-19 in December 2021-January 2022, healthcare professionals at MSK were more likely to have asymptomatic disease at the time of diagnosis compared to those who had COVID from May to October 2021. The most common symptoms were sore throat and cough.
Impact of exercise on susceptibility and severity of COVID-19 in patients with cancer: A retrospective study. [Article]
Bliss JW, Lavery JA (Biostat/Epidemiology), Underwood WP (Medicine), Chun SS (Medicine), Fickera GA (Research Service Centers), Lee CP (Medicine), Corcoran S (Medicine), Maloy MA (Health Informatics), Polubriaginof FC (Health Informatics), Kelly DW (Information Systems), Scott JM (Medicine), Boutros PC, Moskowitz CS (Biostatistics & Epidemiology), Jones LW (Medicine).
Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):1036-1042. doi: 10.1158/1055-9965.EPI-21-1186.
Summary: Self questionnaires of a mixed sample of cancer patients and survivors suggest that moderate exercise may lessen the risk of COVID-19 diagnosis compared to a more sedentary lifestyle, but does not impact disease severity.
The impact of androgen deprivation therapy on COVID-19 illness in men With prostate cancer. [Article]
Shah NJ (Medicine), Patel VG, Zhong X, Pina L, Hawley JE, Lin E, Gartrell BA, Febles VA, Wise DR, Qin Q, Mellgard G, Joshi H, Nauseef JT, Green DA, Vlachostergios PJ, Kwon DH, Huang F, Liaw B, Tagawa S, Kantoff P (Medicine), Morris MJ (Medicine) , Oh WK.
JNCI Cancer Spectr. 2022 May 2;6(3):pkac035. doi: 10.1093/jncics/pkac035.
Summary: This retrospective cohort multicenter study (7 US medical centers) looked at prostate cancer patients (inpatient and outpatient) with a confirmed COVID-19 diagnosis over a 3 month period early in the pandemic (3/1/2020-5/31/2020). Clinical data was collected on 465 patients and analyzed but no statistically significant relationship was found to exist between androgen deprivation therapy use and more severe COVID-19 illness outcomes.
Association between the COVID-19 pandemic and disparities in access to major surgery in the US. [Original Investigation]
Glance LG, Chandrasekar EK, Shippey E, Stone PW, Dutton R, McCormick PJ (Anesthesiology), Shang J, Lustik SJ, Wu IY, Eaton MP, Dick AW.
JAMA Netw Open. 2022 May 2;5(5):e2213527. doi: 10.1001/jamanetworkopen.2022.13527.
Summary: The Centers for Medicare & Medicaid Services (CMS) forced hospitals to stop performing nonessential surgeries during the first wave of COVID-19 in the United States. This study of nearly 3.5 million patients across 719 hospitals found that racial minority groups were not disproportionately impacted by the moratorium.
The continuing impacts of the COVID-19 pandemic on diagnosis and surgical prostate cancer management: a population-based analysis. [Perspective]
Papa N, Roberts MJ, Perera M (Surgery)
ANZ J Surg. 2022 May;92(5):950-952. doi: 10.1111/ans.17646. Epub 2022 Apr 2.
Summary: This paper explores trends in prostate cancer screening and surgery volume in Australia from January 2020 through December 2021 and compares those rates to the preceding 10 years.
Perioperative corneal injury: An unseen casualty of Covid-19. [Article]
Yeoh CB (Anesthesiology), Seier KP (Biostat/Epidemiology), Francis J (Surgery), Abramson DH (Surgery), Tan KS (Biostat/Epidemiology), Tollinche LE (Anesthesiology).
JOJ Ophthalmol. 2022 Apr;9(2):555757. doi: 10.19080/jojo.2022.09.555757. Epub 2022 Apr 26.
Summary: A retrospective cross-sectional observational study of all Reporting to Improve Safety and Quality (RISQ) corneal injury reports at Memorial Sloan Kettering Cancer Center between January 1, 2015 and April 30, 2021, with authors noting an increased incidence in perioperative corneal injuries during the COVID-19 pandemic.
Axillary lymph node characteristics in breast cancer patients versus post-COVID-19 vaccination: Overview of current evidence per imaging modality. [Review]
van Nijnatten TJA, Jochelson MS (Radiology), Lobbes MBI.
Eur J Radiol. 2022 Apr 30;152:110334. doi: 10.1016/j.ejrad.2022.110334. Online ahead of print.
Summary: Lymph node abnormalities resulting from COVID-19 vaccinations often have different characteristics from those caused by cancer. Still, any suspicious lymph nodes on the same side as breast cancer call for biopsy.
Investigation of the readability and reliability of online health Iinformation for cancer patients during the coronavirus pandemic. [Article]
Schluter C, Fefer M, Lee G, Alty IG, Dee EC (Graduate Staff).
J Cancer Educ. 2022 Apr 25;1-5. doi: 10.1007/s13187-022-02140-4. Epub ahead of print.
Summary: Online health information relating to COVID-19 and cancer was found to be of good quality but received readability scores significantly above the recommended grade level 6.
One committee to review it all: A single, multi-disciplinary COVID-19 research committee. [Article]
Migliacci J (Research and Technology Management), Rodavitch A (Research and Technology Management), Riely G (Medicine), Sabbatini P (Medicine), Houston C (Research and Technology Management), Hanley S (Research and Technology Management).
Contemp Clin Trials. 2022 Jun;117:106760. doi: 10.1016/j.cct.2022.106760. Epub 2022 Apr 20.
Summary: This article describes the creation of a COVID-19 Research Committee at MSK that reviewed research protocols with the aim of minimizing bottlenecks, reducing redundancies, and boosting transparency through an internal portal.
COVIDNearTerm: A simple method to forecast COVID-19 hospitalizations. [Article]
Olshen AB, Garcia A, Kapphahn KI, Weng Y, Vargo J, Pugliese JA, Crow D, Wesson PD, Rutherford GW, Gonen M (Biostat/Epidemiology), Desai M.
J Clin Transl Sci. 2022 Apr 19;6(1):e59. doi: 10.1017/cts.2022.389. eCollection 2022.
Summary: A method for predicting hospitalizations from COVID-19 two to four weeks from the time of prediction, evaluated on San Francisco Bay Area hospitalizations.
Remaining Agile in the COVID-19 pandemic healthcare landscape - How we adopted a hybrid telemedicine geriatric oncology care model in an academic tertiary cancer center. [Article]
Chen M, Mohd Said N, Mohd Rais NC, Ho F, Ling N, Chun M, Ng YS, Eng WN, Yao Y, Korc-Grodzicki B (Medicine), Pang A.
J Geriatr Oncol. 2022 Apr 13;S1879-4068(22)00080-7. doi: 10.1016/j.jgo.2022.04.006. Epub ahead of print.
Summary: Nearly 85 percent of a cohort of 250 patients aged 65 and above of the National University Cancer Institute, Singapore (NCIS) were satisfied with a hybrid telemedicine care model.
Effects of COVID-19 on mastectomy and breast reconstruction rates: A national surgical sample. [Research Article]
Rubenstein RN (SKI Surgery), Stern CS (Surgery), Plotsker EL (SKI Surgery), Haglich K (Surgery), Tadros AB (Surgery), Mehrara BJ (Surgery), Matros E (Surgery), Nelson JA (Surgery).
J Surg Oncol. 2022 Aug;126(2):205-213. doi: 10.1002/jso.26889. Epub 2022 Apr 12.
Summary: Using the National Surgical Quality Improvement Program, the authors show that during the first year of the Covid-19 pandemic there was an 11% decline in breast cancer surgeries.
Association between antidiabetic drug use and the risk of COVID-19 hospitalization in the INSIGHT Clinical Research Network in New York City. [Research Letter]
Min JY, Simmons W, Banerjee S, Wang F, Williams N, Zhang Y, Reese AB, Mushlin AI, Flory JH (Medicine).
Diabetes Obes Metab. 2022 Apr 4. doi: 10.1111/dom.14704. Epub ahead of print.
Summary: In the retrospective study, the authors examined antidiabetic drugs' effect on Covid-19 infections and adverse outcomes. 30,747 patients were included in the study.
Vive la résistance: T-cell immunity in the protection against SARS-CoV-2 infection. [Editorial]
McGary LHF (GSK Graduate Student), Vardhana SA (Medicine).
Cancer Discov. 2022 Apr 1;12(4):892-894. doi: 10.1158/2159-8290.CD-22-0080.
Summary: In this spotlight, the authors comment on the article published by Fahrner et al. titled "The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals."
Positive practice changes after the COVID-19 pandemic: From the Advanced Practice Provider perspective. [Meeting Report]
Harvey RD, Begue A (Ld-Advanced Practice Providers), Raine C, Yabroff R.
J Adv Pract Oncol. 2022 Apr;13(3):198-201. doi: 10.6004/jadpro.2022.13.3.2. Epub 2022 May 23.
Summary: Journal of the Advanced Practitioner in Oncology Live Virtual 2021 panelists' perspectives of the COVID-19 pandemic and how to respond to future crises that may impact cancer patients and practices.
Using technology to enhance cancer clinical trial participation. [Article]
Haynes RM, Sirintrapun SJ (Pathology), Gao J, McKenzie AJ.
Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-7. doi: 10.1200/EDBK_349671.
Summary: A description of how the COVID-19 pandemic impacted cancer clinical trials at Memorial Sloan Kettering Cancer Center, the Sarah Cannon Research Institute, the U.S. Food and Drug Administration Oncology Center of Excellence, and for a patient diagnosed with early-stage breast cancer.
Cost-effectiveness analysis of statins for the treatment of hospitalized COVID-19 patients. [Original Article]
Chow R, Simone CB (Radiation Oncology), Prsic EH, Shin HJ.
Ann Palliat Med. 2022 Jul;11(7):2285-2290. doi: 10.21037/apm-21-2797. Epub 2022 Mar 30..
Summary: The authors of this paper underwent a cost-effectiveness study on using statins to treat patients hospitalized with Covid-19. They conclude that additional randomized controlled trials should be done on statins as they appear to be cost-effective candidates.
An autoantigen atlas from human lung HFL1 cells offers clues to neurological and diverse autoimmune manifestations of COVID-19. [Research Article]
Wang JY, Zhang W, Roehrl VB, Roehrl MW, Roehrl MH (Pathology).
Front Immunol. 2022 Mar 24;13:831849. doi: 10.3389/fimmu.2022.831849. eCollection 2022.
Summary: This article describes a COVID autoantigen atlas developed from the proteins from human fetal lung fibroblast HFL11 cells. This autoantigenome information contributes to a detailed molecular map that can be used to investigate neurological and autoimmune manifestations of COVID-19.
Understanding T-cell responses to COVID-19 is essential for informing public health strategies. [Viewpoint]
Vardhana S (Medicine), Baldo L, Morice WG 2nd, Wherry EJ.
Sci Immunol. 2022 May 20;7(71):eabo1303. doi: 10.1126/sciimmunol.abo1303. Epub 2022 May 20.
Summary: In this viewpoint, the authors describe how a better understanding of T-cell response and detection would help with a future public health plan of action toward COVID-19.
Associations between longitudinal changes in sleep disturbance and depressive and anxiety symptoms during the COVID-19 virus pandemic among older women with and without breast cancer in the thinking and living with breast cancer study. [Article]
Bethea TN, Zhai W, Zhou X, Ahles TA (Psychiatry Service), Ahn J, Cohen HJ, Dilawari AA, Graham DMA, Jim HSL, McDonald BC, Nakamura ZM, Patel SK, Rentscher KE, Root J (Psychiatry Service), Saykin AJ, Small BJ, Van Dyk KM, Mandelblatt JS, Carroll JE.
Cancer Med. 2022 Sep;11(17):3352-3363. doi: 10.1002/cam4.4682. Epub 2022 Mar 22.
Summary: In this paper, the authors analyzed if older women with breast cancers and women without cancer had a similar response to lack of sleep because of the Covid-19 pandemic.
SARS-CoV-2 can infect human embryos. [Preprint]
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Developmental Biology), Hadjantonakis AK (Developmental Biology), Coates A, Barnes FL, Zouves CG, Greene WC, Viotti M.
bioRxiv. 2022 Mar 18. doi: https://doi.org/10.1101/2021.01.21.427501
Summary: In this preprint paper, which is not yet peer-reviewed, the authors assess if human embryos could be susceptible to Covid-19 infection.
Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination. [Article]
Horvat JV (Radiology), Sevilimedu V (Biostatistics & Epidemiolgy), Becker AS (Radiology), Perez-Johnston R (Radiology), Yeh R (Radiology), Feigin KN (Radiology).
Eur Radiol. 2022 Mar 5. doi: 10.1007/s00330-022-08655-0. Epub ahead of print.
Summary: In this retrospective cohort study, 357 patients who underwent breast MRI following COVID-19 vaccination (between January 22, 2021 to March 21, 2021) were studied to assess the frequency of ipsilateral axillary adenopathy. It was concluded that adenopathy is a frequent event that can last 4-8 weeks after the second vaccine dose and therefore longer follow-up periods were favored for patients without a current ipsilateral breast cancer diagnosis.
Vulnerabilities in workplace features for essential workers with breast cancer: Implications for the COVID-19 pandemic. [Article]
Klugman M, Patil S (Biostatistics & Epidemiology), Gany F (Psychiatry), Blinder V (Psychiatry).
Work. 2022;71(4):815-823. doi: 10.3233/WOR-211095. Epub 2022 Mar 3.
Summary: In this study looking at the workplace environment of essential workers, data on a cohort of 563 women who underwent breast cancer treatment between 2010-2018 was analyzed based on whether they were essential or non-essential workers and other characteristics. Researchers compared job benefits and perceptions of workplace environment between groups and one of the study findings was that non-union essential workers were more vulnerable in terms of workplace protections.
Development of an easily reproducible cough simulator With droplets and aerosols for rapidly testing novel personal protective equipment. [Technical Report]
Zhou G, Burnett GW, Shah RS (Anesthesiology), Lai CY, Katz D, Fried EA.
Simul Healthc. 2022 Oct 1;17(5):336-342. doi: 10.1097/SIH.0000000000000644. Epub 2022 Mar 4.
Summary: This techical report describes the creation of a cough and particle simulator to test personal protective equipment from droplets and aerosols.
The effect of neutropenia and filgrastim (G-CSF) on cancer patients with coronavirus disease 2019 (COVID-19) infection. [Observational Study]
Morjaria S (Medicine), Zhang AW, Kaltsas A (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Operation Excellence), Predmore J (Ld - Advanced Practice Providers), Perez-Johnston R (Radiology), Jee J (Graduate Fellow), Perales MA (Medicine), Daniyan AF (Medicine), Taur Y (Medicine), Mailankody S (Medicine).
Clin Infect Dis. 2022 Mar 1;74(4):567-574. doi: 10.1093/cid/ciab534.
Summary: The study looked at hospitalized cancer patients with neutropenia (a condition that commonly affects cancer patients and is treated with recombinant human granulocyte colony-stimulating factor, G-CSF, filgrastim) who also had COVID-19 infection. The retrospective study found that neutropenia did not affect the course of COVID-19 infection in such patients but CSF administration did. The authors recommended exercising caution and weighing risks vs benefits of SCF treatment of neutropenic patients with COVID-19 infection.
Use of communication technology to improve clinical trial participation in adolescents and young adults with cancer: Consensus statement from the Children's Oncology Group Adolescent and Young Adult Responsible Investigator Network. [Consensus Statement]
Avutu V (Medicine), Monga V, Mittal N, Saha A, Andolina JR, Bell DE, Fair DB, Flerlage JE, Frediani JN, Heath JL, Kahn JM, Reichek JL, Super L, Terao MA, Freyer DR, Roth ME.
JCO Oncol Pract. 2022 Mar;18(3):224-231. doi: 10.1200/OP.21.00554. Epub 2021 Dec 14.
Summary: This consensus statement by the Children’s Oncology Group (COG) AYA Responsible Investigator (RI) Network "reviews opportunities to use technology to optimize AYA trial enrollment and study conduct, as well as considerations for widespread implementation of these practices," something which became more relevant due to the COVID-19 pandemic when communication technology was more rapidly adopted.
sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs [Article]
Di Gioacchino A, Legendre R, Rahou Y, Najburg V, Charneau P, Greenbaum BD (Biostatistics & Epidemiology), Tangy F, van der Werf S, Cocco S, Komarova AV.
RNA. 2022 Mar;28(3):277-289. doi: 10.1261/rna.078969.121. Epub 2021 Dec 22.
Summary: This article presents the development of a new bioinformatics tool, the sgDI-tector to detect sgRNA expression levels in COVID-19.
A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases. [Article]
Wang JY, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
J Transl Autoimmun. 2022;5:100147. doi: 10.1016/j.jtauto.2022.100147. Epub 2022 Feb 25.
Summary: This article describes a model of how viral infections, and specifically SARS-Cov-2 infection, can lead to autoimmune disease. The authors identified a database of over 700 candidate autoantigens that can be further investigated in regards to the large number of auto-immune-related adverse events due to COVID-19.
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture. [Article]
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W (Structural Biology), Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J.
Commun Biol. 2022 Feb 22;5(1):154. doi: 10.1038/s42003-022-03101-9.
Summary: This study provides further evidence to the use of combination drugs that work against SARS-Cov-2 polymerase and exonuclease to provide better therapeutic responses for effective COVID-19 treatment.
Crimean-Congo haemorrhagic fever during the COVID-19 pandemic in Africa: Efforts, recommendations and challenges at hand. [Commentary]
Greene L (Medicine), Uwishema O, Nicholas A, Kapoor A, Berjaoui C, Adamolekun E, Khoury C, Yagoub FEAM, Onyeaka H.
Afr J Emerg Med. 2022 Feb 21. doi: 10.1016/j.afjem.2022.02.004. Epub ahead of print.
Summary: This commentary describes how one of the affects of the COVID-19 pandemic has been the reallocation of attention and resources from other diseases and outbreaks that are often significantly more fatal, such as the Crimean-Congo Haemorrhagic Fever outbreak in Africa.
Baseline haemoglobin A1c and the risk of COVID-19 hospitalization among patients with diabetes in the INSIGHT Clinical Research Network. [Research Article]
Min JY, Williams N, Simmons W, Banerjee S, Wang F, Zhang Y, Reese AB, Mushlin AI, Flory JH (Medicine).
Diabet Med. 2022 May;39(5):e14815. doi: 10.1111/dme.14815. Epub 2022 Feb 28..
Summary: This research examined the association between the risk of COVID-19 hospitalization in diabetic patients with higher baseline HbA1c. Diabetic patients with poor glucose control are at significantly increased risk for hospitalization from COVID-19 and healthcare providers should be providing increased preventative efforts in these patients.
Duodenal tropism of SARS-CoV-2 and clinical findings in critically ill COVID-19 patients. [Original Paper]
Neuberger M, Jungbluth A (Pathology), Irlbeck M, Streitparth F, Burian M, Kirchner T, Werner J, Rudelius M, Knösel T.
Infection. 2022 Oct;50(5):1111-1120. doi: 10.1007/s15010-022-01769-z. Epub 2022 Feb 18.
Summary: In this retrospective study, the authors show that 8% of critically ill COVID-19 patients could develop a duodenal infection as an adverse event of COVID-19 infection.
What experts think about prostate cancer management during the COVID-19 pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. [Brief Correspondence]
Turco F, Armstrong A, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E, Efstathiou J, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ (Medicine), et al.
Eur Urol. 2022 2022 Jul;82(1):6-11. doi: 10.1016/j.eururo.2022.02.010. Epub 2022 Feb 17.
Summary: In this correspondence, the authors report on experts' advanced prostate cancer management recommendations during the COVID-19 pandemic after attending the Advanced Prostate Cancer Consensus Conference 2021.
Nursing communication skills training: Added importance during crises [Article]
Roman A (Nursing), Pineiro AV (Nursing).
J Nurses Prof Dev. 2022 Feb 17. doi: 10.1097/NND.0000000000000868. Epub ahead of print.
Summary: This article describes how nursing communication and communication skills training are vital during times of crisis such as during the COVID-19 pandemic, and how the pandemic impacted the design of a communication skills training program.
Geriatric risk factors for serious COVID-19 outcomes among older adults with cancer: a cohort study from the COVID-19 and Cancer Consortium. [Article]
Elkrief A, Hennessy C, Kuderer NM, Rubinstein SM, Wulff-Burchfield E, Rosovsky RP, Vega-Luna K, Thompson MA, Panagiotou OA, Desai A, Rivera DR, Khaki AR, Tachiki L, Lynch RC, Stratton C, Elias R, Batist G, Kasi A, Shah DP, Bakouny Z, Cabal A, Clement J, Crowell J, Dixon B, Friese CR, Fry SL, Grover P, Gulati S, Gupta S, Hwang C, Khan H, Kim SJ, (Ld-Advanced Practice Providers), Klein EJ, Labaki C, McKay RR, Nizam A, Pennell NA, Puc M, Schmidt AL, Shahrokni A (Medicine), Shaya JA, Su CT, Wall S, Williams N, Wise-Draper TM, Mishra S, Grivas P, French B, Warner JL, Wildes TM
Lancet Healthy Longev. 2022 Feb 14. doi: 10.1016/S2666-7568(22)00009-5. Epub ahead of print.
Summary: This observational study aimed at quantifying the association of a novel geriatric risk index, comprising patient age and other parameters, with COVID-19 severity and outcomes. The index was found to be able to help clinicians in identifying older adults most at risk for severe COVID-19.
Coinfections in Patients With Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Study. [Article]
Satyanarayana G, Enriquez KT, Sun T, Klein EJ, Abidi M, Advani SM, Awosika J, Bakouny Z, Bashir B, Berg S, Bernardes M (Graduate Staff), Egan PC, Elkrief A, Feldman LE, Friese CR, Goel S, Gomez CG, Grant KL, Griffiths EA, Gulati S, Gupta S, Hwang C, Jain J, Jani C, Kaltsas A (Medicine), Kasi A, Khan H, Knox N, Koshkin VS, Kwon DH, Labaki C, Lyman GH, McKay RR, McNair C, Nagaraj G, Nakasone ES, Nguyen R, Nonato TK, Olszewski AJ, Panagiotou OA, Puc M, Razavi P, Robilotti EV (Medicine), Santos-Dutra M, Schmidt AL, Shah DP, Shah SA, Vieira K, Weissmann LB, Wise-Draper TM, Wu U, Wu JT, Choueiri TK, Mishra S, Warner JL, French B, Farmakiotis D.
Open Forum Infect Dis. 2022 Feb 14;9(3):ofac037. doi: 10.1093/ofid/ofac037. eCollection 2022 Mar.
Summary: This study identified factors associated with the risk of coinfection in cancer patients with COVID-19 with other infections (bacterial, viral and fungal). Clinical and laboratory indicators can guide antimicrobial therapy, which may improve clinical outcomes.
Prevention is political: political party affiliation predicts perceived risk and prevention behaviors for COVID-19. [Research]
Kiviniemi MT, Orom H, Hay JL (Psychiatry), Waters EA.
BMC Public Health. 2022 Feb 14;22(1):298. doi: 10.1186/s12889-022-12649-4.
Summary: In this study, the authors surveyed 410 participants to assess if political affiliation impacted risk perception regarding COVID-19. They found that people affiliated with the Republican party were most likely to have a lower perceived risk for themselves and others and less likely to engage in preventive behavior toward COVID-19.
What Are sustainable solutions for pandemic personal protective equipment? [Editorial]
Kleber J (Nursing).
Clin J Oncol Nurs. 2022 Feb 1;26(1):120. doi: 10.1188/22.CJON.120.
Summary: A brief column discussing challenges with sourcing sufficient single-use personal protective equipment and the environmental concerns with its disposal, along with innovative patient care strategies that resulted when more carefully considering its use.
A definitive prognostication system for patients with thoracic malignancies diagnosed with COVID-19: an update from the TERAVOLT registry. [Article]
Whisenant JG, Baena J, Cortellini A, Huang LC, Lo Russo G, Porcu L, Wong SK, Bestvina CM, Hellmann MD (Medicine), Roca E, Rizvi H (Collaborative Research Centers), Monnet I, Boudjemaa A, Rogado J, Pasello G, Leighl NB, Arrieta O, Aujayeb A, Batra U, Azzam AY, Unk M, Azab MA, Zhumagaliyeva AN, Gomez-Martin C, Blaquier JB, Geraedts E, Mountzios G, Serrano-Montero G, Reinmuth N, Coate L, Marmarelis M, Presley CJ, Hirsch FR, Garrido P, Khan H, Baggi A, Mascaux C, Halmos B, Ceresoli GL, Fidler MJ, Scotti V, Métivier AC, Falchero L, Felip E, Genova C, Mazieres J, Tapan U, Brahmer J, Bria E, Puri S, Popat S, Reckamp KL, Morgillo F, Nadal E, Mazzoni F, Agustoni F, Bar J, Grosso F, Avrillon V, Patel JD, Gomes F, Ibrahim E, Trama A, Bettini AC, Barlesi F, Dingemans AM, Wakelee H, Peters S, Horn L, Garassino MC, Torri V.
J Thorac Oncol. J Thorac Oncol. 2022 May;17(5):661-674. doi: 10.1016/j.jtho.2021.12.015. Epub 2022 Feb 1.
Summary: An international study of 1,491 patients from 18 countries found that COVID outcomes for patients with thoracic cancers depended on seven main factors, including age, cancer stage, and whether or not the patient developed pneumonia.
Yield of flow cytometry in addition to cytology for lymph node sampling in patients with incidental axillary adenopathy without a concurrent diagnosis of primary breast malignancy. [Article]
Lo Gullo R (Radiology), Cloutier Lambert C, Lin O (Pathology), Jochelson MS (Radiology), D'Alessio D (Radiology).
Breast Cancer Res Treat. 2022 Feb;191(3):677-683. doi: 10.1007/s10549-021-06473-4. Epub 2022 Jan 11.
Summary: This retrospective study looked at 222 patients being screened for suspicious lymphadenopathy to analyze the accuracy of fine-needle aspiration biopsy alone versus fine-needle aspiration biopsy combined with other tools such as flow cytometry.
Acute cardiac side effects after COVID-19 mRNA vaccination, a case series. [Preprint]
Freise NF, Kivel M, Grebe O, Meyer C, Wafaisade B, Peiper M, Zeus T, Schmidt J, Neuwahl J, Jazmati D, Luedde T, Bölke E, Feldt T, Jensen BEO, Bode J, Keitel V, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Knoefel WT, Schneider M, Gerber PA, Pedoto A (Anesthesiology), et al.
Research Square. 2021 Dec 28; doi: 10.21203/rs.3.rs-1157175/v1.
Summary: This retrospective study looked at eight patients who came to the hospital with cardiac symptoms following the first or second COVID vaccination. This is a preprint article, not yet peer-reviewed.
Dynamic COVID risk assessment accounting for community virus exposure from a spatial-temporal transmission model. [Article]
Chen Y (Biostat/Epidemiology), Fei W, Wang Q, Zeng D, Wang Y.
Adv Neural Inf Process Syst. 2021 Dec;34:27747-27760.
Summary: Proposed models and methods to assist public health decision-making and the clinical management of COVID-19 patients.
Postmortem biopsies of the lung, heart, liver, and spleen of COVID-19 patients. [Article]
Yurdaisik I, Demiroz AS, Oz AB, Akker M, Agirman A, Aksoy SH, Nurili F (Radiology).
Cureus. 2021 Dec 27;13(12):e20734. doi: 10.7759/cureus.20734.
Summary: This study reports on postmortem biopsies aimed at evaluating histopathologic changes in major organs of deceased COVID-19 patients.
sgDI-tector: Defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs. [Article]
Di Gioacchino A, Legendre R, Rahou Y, Najburg V, Charneau P, Greenbaum BD (Biostat/Epidemiology), Tangy F, van der Werf S, Cocco S, Komarova AV.
RNA. 2021 Dec 22;rna.078969.121. doi: 10.1261/rna.078969.121. (Epub ahead of print.)
Summary: This article reports on the development of a bioinformatics tool to be used in the study of the molecular mechanisms of SARS-CoV-2.
The hardest weeks of my life: A qualitative study of experiences, practice changes, and emotional burden of New York City oncology physicians during the COVID-19 surge in 2020. [Article]
Lynch KA (Psychiatry Service), Green A (Medicine), Saltz L (Medicine), Epstein AS (Medicine), Romano DR (Medicine), Vera J (Psychiatry Service), Nelson JE (Medicine).
JCO Oncol Pract. 2022 May;18(5):e669-e676. doi: 10.1200/OP.21.00585. Epub 2021 Dec 22.
Summary: Eighteen physicians were surveyed to share their experience as oncologists providing care during the 2020 COVID-19 surge. The authors hope to give guidance for future pandemics.
The association between Memorial Sloan Kettering Frailty Index with 30-day survival among patients aged ≥ 75 with cancer and COVID-19. [Article]
Kim SJ (Ld-Advanced Practice Providers), Fessele KL (Nursing), Tin AL (Biostat/Epidemiology), Malling C (SKI Psychiatry), Litchfield H (Medicine), Korc-Grodzicki B (Medicine), Shahrokni A. (Medicine)
J Geriatr Oncol. 2022 May;13(4):416-419. doi: 10.1016/j.jgo.2021.12.014. Epub 2021 Dec 21.
Summary: This study underscored the importance of frailty screening in the care management of older Covid-19 patients with cancer.
Telemedicine and dermatology hospital consultations during the COVID-19 pandemic: A multi-center observational Study on resource utilization and conversion to in-person consultations during the COVID-19 pandemic. [Letter to the Editor]
Trinidad J, Gabel CK, Bonomo L, Cartron A, Chand S, Coburn W, Daveluy S, Davis M, DeNiro KL, Guggina LM, Han JJ, Hennessy K, Hoffman M, Katz K, Keller JJ, Kim SJ, Konda S, Lake E, Lincoln FN, Lo JA, Markova A (Medicine), Marvin EK, Micheletti RG, Newman S, Nutan F, Nguyen CV, Pahalyants V, Patel J, Rahnama-Moghadam S, Rambhatla PV, Riegert M, Reingold RE (Graduate Student), Robinson DB, Rrapi R, Sartori-Valinotti JC, Seminario-Vidal L, Sharif-Sidi Z, Smogorzewski J, Spaccarelli N, Stewart JR, Tuttle SD, Ulrich MN, Wanat KA, Xia FD, Kaffenberger B, Kroshinsky D.
J Eur Acad Dermatol Venereol. 2022 May;36(5):e323-e325. doi: 10.1111/jdv.17898. Epub 2022 Jan 20.
Summary: This retrospective multi-center study, conducted from March to June 2020, assessed the utility of tele-dermatology in inpatient consultations.
Accelerated implementation of a virtual neurology clerkship amid a global crisis. [Review]
Govindarajan R, Vu AN, Salas RME, Miller AM (Neurology), Sandness DJ, Said RR, Southerland AM, Fernandez A, Romano S, Sennott BJ, Patino-Murillas J, Soni M; AAN Undergraduate Education Subcommittee and Education Committee.
Neurology. 2021 Dec 17;10.1212/WNL.0000000000013222. doi: 10.1212/WNL.0000000000013222. (Epub ahead of print.)
Summary: The Covid-19 pandemic changed the ways medical schools offered clerkships, or clinical experience, to medical students as part of their curricula. This article discusses different methods of virtual instruction, hybrid models of clerkship training, and implementation challenges in Neurology clerkship settings.
Pilot survey of adoption of telemedicine in Mohs surgery during the COVID-19 pandemic. [Article]
Maruthur M (Medicine), Lee E (Medicine), Dusza S (Medicine), Nehal K (Medicine), Rossi A. (Medicine)
Dermatol Surg. 2022 Feb 1;48(2):187-190. doi: 10.1097/DSS.0000000000003352. Epub Dec 14.
Summary: The article reports on the results of an online survey on telemedicine adoption distrubuted to the American College of Mohs Surgeons. The survey responses demonstrated that the Covid-19 pandemic triggered the use of telemedicine in managing patients undergoing Mohs surgery and identified the most common uses, barriers, and future plans for telemedicine in this settings.
Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: a comparative analysis across two New York hospitals. [Preprint]
Lambert B, Stopard IJ, Momeni-Boroujeni A (Graduate Fellow), Mendoza R, Zuretti A.
medRxiv. 2021 Dec 8. doi: 10.1101/2021.11.12.21266248.
Summary: This preprint describes a study of patients in two hospitals in NYC: SUNY Downstate Health Sciences University and Maimonides Medical Center. The researchers undertook quantifying the mortality risk associated not only with static data (e.g. demographics and patient history) but also with dynamic factors, such as changes in biomarkers, throughout hospitalisation.
COVID-19 outcomes of patients with gynecologic cancer in New York City: An updated analysis from the initial surge of the pandemic. [Article]
Lara OD, Smith M, Wang Y, O'Cearbhaill RE (Medicine), Blank SV, Kolev V, Carr C, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Cohen S, Fehniger J, Lee YC, Isani S, Liu M, Wright JD, Pothuri B.
Gynecol Oncol. 2022 Feb;164(2):304-310. doi: 10.1016/j.ygyno.2021.12.004. Epub 2021 Dec 7.
Summary: This article offers an update on COVID-19 outcomes among patients with gynecologic cancers in New York City during the initial surge of COVID-19. The data came from 8 NYC area hospital systems between March and June 2020.
Impact of COVID-19 delays on skin cancer worry and Mohs surgery for keratinocytic carcinoma. [Article]
Ruiz ES, Veldhuizen IJ (SKI Medicine), Abdullah A, Rossi A (Medicine), Nehal KS (Medicine), Schmults C, Waldman A, Lee EH (Medicine).
J Am Acad Dermatol. 2022 Oct;87(4):878-880. doi: 10.1016/j.jaad.2021.11.052. Epub 2021 Dec 4.
Summary: In this letter to the editor, the authors report the results of their study on cancer patients worrying about their skin cancer versus worrying about surgery delays caused by COVID-19.
Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study. [Article]
Rognvaldsson S, Eythorsson E, Thorsteinsdottir S, Vidarsson B, Onundarson PT, Agnarsson BA, Sigurdardottir M, Thorsteinsdóttir I, Olafsson I, Runolfsdottir HL, Helgason D, Emilsdottir AR, Agustsson AS, Bjornsson AH, Kristjansdottir G, Thordardottir AR, Indridason OS, Jonsson A, Gislason GK, Olafsson A, Steingrimsdottir H, Kampanis P, Hultcrantz M (Medicine), Durie BGM, Harding S, Landgren O, Palsson R, Love TJ, Kristinsson SY.
Blood Cancer J. 2021 Dec 1;11(12):191. doi: 10.1038/s41408-021-00580-7.
Summary: In this cohort study of 75,422 Icelandic patients, the authors studied the impact of monoclonal gammopathy of undetermined significance (MGUS) on being infected with COVID-19 and the severity of the disease. MGUS is a precursor of multiple myeloma.
FDG PET/CT imaging features and clinical utility in COVID-19. [Article]
Yeh R (Radiology), Elsakka A (Fellow), Wray R (Radiology), Perez Johnston R (Radiology), Gangai NC (Radiology), Yarmohammadi H (Radiology), Schoder H (Radiology), Pandit-Taskar N (Radiology).
Clin Imaging.. 2021 Dec;80:262-267. doi: 10.1016/j.clinimag.2021.08.002. Epub 2021 Aug 8.
Summary: Researchers retrospectively read FDG PET/CT scans from 31 patients and had a SARS-CoV-2 detection rate of 41.9%. Patients with FDG PET/CT-detectable infection were more likely to be symptomatic and hospitalized.
Prolonged SARS-CoV-2 infection in patients with lymphoid malignancies. [Research Article]
Lee CY (Medicine), Shah MK (Medicine), Hoyos D (Biostat/Epidemiology), Solovyov A (Biostat/Epidemiology), Douglas M (Medicine), Taur Y (Medicine), Maslak PG (Laboratory Medicine), Esther Babady N (Laboratory Medicine), Greenbaum B (Biostat/Epidemiology), Kamboj M (Medicine), Vardhana SA (Medicine).
Cancer Discov. 2022 Jan;12(1):62-73. doi: 10.1158/2159-8290.CD-21-1033. Epub 2021 Nov 9.
Summary: The article describes persistent symptomatic COVID-19 infection in patients with lymphoid malignancies. It identifies B-cell depletion as the key immunologic driver of persistent infection and demonstrates viral evolution in these patients.
Serum antibody response in patients with philadelphia-chromosome positive or negative myeloproliferative neoplasms following vaccination with SARS-CoV-2 spike protein messenger RNA (mRNA) vaccines. [Letter]
Kozak KE (Leukemia Service), Ouyang L (Ld - Advanced Practice Providers), Derkach A (Biostat/Epidemiology), Sherman A (Leukemia Service), McCall SJ (Ld - Advanced Practice Providers), Famulare C (Collaborative Research Centers - PIC Directed), Chervin J (Collaborative Research Centers - PIC Directed), Daley RJ (Pharmacy), Morjaria S (Medicine), Mauro MJ (Medicine), Rampal RK (Medicine).
Leukemia. 2021 Dec;35(12):3578-3580. doi: 10.1038/s41375-021-01457-1. Epub 2021 Nov 5.
Summary: This letter to the editor describes the study on the SARS-CoV-2 mRNA vaccines antibody response in patients with certain hematologic malignancies, specifically in patients with Philadelphia-chromosome positive and negative Myeloproliferative Neoplasms (MPNs).
Cross-sectional study evaluating the seroprevalence of SARS-CoV-2 antibodies among healthcare workers and factors associated with exposure during the first wave of the COVID-19 pandemic in New York. [Original Research]
Bryan A, Tatem K, Diuguid-Gerber J, Cooke C, Romanoff A (SKI Surgery), Choudhury N, Scanlon M, Kishore P, Sydney E, Masci J, Bakshi P, Pemmasani S, Davis NJ, Maru D.
BMJ Open. 2021 Nov 3;11(11):e053158. doi: 10.1136/bmjopen-2021-053158.
Summary: This paper reports on the results of serological testing of 19,107 staff members (from 30 April to 30 June, 2020) employed at New York City Health and Hospitals (NYC H+H) who also responded to a survey to assess demographic and occupational factors associated with serostatus. The findings showed a "seropositivity rate of 29% during the first wave of the COVID-19 epidemic" and that the "risk of exposure varied significantly by employee demographics, occupation and work location."
Telehealth Delivery of Tobacco Cessation Treatment in Cancer Care: An Ongoing Innovation Accelerated by the COVID-19 Pandemic. [Article]
Cancer Center Cessation Initiative Telehealth Working Group: Rigotti NA, Taylor KL, Beneventi D, King A, Kotsen C (Psychiatry Service), Fleisher L, Goldstein AO, Park ER, Sherman SE, Steinberg MB, Albert DA, Sanderson Cox L, Hayes RB, Hohl SD, Sheffer CE, Shoenbill KA, Simmons VN, Warren GW, Adsit R, Minion M, Pauk D, Rolland B.
J Natl Compr Canc Netw. 2021 Nov;19(Suppl_1):S21-S24. doi: 10.6004/jnccn.2021.7092.
Summary: This article describes how the shift to virtual telehealth services prompted by the COVID-19 pandemic occured in three healthcare institutions: Memorial Sloan Kettering Cancer Center, MD Anderson Cancer Center and the University of Chicago, and explores future avenues of investigation to advance telehealth for tobacco cessation treatment in cancer care.
Feasibility of organ preservation with short course radiation therapy as part of total neoadjuvant therapy in locally advanced rectal cancer during the COVID-19 pandemic. [Meeting Abstract]
Sarkar RR (Graduate Staff), Wu AJ (Radiation Oncology), Reyngold M (Radiation Oncology), Cuaron JJ (Radiation Oncology), Zinovoy M (Radiation Oncology), Hajj C (Radiation Oncology), Pappou E (Surgery), Segal N (Medicine), Yaeger R (Medicine), Wei IH (Surgery), Widmar M (Surgery), Weiser M (Surgery), Paty P (Surgery), Cercek A (Medicine), Smith JJ (Surgery), Saltz L (Medicine), Garcia-Aguilar J (Surgery), Crane CH (Radiation Oncology), Romesser PB (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e73-e74. doi: 10.1016/j.ijrobp.2021.07.434.
Summary: This study investigated whether short-course radiation therapy (SCRT) as part of total neoadjuvant therapy (TNT) is safe and feasible for patients by following a cohort of 42 patients who were treated with SCRT during an institutional COVID-19 pandemic mandate (from March to June of 2020), when all patients undergoing radiation therapy for locally advanced rectal cancer were treated with SCRT. The findings suggest that a watch-and-wait (WW) strategy after SCRT-TNT is feasible, but more long-term research is needed to establish oncologic safety.
Oropharyngeal cancer early outcomes and challenges during the COVID-19 pandemic. [Meeting Abstract]
Kang JJ (Radiation Oncology), Wu Y(Radiation Oncology), Rybkin A (Radiation Oncology), Yu Y (Radiation Oncology), Chen L (Radiation Oncology), Zakeri K (Radiation Oncology), McBride S (Radiation Oncology), Riaz N (Radiation Oncology), Tsai CJ (Radiation Oncology), Gelblum D (Radiation Oncology), Wong RJ (Surgery), Sherman E (Medicine), Pfister DG (Medicine), Lee NY (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e412. doi: 10.1016/j.ijrobp.2021.07.1185.
Summary: By comparing a cohort of new patients early in the Covid pandemic (March 17, 2020-July 2020) versus a historical, contemporary pre-Covid patient cohort (November 2019-March 16, 2020), the study authors were able to evaluate if "early oropharyngeal cancer (OPC) outcomes with radiation therapy (RT) were affected" by Covid pandemic-related practice changes. Although "no difference in early 6 month outcomes" between cohorts were found, important clinical trends were identified that may not be favorable to long-term outcomes.
Efficacy and toxicity of alternative radiation treatment schemes for patients with hematologic malignancies: A collaborative ILROG COVID era report. [Meeting Abstract]
Gunther JR, Yang JC, Hajj C (Radiation Oncology), Ng AK, Brady JL, Cheng S, Levis M, Qi S, Mikhaeel G, Ricardi U, Illidge T, Turin A, Knafl M, Specht L, Dabaja B, Yahalom J (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e308-e309. doi: 10.1016/j.ijrobp.2021.07.961.
Summary: This multi-center study that included ninety-three patients with hematologic malignancies from 4 institutions (114 RT courses), evaluated the preliminary efficacy and toxicity of novel hypofractionated radiation therapy regimens that were adopted during the Covid pandemic (1/1/2020 to 8/31/2020) according to guidelines published by the International Lymphoma Radiation Oncology Group (ILROG). The preliminary findings showed "low rates of acute toxicity and reasonable short-term treatment efficacy" but longer follow-up and further control group analysis is needed and forthcoming.
"Big Boom" radiation treatment (RT) of 4 Gy single fraction: Is it an acceptable alternative to "boom boom" radiation treatment 2 Gyx2 fractions for non-Hodgkin lymphomas (NHL)? [Meeting Abstract]
Hajj C (Radiation Oncology), Lee J (Radiation Oncology), Fregonese B (Radiation Oncology), Imber BS (Radiation Oncology), Wijetunga NA (Graduate Staff), Yang JC, Casey DL (Graduate Staff), Yahalom J (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e306. doi: 10.1016/j.ijrobp.2021.07.956.
Summary: This study evaluates a single center's experience adopting emergency guidelines published by the International Lymphoma Radiation Oncology Group (ILROG) to support hypofractionation across multiple dose regimens for 36 non-Hodgkin lymphoma patients. The group reported that early response rates to the one dose regimen (adopted between March 30, 2020 through November 30, 2020 due to the Covid-19 pandemic) are similar but that "longer term follow-up is required to confirm the durability of these results."
Safety and satisfaction of patients opting for fully remote consultation and on-treatment management visits during COVID-19 [Meeting Abstract]
Cuaron JJ (Radiation Oncology), Gillespie EF (Radiation Oncology), Shaverdian N (Radiation Oncology), Benvengo S (Radiation Oncology), Washington CM (Hospital Administration), Cahlon O (Radiation Oncology), Gomez DR (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S111. doi: 10.1016/j.ijrobp.2021.07.256.
Summary: This paper reports on the experience of 192 patients (treated at 208 sites) who - after the pandemic restrictions were relaxed - opted for fully remote management via telemedicine. The safety data that was prospectively collected and the data from patient satisfaction surveys (administered before, during, and after treatment) showed that "treatment with fully remote providers is safe and feasible" and that there was high patient satisfaction.
SARS-CoV-2 exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems. [Article]
Savitt AG, Manimala S, White T, Fandaros M, Yin W, Duan H, Xu X, Geisbrecht BV, Rubenstein DA, Kaplan AP, Peerschke EI (Laboratory Medicine), Ghebrehiwet B.
Front Immunol. 2021 Nov 5;12:767347. doi: 10.3389/fimmu.2021.767347. eCollection 2021.
Summary: In this paper, the researchers analyzed four major proteins from the genome of SARS-CoV-2 to understand if they were all involved in triggering the life-threatening cytokine storm.
Association between androgen deprivation therapy and mortality among patients with prostate cancer and COVID-19. [Article]
Schmidt AL, Tucker MD, Bakouny Z, Labaki C, Hsu CY, Shyr Y, Armstrong AJ, Beer TM, Bijjula RR, Bilen MA, Connell CF, Dawsey SJ, Faller B, Gao X, Gartrell BA, Gill D, Gulati S, Halabi S, Hwang C, Joshi M, Khaki AR, Menon H, Morris MJ (Medicine), Puc M, Russell KB, Shah NJ (Medicine), Sharifi N, Shaya J, Schweizer MT, Steinharter J, Wulff-Burchfield EM, Xu W, Zhu J, Mishra S, Grivas P, Rini BI, Warner JL, Zhang T, Choueiri TK, Gupta S, McKay RR.
JAMA Netw Open. 2021 Nov;4(11):e2134330. doi: 10.1001/jamanetworkopen.2021.34330.
Summary: This study investigated whether being on androgen deprivation therapy (ADT) is associated with decreased rate of 30-day mortality from COVID-19 among patients with prostate cancer. Findings based on a cohort of 1106 male patients did "not support the hypothesis that ADT may be useful in reducing the mortality or severity of SARS-CoV-2 infection" as no statistically significant difference was observed, however, ongoing prospective trials will further explore the potential role for ADT in affecting the course or outcomes of COVID-19 infection.
A call for quality: Substandard research in male sexual and reproductive medicine during the COVID-19 pandemic. [Expert Opinion]
Pastuszak AW, Patel DP, Jenkins LC, Hsieh TC, Yafi FA, Mumford SL, Mulhall JP (Surgery), Hotaling JM.
J Sex Med. 2022 Jan;19(1):1-4. doi: 10.1016/j.jsxm.2021.10.003. Epub 2021 Oct 30.
Summary: In the expert opinion, the authors report on quality issues from papers published during the COVID-19 pandemic. They specifically looked at research papers on the topic of male sexual and reproductive medicine, but their findings could apply to other fields.
COVID-19 in patients with cancer: can baseline radiologic severity and early evolution predict clinical outcomes? [Article]
Perez-Johnston R (Radiology), Araujo-Filho J (SKI Radiology), Mckenney AS (Graduate Staff), Gangai N (Radiology), Plodkowski AJ (Radiology), Liu CC (Radiology), Sawan P (Radiology), Taur Y (Medicine), Morjaria SM (Medicine), Ginsberg MS (Radiology).
Eur Radiol. 2022 Apr;32(4):2661-2671. doi: 10.1007/s00330-021-08341-7. Epub 2021 Oct 30.
Summary: In this retrospective study of 627 COVID-19-positive cancer patients, the researchers looked at the results of chest radiographs to analyze if there is an association with COVID-19 adverse outcomes in cancer patients.
Outcomes of patients with COVID-19 from a specialized cancer care emergency room. [Research Article]
Nath SS (Urgent Care Center), Yadav NU (Medicine), Derkach A (Biost/Epidemiology), Perez-Johnston R (Radiology), Tachiki L, Maguire K (Nursing), Babar A (Urgent Care Center), Maloy MA (Health Informatics), Klotz A (Medicine), Jee J (Graduate Staff), Taur Y (Medicine), Chawla S (Anesthesiology), Babady E (Laboratory Medicine), Khaki AR, Madeleine MM, Grivas P, Henning DJ, Aaltonen L, Lyman GH, Groeger J (Medicine).
Cancer Invest. 2021 2022 Jan;40(1):17-25. doi: 10.1080/07357907.2021.1985134. Epub 2021 Oct 28.
Summary: This retrospective analysis followed 255 adult patients with a history of cancer who presented to Memorial Sloan Kettering Cancer Center (MSKCC) urgent care center (UCC) with concurrent COVID-19 infection (from March 1, 2020 to May 31, 2020) to try to identify "vital signs, labs, and imaging at presentation" that can help predict outcomes and "have implications in triage and disposition planning in the urgent care and emergency settings."
Functional Effects of Cardiomyocyte Injury in COVID-19. [Article]
Siddiq MM, Chan AT (Medicine), Miorin L, Yadaw AS, Beaumont KG, Kehrer T, Cupic A, White KM, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Sebra R, Martinez P, Prabha S, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Albrecht RA, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R.
J Virol. 2022 Jan 26;96(2):e0106321. doi: 10.1128/JVI.01063-21. Epub 2021 Oct 20.
Summary: This article reports on a study which explored how COVID-19 affects heart heatlh, specifically cardiomyocytes (cardiac muscle cells), of people without a history of heart disease.
Factors influencing patient preferences for telehealth cancer genetic counseling during the COVID-19 pandemic. [Article]
Breen KE (Medicine), Tuman M (SKI Psychiatry), Bertelsen CE (Strategy and Innovation), Sheehan M (Medicine), Wylie D (Medicine), Fleischut MH (Medicine), Offit K (Medicine), Stadler ZK (Medicine), Salo-Mullen (Medicine) EE, Hamilton JG (Psychiatry Service).
JCO Oncol Pract. 2022 Apr;18(4):e462-e471. doi: 10.1200/OP.21.00301. Epub 2021 Oct 15..
Summary: This study surveyed 380 patients during the first 6 months of the pandemic (March-August 2020) about their experiences and preferences regarding their cancer genetic counseling clinic appointments provided as telehealth visits. Overall findings illustrated "that as the pandemic progressed, patients expressed less concern regarding the quality of telehealth care and an increasing preference for and satisfaction with telehealth."
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 [Article]
D'Agnillo F, Walters KA, Xiao Y, Sheng ZM, Scherler K, Park J, Gygli S, Rosas LA, Sadtler K, Kalish H, Blatti CA 3rd, Zhu R, Gatzke L, Bushell C, Memoli MJ, O'Day SJ, Fischer TD, Hammond TC, Lee RC, Cash JC, Powers ME, O'Keefe GE, Butnor KJ, Rapkiewicz AV, Travis WD (Pathology), Layne SP, Kash JC, Taubenberger JK.
Sci Transl Med. 2021 Nov 17;13(620):eabj7790. doi: 10.1126/scitranslmed.abj7790.
Summary: This article reports on the molecular, immunological, and pathological findings of a study of lung autopsy samples from 18 patients with fatal COVID-19 that may support the "development of relevant disease markers and urgently needed therapeutics."
Replication and single-cycle delivery of SARS-CoV-2 replicons [Article]
Ricardo-Lax I, Luna JM, Thao TTN, Le Pen J, Yu Y, Hoffmann HH, Schneider WM, Razooky BS, Fernandez-Martinez J, Schmidt F, Weisblum Y, Trüeb BS, Berenguer Veiga I, Schmied K, Ebert N, Michailidis E, Peace A, Sánchez-Rivera FJ (Cancer Biology and Genetics), Lowe SW (Cancer Biology and Genetics), Rout MP, Hatziioannou T, Bieniasz PD, Poirier JT, MacDonald MR, Thiel V, Rice CM.
Science. 2021 Nov 26;374(6571):1099-1106. doi: 10.1126/science.abj8430. Epub 2021 Oct 14.
Summary: The authors created a system that allows for the study of SARS-CoV-2, including the development of new therapeutics, without the need for high-level biocontainment.
of SARS CoV-2 infections in mRNA vaccinated health care personnel in New York City. [Article]
Robilotti E (Medicine), Whiting K (Biostat/Epidemiology), Lucca A (Employee Health & Wellness), Poon C (DigITs), Guest R (Human Resources), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Solovyov A (SKI Epidemiology & Biostatistics), Kelson S (Health Informatics), Browne K (Nursing), Freeswick S (Hospital Administration), Hohl TM (Medicine), Korenstein D (Medicine), Ruchnewitz D, Lässig M, Łuksza M, Greenbaum B (Biostat/Epidemiology), Seshan VE (Biostat/Epidemiology), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 Aug 24;75(1):e774-e782. doi: 10.1093/cid/ciab886. Epub 2021 Oct 13.
Summary: This study explored SARS CoV-2 infection in vaccinated and unvaccinated healthcare professionals during an 8 months follow-up period after the initial COVID-19 vaccine rollout. Researchers investigated the effectiveness and durability of the vaccine in the context of new variants of the virus.
Clonal hematopoiesis is associated with risk of severe COVID-19. [Article]
Bolton KL, Koh Y, Foote MB (Graduate Fellow), Im H, Jee J (Graduate Fellow), Sun CH, Safonov A (Medicine), Ptashkin R (Pathology), Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M (Collaborative Research Centers), Derkach A (Biostat/Epidemiology), GedvilaiteE (Pathology), Tkachuk KA (Medicine), Wiley BJ, Chan IC, Braunstein LZ (Radiation Oncology), Gao T (Collaborative Research Centers), Papaemmanuil E (Biostat/Epidemiology), Babady NE (Laboratory Medicine), Pessin MS (Laboratory Medicine), Kamboj M (Medicine), Diaz LA Jr (Medicine), Ladanyi M (Pathology), Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V (Medicine), Offit K (Medicine), Norton L (Office of the Pres & CEO), Berger MF (Pathology), Levine RL (Human Oncology & Pathogenesis), Kim ES, Kim NJ, Zehir A (Pathology).
Nat Commun. 2021 Oct 13;12:5975. doi: 10.1038/s41467-021-26138-6.
Summary: This study used the sequencing data of CH (Clonal hematopoiesis)-associated genes and Covid-19 infection data of two patient cohorts: one composed of patients with solid tumors treated at MSK and the other of previously healthy individuals without cancer who were hospitalized for Covid-19 between January and April 2020 at four tertiary hospitals in South Korea (KoCH cohort). The results suggested that there is a relationship between CH and risk of different types of severe infections, including risk of severe Covid-19.
Hematopoietic cell transplantation is feasible in patients with prior COVID-19 infection [Article]
Shah N (Medicine), Dahi PB (Medicine), Ponce DM (Medicine), Sauter CS (Medicine), Shaffer BC (Medicine), Chung DJ (Medicine), Politikos I (Medicine), Lin RJ (Medicine), Giralt SA (Medicine), Papanicolaou G (Medicine), Ramanathan LV (Medicine), Perales MA (Medicine), Kamboj M (Medicine), Shah GL (Medicine), Gyurkocza B (Medicine).
Transplant Cell Ther. 2022 Jan;28(1):55.e1-55.e5. doi: 10.1016/j.jtct.2021.10.004. Epub 2021 Oct 11.
Summary: A retrospective study of 15 patients with past COVID-19 infections finds that subsequent hematopoietic cell transplantations can be performed safely.
COVIDNearTerm: A simple method to forecast COVID-19 hospitalizations [Preprint]
Olshen AB, Garcia A, Kapphahn KI, Weng Y, Wesson PD, Rutherford GW, Gonen M (Biostat/Epidemiology), Desai M.
medRxiv. 2021 Oct 9. doi: 10.1101/2021.10.08.21264785.
Summary: This preprint describes a model for predicting hospitalizations from COVID in the San Francisco area two to four weeks ahead of time. It has not been peer reviewed.
Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: What are the findings? [Article]
Taya M, Paroder V (Radiology), Redelman-Sidi G (Medicine), Gangai N (Radiology), Golia Pernicka JS (Radiology), Gollub MJ (Radiology), Javed-Tayyab S (Radiology), Petkovska I (Radiology), Bates DDB (Radiology).
Emerg Radiol. 2021 Dec;28(6):1087-1096. doi: 10.1007/s10140-021-01986-3. Epub 2021 Oct 3.
Summary: This retrospective cross-sectional study conducted at a tertiary oncologic center looked at the contrast-enhanced CT of the abdomen and pelvis of 63 patients with COVID-19. The most common new imaging abnormality found in this study's cohort was "features of gastric or bowel thickening, followed by small volume ascites, gallbladder distention, and isolated cases of pancreatitis and portal vein thrombosis."
Impact of the early COVID-19 pandemic on gender participation in academic publishing in radiation oncology. [Research Letter]
Anabaraonye N, Tsai CJ (Radiation Oncology), Saeed H, Chino F (Radiation Oncology), Ekpo E, Ahuja S, Garcia O, Miller RC.
Adv Radiat Oncol. 2021 Nov 18;7(2):100845. doi: 10.1016/j.adro.2021.100845.
Summary: This letter compares gender and other data points for all articles published by the journal Advances in Radiation Oncology between its inception in December 2015 and the end of February 2020 and between March 1, 2020 and May 31, 2020 when the COVID-19 pandemic in North America began, with authors noting nonsenior female researchers participated less in article publishing during the latter time period.
Global palliative nursing partnerships in the face of COVID-19. [Research]
Rosa WE (SKI Psychiatry), Downing J, Ferrell BR, Grant L, Matula ST, Pandey S, Sey-Sawo J, Sowe M, Upvall M.
Int J Palliat Nurs. 2021 Oct 2;27(8):410-416. doi: 10.12968/ijpn.2021.27.8.410.
Summary: This article explores how global nursing partnerships improved palliative care during the COVID pandemic.
Factors associated with colon and rectal surgery fellowship program ranking before and after the COVID-19 pandemic. [Commentary]
Goffredo P (Graduate Staff), Sun M, Jensen C, Trudel J, Madoff R, Lowry A, Gaertner, W.
Dis Colon Rectum. 2021 Oct 1;64(10):1163-1166. doi: 10.1097/DCR.0000000000002193.
Summary: Researchers found that virtual interviews and visits slightly changed the importance of several factors for colon and rectal surgery (CRS) fellowship applicants. Compared to those with in-person meetings, those with the virtual process were less swayed by location and more concerned with a fellowship site's online presence and post-fellowship careers of alumni.
Impact of the early COVID-19 pandemic on sex participation in academic publishing in radiation oncology. [Meeting Abstract]
Miller R, Anabaraonye N, Tsai J (Radiation Oncology), Saeed H, Chino F (Radiation Oncology), Garcia O, Ekpo E, Ahuja S, Lauro C.
J Am J Clin Oncol. 2021 Oct 1; 44(10); doi:10.1097/COC.0000000000000862.
Summary: The authors of this conference abstract (P107) found that early career female first authorship declined in the journal ASTRO Advances in Radiation Oncology during the early pandemic compared to the pre-pandemic rate.
Trends in diagnosis and treatment of early breast cancer (eBC) in the United States (US) during the COVID-19 era [Meeting Abstract]
Ackerman B, Keane C, Beaver JA, Kluetz PG, Rivera D, Paliwal P, Singh H, Mpofu P, Amiri-Kordestani L, Baxi SS (Medicine).
Journal of Clinical Oncology. 2021 Oct;39(28 Suppl.) doi: 10.1200/JCO.2020.39.28_suppl.227.
Summary: This meeting abstract finds that early breast cancer diagnoses declined in April and May 2020 compared to March 2020, a decline not present in a 2019 cohort. Those diagnosed February-June 2020 were more likely than those diagnosed the year before to have systemic therapy as their primary treatment.
Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19. [Research]
Fischer JC, Schmidt AG, Bölke E, Uhrberg M, Keitel V, Feldt T, Jensen B, Häussinger D, Adams O, Schneider EM, Balz V, Enczmann J, Rox J, Hermsen D, Schulze-Bosse K, Kindgen-Milles D, Knoefel WT, van Griensven M, Haussmann J, Tamaskovics B, Plettenberg C, Scheckenbach K, Corradini S, Pedoto A (Anesthesiology), Maas K, Schmidt L, Grebe O, Esposito I, Ehrhardt A, Peiper M, Buhren BA, Calles C, Stöhr A, Lichtenberg A, Freise NF, Lutterbeck M, Rezazadeh A, Budach W, Matuschek C.
Eur J Med Res. 2021 Sep 16;26:107. doi: 10.1186/s40001-021-00560-4.
Summary: This exploratory observational study followed 157 adult COVID-19 convalescent patients to try to better understand the immune mechanisms underlying the variability in COVID-19 clinical courses by identifying immunogenetic background characteristics and evaluating whether they are associated with reduced or increased severity of the disease. Results showed that "severity of the disease seems to be strongly associated with the AB0 blood group allele status of the patients."
Federated learning for predicting clinical outcomes in patients with COVID-19. [Article]
Dayan I, Roth HR, Zhong A, Harouni A, Gentili A, Abidin AZ, Liu A, Costa AB, Wood BJ, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan P, Xu D, Wu D, Huang E, Kitamura FC, Lacey G, de Antônio Corradi GC, Nino G, Shih HH (Radiology), Obinata H, Ren H, Crane JC, Tetreault J, Guan J, Garrett JW, Kaggie JD, Park JG, Dreyer K, Juluru K (Radiology), Kersten K, Rockenbach MABC, Linguraru MG, Haider MA, AbdelMaseeh M, Rieke N, Damasceno PF, E Silva PMC, Wang P, Xu S, Kawano S, Sriswasdi S, Park SY, Grist TM, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon YJ, Quraini A, Feng A, Priest AN, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Díez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess CP, Compas C, Bhatia D, Oermann EK, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Keshava Murthy KN (Radiology), Fu LC, de Mendonça MRF, Fralick M, Kang MK, Adil M, Gangai N (Radiology), Vateekul P, Elnajjar P (Radiology), Hickman S, Majumdar S, McLeod SL, Reed S, Gräf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, de Lavor VL, Rakvongthai Y, Lee YR, Wen Y, Gilbert FJ, Flores MG, Li Q.
Nat Med. 2021 Oct;27(10):1735-1743. doi: 10.1038/s41591-021-01506-3. Epub 2021 Sep 15.
Summary: In this study, data from 20 institutions worldwide was used to train artificial intelligence models using a method called federated learning to predict the future oxygen requirements of symptomatic patients with COVID-19. The authors believe that "it provides a powerful proof-of-concept of the feasibility of using FL for fast and collaborative development of needed AI models in healthcare."
Medical care disruptions during the first six months of the COVID-19 pandemic: the experience of older breast cancer survivors. [Article]
Dilawari A, Rentscher KE, Zhai W, Zhou X, Ahles TA (Psychiatry Service), Ahn J, Bethea TN, Carroll JE, Cohen HJ, Graham DA, Jim HSL, McDonald B, Nakamura ZM, Patel SK, Root JC (Psychiatry Service), Small BJ, Saykin AJ, Tometich D, Van Dyk K, Mandelblatt JS.
Breast Cancer Res Treat. 2021 Nov;190(2):287-293. doi: 10.1007/s10549-021-06362-w. Epub 2021 Sep 13.
Summary: This study investigated the types and factors associated with medical care disruptions experienced by participants in a longitudinal cohort of non-metastatic breast cancer survivors (aged 60–98) across five US regions. The study showed that there was a high rate of disruptions for this cohort during the first 6 months of the pandemic and that "psychosocial factors were associated with care disruptions."
Predictors of humoral response to SARS-CoV-2 vaccination after hematopoietic cell transplantation and CAR T-cell therapy. [Article]
Tamari R (Medicine), Politikos I (Medicine), Knorr DA (Medicine), Vardhana SA (Medicine), Young, JC (Medicine), Marcello LT (Medicine), Doddi S (Laboratory Medicine), Delvin SM (Epidemiology and Biostatistics), Ramanathan LV (Laboratory Medicine), Pessin MS (Labaratory Medicine), Dunn E (Nursing), Palazzo M (Nursing), Bravo CD (Collaborative Research), Papanicolaou GA (Medicine), Kamboj M (Medicine), Perales MA (Medicine), Chung DJ (Medicine), Shah GL (Medicine).
Blood Cancer Discov. 2020 Sep 13; 2(6). doi: 10.1158/2643-3230.BCD-21-0142.
Summary: The immune response to mRNA COVID vaccines in 217 cancer patients receiving cellular therapies was high. The timing of vaccination after treatment impacted the response.
Disease- and therapy-specific impact on humoral immune responses to COVID-19 vaccination in hematologic malignancies. [Article]
Chung DJ (Medicine), Shah GL (Medicine), Delvin SM (Epidemiology and Biostatistics), Ramanathan LV (Laboratory Medicine), Doddi S (Laboratory Medicine), Pessin MS (Labaratory Medicine), Hoover E (Medicine), Marcello LT (Medicine), Young, JC (Medicine), Boutemine SR (Medicine), Serrano E (Medicine), Sharan S (Medicine), Momotaj S (Medicine), Margetich L (Medicine), Bravo CD (Collaborative Research), Papanicolaou GA (Medicine), Kamboj M (Medicine), Mato AR (Medicine), Roeker LE (Medicine), Hultcrantz M (Medicine), Mailankody S (Medicine), Lesokhin AM (Medicine), Vardhana SA (Medicine), Knorr DA (Medicine).
Blood Cancer Discov. 2020 Sep 13; 2(6). doi: 10.1158/2643-3230.BCD-21-0139.
Summary: A cohort of 551 leukemia, lymphoma, and multiple myeloma patients showed suppressed responses to COVID-19 vaccination compared to healthy controls.
The report from ASFA COVID-19 taskforce: Considerations and prioritization on apheresis procedures during the SARS-CoV-2 coronavirus disease (COVID-19) pandemic. [Review]
Yamada C, Hofmann JC, Witt V, Gupta GK (Laboratory Medicine), Winters JL, The ASFA COVID-19 Taskforce.
J Clin Apher.. J Clin Apher. 2021 Dec;36(6):878-881. doi: 10.1002/jca.21939. Epub 2021 Sep 12.
Summary: The American Society for Apheresis (ASFA) Task Force's report mapping out the issues and considerations that should be made when apheresis procedures are requested in the COVID-19 pandemic to ensure "efficient and optimum use of apheresis resources."
Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic. [Original Research]
Bunzli S, O'Brien P, Aston W, Ayerza MA, Chan L, Cherix S, de Las Heras J, Donati D, Eyesan U, Fabbri N (Surgery), Ghert M, Hilton T, Idowu OK, Imanishi J, Puri A, Rose P, Sabah D, Turcotte R, Weber K, Dowsey MM, Choong PFM.
BMJ Open. 2021 Sep 2;11(9):e047175. doi: 10.1136/bmjopen-2020-047175.
Summary: A survey of 18 sarcoma surgeons from 14 countries led to the development of a COVID-informed decision-making framework for patient care.
Developing and validating multi-modal models for mortality prediction in COVID-19 patients: A multi-center retrospective study [Preprint]
Wu JTY, de la Hoz MAA, Kuo PC, Paguio JA, Yao JS, Dee EC (Graduate Staff), Yeung W, Jurado J, Moulick A, Milazzo C, Peinado P, Villares P, Cubillo A, Varona JF, Lee HC, Estirado A, Castellano JM, Celi LA.
arXiv.org. 2021 Sep 1. arXiv:2109.02439 [cs.LG].
Summary: The authors used machine learning to create a COVID-19 mortality prediction model, taking data from electronic health records and chest X-rays. This preprint has not been peer reviewed.
The global impact of COVID-19 on telehealth and care for persons with thoracic cancers. [Meeting Abstract]
Smeltzer M, Bunn B, Choi YS, Coate L, Corona-Cruz J, Drilon A (Medicine), Duma N, Edelman M, Fidler MJ, Gadgeel S, Goto Y, Herbst R, Hesdorffer M, Higgins K, Labdi B, Leal T, Liu S, Mazotti J, Novello S, Patel S.
J Thorac Oncol. 2021 Sept 1; 16(10); doi:10.1016/j.jtho.2021.08.093.
Summary: This conference abstract looked at how telehealth was used during the COVID-19 pandemic and how it impacts thoracic cancer care.
Assessing the quality of life of head and neck healthcare workers during the COVID-19 pandemic - A self-reported global cross-sectional questionnaire study by the International Federation of Head and Neck Oncologic Societies. [Article]
Singh A, Garg A, Mandlik D, Vander Poorten V, Patel SG (Surgery), O'Neill JP, Spriano G, Shaha A (Surgery), Chaturvedi P, Cernea C, Shah J (Surgery).
J Surg Oncol. 2021 Sep;124(4):476-482. doi: 10.1002/jso.26571. Epub 2021 Jun 9.
Summary: This paper reports on a cross-sectional self-reported QOL assessment administered between July and September 2020 to 979 individuals (from 53 countries), including surgeons, physicians, dentists, and nurses who see patients with head and neck diseases. Factors that adversely influenced the QOL of head and neck healthcare workers during the early period of the COVID pandemic were characterized.
COVID mortality prediction with machine learning methods: A systematic review and critical appraisal. [Review]
Bottino F, Tagliente E, Pasquini L (Radiology), Napoli AD, Lucignani M, Figà-Talamanca L, Napolitano A.
J Pers Med. 2021 Sep;11(9):893. doi: 10.3390/jpm11090893.
Summary: This systematic review of the literature aims to describe the current machine learning techniques that are being used to predict mortality in COVID patients, summarizing the different models being used and the data and clinical features that they are considering making their prediction assessments.
Pre-hospital antiplatelet medication use on COVID-19 disease severity. [Article]
Pan D (Medicine), Ip A, Zhan S, Wasserman I, Snyder DJ, Agathis AZ, Shamapant N, Yang JY, Pai A, Mazumdar M, Poor H.
Heart Lung. Sep-Oct 2021;50(5):618-621. doi: 10.1016/j.hrtlng.2021.04.010. Epub 2021 May 27.
Summary: This retrospective study looked at pre-hospitalization use of antiplatelet medications (a class of anti-thrombotic drugs such as Aspirin, etc.) in a sample of patients hospitalized with COVID-19 infection in March-April 2020. The study found that although patients on antiplatelet drugs were older and had more comorbidities, severity of COVID-19 disease course was not significantly different between users and non-users of antiplatelet drugs.
Impact of COVID-19 on endoscopy training: Perspectives from a global survey of program directors and endoscopy trainers. [Original Article]
Vignesh S, Butt AS, Alboraie M, Costa Martins B, Piscoya A, Tran QT, Yew DTM, Ghazanfar S, Alavinejad P, Kamau E, Verma AM, Mendelsohn RB (Medicine), Khor C, Moss A, Liao DWC, Huang CS, Tsai FC.
Clin Endosc. 2021 Sep;54(5):678-687. doi: 10.5946/ce.2021.140. Epub 2021 Sep 30.
Summary: This study surveyed teaching faculty in gastroenterology training programs on how the COVID-19 pandemic impacted their training programs and various aspects of endoscopy training.
positive cancer patients: Blood product utilization trends and transfusion reaction investigations in this population [Meeting Abstract]
Budahi A (Laboratory Medicine), Vickerie S (Laboratory Medicine), Ahmed S, Bakker T (Information Systems), Venditti CJ (Laboratory Medicine), Pessin MS (Laboratory Medicine), Adem P (Laboratory Medicine).
Transfusion.2021 Sep;61 Suppl 3:1A-272A. doi: 10.1111/trf.16620.
Summary: A review of blood product utilization and transfusion reaction reports of cancer patients with COVID-19, with authors noting this population requires a significant commitment of resources from the transfusion service.
Racial/ethnic differences in prosocial beliefs and prevention behavior during the COVID-19 pandemic. [Article]
Orom H, Allard NC, Kiviniemi MT, Hay JL (Psychiatry Service), Waters EA, Schofield E (Psychiatry Service), Thomas SN, Tuman M.
J Racial Ethn Health Disparities. 2022 Oct;9(5):1807-1817. doi: 10.1007/s40615-021-01117-1. Epub 2021 Aug 30.
Summary: A June 2020 survey of 50,000 adults in the United States found that Black and Latinx participants were more likely than whites to perceive COVID-19 as a higher risk and to take precautionary measures, like social distancing and masking, to prevent its spread.
Prolonged SARS-CoV-2 infection in patients with lymphoid malignancies. [Preprint]
Lee CY (Medicine), Shah MK (Medicine), Hoyos D (Biostat/Epidemiology), Solovyov A (Biostat/Epidemiology), Douglas M (Medicine), Taur Y (Medicine), Maslak PG (Laboratory Medicine), Esther Babady N (Laboratory Medicine), Greenbaum B (Biostat/Epidemiology), Kamboj M (Medicine), Vardhana SA (Medicine).
medRxiv. 2021 Aug 29. doi: 10.1101/2021.08.25.21262417.
Summary: A study of 382 patients with lymphomas and COVID-19 diagnoses found that 13.9% of the surviving 368 patients still showed persistent COVID symptoms 30 days after testing positive. This preprint has not been peer reviewed.
Variable duration of viral shedding in cancer patients with COVID-19. [Original Article]
Esther Babady N (Laboratory Medicine), Cohen B, McClure T, Chow K, Caldararo M (Graduate Fellow), Jani K (Laboratory Medicine), McMillen T (Laboratory Medicine), Taur Y (Medicine), Shah M (Medicine), Robilotti E (Medicine), Aslam A (Infection Control), Kamboj M (Medicine).
Infect Control Hosp Epidemiol. 2022 Oct;43(10):1413-1415. doi: 10.1017/ice.2021.378. Epub 2021 Aug 27.
Summary: A retrospective study of 105 cancer patients with COVID-19 infections found that patients with hematological cancers took longer to clear the infection and were likely infectious for longer than patients with solid tumors.
Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: A rare clinical reaction. [Article]
Hoff NP, Freise N, Schmidt AG, Firouzi-Memarpuri P, Reifenberger J, Luedde T, Böelke E, Meller S, Homey B, Feldt T, Ole Jensen BE, Keitel V, Schmidt L, Maas K, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Buhren BA, Knoefel WT, Schneider M, Gerber PA, Pedotoa A (Anesthesiology), Häussinger D, Grebe O, van Griensven M, Braun SA, Salzmann S, Rezazadeh A, Matuschek C.
Eur J Med Res. 2021 Aug 25;26:98. doi: 10.1186/s40001-021-00557-z.
Summary: Delayed skin reactions, appearing days after the first or second dose of the Moderna vaccine, are rare, benign, and treatable with topical glucocorticosteroids or oral antihistamines.
Axillary lymphadenopathy at the time of COVID-19 vaccination: Ten recommendations from the European Society of Breast Imaging (EUSOBI). [Guidelines]
Schiaffino S, Pinker K (Radiology), Magni V, Cozzi A, Athanasiou A, Baltzer PAT, Camps Herrero J, Clauser P, Fallenberg EM, Forrai G, Fuchsjäger MH, Helbich TH, Kilburn-Toppin F, Kuhl CK, Lesaru M, Mann RM, Panizza P, Pediconi F, Pijnappel RM, Sella T, Thomassin-Naggara I, Zackrisson S, Gilbert FJ, Sardanelli F.
Insights Imaging.. 2021 Aug 20;12:119. doi: 10.1186/s13244-021-01062-x.
Summary: The European Society of Breast Imaging (EUSOBI)'s recommendations for breast imaging and COVID vaccination to prevent unnecessary imaging and procedures resulting from COVID vaccine-related enlarged lymph nodes.
Association of antineoplastic therapy with decreased SARS-CoV-2 infection rates in patients with cancer. [Brief Report]
Foote MB (Graduate Fellow), White JR, Jee J (Graduate Fellow), Argilés G (SKI Medicine), Wan JCM (SKI Medicine), Rousseau B (SKI Medicine), Pessin MS (Laboratory Medicine), Diaz LA Jr (Medicine).
JAMA Oncol. 2021 Nov 1;7(11):1686-1691. doi: 10.1001/jamaoncol.2021.3585. Epub 2021 Aug 19.
Summary: Cancer patients on mTOR/PI3K inhibitors and antimetabolites showed reduced SARS-CoV-2 positivity rates than those treated with other therapies.
Thromboinflammation supports complement activation in cancer patients with COVID-19. [Original Research Article]
Peerschke EI (Laboratory Medicine), Valentino A (Laboratory Medicine), So RJ (Laboratory Medicine), Shulman S (Laboratory Medicine), Ravinder (Laboratory Medicine).
Front Immunol. 2021 Aug 18;12:716361. doi: 10.3389/fimmu.2021.716361.
Summary: Researchers evaluated certain plasma markers in cancer patients and found that COVID-19 increased complement activation, the stimulation of plasma proteins that can lead to inflammatory reactions.
Neurology podcast utilization during the COVID-19 pandemic. [Article]
Siegler JE, Boreskie PE, Strowd R, Rook R, Goss A, Al-Mufti F, Rossow B, Miller A (Neurology), Chamberlain A, London Z, Hurley J, Geocadin R, Richie M, Isaacson R, Rybinnik I, Chan TM.
Neurol Sci. 2021 Nov;42(11):4437-4445. doi: 10.1007/s10072-021-05549-9. Epub 2021 Aug 12.
Summary: This study looked at academic neurology-themed podcasts, and whether the COVID-19 pandemic impacted the utilization of these podcasts. The study found that there was no significant increase in downloads during the early months of the pandemic, but that more general and other subspecialty podcasts would be analyzed.
Bursting at the seams: Barotrauma in coronavirus disease 2019 acute respiratory distress syndrome patients. [Editorial]
Hossain S (Anesthesiology), Pastores SM (Anesthesiology).
Crit Care Med.. 2021 Aug 11. doi: 10.1097/CCM.0000000000005291. (Epub ahead of print).
Summary: This editorial reviews a recent systematic review of COVID-19 patients with acute respiratory distress syndrome (ARDS) and how COVID-19 ARDS differs from classical ARDS. The review discussed in this editorial found that barotrauma, or the development of pneumothorax or pneumomediastinum, was a defining feature of COVID-19 ARDS. The authors of this editorial raise the question of whether baratrauma is unique to COVID-19 ARDS, or simply a marker for severe disease.
Economic distress, financial toxicity, and medical cost-coping in young adult cancer survivors during the COVID-19 pandemic: Findings from an online sample. [Original Article]
Thom B (Medicine), Benedict C, Friedman DN (Pediatrics), Watson SE, Zeitler MS, Chino F (Radiation Oncology).
Cancer. 2021 Dec 1;127(23):4481-4491. doi: 10.1002/cncr.33823. Epub 2021 Aug 5.
Summary: This study used a survey to look at the financial situation of young adult cancer survivors in the COVID-19 pandemic. The study found that the pandemic significantly worsened cancer-related financial toxicity and overall financial hardship in this category of patients and led to test or treatment skipping and other such behaviors that jeopardized survivorship care and health outcomes.
A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases. [Preprint]
Wang JY, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Aug 4. doi: 10.1101/2021.07.30.454526.
Summary: This study investigates the connections between viral infections, such as COVID-19, and autoimmune disease.
Risk of healthcare-associated transmission of SARS-CoV-2 in hospitalized cancer patients. [Article]
Chow K (Infection Control), Aslam A (Infection Control), McClure T (Infection Control), Singh J (Infection Control), Burns J (Nursing), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Lucca A (Employee Health & Wellness), Bubb T (Infection Control), Robilotti E (Medicine), Babady E (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 May 3;74(9):1579-1585. doi: 10.1093/cid/ciab670. Epub 2021 Jul 30.
Summary: This study aimed at assessing the risk of hospital SARS-Cov-2 infection included hospitalized cancer patients not sick with COVID-19 at admission but diagnosed with coronavirus during their hospitalization. The study found that there was low risk of getting infected in the inpatient setting.
Rapid detection of SARS-CoV-2 using a radiolabeled antibody. [Article]
Pirovano G (SKI Radiology), Ordonez AA, Jain SK, Reiner T (Radiology), Carroll LS, Pillarsetty NVK (Radiology).
Nucl Med Biol. 2021 Jul-Aug;98-99:69-75. doi: 10.1016/j.nucmedbio.2021.05.002.
Summary: The authors of this report used their experience with radiolabeled antibodies for oncology applications to develop a SARS-CoV-2 detection system based on "the combination of a specific radiolabeled antibody and a separation membrane."
COVID-19 in patients with CLL: Improved survival outcomes and update on management strategies. [Letter]
Roeker LE (Medicine), Eyre TA, Thompson MC (Graduate Staff), Lamanna N, Coltoff A, Davids MS, Baker P, Leslie LA, Rogers KA, Allan JN, Cordoba R, Lopez-Garcia A, Antic D, Pagel JM, Martinez-Calle N, Garcia-Marco JA, Hernández-Rivas JÁ, Miras F, Coombs CC, Österborg A, Seddon AN, López-Jiménez J, Wilson MR, El-Sharkawi D, Wojenski D, Ma S, Munir T, Valenciano S, Seymour E, Barr PM, Pu JJ, Patten PE, Perini GF, Huntington SF, Parry H, Sundaram S, Skarbnik AP, Kamdar M, Jacobs RW, Walter HS, Walewska R, Broom A, Lebowitz S (Medicine), Isaac K, Portell CA, Ahn IE, Ujjani C, Shadman M, Skånland SS, Chong EA, Mato AR (Medicine).
Blood. 2021 Nov 4;138(18):1768-1773. doi: 10.1182/blood.2021011841.Epub 2021 Jul 23.
Summary: In this retrospective study, investigators from 45 centers studied the case fatality rate in patients with chroniclymphocytic leukemia (CLL) diagnosed with COVID-19. The study found that the overall trend in case fatality rate for CLL patients is similar to the improved overall survival observed for patients with COVID-19 in the general population.
Combination of antiviral drugs to inhibit SARS-CoV-2 polymerase and exonuclease as potential COVID-19 therapeutics. [Preprint]
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W (Structural Biology), Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J.
bioRxiv. 2021 Jul 21. doi: 10.1101/2021.07.21.453274.
Summary: This preprint reports on the identification of two hepatitis C NS5A inhibitors (Pibrentasvir and Ombitasvir) as potential drugs to work in combination with current treatments such as Remdesivir, to reduce the viral RNA replication of SARS-CoV-2. This preprint descibes a potential combination therapy for treatment of COVID-19.
Association of varying clinical manifestations and positive anti-SARS-CoV-2 IgG antibodies: A cross-sectional observational study. [Article]
Silverberg JI, Zyskind I, Naiditch H, Zimmerman J, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Rosenberg AZ..
J Allergy Clin Immunol Pract. 2021 Sep;9(9):3331-3338.e2. doi: 10.1016/j.jaip.2021.06.046. Epub 2021 Jul 15.
Summary: This research paper surveyed 9507 adults to look at the association between COVID-19 symptoms and the antibody response.
A call to action: Antiracist patient engagement in adolescent and young adult oncology research and advocacy. [Review]
Cheung CK, Tucker-Seeley R, Davies S, Gilman M (AYA Psychiatry), Miller KA, Lopes G, Betz GD, Katerere-Virima T, Helbling LE, Thomas BN, Lewis MA.
Future Oncol. 2021 Jul 15. doi: 10.2217/fon-2020-1213. (Epub ahead of print)
Summary: This review describes how the COVID-19 pandemic was a catalyst to expose the long-standing racial crises against Blacks and Asians, and how anti-Black and anti-Asian racism impacts healthcare. The authors describe how adolescent and young adult (AYA) oncology researchers must protect young BIPOC cancer patients' exploitation, and how to provide ethical and effective methods of patient engagement and research that is antiracist.
Bimatoprost drug delivery with laser and microneedling for the management of COVID-19 prone positioning-induced atrophy and hypopigmentation. [Case Report]
Wilson BN (Graduate Staff), Aleisa A (Graduate Staff), Menzer C (SKI Medicine), Rossi AM (Medicine).
JAAD Case Rep. JAAD Case Rep. 2021 Sep;15:26-29. doi: 10.1016/j.jdcr.2021.07.004. Epub 2021 Jul 15.
Summary: This case report describes a novel treatment for facial atrophy and depigmentation in a COVID-19 patient who was in prone position. The authors used a Co2 laser delivery system of the drug bimatoprost and microneedling to achieve repigmentation of the facial skin.
Oncologist perspectives on telemedicine for patients with cancer: A National Comprehensive Cancer Network survey. [Original Contribution]
Tevaarwerk AJ, Chandereng T, Osterman T, Arafat W, Smerage J, Polubriaginof FCG (Health Informatics), Heinrichs T, Sugalski J, Martin DB.
JCO Oncol Pract. 2021 Sep;17(9):e1318-e1326. doi: 10.1200/OP.21.00195. Epub 2021 Jul 15.
Summary: With the COVID-19 pandemic accelerating the adoption of telemedicine, this National Comprehensive Cancer Network survey of >1000 oncologists from 26 institutions to investigate the providers' assessment of telemedicine used with cancer patients. The survey results suggested that respondents viewed telemedicine "as safe and effective for cancer care within certain clinical scenarios" and demonstrated "an ongoing role for telemedicine in oncology."
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. [Article]
Starr TN, Czudnochowski N, Liu Z, Zatta F, Park YJ, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG (Computational and Systems Biology), Zhang I (Graduate Student), Dingens AS, Bowen JE, Tortorici MA, Walls AC, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Dillen J, Tucker H, Bassi J, Silacci-Fregni C, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota E, Abdelnabi R, Foo SC, Cameroni E, Stumpf S, Croll TI, Nix JC, Havenar-Daughton C, Piccoli L, Benigni F, Neyts J, Telenti A, Lempp FA, Pizzuto MS, Chodera JD (Computational and Systems Biology), Hebner CM, Virgin HW, Whelan SPJ, Veesler D, Corti D, Bloom JD, Snell G.
Nature. 2021 Sep 2;597(7874):97-102. doi: 10.1038/s41586-021-03807-6. Epub 2021 Jul 14.
Summary: This article describes how antibodies are used to neutralize the SARS-CoV-2 virus by targing their receptor-binding domain. The data reported shows how these antibodies work, and how this research can be used for therapeutics against both SARS-CoV-2 infection as well as potential future pandemics.
Clinical subphenotypes in COVID-19: Derivation, validation, prediction, temporal patterns, and interaction with social determinants of health. [Article]
Su C, Zhang Y, Flory JH (Medicine), Weiner MG, Kaushal R, Schenck EJ, Wang F.
NPJ Digit Med. 2021 Jul 14;4:110. doi: 10.1038/s41746-021-00481-w.
Summary: This retrospective study looked at nearly 15,000 COVID-19 patients in NYC in the early surge of the pandemic. The authors identified four biologically distinct subphenotypes, and these subphenotypes were highly predictive of clinical outcomes. For one subphenotype (IV) it was found that mortality was highly correlated to social determinants of health, specifically age, comorbidities, and clinical manifestation of disease. The findings provide a more complete understanding of how COVID-19 impacts different populations.
Reduction in the number of early melanomas diagnosed during the COVID-19 pandemic: a single-center cohort study. [Letter to the Editor]
Koch E, Villanueva F, Marchetti MA (Medicine), Abarzúa Á, Cárdenas C, Castro JC, Dominguez F, Droppelmann K, Droppelmann N, Galindo H, León A, Madrid J, Molgó M, Mondaca S, Montero P, Uribe P, Villaseca MA, Vinés E, Navarrete-Dechent C.
J Eur Acad Dermatol Venereol. 2021 Nov;35(11):e735-e737. doi: 10.1111/jdv.17522. Epub 2021 Jul 26.
Summary: This letter to the editor describes a retrospective study from January 2019 through March 2021 from Chile that showed a 31% decrease in melanoma diagnoses each month during the pandemic, compared to the control year. The authors describe how skin cancer screening is still a vital cancer prevention tool and that delays in diagnosis due to the pandemic lead to increased stage at diagnosis and increased mortality rates.
Commentary: Cancer cannot wait – esophagectomy during the COVID-19 pandemic. [Commentary]
Harrington CA (Surgery), Molena D (Surgery).
Semin Thorac Cardiovasc Surg. 2021 Jul 13;S1043-0679(21)00322-1. doi: 10.1053/j.semtcvs.2021.07.010. (Epub ahead of print).
Summary: In this commentary, the authors report that cancer surgery for esophageal cancer, esophagectomy, should not be postponed during a pandemic.
Respiratory disease with SARS-COV2 infection. [Book Chapter]
Hasan AN (Pediatrics).
Image-Guided Management of COVID-19 Lung Disease. 2020 Jul 10. doi: 10.1007/978-3-030-66614-9_10.
Summary: This book chapter describes how COVID-19 can lead to severe respiratory disease, the clinical course of the disease, clinical symptoms and signs, clinical assessments, and therapies to treat respiratory disease from COVID-19 infection.
An autoantigen profile from Jurkat T-lymphoblasts provides a molecular guide for investigating autoimmune sequelae of COVID-19. [Preprint]
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Jul 7. doi: 10.1101/2021.07.05.451199.
Summary: In this preprint, the authors studied autoantigens from human Jurkat T-cells. This study allows growing the autoantigens database to better understand post-Covid syndromes, such as autoimmune effects.
Protease inhibitor plasma concentrations associate with COVID-19 infection. [Article]
Medjeral-Thomas NR, Troldborg A, Hanse AG, Pihl R (Chemical Biology Program), Clarke CL, Peters JE, Thomas DC, Willicombe M, Palarasah Y, Botto M, Pickering MC, Thiel S.
Oxf Open Immunol. 2021 Jul 7;2(1):iqab014. doi: 10.1093/oxfimm/iqab014. eCollection 2021.
Summary: This study measured and compared the level of protease inhibitors in hemodialysis patients infected with COVID-19 and non-infected patients. The authors observed different inhibitors' levels. Therefore additional studies are needed to understand the mechanisms.
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: The COVIDSurg mortality score. (Article)
COVIDSurg Collaborative (Ganly I (Surgery), Brown L (Graduate Staff) in group).
Br J Surg. 2021 Jul 6;znab183. doi: 10.1093/bjs/znab183. (Epub ahead of print).
Summary: This large international study used artificial intelligence to create a COVIDsurg Morality Score, a predictive score for mortality in surgical patients infected with SARS-CoV-2. The study concluded that it would be safe to restart the wide range of elective surgeries for patients for whom the score predicts low risk.
Comments on the letter: "Role of religious and spiritual aid in quarantine hospitalization due to SARS-COV-2" - What about existential needs of for those who are without a religion? [Letter to the Editor]
da Ponte G, Ouakinin S, Breitbart W (Psychiatry Service).
J Acad Consult Liaison Psychiatry. . 2021 Nov-Dec;62(6):669-670. doi: 10.1016/j.jaclp.2021.06.004. Epub 2021 Jul 6.
Summary: In this letter to the editor, the authors comment on a recently published letter “The role of religious and spiritual aid in quarantine hospitalization due to SARS-CoV-2” and highlight that Meaning Centered Psychotherapy may help non-religious as well as religious patients.
Blunted humoral response after mRNA vaccine in patients with haematological malignancies. [Editorial]
Kamboj M (Medicine).
Lancet Haematol. 2021 Jul 2;S2352-3026(21)00197-6. doi: 10.1016/S2352-3026(21)00197-6. (Epub ahead of print).
Summary: This comment discusses the article "Immunogenicity of the BNT162b2 COVID-19 mRNA vaccine and early clinical outcomes in patients with haematological malignancies in Lithuania: a national prospective cohort study," where the authors study the response to COVID-19 mRNA vaccines for patients with haematological malignancies.
Probing the SAM binding site of SARS-CoV-2 Nsp14 in vitro using SAM competitive inhibitors guides developing selective bisubstrate inhibitors. [Article]
Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K (Chemical Biology Program), Li D (Chemical Biology Program), Liu J, Smil D, Luo M (Chemical Biology Program), Jin J, Fish PV, Brown PJ, Vedadi M.
SLAS Discov. 2021 Oct;26(9):1200-1211. doi: 10.1177/24725552211026261. Epub 2021 Jul 1.
Summary: In this article, the authors describe the development of an assay to screen S-adenosylmethionine (SAM) competitive MTase inhibitors and SAM analogs with the hope of developing future drugs against COVID-19.
Nurses promoting inclusive, safe, resilient, and sustainable cities and communities: Taking action on COVID-19, systemic racism, and climate change. [Miscellaneous Article]
Schenk EC, Potter TM, Cook C, Huffling K, Rosa WE (SKI Psychiatry/Counseling).
Am J Nurs. 2021 Jul 1;121(7):66-69. doi: 10.1097/01.NAJ.0000758540.26343.2e.
Summary: This article discusses how nurses can help with attaining the United Nations (UN) Sustainable Development Goal 11 (SDG-11), making "cities and human settlements inclusive, safe, resilient and sustainable."
Remote management of immunotherapy-induced bullous pemphigoid during the COVID-19 pandemic. [Meeting Abstract]
Jonathan K (Medicine), Edwards C, Heelan K, Harwood C, Fearfield L.
Br J Dermatol.2021 Jul;185 Suppl 1:3-185. doi: 10.1111/bjd.20130.
Summary: This conference abstract looked at how teledermatology provided support to patients experiencing immune checkpoint inhibitor toxicity during the height of the COVID-19 pandemic.
Program and candidate experience with virtual interviews for the 2020 Complex General Surgical Oncology interview season during the COVID pandemic. [Original Research Article]
Hill MV, Ross EA, Crawford D, Lai L, Turaga K, Grubbs EG, Mullen J, Dineen S, D'Angelica M (Surgery), Reddy S, Farma JM.
Am J Surg. 2021 Jul;222(1):99-103. doi: 10.1016/j.amjsurg.2020.11.007. Epub 2020 Nov 8.
Summary: This article examines the virtual experience of program directors and candidates via surveys during the 2020 Complex General Surgical Oncology interview season.
Digestive manifestations in patients hospitalized with Coronavirus disease 2019. [Original Article]
Elmunzer BJ, Spitzer RL, Foster LD, Merchant AA, Howard EF, Patel VA, West MK, Qayed E, Nustas R, Zakaria A, Piper MS, Taylor JR, Jaza L, Forbes N, Chau M, Lara LF, Papachristou GI, Volk ML, Hilson LG, Zhou S, Kushnir VM, Lenyo AM, McLeod CG, Amin S, Kuftinec GN, Yadav D, Fox C, Kolb JM, Pawa S, Pawa R, Canakis A, Huang C, Jamil LH, Aneese AM, Glamour BK, Smith ZL, Hanley KA, Wood J, Patel HK, Shah JN, Agarunov E, Sethi A, Fogel EL, McNulty G, Haseeb A, Trieu JA, Dixon RE, Yang JY, Mendelsohn RB (Medicine), Calo D (Medicine), Aroniadis OC, LaComb JF, Scheiman JM, Sauer BG, Dang DT, Piraka CR, Shah ED, Pohl H, Tierney WM, Mitchell S, Condon A, Lenhart A, Dua KS, Kanagala VS, Kamal A, Singh VK, Pinto-Sanchez MI, Hutchinson JM, Kwon RS, Korsnes SJ, Singh H, Solati Z, Willingham FF, Yachimski PS, Conwell DL, Mosier E, Azab M, Patel A, Buxbaum J, Wani S, Chak A, Hosmer AE, Keswani RN, DiMaio CJ, Bronze MS, Muthusamy R, Canto MI, Gjeorgjievski VM, Imam Z, Odish F, Edhi AI, Orosey M, Tiwari A, Patwardhan S, Brown NG, Patel AA, Ordiah CO, Sloan IP, Cruz L, Koza CL, Okafor U, Hollander T, Furey N, Reykhart O, Zbib NH, Damianos JA, Esteban J, Hajidiacos N, Saul M, Mays M, Anderson G, Wood K, Mathews L, Diakova G, Caisse M, Wakefield L, Nitchie H, Waljee AK, Tang W, Zhang Y, Zhu J, Deshpande AR, Rockey DC, Alford TB, Durkalski V; for the North American Alliance for the Study of Digestive Manifestations of COVID-19.
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1355-1365.e4. doi: 10.1016/j.cgh.2020.09.041. Epub 2020 Oct 1.
Summary: The authors studied gastrointestinal symptoms among 1992 patients hospitalized with COVID-19 and found that most symptoms were mild and not an indicator of the severity of the disease.
Disease course and outcomes of COVID-19 among hospitalized patients with gastrointestinal manifestations. [Original Article]
Laszkowska M (Medicine), Faye AS, Kim J, Truong H, Silver ER, Ingram M, May B, Ascherman B, Bartram L, Zucker J, Sobieszczyk ME, Abrams JA, Lebwohl B, Freedberg DE, Hur C6.
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1402-1409.e1. doi: 10.1016/j.cgh.2020.09.037. Epub 2020 Sep 30.
Summary: This retrospective study looked at gastrointestinal (GI) symptoms among 2804 hospitalized patients with COVID-19. The authors observed that patients with GI symptoms had less severe COVID-19 disease.
Neutropenia in adult acute myeloid leukemia patients represents a powerful risk factor for COVID-19 related mortality. [Article]
Stahl M (Graduate Fellow), Narendra V (Graduate Fellow), Jee J (Graduate Fellow), Derkach A (Biostat/Epidemiology), Maloy M (Health Informatics), Geyer MB (Medicine), Mato AR (Medicine), Roeker LE (Medicine), Tallman MS (Medicine), Shah GL (Medicine), Daniyan A (Medicine), Goldberg AD (Medicine).
Leuk Lymphoma. 2021 Aug;62(8):1940-1948. doi: 10.1080/10428194.2021.1885664. Epub 2021 Jun 28.
Summary: This research article found that patients with hematological cancers were at significantly higher risk for poorer outcomes when diagnosed with Covid-19. They found that a diagnosis of AML, active treatment in the previous 3 months, neutropenia within 7 days prior to and within 28 days after Covid-19 diagnosis, or more than 3 comorbidities, all increased odds of death.
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for
SARS-CoV-2. [Article]
Frank MO, Blachere NE, Parveen S, Hacisuleyman E, Fak J, Luna JM, Michailidis E, Wright S, Stark P, Campbell A, Foo A, Sakmar TP, Huffman V, Bergh M, Goldfarb A, Mansisidor A, Patriotis AL, Palmquist KH, Poulton N, Leicher R, Vargas CDM, Duba I, Hurley A, Colagreco J, Pagane N, Orange DE, Mora K, Rakeman JL, Fowler RC, Fernandes H, Lamendola-Essel MF (SKI Medicine), Didkovsky N, Silvera L, Masci J, Allen M, Rice CM, Darnell RB.
PLoS One. 2021 Jun 25;16(6):e0252949. doi: 10.1371/journal.pone.0252949. eCollection 2021.
Summary: The authors report their results in this study on validating a PCR-based saliva assay, the Darnell Rockefeller University Laboratory (DRUL) saliva assay, in a preschool program setting.
Strategic thinking in test selection for mass SARS-CoV-2 testing. [Editorial]
Morjaria S (Medicine), Nouovini R (Medicine), Sirintrapun SJ (Pathology).
J Appl Lab Med. J Appl Lab Med. 2021 Nov 1;6(6):1688-1693. doi: 10.1093/jalm/jfab078. Epub 2021 Nov 9.
Summary: This article presents a COVID-19 testing framework based on thought experiments used for four frequently encountered community scenarios.
Assessing immune response upon systemic RNA vaccination on [18F]-FDG PET/CT for COVID-19 vaccine and then for
immuno-oncology? [Correspondence]
Seban RD, Champion L, Yeh R (Radiology), Schwartz LH, Dercle L.
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3351-3352. doi: 10.1007/s00259-021-05468-z. Epub 2021 Jun 23.
Summary: In this letter to the editor, the authors report on the potential theranostic value of [18F]-FDG PET in the era of RNA vaccination.
Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls. [Article]
Rentscher KE, Zhao X, Small BJ, Cohen HJ, Dilawari AA, Patel SK, Bethea TN, Van Dyk KM, Nakamura ZM, Ahn J, Zhai W, Ahles TA (Psychiatry Service), Jim HSL, McDonald BC, Saykin AJ, Root JC (Psychiatry Service), Graham DMA, Carroll JE, Mandelblatt JS.
Cancer. 2021 Oct 1;127(19):3671-3679. doi: 10.1002/cncr.33687. Epub 2021 Jun 23.
Summary: This original article describes the impact of Covid-19 loneliness and mental health on older breast cancer survivors, but found that both cancer survivors and women without cancer experienced similar changes to their mental health. They concluded that screening for loneliness is important for all older women at risk during the pandemic.
A white-knuckle ride of open COVID drug discovery. [Comment]
von Delft, Frank, Calmiano M, Chodera J (Computational and Systems Biology Program), Griffen E, Lee A, London N, Matviuk T, Perry B, Robinson M, von Delft A.
Nature. 2021 Jun 17;594:330-332. doi: 10.1038/d41586-021-01571-1.
Summary: In this comment, the authors report on a team assembled from Twitter called the COVID moonshot. One hundred fifty collaborators work on open drug-discovery research.
Association of convalescent plasma therapy with survival in patients with hematologic cancers and COVID-19. [Article]
Thompson MA, Henderson JP, Shah PK, Rubinstein SM, Joyner MJ, Choueiri TK, Flora DB, Griffiths EA, Gulati AP, Hwang C, Koshkin VS, Papadopoulos EB (Medicine), Robilotti EV (Medicine), Su CT, Wulff-Burchfield EM, Xie Z, Yu PP, Mishra S, Senefeld JW, Shah DP, Warner JL.
JAMA Oncol. 2021 Jun 17. doi: 10.1001/jamaoncol.2021.1799. (Epub ahead of print)
Summary: This original research describes the potential benefit of convalescent plasma for patients with hematological cancer and Covid-19 infection.
Association of HLA and mutated CCR5 with the clinical course of the disease in subjects with mild / moderate disease following COVID-19 infection. [Preprint]
Fischer JC, Schmidt AG, Boelke E, Uhrberg M, Keitel V, Feldt T, Jensen B, Häussinger D, Adams O, Schneider EM, Balz V, Enczmann J, Rox J, Hermsen D, Schulze-Bosse K, Kindgen-Milles D, Knoefel WT, van Griensven M, Haussmann J, Tamaskovics B, Plettenberg C, Scheckenbach K, Corradini S, Pedoto A (Anesthesiology), Maas K, Schmidt L, Grebe O, Esposito I, Erhardt A, Peiper M, Buhren BA, Calles C, Stöhr A, Lichtenberg A, Freise N, Lutterbeck M, Rezazadeh A, Budach W, Matuschek C.
Research Square. 2021 June 16. doi: 10.21203/rs.3.rs-600023/v1.
Summary: In this observatory study, the authors studied if specific HLA alleles in 157 adult COVID-19 patients could be associated with the severity of the disease.
The effect of neutropenia and filgrastim (G-CSF) in cancer patients with COVID-19 infection. [Preprint]
Zhang WA, Morjaria S (Medicine), Kaltsas A (Medicine), Hohl TM (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Ld - Advanced Practice Providers), Predmore J, Perez-Johnston R (Radiology), Jee J (Graduate Staff), Daniyan AF (Medicine), Perales M (Medicine), Taur Y (Medicine).
Clin Infect Dis. 2021 Jun 10;ciab534. doi: 10.1093/cid/ciab534. (Epub ahead of print)
Summary: In this retrospective cohort study of 379 cancer patients infected with COVID-19, the authors study if the administration of filgrastim because of neutropenia impacted the severity of COVID
Assessing the quality of life of head and neck healthcare workers during the COVID-19 pandemic—A self-reported global cross-sectional questionnaire study by the International Federation of Head and Neck Oncologic Societies. [Article]
Singh A, Garg A, Mandlik D, Vander Poorten V, Patel SG (Surgery), O'Neill JP, Spirano G, Shaha A (Surgery), Chaturvedi P, Cernea C, Shah J (Surgery).
J Surg Oncol. 2021 Jun 9. doi: 10.1002/jso.26571. (Epub ahead of print)
Summary: This article reports on the results of an international survey on the quality of life among health practitioners caring for Head and Neck Cancer patients during the COVID-19 pandemic.
Virtual mind-body programming for patients with cancer during the COVID-19 pandemic: Qualitative study. [Original Paper]
Emard N (SKI Integrative Medicine), Lynch KA (SKI Psychiatry/Counseling), Liou KT (Integrative Medicine), Atkinson T (Psychiatry Service), Green AK (Medicine), Daly B (Medicine), Trevino K (Psychiatry Service), Mao JJ (Integrative Medicine).
JMIR Cancer. 2021 Jun 8;7(2):e27384. doi: 10.2196/27384. Epub 2021 Jan 22.
Summary: This article reports on a study of 30 cancer patients who participated in a virtual mind-body program during the COVID-19 pandemic to determine the program's impact on the patients’ psychosocial well-being. It demonstrated the program's potential for addressing behavioral, psychological, and social challenges faced by cancer patients.
Cardio-oncology training in the COVID-19 Era. [Opinion Statement]
Feldman S (Graduate Staff), Liu J (Medicine), Steingart R (Medicine), Gupta D (Medicine).
Curr Treat Options Oncol. 2021 Jul; 22(7)58. doi: 10.1007/s11864-021-00855-y. Epub 2021 Jun 7.
Summary: This article describes how Covid-19 impacted training for cardio-oncology and how programs and trainees can adapt to the challenges.
Association of prior radiation dose to the cardiopulmonary system with COVID-19 outcomes in patients with cancer. [Letter to the Editor]
LaPlant Q (Radiation Oncology), Thor M (Medical Physics), Shaverdian N (Radiation Oncology), Shin JY (Radiation Oncology), Gilbo P (Radiation Oncology), Luo J (Graduate Staff), Gomez DR (Radiation Oncology), Gelblum DY (Radiation Oncology).
Radiother Oncol. 2021 Jun 6;S0167-8140(21)06574-9. doi: 10.1016/j.radonc.2021.06.002.
Summary: This Letter to the Editor describes research conducted at Memorial Sloan Kettering Cancer Center aimed at establishing the possible impact of radiation therapy (RT) to cardiopulmonary structures on the outcomes of COVID-19 infection in cancer patients who underwent RT prior to contracting COVID-19. While some impact was found to be related to the risk of hospitalization due to COVID-19, the study did not find the increased risk of severe infection or death. The researchers conclude that, while cancer patients with a history of thoracic RT should be closely monitored, RT should continue to be used when treating cancer patients during the COVID-19 pandemic.
Oncology patients' perspectives on remote patient monitoring for COVID-19. [Article]
Daly B (Medicine), Lauria TS (Nursing), Holland JC (Nursing), Garcia J (Nursing), Majeed J (Ld-Advanced Practice Providers), Walters CB (Patient & Caregiver Engagement), Zablocki M (Strategy and Analytics), Chow K (Ld-Advanced Pratice Providers), Strachna O (Health Informatics), Giles CE (Ld-Advanced Practice Providers), Kelly MF (Ld-Advanced Practice Providers), Housen A (Ld-Advanced Practice Providers), Canavan M (Ld-Advanced Practice Provdiers), Maresca NM (Ld-Advanced Practice Providers), Baser R (Biostatistics & Epidemiology), Salvaggio R (Nursing), Robson ME (Medicine), Reidy-Lagunes DL (Medicine).
JCO Oncol Pract. 2021 Sep;17(9):e1278-e1285. doi: 10.1200/OP.21.00269. Epub 2021 Jun 4.
Summary: This study describes patient perspectives on remote monitoring at home of oncology patients for Covid-19 infections.
Intravenous ketamine for cancer pain management including flares during the COVID-19 pandemic: A retrospective study. [Article]
Oh D, Haffey P, Patel A, Gulati A (Anesthesiology).
Pain Med. 2021 Ju1;22(7):1642-1650. doi: 10.1093/pm/pnab163. Epub 2021 Jun 4.
Summary: This study looks at intravenous ketamine for cancer-related neuropathy. The study was conducted during the COVID-19 pandemic.
Using the nurse coaching process to support bereaved staff during the COVID-19 crisis. [Article]
Rosa WE (SKI Psychiatry/Counseling), Levoy K, Battista V, Dahlin C, Thaxton C, Greer K.
J Hosp Palliat Nurs. 2021 Jun 2. doi: 10.1097/NJH.0000000000000773. (Epub ahead of print)
Summary: This article presents a step by step coaching process for nurses intended to mitigate psychological distress in health practitioners caused by mass bereavement during COVID-19 pandemic.
Transplant infectious disease landscape in the COVID19-Era. [Editorial]
Papanicolaou GA (Medicine), Neofytos D.
Curr Opin Infect Dis. 2021 Aug 1;34(4):273-274. doi: 10.1097/QCO.0000000000000744.
Summary: This editorial describes how even during the Covid-19 pandemic patients were still receiving transplants, however Covid-19 presented significant challenges for patients post-transplant.
Effectivity of a program for the control and prevention of COVID-19 healthcare-associated infections in a Spanish academic hospital. [Article]
Gras-Valentí P, Mora-Muriel JG, Chico-Sánchez P, Algado-Sellés N, Soler-Molina VM, Hernández-Maldonado M, Lameiras-Azevedo AS, Jiménez Sepúlveda NJ, Gómez Sotero IL, Villanueva-Ruiz CO, Barrenengoa-Sañudo J, Fuster-Pérez M, Cánovas-Jávega S, Cerezo-Milan P, Monerris-Palmer M, Llorens-Soriano P, Merino-Lucas E, Rodríguez-Diaz JC, Gil-Carbonell J, Sánchez-Martínez R, Pastor-Cesteros R, Mena-Esquivias L, Galiana-Ivars M, Jaime-Sánchez FA, Margarit-Ferri C, Gonzalez-deDios J, Lloret G, García-Alonso MA, Sánchez-Vela P (Human Oncology & Pathogenesis Program), Sánchez-Payá J.
J Patient Saf. 2021 Jun 1;17(4):323-330. doi: 10.1097/PTS.0000000000000852. Epub 2021 Apr 7.
Summary: This study of healthcare worker exposure to COVID recommended the continuous wearing of surgical masks in both patient and staff areas of the hospital.
An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19. [Article]
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
J Autoimmun. 2021 Jun;120:102644. doi: 10.1016/j.jaut.2021.102644. Epub 2021 Apr 27.
Summary: The research reported in this article was aimed at exploring autoimmune symptoms caused by SARS-CoV-2 infection. The researchers created a comprehensive resource and atlas for the investigation of autoimmune sequelae of COVID-19 (“long COVID”). This is a second study resulting from this research with new contribution to the knowledge of the relationships between COVID infection and autoimmunity. This research and the atlas contributes to ongoing and future studies into the mechanisms of long-term autoimmune consequences after acute COVID.
Changes, challenges and opportunities in cancer care during the COVID-19 era and beyond: Building on lessons learned from the pandemic. [Review]
Motzer J (Medicine), Jonasch EA, McGregor BA, Figlin RA.
Kidney Cancer J. 2021 Jun;19(2):42-47. doi: 10.52733/KCJ19n2-r1.
Summary: In this roundtable discussion, leading cancer experts from across the United States share their views on current changes, challenges and opportunities for delivering cancer care during the COVID-19 pandemic.
Experience of infection preventionists during the first wave of COVID-19 outside of China. [Meeting Abstract]
Bubb TN (Medicine), Haas JP.
Am J Infect Control. 2021 Jun;49(6 Suppl.): S8-S9. doi: 10.1016/j.ajic.2021.04.034.
Summary: This conference abstract reports on the results of a survey posted periodically on social media in the first half of 2020 and completed by specialized healthcare workers - Infection Preventionists (IPs) - from 16 US states and 4 countries, working predominantly in Acute Care. The reported experiences of IPs during the beginning of the pandemic included working long hours/overtime, shortages of protective equipment, stress and emotional exhaustion, etc. At the same time the survey respondents felt that their profession's standing was boosted.
SARS-CoV-2 infection in 50 patients with primary CNS lymphoma: Presentation, effects on tumor treatment and outcome in a series of the International PCNSL Collaborative Group. [Meeting Abstract]
Ferreri AJM, Steffanoni S, Calimeri T, Laurenge A, Fox CP, Soussain C, Grommes C (Neurology), Sassone MC, Touat M, Boot J, Crosbie N, Chaganti S, Dietrich J, Alencar A, Itchaki G, Hoang Xuan K, Batchelor T, Cwynarski K.
Hematol Oncol. 2021 Jun;39 (Suppl. 2):227-229. doi: 10.1002/hon.68_2880.
Summary: This conference abstract reports an international study of 50 patients with CNS lymphoma and concurrent COVID-19.
The care of children with cancer during the COVID-19 pandemic. [Review]
Moreira DC, Millen GC, Sands S (Psychiatry Service), Kearns PR, Hawkins DS.
Am Soc Clin Oncol Educ Book. 2021;41:1-10. doi: 10.1200/EDBK_321497.
Summary: The article is a review of the challenges and direct and collateral effects of the COVID-19 pandemic on the care of children with cancer. Reviewed are such aspects as the severity of COVID-19 in pediatric cancer patients, adaptation of health care delivery to the pandemic challenges, patient access to cancer diagnosis and care during the pandemic, impact on clinical trials in pediatric oncology, etc.
Making the invisible enemy visible. [Comment]
Croll TI, Diederichs K, Fischer F, Fyfe CD, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne AM (Graduate Studies), Reeves M, Richardson JS, Santoni G, Stäb S, Tronrud DE, von Soosten LC, Williams CJ, Thorn A.
Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7.
Summary: This article reports on the ongoing efforts of structural biology scientists in improving and deepening accumulated knowledge about the structures of SARS-CoV-2 proteins.
Overview and summary: The COVID-19 pandemic and nurses: Caring for others and ourselves. [Overview and summary]
Rosa WE (SKI Psychiatry/Counseling).
Online J Issues Nurs. 2021 May 31;26(2). doi: 10.3912/OJIN.Vol26No02ManOS.
Summary: This overview describes the impact of the Covid-19 pandemic on nurses and the nursing profession.
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19. [Research Article]
Mendoza R, Saha N (Structural Biology), Momeni A, Gabutan E, Alawad M, Dehghani A, Diks J, Lin B, Wang D, Alshal M, Fyke W, Wang B, Himanen JP (Structural Biology), Premsrirut P, Nikolov DB (Structural Biology).
Heliyon. Heliyon. 2021 Jun;7(6):e07200. doi: 10.1016/j.heliyon.2021.e07200. Epub 2021 May 31.
Summary: This research article describes a potential pharmacological target for treating Covid-19-related inflammation.
Blood cancer caregiving during COVID-19: Understanding caregivers' needs. [Article]
Fisher CL, Wright KB, Hampton CN, Vasquez TS, Kastrinos A, Applebaum AJ (Psychiatry Service), Sae-Hau M, Weiss ES, Lincoln G, Bylund CL.
Transl Behav Med. 2021 May 25;11(5):1187-1197. doi: 10.1093/tbm/ibab021.
Summary: This article reports on the results of a survey of adult child caregivers caring for a parent diagnosed with a blood cancer during the COVID-19 pandemic. This study revealed the patterns of uncertainty caregivers experienced, and established the need for the supportive services to help caregivers provide care and deal with the psychological burden experienced during the global health crisis.
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome. [Article]
Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP (Graduate Studies), Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD (Computational and Systems Biology Program), Bowman GR.
Nat Chem. 2021 Jul;13(7):651-659. doi: 10.1038/s41557-021-00707-0. Epub 2021 May 24.
Summary: This paper reports on the efforts of over a million citizen scientists that participated in the Folding@home initiative to learn more about the SARS-CoV-2 protein structures and their conformational changes. They developed a "distributed computing project to create the first exascale computer and simulate 0.1 seconds of the viral proteome."
CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer. [Article]
Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA (Human Oncology and Pathogenesis Program), Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE (Laboratory Medicine), Kumar A (Medicine), Widman AJ (Graduate Fellow), DeWolf S (Medicine), Boutemine SR (Medicine), Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, Maxwell KN, Reilly JP, Maslak PG (Laboratory Medicine), Vonderheide RH, Wolchok JD (Human Oncology and Pathogenesis Program), Hensley SE, Wherry EJ, Meyer NJ, DeMichele AM, Vardhana SA (Medicine), Mamtani R, Huang AC.
Nat Med. 2021 Jul;27(7):1280-1289. doi: 10.1038/s41591-021-01386-7. Epub 2021 May 20.
Summary: This study reports on a prospective observational cohort study of patients with cancer hospitalized with COVID-19 that found that CD8 T cells might influence recovery from COVID-19 when humoral immunity is deficient, suggesting that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer in this situation.
Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model. [Communication]
Morris A, McCorkindale W, The COVID Moonshot Consortium (Bruce Macdonald H (Computational and Systems Biology Program), Rufa D (Graduate Studies), Wittmann M (Computational and Systems Biology Program), Boby ML (Graduate Studies), Glass W (Computational and Systems Biology Program) in group), Drayman N, Chodera JD (Computational and Systems Biology Program), Tay S, London N, Lee AA. Chem Commun. 2021 Jun 18;57(48):5909-5912. doi: 10.1039/d1cc00050k. Epub 2021 May 6.
Summary: This paper reports on the work of researchers participating in the COVID Moonshot initiative and their use of machine learning to make predictions about chemical targets in their attempt to "develop patent-free antivirals with open science and open data."
Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2. [Preprint]
Hoff NP, Freise N, Schmidt AG, Firouzi-Memarpuri P, JReifenberger J, Lüdde T, Boelke E, Meller S, Homey B, Torsten Feldt T, Ole Jensen BE, Keitel V, Schmidt L, Maas K, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Buhren BA, Knoefel WT, Schneider M, Gerber PA, Pedotoa A (Anesthesiology), Häussinger D, Grebe O, van Griensven M, Braun SA, Salzmann S, Rezazadeh A, Matuschek C.
Research Square. 2021 May 13. doi: 10.21203/rs.3.rs-507024/v1.
Summary: This preprint reports on an analysis of patients with "COVID arm," a delayed skin reaction that has occurred in patients who received the mRNA-based COVID-19 vaccines. The authors concluded that although most cases resolve spontaneously, "topical glucocorticosteroids and oral anti histamines are effective in resolving the skin lesions and controlling symptoms."
COVID-19 vaccine efficacy in patients with chronic lymphocytic leukemia. [Research Letter]
Roeker LE (Medicine), Knorr DA (Medicine), Thompson MC (Graduate Fellow), Nivar M (Medicine), Lebowitz S (Outpatient Operations), Peters N (Outpatient Operations), Deonarine I Jr (Information Systems), Momotaj S (Medicine), Sharan S (Research Service Centers), Chanlatte V (Medicine), Hampton B (Medicine), Butala L (Nursing), Amato L (Nursing), Richford A (Nursing), Lunkenheimer J (Nursing), Battiato K (Nursing), Laudati C (Nursing), Mato AR (Medicine).
Leukemia. 2021 Sep;35(9):2703-2705. doi: 10.1038/s41375-021-01270-w. Epub 2021 May 13.
Summary: The study reported in this Letter to the Editor demonstrated the diminished immune response to SARS-CoV-2 mRNA vaccines in patients with chronic lymphocytic leukemia (CLL). Vaccination in patients with CLL may not have the same efficacy as in the general population, especially in patients receiving CLL-directed therapy
Universal engraftment after allogeneic hematopoietic cell transplantation using cryopreserved CD34 selected grafts. [Article]
Jacob RP (Laboratory Medicine), Flynn J (Biostat/Epidemiology), Devlin SM (Biostat/Epidemiology), Maloy M (Health Informatics), Giralt SA (Medicine), Maslak P (Laboratory Medicine), O'Reilly RJ (Pediatrics), Tonon JA (Laboratory Medicine), Perales MA (Medicine), Avecilla ST (Laboratory Medicine), Cho C (Medicine).
Transplant Cell Ther. 2021 Aug;27(8):697.e1-697.e5. doi: 10.1016/j.jtct.2021.04.026. Epub 2021 May 13.
Summary: Since the COVID-19 pandemic has resulted in most medical centers using cryopreserved grafts for allogeneic hematopoietic cell transplantation, this single-center analysis of adult patients with hematologic malignancies who underwent allo-HCT with cryopreserved CD34-selected allo-HCT grafts is timely as it demonstrates that cryopreservation of CD34+ HPC grafts used in allo-HCT is a safe and practical option during COVID-19 times.
Translating inspiration from COVID-19 vaccine trials to innovations in clinical cancer research. [Letter]
Choudhury NJ (Medicine), Riely GJ (Medicine), Sabbatini PJ (Physician in Chief), Hellmann MD (Medical Physics).
Cancer Cell. 2021 Jul 12;39(7):897-899. doi: 10.1016/j.ccell.2021.05.001. Epub 2021 May 7.
Summary: The authors of this Letter suggest applying the lessons and experience of conducting COVID-19 vaccine clinical trials to clinical cancer trials. They emphasize: increasing public trust in clinical research, increasing the understanding of the value of clinical trials (thus making the recruitment of volunteers speedier), simplifying clinical cancer trials design, increasing the transparency of clinical cancer trial protocols, and the efficient delivery of clinical trial results.
The New York State SARS-CoV-2 testing consortium: Regional communication in response to the COVID-19 pandemic. [Article]
Crawford JM, Aguero-Rosenfeld ME, Aifantis I, Cadoff EM, Cangiarella JF, Cordon-Cardo C, Cushing M, Firpo-Betancourt A, Fox AS, Furuya Y, Hacking S, Jhang J, Leonard DGB, Libien J, Loda M, Mendu DR, Mulligan MJ, Nasr MR, Pecora ND, Pessin MS (Laboratory Medicine), Prystowsky MB, Ramanathan LV (Laboratory Medicine), Rauch MB, Riddell S, Roach K, Roth KA, Shroyer KR, Smoller BR, Spitalnik SL, Spitzer ED, Tomaszewski JE, Waltman S, Willis L, Sumer-King Z.
Acad Pathol. 2021 May 7. doi: 10.1177/23742895211006818.
Summary: Eleven academic medical institutions formed the New York State SARS-CoV-2 Testing Consortium in April 2020 to establish and improve communication at the height of the pandemic, and to create and share knowledge between the institutions and the state.
Hairy cell leukemia and COVID-19 adaptation of treatment guidelines. [Review]
Grever M, Andritsos L, Banerji V, Barrientos JC, Bhat S, Blachly JS, Call T, Cross M, Dearden C, Demeter J, Dietrich S, Falini B, Forconi F, Gladstone DE, Gozzetti A, Iyengar S, Johnston JB, Juliusson G, Kraut E, Kreitman RJ, Lauria F, Lozanski G, Parikh SA, Park J (Medicine), Polliack A, Ravandi F, Robak T, Rogers KA, Saven A, Seymour JF, Tadmor T, Tallman MS (Medicine), Tam CS, Tiacci E, Troussard X, Zent C, Zenz T, Zinzani PL, Wörmann B.
Leukemia. 2021 Jul;35(7):1864-1872. doi: 10.1038/s41375-021-01257-7. Epub 2021 May 4.
Summary: This paper reports on the recommendations for the diagnosis and management of classic hairy cell leukemia (cHCL) that were updated to meet the concerns of and offer preventative measures for the COVID-19 pandemic. Since these patients are generally treated with first-line therapies that puts them in a state of prolonged immunosuppression, this increases their susceptibility to infections and the risk for a severe course of COVID-19.
Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning. [Article]
Navlakha S, Morjaria S (Medicine), Perez-Johnston R (Radiology), Zhang A, Taur Y (Medicine).
BMC Infect Dis. 2021 May 4;21:391. doi: 10.1186/s12879-021-06038-2.
Summary: The authors developed and used a machine learning algorithm based on 267 clinical variables to identify cancer patients at high risk of severe COVID-19 outcomes.
First Surgical National Consensus Conference of the Italian Breast Surgeons association (ANISC) on breast cancer management in neoadjuvant setting: Results and summary. [Editorial]
De Luca A, Frusone F, Buzzacchino F, Amabile MI, Taffurelli M, Del Mastro L, Rutgers EJT, Sacchini V (Surgery), Caruso F, Minelli M, Fortunato L.
Eur J Surg Oncol. 2021 May 3;S0748-7983(21)00469-8. doi: 10.1016/j.ejso.2021.04.037. (Epub ahead of print)
Summary: This paper reports on a consenus conference on neoadjuvanr chemotherapy in breast cancer management which was held online due to the COVID-19 pandemic.
A comprehensive review of imaging findings in COVID-19 - Status in early 2021. [Review]
Afshar-Oromieh A, Prosch H, Schaefer-Prokop C, Bohn KP, Alberts I, Mingels C, Thurnher M, Cumming P, Shi K, Peters A, Geleff S, Lan X, Wang F, Huber A, Gräni C, Heverhagen JT, Rominger A, Fontanellaz M, Schöder H (Radiology), Christe A, Mougiakakou S, Ebner L.
Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2500-2524. doi: 10.1007/s00259-021-05375-3. Epub 2021 May 1.
Summary: A review of the role of imaging technologies in detecting 19 pathologies related to COVID-19.
Racial and ethnic disparities among patients with breast cancer and COVID-19. [Meeting Abstract]
Nagaraj G, Accordino MK, French B, Kuderer NM, Lyman GH, Stover DG, Blinder VS (Psychiatry Service), Schmidt AL, Shatsky RA, Grover P, Puc M, Hwang C, Wulff-Burchfield EM, Lewis MA, Menendez AG, Bilen MA, Warner JL, Lustberg MB, Shah DP.
Journal of Clinical Oncology. 2021 May 20;39(15 Suppl.). doi: 10.1200/JCO.2021.39.15_suppl.6500.
Summary: A study of 1,133 patients identified within the COVID-19 and Cancer Consortium registry who are in the United States, have invasive breast cancer, and received a laboratory-confirmed SARS-CoV-2 diagnosis between March 6, 2020 and February 4, 2021.
Lower respiratory tract disease (LRTD) in patients with cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) study. [Meeting Abstract]
Shah DP, Shah P, Schmidt AL, Bakouny Z, Farmakiotis D, Abidi M, Rubinstein SM, Figueroa CJ (Medicine), Labaki C, Friese CR, Rathmann J, Hwang C, McKay RR, Park C, Puc M, Nagaraj G, French B, Warner JL, Shete S.
Journal of Clinical Oncology. 2021 May 20;39(15 Suppl.). doi: 10.1200/JCO.2021.39.15_suppl.6563.
Summary: A review of 7,289 adult cancer patients with laboratory-confirmed SARS-CoV-2 infection reported between March 16, 2020 and February 6, 2021 in the international COVID-19 and Cancer Consortium registry, with authors noting that the COVID-19-related lower respiratory tract disease rate is high and associated with worse mortality rates in cancer patients.
A virtual coaching workshop for a nurse-led community-based palliative care team in Liberia, West Africa, to promote staff well-being during COVID-19. [Article]
Rosa WE (SKI Psychiatry/Counseling), Karanja V, Kpoeh JDN, McMahon C, Booth J.
Nurs Educ Perspect. 2021 Apr 30. doi: 10.1097/01.NEP.0000000000000828. (Epub ahead of print)
Summary: The authors describe their experiences with a 90-minute Partners in Health teleconference with Liberian nurses on challenges and fears related to working during the pandemic.
A molecular single-cell lung atlas of lethal COVID-19. [Article]
Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, Fang Y, Ravichandran H, Clausi MG, Alba GA, Rogava M, Chen SW, Ho P, Montoro DT, Kornberg AE, Han AS, Bakhoum MF (Radiation Oncology), Anandasabapathy N, Suárez-Fariñas M, Bakhoum SF, Bram Y, Borczuk A, Guo XV, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE, Elemento O, Saqi A, Hibshoosh H, Que J, Izar B.
Nature. 2021 Jul;595(7865):114-119. doi: 10.1038/s41586-021-03569-1. Epub 2021 Apr 29.
Summary: By comparing samples from COVID-19-infected lungs to samples from control lungs, the researchers developed an atlas of lethal COVID-19 on a cellular level.
COVID-19 has changed the way we think about training future pediatric hematologists/oncologists. [Special Report]
Moerdler S, Gampel B, Levine JM, Chou A, Madhusoodhan P, Oberg JA, Pierro J, Roberts SS (Pediatrics), Satwani P.
Pediatr Blood Cancer. 2021 Aug;68(8):e29088. doi: 10.1002/pbc.29088. Epub 2021 Apr 29.
Summary: The development of a pediatric hematology oncology fellows education initiative during the pandemic, especially a multi-institutional collaborative education series, promises to reshape curriculum and educational opportunities moving forward.
Digital pathology operations at an NYC tertiary cancer center during the first 4 months of COVID-19 pandemic response. [Article]
Ardon O (Pathology), Reuter VE (Pathology), Hameed M (Pathology), Corsale L (Pathology), Manzo A (Pathology), Sirintrapun SJ (Pathology), Ntiamoah P (Pathology), Stamelos E (Information Systems), Schueffler PJ (Collaborative Research Centers - PIC Directed), England C (Hospital Administration), Klimstra DS (Pathology), Hanna MG (Pathology).
Acad Pathol. 2021 Apr 28. doi: 10.1177/23742895211010276.
Summary: A description of how the pandemic impacted MSK's digital pathology workflow from March-June 2020.
COVID-19 imperils access to health and human services in El Paso, Texas and New York City: Perspectives from Hispanic parents. [Preprint]
Moya EM, Zamore C (SKI Psychiatry/Counseling), Perez LM, Tellez K (SKI Psychiatry/Counseling), Avila A, Aragones A (Psychiatry Service).
J Racial Ethn Health Disparities. 2022 Jun;9(3):1024-1029. doi: 10.1007/s40615-021-01041-4. Epub 2021 Apr 26.
Summary: A comparison of the impact of COVID-19 on low-income Mexican-born parents in New York City and El Paso, TX, including financial, mental health, and healthcare access repercussions.
Reply: Potential use of radiolabeled antibodies for imaging and treatment of COVID-19. [Letter]
Pillarsetty N (Radiology), Carter L (SKI Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2021 Jul 1;62(7):1020-1021. doi: 10.2967/jnumed.121.261950.
Summary: This article is an author's response to the comment on their Brief Communication “Oncology-Inspired Treatment Options for COVID-19” published in the Journal of Nuclear Medicine in July of 2020. The authors addressed the issues raised in the comment on their article.
COVID-19 and Hematopoietic Cell Transplant Center-specific survival analysis: Can we adjust for the impact of the pandemic? Recommendations of the COVID-19 Taskforce of the 2020 CIBMTR Center Outcomes Forum. [Recommendations]
Wingard JR, Ahn KW, Dandoy C, Perales MA (Medicine), Wood WA, Logan B, Riches M, Rizzo JD.
Transplant Cell Ther. 2021 Jul;27(7):533-539. doi: 10.1016/j.jtct.2021.04.008. Epub 2021 Apr 22.
Summary: This article reports on the recommendations, developed by The Center of International Blood and Marrow Transplantation Research (CIBMTR), for COVID-19 related adjustments for centers that perfrom hematopoietic cell transplantations.
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19. [Article]
Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Da Silva APD, Dias SDSG, da Silva CDS, Ferreira AC, Mattos M, Pão CRR, de Freitas CS, Soares VC, Hoelz LVB, Fernandes TVA, Branco FSC, Bastos MM, Boechat N, Saraiva FB, Ferreira MA, Jockusch S, Wang X, Tao C, Chien M, Xie W (Structural Biology), Patel D (Structural Biology), Garzia A, Tuschl T, Russo JJ, Rajoli RKR, Pedrosa CSG, Vitória G, Souza LRQ, Goto-Silva L, Guimarães MZ, Rehen SK, Owen A, Bozza FA, Bou-Habib DC, Ju J, Bozza PT, Souza TML.
J Antimicrob Chemother. 2021 Jun 18;76(7):1874-1885. doi: 10.1093/jac/dkab072. Epub 2021 Apr 21.
Summary: Identifying exisiting drugs that can be repurposed for use against SARS-Cov-2 became common during the COVID-19 pandemic. This article reports on the research into 2 such drugs, ofosbuvir and daclatasvir, that belong to the anti-HCV class of drugs. The laboratory research confirmed that the drugs in question have potential for treating COVID-19 infection but that further research is needed.
Corticosteroids in COVID-19 and non-COVID-19 ARDS: A systematic review and meta-analysis. [Systematic Review]
Chaudhuri D, Sasaki K, Karkar A, Sharif S, Lewis K, Mammen MJ, Alexander P, Ye Z, Lozano LEC, Munch MW, Perner A, Du B, Mbuagbaw L, Alhazzani W, Pastores SM (Anesthesiology), Marshall J, Lamontagne F, Annane D, Meduri GU, Rochwerg B.
Intensive Care Med. 2021 May;47(5):521-537. doi: 10.1007/s00134-021-06394-2. Epub 2021 Apr 19.
Summary: This systematic review of randomized controlled clinical trials (RCTs) on the use of corticosteroid drugs in COVID-19 and non-COVID-19 related acute respiratory distress syndrome (ARDS) found that the use of corticosteroids probably reduces mortality in patients with ARDS.
Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia. [Article]
Herishanu Y, Avivi I, Aharon A, Shefer G, Levi S, Bronstein Y, Moshiashvili MM, Ziv-Baran T, Shorer Y, Scarfo L, Joffe E (Medicine), Perry C, Ghia P.
Blood. 2021 Jun 10;137(23):3165-3173. doi: 10.1182/blood.2021011568. Epub 2021 Apr 16.
Summary: About 40% of patients with chronic lymphocytic leukemia (66/167) showed an immune response to the Pfizer mRNA vaccine. Those who had a response tended to be younger, at an earlier disease stage, treatment naïve, or a year or more post-treatment.
Seroepidemiology among employees of New York City Health and Hospitals during the first wave of the SARS-CoV-2 epidemic. [Preprint]
Bryan AD, Tatem K, Diuguid-Gerber J, Cooke C, Romanoff A (SKI Surgery), Choudhury N, Scanlon M, Kishore P, Sydney E, Masci J, Bakshi P, Pemmasani S, Davis NJ, Maru D.
medRxiv. 2021 Apr 15. doi: 10.1101/2021.04.12.21255344.
Summary: Researchers determined the prevalence of SARS-CoV-2 antibodies among 727 New York City Health + Hospitals healthcare workers between April 30 and June 30, 2020. Black workers, workers with household COVID exposure, those living in Queens, Brooklyn and the Bronx, and those in non-clinical patient-facing roles were more likely to have positive antibodies. This article is a preprint and has not been peer reviewed.
The Society for Integrative Oncology Practice Recommendations for online consultation and treatment during the COVID-19 pandemic. [Special Article]
Ben-Arye E, Paller CJ, Lopez AM, White S, Pendleton E (Integrative Medicine), Kienle GS, Samuels N, Abbawaajii N, Balneaves LG.
Support Care Cancer. 2021 Oct;29(10):6155-6165. doi: 10.1007/s00520-021-06205-w. Epub 2021 Apr 14.
Summary: The Society for Integrative Oncology Practice recommendations include recommendations for online practice of manual, acupuncture, movement, mind-body, herbal, and expressive art therapies.
Medical care disruptions during the first six-months of the COVID19 pandemic: The experience of older breast cancer survivors. [Article]
Dilawari A, Rentscher K, Zhai W, Ahles TA (Psychiatry Service), Ahn J, Bethea T, Carroll JE, Cohen H, Graham D, Jim H, McDonald BC, Nakamura Z, Patel S, Root J, Small B, Saykin A, Tometich D, VanDyk K, Mandelblatt J.
Res Sq. 2021 Apr 14;rs.3.rs-416077. doi: 10.21203/rs.3.rs-416077/v1. (Epub ahead of print)
Summary: This article reports on the results of a survey, administered to older breast cancer survivors in 5 U.S. regions, on medical care disruptions (such as interruptions in the ability to see doctors, receive treatment or supportive therapies, or fill prescriptions) during the COVID-19 pandemic and analyzes the patterns discerned from the responses to the survey.
Impact of COVID-19 on interventional pulmonology training. [Article]
Kalchiem-Dekel O (Medicine), Schwalk AJ, Patel NM, Lin IH (Biostat/Epidemiology), Beattie JA (Medicine), Husta BC (Medicine), Chawla M (Medicine), Sachdeva A, Akulian JA, Musani AI, Argento AC, Lee HJ, Mullon JJ, Desai NR, Hsia DW, Lee RP (Medicine).
ATS Scholar. 2021 Jun;2(2):236-248. doi: 10.34197/ats-scholar.2020-0126OC. Epub 2021 Apr 13.
Summary: The COVID-19 pandemic had an impact not only on patient care but also on medical education. This article describes the challenges faced by such a hands-on area of medical education as interventional pulmonology. The analysis of the challenges and solutions found could be useful for addressing similar situations in the future.
Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape. [Preprint]
Starr TN, Czudnochowski N, Zatta F, Park YJ, Liu Z, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG (Computational and Systems Biology), Zhang I (Computational and Systems Biology), Dingens AS, Bowen JE, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Tucker H, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota E, Cameroni E, Croll TI, Nix JC, Havenar-Daughton C, Telenti A, Lempp FA, Pizzuto MS, Chodera JD (Computational and Systems Biology), Hebner CM, Whelan SPJ, Virgin HW, Veesler D, Corti D, Bloom JD, Snell G.
bioRxiv. 2021 Apr 8;2021.04.06.438709. doi: 10.1101/2021.04.06.438709.
Summary: The authors characterize the structure of a particular SARS-CoV-2 antibody type to determine features that might be targeted by vaccines and therapeutics in COVID-19 and other diseases. This article is a preprint and has not been peer reviewed.
Virtual mind-body programming for patients with cancer during COVID-19: A qualitative study. [Preprint]
Emard N (SKI Integrative Medicine), Lynch KA (SKI Psychiatry/Counseling), Liou KT (Integrative Medicine), Atkinson T (Psychiatry Service), Green AK (Medicine), Daly B (Medicine), Trevino K (Psychiatry Service), Mao JJ (Integrative Medicine).
JMIR Cancer. 2021 Apr 7. doi: 10.2196/27384.
Summary: This preprint reports on a study of 30 cancer patients who participated in a virtual mind-body program during the COVID-19 pandemic to determine the program's impact on the patients’ psychosocial well-being. It demonstrated the program's potential for addressing behavioral, psychological, and social challenges faced by cancer patients.
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2. [Preprint]
Frank MO, Blachere NE, Parveen S, Hacisuleyman E, Fak J, Luna JM, Michailidis E, Wright S, Stark P, Campbell A, Foo A, Sakmar TP, Huffman V, Bergh M, Goldfarb A, Mansisidor A, Patriotis AL, Palmquist KH, Poulton N, Leicher R, Vargas CDM, Duba I, Hurley A, Colagreco J, Pagane N, Orange DE, Mora K, Rakeman JL, Fowler RC, Fernandes H, Lamendola-Essel MF (SKI Medicine), Didkovsky N, Silvera L, Masci J, Allen M, Rice CM, Darnell RB.
medRxiv. 2021 Apr 6. doi: 10.1101/2021.04.03.21254873.
Summary: The authors developed a saliva test for SARS CoV-2 using a self-collection kit. Its use aided the safe reopening of a child care center. This article is a preprint and has not been peer reviewed.
Thyroid cancer and telemedicine during the COVID-19 pandemic. [Editorial]
Chablani SV, Sabra MM (Medicine).
J Endocr Soc. 2021 Apr;5(6):bvab059. doi: 10.1210/jendso/bvab059.
Summary: A survey of nine MSK endocrinologists and endocrine surgeons shows that while physicians were overall satisfied with providing care via telemedicine, work can be done to improve technical, communication, and insurance barriers.
Sizing of airborne particles in an operating room. [Article]
Tkacik PT, Dahlberg JL, Johnson JE, Hoth JJ, Szer RA, Hellman SE (Medical Physics).
PLoS One. 2021 Apr 5;16(4):e0249586. doi: 10.1371/journal.pone.0249586.
Summary: A study of the size and quantity of aerosolized particles resulting from surgery. The authors developed a method for measuring the airborne particles in an operating room setting.
ASH-ASTCT COVID-19 vaccination for HCT and CAR-T cell recipients: Frequently asked questions (V2.0). [COVID-19 Resource Community]
Khawaja F, Chemaly RF, Dadwal S, Pergam S, Wingard J, Auletta J, El Boghdadly Z, Abidi M, Waghmare A, Shahid Z, Pabinger-Fasching I, Michaels L, Hill J, Hohl T (Medicine), Kamboj M (Medicine), Papanicolaou G (Medicine), Boeckh M.
ASTCT. 2021 Apr 1. url: https://www.astct.org/viewdocument/ash-astct-covid-19-vaccination-for-1. (Epub only)
Summary: This document presents the American Society for Transplantation and Cellular Therapy and the American Society of Hematology (ASTCT/ASH) answers to the frequently asked questions on COVID-19 vaccine use in patients undergoing hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR) T-cell therapy. The overall recommendation (as of the time of publication in April 2021) for these patients is to get vaccinated due to the proven efficacy and safety of the COVID-19 vaccines currently approved under Emergency Use Authorization in the US (Moderna, Pfizer & BioNTech and J&J). "All current guidance and responses are based on opinions of the ASTCT/ASH COVID-19 Vaccine expert panel. This document will be updated periodically when new data becomes available."
Intraoperative aerosol box use: Does an educational visual aid reduce contamination?. [Article]
Burnett GW, Zhou G, Fried EA, Shah RS (Anesthesiology), Park C, Katz D.
Korean J Anesthesiol. 2021 Apr;74(2):158-164. doi: 10.4097/kja.20511. Epub 2020 Nov 17.
Summary: This paper reports on a randomized study of forty-four anesthesiology trainees and faculty who completed a simulated anesthetic case in order to determine if a preoperative educational visual aid led to improved decontamination practices during their use of an aerosol box (which was developed to minimize viral exposure during aerosolizing procedures during the COVID-19 pandemic).
Pathology informatics education during the COVID-19 pandemic at Memorial Sloan Kettering Cancer Center (MSKCC). [Narrative Review]
Kim D, Hanna MG (Pathology), Vanderbilt C (Pathology), Sirintrapun SJ (Pathology).
Acta Med Acad. 2021 Apr;50(1):136-142. doi: 10.5644/ama2006-124.331.
Summary: This review details the development and structure of the pathology informatics rotation during Covid-19.
Primary palliative care clinical implications: Oncology nursing during the COVID-19 pandemic. [Review]
Rosa WE (SKI Psychiatry/Counseling), Dahlin C, Battista V, Finlayson CS (Nursing), Wisniewski RE (Ld - Advanced Practice Providers), Greer K, Ferrell BR.
Clin J Oncol Nurs. 2021 Apr;25(2):119-125. doi: 10.1188/21.CJON.119-125.
Summary: This article describes the need that emerged during the COVID-19 pandemic for oncology nurses to acquire palliative care skills to be better equipped for meeting the needs of patients with cancer. The article supports and advocates for incorporating primary palliative care education into the oncology nursing practice.
SARS-CoV-2 and splenic infarction: A rarely described thromboembolic presentation. [Research Letter]
Fernandes DA, Araújo Filho JAB (Radiology), de Jesus AR.
Rev Esp Enferm Dig. 2021 Mar 25. doi: 10.17235/reed.2021.7964/2021. (Epub ahead of print)
Summary: With this case report, the authors would like to make health care workers aware of rare thromboembolic events as another possible complication of COVID-19.
Is it safe to perform elective colorectal surgical procedures during the COVID-19 pandemic? A single institution experience with 103 patients. [Article]
Sobrado LF, Nahas CSR, Marques CFS, de Castro Cotti GC, Imperiale AR, Averbach P, de Meira Júnior JD, Horvat N (Radiology), Ribeiro-Júnior U, Cecconello I, Nahas SC.
Clinics (Sao Paulo). 2021 Mar 24;76:e2507. doi: 10.6061/clinics/2021/e2507.
Summary: The study was conducted by a group of researchers from Brazil to evaluate the safety of performing elective surgery for colorectal cancer and Inflammatory Bowel Disease at the time of the COVID-19 pandemic. This retrospective study evaluated the outcomes of elective laparascopic, open, and robotic colorectal surgeries performed at a single tertiary oncological hospital between March 10 and September 9, 2020. The study established that elective colorectal surgeries could be safely performed during the pandemic but preoperative screening for SARS-CoV-2 should be done to decrease the risk of in-hospital cross infection.
Staff experiences at a New York City medical center during the spring peak of the Covid-19 pandemic: A qualitative study. [Preprint]
Blackler L (Physician in Chief), Scharf AE (Physician in Chief), Masciale JN (Quality of Care Initiative), Lynch KA (Psychiatry/Counseling), Riches JC (Medicine), Matsoukas K (Information Systems), Colletti M (Ld - Advanced Practice Providers), Wall L (Nursing), Chawla S (Anesthesiology), Coyle N (Neurology), Alici Y (Psychiatry Service), Guest R (Human Resources), Voigt LP (Anesthesiology).
Res Sq. 2021 Mar 24:rs.3.rs-268807. doi: 10.21203/rs.3.rs-268807/v1. (Epub ahead of print)
Summary: In this paper, the authors report the results of a survey sent to Memorial Sloan Kettering workers (clinical and non-clinical) in June 2020 during a COVID-19 peak. In addition, they outline suggestions in the case of a new surge or in the event of another public health crisis.
Towards collective moral resilience: The potential of communities of practice during the COVID-19 pandemic and beyond. [Editorial]
Delgado J, Siow S, de Groot J, McLane B, Hedlin M (Medicine).
J Med Ethics. 2021 Jun;47(6):374-382. doi: 10.1136/medethics-2020-106764. Epub 2021 Mar 24.
Summary: This article explores the increased potential for moral distress in healthcare professionals during the COVID-19 pandemic. It introduces the new term 'collective moral resilience' to help conceptualize the impact of group settings on addressing potential moral distress experienced by healthcare professionals during trying and challenging times, such as the COVID-19 pandemic.
The intersection of work and home challenges faced by physician mothers during the coronavirus disease 2019 pandemic: A mixed-methods analysis. [Article]
Halley MC, Mathews KS, Diamond LC (Psychiatry Service), Linos E, Sarkar U, Mangurian C, Sabry H, Goyal MK, Olazo K, Miller EG, Jagsi R, Linos E.
J Womens Health (Larchmt). 2021 Apr;30(4):514-524. doi: 10.1089/jwh.2020.8964. Epub 2021 Mar 23.
Summary: This study reports on the results of an online survey administered to the Physician Moms Group (PMG) and PMG COVID-19 Subgroup on Facebook, to understand their work-related and home life concerns during the COVID-19 pandemic. The survey results demonstrated that the concerns of physicians varied somewhat depending on their work settings (e.g. frontline vs non-frontline physicians) and family situation (e.g., children of certain ages). The expressed concerns were related to the following themes: Community and Government Support, Personal Health and Safety, Organizational Communication and Relationships, Family Health and Safety, Patient Care and Safety Financial/Job Security, Parenting/Homeschooling, Work/Life Balance, Access to Childcare, and Spouse/Partner Relationships.
COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials. [Perspective]
Desai A, Gainor JF, Hegde A, Schram AM (Medicine), Curigliano G, Pal S, Liu SV, Halmos B, Groisberg R, Grande E, Dragovich T, Matrana M, Agarwal N, Chawla S, Kato S, Morgan G, Kasi PM, Solomon B, Loong HH, Park H, Choueiri TK, Subbiah IM, Pemmaraju N, Subbiah V.
Nat Rev Clin Oncol. 2021 May;18(5):313-319. doi: 10.1038/s41571-021-00487-z. Epub 2021 Mar 15.
Summary: With this paper, the authors seek to give guidance on COVID-19 vaccination for patients enrolled or about to get enrolled in oncologic clinical trials. They conclude that COVID-19 vaccination should be standard of care for those patients with some rare exceptions where it would appear not to serve the patient's best interest.
The inaugural United States World Hospice and Palliative Care Day Celebration: A virtual coming together. [Review]
Rosa WE (SKI Psychiatry/Counseling), Pandey S (Nursing), Epstein AS (Medicine), Connor SR, Nelson JE (Medicine).
Palliat Support Care. 2021 Mar 15:1-5. doi: 10.1017/S1478951521000237. (Epub ahead of print)
Summary: In this article, the authors report Memorial Sloan Kettering Cancer Center's experience on hosting the United States World Hospice and Palliative Care Day (WHPCD) Celebration. Two hundred seventy participants from at least 16 countries joined the virtual event on October 10, 2020.
The hidden curve behind COVID-19 outbreak: The impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying - The head and neck cancer model. [Article]
Matos LL, Forster CHQ, Marta GN, Castro Junior G, Ridge JA, Hirata D, Miranda-Filho A, Hosny A, Sanabria A, Gregoire V, Patel SG (Surgery), Fagan JJ, D'Cruz AK, Licitra L, Mehanna H, Hao SP, Psyrri A, Porceddu S, Galloway TJ, Golusinski W, Lee NY (Radiation Oncology), Shiguemori EH, Matieli JE, Shiguemori APAC, Diamantino LR, Schiaveto LF, Leão L, Castro AF, Carvalho AL, Kowalski LP.
Cancer Causes Control. 2021 May;32(5):459-471. doi: 10.1007/s10552-021-01411-7. Epub 2021 Mar 11.
Summary: The authors used a model of head and neck squamous cell carcinoma progression to estimate the increased mortality burden of the pandemic on cancer patients. This preprint has not been peer reviewed.
Evaluation of sample pooling for SARS-CoV-2 RNA detection in nasopharyngeal swabs and salivas on the Roche Cobas 6800. [Short Communication]
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Babady NE (Laboratory Medicine).
J Clin Virol. 2021 May;138:104790. doi: 10.1016/j.jcv.2021.104790. Epub 2021 Mar 10.
Summary: This meeting abstract reports on the results of a study (that used a pool of 8 samples) evaluating sample pooling for SARS-CoV-2 testing. It was found to be a viable option worth investigating further.
Supporting virtual dermatology consultation in the setting of COVID-19. [Report]
Kutner A (Medicine), Love D (Medicine), Markova A (Medicine), Rossi A (Medicine), Lee E (Medicine), Nehal K (Medicine), Lacouture M (Medicine), Rotemberg V (Medicine).
J Digit Imaging. 2021 Apr;34(2):284-289. doi: 10.1007/s10278-021-00425-6. Epub 2021 Mar 10.
Summary: This experience report details the teledermatology consultations at MSKCC and how this can impact future improvements to the service.
Dermoscopy in the COVID-19 era: Magnifying the gap for clinicians. [Editorial]
Hussain K, Marghoob AA (Medicine), Patel NP.
Dermatol Pract Concept. 2021 Mar 8;11(2):e2021069. doi: 10.5826/dpc.1102a69.
Summary: This article describes the evolution of teledermoscopy and how clinicians need to use the technique to its full potential to provide both static and dynamic clues.
Decreased public pursuit of cancer-related information during the COVID-19 pandemic in the United States. [Article]
Adelhoefer S, Berning P, Solomon SB (Radiology), Maybody M (Radiology), Whelton SP, Blaha MJ, Dzaye O.
Cancer Causes Control. 2021 Jun;32(6):577-585. doi: 10.1007/s10552-021-01409-1. Epub 2021 Mar 8.
Summary: This study describes the decrease in cancer-related searches during the Covid-19 pandemic, beginning in March 2020. This decline mirrors the decline in cancer diagnoses during the same time frame.
Stepwise strategic mitigation planning in a pediatric oncology center during the COVID-19 pandemic. [Process Paper]
Szenes V (Nursing), Bright R (Nursing), Diotallevi D (Nursing), Melendez G (Nursing), Martinez C (Ld - Advanced Practice Providers), Zakak N, (Ld - Advanced Practice Providers), Killinger J (Pediatrics), Gilheeney S (Pediatrics), Roberts SS (Pediatrics), Kamboj M (Medicine), Bender JG (Pediatrics), Kung AL (Pediatrics), Boulad F (Pediatrics).
J Pediatr Oncol Nurs. May-Jun 2021;38(3):176-184. doi: 10.1177/1043454221992301. Epub 2021 Mar 8.
Summary: This paper describes a model developed by MSK Kids during the COVID-19 pandemic for planning continued preparedness that will anticipate "the need to develop plans for the screening, testing, and treating of patients, as well as specific mitigation plans."
The SIOG COVID-19 working group recommendations on the rollout of COVID-19 vaccines among older adults with cancer. [Guidelines]
Mislang AR, Soto-Perez-de-Celis E, Russo C, Colloca G, Williams GR, O'Hanlon S, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrió RG, Stauder R, Jaklitsch M, Cairo C, Gil LA Jr, Sattar S, Kantilal K, Loh KP, Lichtman SM (Medicine), Brain E, Wildiers H, Kanesvaran R, Battisti NML.
J Geriatr Oncol. 2021 Jun;12(5):848-850. doi: 10.1016/j.jgo.2021.03.003. Epub 2021 Mar 5.
Summary: The International Society of Geriatric Oncology (SIOG) offers Covid-19 vaccination rollout guidelines to prioritize higher risk older patients with cancer.
Neoadjuvant endocrine therapy use in early stage breast cancer during the COVID-19 pandemic. [Article]
Park KU, Gregory M, Bazan J, Lustberg M, Rosenberg S, Blinder V (Psychiatry), Sharma P, Pusztai L, Shen C, Partridge A, Thompson A.
Breast Cancer Res Treat.2021 Jul;188(1):249-258. doi: 10.1007/s10549-021-06153-3. Epub 2021 Mar 2.
Summary: This study explored the pandemic-related changes in the practice patterns of medical oncologists, radiation oncologists, and surgeons with regards to their use of neoadjuvant endocrine therapy (NET) for early stage breast cancer. Physicians were surveyed during the initial phase of the pandemic, in May-June2020, when NET was being recommended as an option that made possible the safe deferral of surgery.
Global integration of palliative nursing education to improve health crisis preparedness. [Article]
Rosa WE (SKI Psychiatry/Counseling), Ferrell BR, Mazanec P.
J Contin Educ Nurs. 2021 Mar 1;52(3):130-135. doi: 10.3928/00220124-20210216-07.
Summary: The authors use the framework of the National Consensus Project Clinical Practice Guidelines for Quality Palliative Care to explore ways to improve nurse education about palliative care.
SARS-CoV-2 seroprevalence and symptom onset in culturally linked Orthodox Jewish communities across multiple regions in the United States. [Article]
Zyskind I, Rosenberg AZ, Zimmerman J, Naiditch H, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Silverberg JI.
JAMA Netw Open. 2021 Mar 1;4(3):e212816. doi: 10.1001/jamanetworkopen.2021.2816.
Summary: This article describes how in culturally bound communities, outbreaks can occur outside of geographic areas, especially during holiday seasons. This study found an increase in outbreaks related to social events during Purim in Orthodox Jewish communities in five different states.
Oncologic immunomodulatory agents in patients with cancer and COVID-19. [Article]
Jee J (Graduate Staff), Stonestrom AJ (Graduate Staff), Devlin S (Biostat/Epidemiology), Nguyentran T (Ld - Advanced Practice Providers), Wills B (Graduate Staff), Narendra V (Graduate Staff), Foote MB (Graduate Staff), Lumish M (Graduate Staff), Vardhana S (Medicine), Pastores SM (Anesthesiology), Korde N (Medicine), Patel D (Medicine), Horwitz S (Medicine), Scordo M (Medicine), Daniyan A (Medicine).
Sci Rep. 2021 Mar 1;11(1):4814. doi: 10.1038/s41598-021-84137-5.
Summary: This study provides a retrospective analysis investigating the effects of oncologic immunomodulatory agents on 820 adult cancer patients (inpatient or outpatient) seen at MSK who were diagnosed with COVID-19 between March 8, 2020 and June 2, 2020.
COVID-19-related ethics consultations at a cancer center in New York City: A content review of ethics consultations during the early stages of the pandemic. [Article]
Friedman DN (Pediatrics), Blackler L (Ethics), Alici Y (Psychiatry Service), Scharf AE (Ethics), Chin M (Psychiatry), Chawla S (Anesthesiology), James MC (Psychiatry), Voigt LP (Anesthesiology).
JCO Oncol Pract. 2021 Mar;17(3):e369-e376. doi: 10.1200/OP.20.00440. Epub 2020 Aug 27
Summary: Treating cancer patients in the time of COVID-19, often in the presence of both cancer and COVID-19 diagnosis, inevitably triggers situations that may raise ethical issues. Clinical ethics consultations in a hospital setting is an instrument aimed at addressing ethical issues that occur in the course of patient care and which concerns clinicians, patients and/or patients' families. This article reviewed Memorial Sloan Kettering Cancer Center clinical ethics consultations that took place in the early and most difficult months of the COVID-19 pandemic, when totally new challenges faced society as a whole, and cancer care in particular.
Radiotherapy-associated CT imaging as a potential screening tool for COVID-19. [Meeting Abstract]
Wu A (Radiation Oncology), Plodkowski A (Radiology), Ginsberg M (Radiology), Shin J (Surgery), Laplant Q (Radiation Oncology), Shepherd A (Radiation Oncology), Shaverdian N (Radiation Oncology), Ng V (Graduate Staff), Yue Y (Radiation Oncology), Gilbo P (Radiation Oncology), Gelblum D (Radiation Oncology), Braunstein L (Radiation Oncology), Gomez D (Radiation Oncology), Rimner A (Radiation Oncology).
J Thorac Oncol 2021 Mar; 16(3 Suppl.)S252. doi: 10.1016/j.jtho.2021.01.362.
Summary: A review of 414 computed tomography simulation scans performed on 400 radiotherapy patients between March 1, 2020 and April 13, 2020, with authors noting that these scans obtained for radiation treatment planning can be reviewed for signs of COVID-19 pneumonia.
A remote symptom monitoring program for oncology patients diagnosed with COVID-19. [Meeting Abstract]
Lauria T (Nursing), Chow K (Nursing), Polskin L (Nursing), Giles C (Physician Assistant), Holland J (Nursing), Majeed J (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):19. doi: 10.1188/21.ONF.E1.
Summary: A description of the patient experience with remote COVID-19 symptom monitoring as implemented by Memorial Sloan Kettering Cancer Center's COVID Cohort Monitoring Team.
Utilizing designated ICU nurses to uptrain oncology stepdown nurses in caring for critically ill patients during the COVID-19 pandemic. [Meeting Abstract]
Rogers R (Nursing), Singh N (Nursing), Dolan B (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):42. doi: 10.1188/21.ONF.E2.
Summary: A description of the creation of the "Support RN" role within the intensive care unit to help transition step-down nurses to critical care nursing during the COVID-19 pandemic.
Manual proning of COVID+ patients in an oncology ICU. [Meeting Abstract]
Ruby J (Nursing), Noon B (Nursing), Carmody C (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):25. doi: 10.1188/21.ONF.E1.
Summary: A description of a clinical practice change to include manual proning as a standard practice with COVID-19 patients who were mechanically ventilated.
Successful continuation of enrollment and prompt treatment during COVID-19 in a concurrent radiation and chemotherapy head and neck protocol. [Meeting Abstract]
Sales R (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):34. doi: 10.1188/21.ONF.E2.
Summary: A description of how the COVID-19 pandemic impacted the second cohort of a two cohort, non-randomized study to treat patients with oropharyngeal carcinoma and how oncology nurse navigators and oncology nurses responded.
Surviving the pandemic: A retrospective review of older cancer patients admitted with COVID-19. [Meeting Abstract]
Kim SJ (Nursing), Shahrokni A (Medicine), Korc-Grodzicki B (Medicine), Litchfield H (Medicine), Malling C (Psychiatry), Fessele K (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):26-27. doi: 10.1188/21.ONF.E3.
Summary: A retrospective review of 70 cancer patients over the age of 75 admitted between March 1, 2020 and May 31, 2020 who tested positive for COVID-19 within 72 hours of admission.
Implementing standardized care for COVID-19 and an oncology institution's experience. [Meeting Abstract]
Hole A (Nursing), Houlihan N (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):51. doi: 10.1188/21.ONF.E2.
Summary: A description of the experience of standardizing acute and ongoing care for cancer patients during a COVID-19 surge.
Strategic planning for advanced practice inpatient management of COVID positive medical oncology patients. [Meeting Abstract]
Cerulli J (Ld - Advanced Practice Providers), Haviland K (Ld - Advanced Practice Providers).
Oncol Nurs Forum. 2021 Mar;48(2):5-6. doi: 10.1188/21.ONF.E2.
Summary: A description of a COVID-19 pandemic surge plan to meet the needs of cancer patients who were at an increased risk for infection during hospitalization.
Operationalizing surge staffing in an oncology ICU during the COVID-19 pandemic. [Meeting Abstract]
Chu S (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):64. doi: 10.1188/21.ONF.E2.
Summary: An outline of nursing care strategies for critically ill oncology patients during the COVID-19-related surge in intensive care unit patient volume.
An impact of COVID-19 pandemic on pathology resident training. [Meeting Abstract]
Chahar C (Graduate Staff), Choudhary L, Ahuja R, Sreeram K, Choudhary A.
Mod Pathol. 2021 Mar;34(Suppl. 2):325-326. doi: 10.1038/s41379-021-00756-3.
Summary: Results of an electronic survey of 118 pathology trainees to identify how the COVID-19 pandemic impacted their education and training.
Remote digital pathology for clinical trials and research during the COVID-19 pandemic. [Meeting Abstract]
Bhanot U (Research Facilities), Kombak FE (Collaborative Research Centers - PIC Directed), Ray-Kirton J (Pathology), Taylor-Mason F (Pathology), Tanaka A (SKI Pathology), Xiaoqing S (Research Facilities), Silber J (Pathology), Roehrl M (Pathology).
Mod Pathol. 2021 Mar;34(Suppl. 2):933. doi: 10.1038/s41379-021-00765-2.
Summary: A description of the experience of the Precision Pathology Center at Memorial Sloan Kettering Cancer Center adopting digital and remote pathology solutions during the COVID-19 pandemic.
An impact of COVID-19 pandemic on pathology resident training. [Meeting Abstract]
Chahar C (Graduate Staff), Choudhary L, Ahuja R, Sreeram K, Choudhary A.
Lab Invest. 2021 Mar;101(Suppl. 1):325-326. doi: 10.1038/s41374-021-00554-0.
Summary: Results of an electronic survey of 118 pathology trainees to identify how the COVID-19 pandemic impacted their education and training.
Remote digital pathology for clinical trials and research during the COVID-19 pandemic. [Meeting Abstract]
Bhanot U (Research Facilities), Kombak FE (Collaborative Research Centers - PIC Directed), Ray-Kirton J (Pathology), Taylor-Mason F (Pathology), Tanaka A (SKI Pathology), Xiaoqing S (Research Facilities), Silber J (Pathology), Roehrl M (Pathology).
Lab Invest. 2021 Mar;101(Suppl. 1):933. doi: 10.1038/s41374-021-00563-z.
Summary: A description of the experience of the Precision Pathology Center at Memorial Sloan Kettering Cancer Center adopting digital and remote pathology solutions during the COVID-19 pandemic.
A COVID-19 obituary. [Editorial]
Breitbart W (Psychiatry Service).
Palliat Support Care. 2021 Feb;19(1):1-2. doi: 10.1017/S1478951521000043. (Epub ahead of print)
Summary: This editorial by William Breitbart reflects on the power of reading obituries and thus touching the life stories of those for whom the obituries were written. He highlights the story behind one of the COVID-19 era obituries, that of a Holocaust survivor whose childhood was marred by the tragedy of the genocide of Jews during the Second World War.
Novel clinical subphenotypes in COVID-19: Derivation, validation, prediction, temporal patterns, and interaction with social determinants of health. [Preprint]
Su C, Zhang Y, Flory JH (Medicine), Weiner MG, Kaushal R, Schenck EJ, Wang F.
medRxiv. 2021 Feb 28. doi: https://doi.org/10.1101/2021.02.28.21252645.
Summary: This retrospective study analyzed "14418 COVID-19 patients in five major medical centers in New York City (NYC), between March 1 and June 12, 2020," using machine learning and routinely collected clinical data. The goal of the study was to "derive and validate COVID-19 subphenotypes to assess temporal patterns of these subphenotypes during the pandemic course and examine their interaction with social determinants of health (SDoH)."
Multidisciplinary recommendations regarding post-vaccine adenopathy and radiologic imaging: Radiology scientific expert panel. [Special Report]
Becker AS (Fellow), Perez-Johnston R (Radiology), Chikarmane SA, Chen MM, El Homsi M (Radiology), Feigin KN (Radiology), Gallagher KM (Radiology), Hanna EY, Hicks M, Ilica AT (Fellow), Mayer EL, Shinagare AB, Yeh R (Radiology), Mayerhoefer ME (Radiology), Hricak H (Radiology), Vargas HA (Radiology).
Radiology. 2021 Aug;300(2):E323-E327. doi: 10.1148/radiol.2021210436. Epub 2021 Feb 24.
Summary: People may experience swollen lymph nodes as a side effect of receiving a COVID vaccine. The authors recommend scheduling routine cancer imaging screenings either before vaccination or six weeks after. Patients should not delay getting either the vaccine or clinically urgent imaging.
An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19. [Preprint]
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehr MH (Pathology).
bioRxiv. 2021 Feb 22. doi: 10.1101/2021.02.21.432171.
Summary: This preprint describes the identification of an autoantigen atlas from human lung epithelium-like A549 cells. The authors hope to understand better the autoimmune diseases caused by COVID-19.
Highlights of the 33rd annual scientific meeting of the Association of Medical Laboratory Immunologists (AMLI). [Review]
Knight V, Askar MZ, Ntrivalas E (Laboratory Medicine), Nandiwada SL, Peterson LK, Tebo AE, Kadkhoda K, Schmitz JL, Naides SJ, Snyder MR, Sadighi Akha AA.
J Immunol Methods. 2021 May;492:112994. doi: 10.1016/j.jim.2021.112994. Epub 2021 Feb 21.
Summary: A summary of research presented at the virtual conference. MSK's Dr. Susan Prockop spoke about methods for improving transplant outcomes, and Dr. Evangelos Ntrivalas discussed flow cytometry.
Probing the SAM binding site of SARS-CoV-2 nsp14 in vitro using SAM competitive inhibitors guides developing selective bi-substrate inhibitors. [Preprint]
Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K (Chemical Biology Program), Li D (Chemical Biology Program), Liu J, Smil D, Luo M (Chemical Biology Program), Jin J, Fish PV, Brown PJ, Vedadi M.
bioRxiv. 2021 Feb 19. doi: 10.1101/2021.02.19.424337.
Summary: In this preprint, the authors present their work on non-structural protein (nsp) 14 to help with developing anti-viral therapeutics against COVID-19.
Intraluminal gas escape from biopsy valves and endoscopic devices during endoscopy: Caution advised during the COVID-19 era. [Article]
Urakawa S, Hirashita T, Momose K, Nishimura M (Medicine), Nakajima K, Milsom JW.
Endosc Int Open. 2021 Mar; 9(3):E443-E449. doi: 10.1055/a-1336-2766. Epub 2021 Feb 19.
Summary: The authors make recommendations for endoscopic procedures based on their research into the amount of gas leakage that occurs from a range of devices and use cases.
Letter to President Biden and Leaders of State Public Health Departments: Prioritizing Covid-19 vaccines for patients with cancer and survivors of cancer. [Correspondence]
Abramson Cancer Center at the University of Pennsylvania, American Association for Cancer Research, American Brain Tumor Association, American Cancer Society Cancer Action Network Inc., American Liver Foundation, American Radium Society, American Society for Radiation Oncology, American Society of Hematology, ArmorUp for Life, Association for Clinical Oncology, Association of American Cancer Institutes, Ben & Catherine Ivy Foundation, Blue Hat Foundation, Boston University - Boston Medical Center Cancer Center, Breast Cancer Research Foundation, CancerCare, Cancer Center at Brown University, Cancer Center at Illinois, Cancer Forum of the American Public Health Association, Cancer Support Community, Cardinal Bernardin Cancer Center Stritch School of Medicine Loyola University Chicago, Case Comprehensive Cancer Center at Case Western Reserve University, Chao Family Comprehensive Cancer Center at The University of California Irvine, Children’s Cancer Cause, Cholangiocarcinoma Foundation, Chris Draft Family Foundation, City of Hope, Cleveland Clinic Taussig Cancer Institute, Cold Spring Harbor Laboratory Cancer Center, Colorectal Cancer Alliance, Columbia University Herbert Irving Comprehensive Cancer Center, Community Oncology Alliance, Cure Breast Cancer Foundation, Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, Dana-Farber Cancer Institute, Deadliest Cancers Coalition, Debbie’s Dream Foundation, Duke Cancer Institute, ECAN Esophageal Cancer Action Network, ESMO, EVAN Foundation, FORCE: Facing Our Risk of Cancer Empowered, Fox Chase Cancer Center, Fred & Pamela Buffett Cancer Center at the University of Nebraska Medical Center, Fred Hutchinson Cancer Research Center, Friends of Cancer Research, Global Liver Institute, Georgetown Lombardi Comprehensive Cancer Center, Georgia Cancer Center, GI Cancers Alliance, GO2 Foundation for Lung Cancer, Head and Neck Cancer Alliance, Hope for Stomach Cancer, Huntsman Cancer Institute at The University of Utah, Imerman Angels, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, International Association for the Study of Lung Cancer, International Waldenstrom’s Macroglobulinemia Foundation, Jackson Laboratory, Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, Lazarex Cancer Foundation, Leukemia & Lymphoma Society, Livestrong, Living Beyond Breast Cancer, Loma Linda University Cancer Center, Lung Cancer Action Network, Lung Cancer Research Foundation, LUNGevity, Masonic Cancer Center, University of Minnesota, Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, Melanoma Research Foundation, Memorial Sloan Kettering Cancer Center, Men’s Health Network, Mesothelioma Applied Research Foundation, METAvivor Research and Support, Moffitt Cancer Center, Multiple Myeloma Research Foundation, MUSC Hollings Cancer Center, National Brain Tumor Society, National Cancer Registrars Association, National Comprehensive Cancer Network, National Pancreas Foundation, Norris Cotton Cancer Center at Dartmouth, Oncology Nursing Society, Ovarian Cancer Research Alliance, Penn State Cancer Institute, Raymond Foundation, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Roswell Park Comprehensive Cancer Center, Rutgers Cancer Institute of New Jersey, Sanford Burnham Prebys Medical Discovery Institute, Sarcoma Foundation of America, Shepherd Foundation, Sidney Kimmel Cancer Center at Thomas Jefferson University, Society for Immunotherapy of Cancer (SITC), Society of Surgical Oncology, St. Baldrick’s Foundation, Stand Up To Cancer, Stanford Cancer Institute, Stephenson Cancer Center at The University of Oklahoma, Students Supporting Brain Tumor Research, Stupid Cancer Inc., Susan G. Komen, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, The Advocates for Collaborative Education, The Alliance of Dedicated Cancer Centers, The Mark Foundation for Cancer Research, The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove, Research Institute, The Salk Institute, The University of Kansas Cancer Center, Tigerlily Foundation, Triage Cancer, UC Davis Comprehensive Cancer Center, UC San Diego Moores Cancer Center, UCLA Health Jonsson Comprehensive Cancer Center, UCSF Helen Diller Family Comprehensive Cancer Center, UNC Lineberger Comprehensive Cancer Center, Unite for HER, University of Arizona Cancer Center, University of Chicago Medicine Comprehensive Cancer Center, University of Cincinnati Cancer Center, University of Iowa Holden Comprehensive Cancer Center, University of Michigan Rogel Cancer Center, University of New Mexico Comprehensive Cancer Center, University of Puerto Rico Comprehensive Cancer Center, University of Rochester Wilmot Cancer Institute, University of Vermont Cancer Center, UPMC Hillman Cancer Center, USC Norris Comprehensive Cancer Center, UT Southwestern Simmons Cancer Center, V Foundation for Cancer Research, VCU Medical Center, Winship Cancer Institute of Emory University, Yale Cancer Center, ZERO – The End of Prostate Cancer.
AACR. 2021 Feb 17. https://www.aacr.org/professionals/policy-and-advocacy/aacr-and-the-biden-administration/prioritizing-covid19-vaccines-for-cancer-patients/. (Epub ahead of print)
Summary: This letter published on the American Association for Cancer Research website was sent in February 2021 to President Biden "to underscore the urgency of prioritizing access to a COVID-19 vaccine for patients with active cancer and survivors of cancer."
A novel patient values tab for the electronic health record: A user-centered design approach. [Article]
Desai AV (Medicine), Michael CL (Health Informatics), Kuperman GJ (Health Informatics), Jordan G (Information Systems), Mittelstaedt H (Information Systems), Epstein AS (Medicine), Connor M (Hospital Administration), Villar RPB (Nursing), Bernal C (Medicine), Kramer D (Ld - Advanced Practice Providers), Davis ME (Nursing), Chen Y (Health Informatics), Malisse C (Medicine), Markose G (Nursing), Nelson JE (Medicine).
J Med Internet Res. 2021 Feb;23(2):e21615. doi: 10.2196/21615.
Summary: This article describes a unique approach at Memorial Sloan Kettering Cancer Center to making each patient's personal values visible to and readily accessible by their care providers. MSKCC incorporated the information about each patient's personal health-related values derived from the nurse-led discussions with patients into the electronic health record (an electronic version of a patient chart) creating a special Patient Values tab where this information is stored. In this way health care providers at MSKCC have individual patient's values, goals, and preferences at their fingertips, so that they can take these preferences into consideration when caring for their patients. It is an example of real steps taken by a health care institution to put the patient values principle into practice.
Risk management during COVID-19: Safety procedures for otolaryngologists. [Review]
Spinato G, Gaudioso P, Boscolo Rizzo P, Fabbris C, Menegaldo A, Mularoni F, Singh B (Surgery), Maniaci A, Cocuzza S, Frezza D.
Acta Biomed. 2021 Feb 16;92(1):e2021105. doi: 10.23750/abm.v92i1.11281.
Summary: This review presents ways for Otolaryngologists to decrease their risks when caring for Covid-19 patients, such as preventative measures and fewer invasive procedures.
Administration of high titer convalescent anti-SARS-CoV-2 plasma: From donor selection to monitoring recipient outcomes. [Article]
Mendoza RP, Fyke W, Daniel D, Gabutan E, Das B, Bajaj H, Easy M, Vasileva A, Colbourn R, Alawad M, Dehghani A, Lin B, Emechebe D, Patel P, Jabbar A, Nikolov DB (SKI Structural Biology), Giovaniello D, Kang S, Tatem L, Bromberg K, Augenbraun M, Premsrirut P, Libien J, Norin AJ.
Hum Immunol. 2021 Apr;82(4):255-263. doi: 10.1016/j.humimm.2021.02.007. Epub 2021 Feb 16.
Summary: A description of the process and outcomes of the convalescent plasma program at University Hospital Brooklyn from April to June 2020.
Cellular therapy during COVID-19: Lessons learned and preparing for subsequent waves. [Article]
Nawas MT (Fellow), Shah GL (Medicine), Feldman DR (Medicine), Ruiz JD (Medicine), Robilotti EV (Medicine), Aslam AA (Infection Control), Dundas M (Infection Control), Kamboj M (Medicine), Barker JN (Medicine), Cho C (Medicine), Chung DJ (Medicine), Dahi PB (Medicine), Giralt SA (Medicine), Gyurkocza B (Medicine), Lahoud OB (Medicine), Landau HJ (Medicine), Lin RJ (Medicine), Mailankody S (Medicine), Palomba ML (Medicine), Papadopoulos EB (Medicine), Politikos I (Medicine), Ponce DM (Medicine), Sauter CS (Medicine), Shaffer BC (Medicine), Scordo M (Medicine), van den Brink MRM (Medicine), Perales MA (Medicine), Tamari R (Medicine).
Transplant Cell Ther. May;27(5):438.e1-438.e6. doi: 10.1016/j.jtct.2021.02.011. Epub 2021 Feb 14.
Summary: The study at Memorial Sloan Kettering Cancer Center evaluated the impact of delays in scheduling hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy caused by the COVID-19 pandemic and found that for patients with high-risk disease treament, delay could be devastating and should be avoided as much as possible.
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. [Article]
Li F, Han M, Dai P, Xu W, He J, Tao X, Wu Y, Tong X, Xia X, Guo W, Zhou Y, Li Y, Zhu Y, Zhang X, Liu Z, Aji R, Cai X, Li Y, Qu D, Chen Y (Medicine), Jiang S, Wang Q, Ji H, Xie Y, Sun Y, Lu L, Gao D.
Nat Commun. 2021 Feb 8;12:866. doi: 10.1038/s41467-021-21171-x.
Summary: This study evaluated an existing drug, enzalutamide, for possible repurposing as an anti-COVID-19 agent. This thoroughly designed study concludes that this drug cannot be used for COVID-19 treatment, contrary to some previous studies that suggested such possibility.
The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2. [Article]
Di Gioacchino A, Šulc P, Komarova AV, Greenbaum BD (Biostat/Epidemiology), Monasson R, Cocco S.
Mol Biol Evol. 2021 Jun;38(6):2428-2445. doi: 10.1093/molbev/msab036. Epub 2021 Feb 8.
Summary: To better understand how COVID-19 can induce acute respiratory syndrome in some patients, the authors conducted a genomic study using a model.
Impact of the COVID-19 pandemic on oncologist burnout, emotional well-being, and moral distress: Considerations for the cancer organization's response for readiness, mitigation, and resilience. [Editorial]
Hlubocky FJ, Symington BE, McFarland DC (Fellow), Gallagher CM, Dragnev KH, Burke JM, Lee RT, El-Jawahri A, Popp B, Rosenberg AR, Thompson MA, Dizon DS, Srivastava P, Patel MI, Kamal AH, Daugherty CK, Back AL, Dokucu ME, Shanafelt TD.
JCO Oncol Pract. 2021 Jul;17(7):365-374. doi: 10.1200/OP.20.00937. Epub 2021 Feb 8.
Summary: In this editorial, the authors describe how COVID-19 has impacted oncologists and offer recommendations to prevent or reduce the associated burdens.
Communicating effectively via tele-oncology (Comskil TeleOnc): A guide for best practices for communication skills in virtual cancer care. [Preprint]
Banerjee SC (Psychiatry Service), Staley JM (Psychiatry Service), Howell F (Psychiatry Service), Malling C (SKI Psychiatry/Counseling), Moreno A (Psychiatry Service), Kotsen C (Psychiatry Service), Parikh D (Radiation Oncology), Parker PA (Psychiatry Service).
J Cancer Educ. 2021 Feb 5;1-6. doi: 10.1007/s13187-021-01959-7. (Epub ahead of print)
Summary: With this guide (Comskil TeleOnc), the authors offer strategies to provide the best cancer patient care possible during tele-oncology visits.
Convalescent plasma and improved survival in patients with hematologic malignancies and COVID-19. [Preprint]
Thompson MA, Henderson JP, Shah PK, Rubinstein SM, Joyner MJ, Choueiri TK, Flora DB, Griffiths EA, Gulati AP, Hwang C, Koshkin VS, Papadopoulos EB (Medicine), Robilotti EV (Medicine), Su CT, Wulff-Burchfield EM, Xie Z, Yu PP, Mishra S, Senefeld JW, Shah DP, Warner JL.
medRxiv. 2021 Feb 5;21250953; doi: https://doi.org/10.1101/2021.02.05.21250953.
Summary: A retrospective cohort study of 966 patients with a hematologic malignancy who also have a COVID-19 diagnosis. Of this cohort, 143 (14.8%) received convalescent plasma and were found to have higher 30-day mortality rates than the control group. This preprint has not been peer reviewed.
COVID-19 and beyond: A prototype for remote/virtual social work field placement. [Article]
Mitchell B (Psychosocial Support), Sarfati D (Psychosocial Support), Stewart M (Psychosocial Support).
Clin Soc Work J. 2021 Feb 4;1-8. doi: 10.1007/s10615-021-00788-x. (Epub ahead of print)
Summary: The COVID-19 pandemic affected both clinical practice and education. This article describes how clinical education for students in social work adjusted to the COVID-19 pandemic, and specifically, how an educational program for oncology social work interns from the graduate school was redesigned for remote/virtual learning.
Using automated machine learning to predict the mortality of patients with COVID-19: Prediction model development study. [Article]
Ikemura K, Bellin E, Yagi Y (Pathology), Billett H, Saada M, Simone K, Stahl L, Szymanski J, Goldstein DY, Reyes Gil M.
J Med Internet Res. 2021 Feb;23(2):e23458. doi: 10.2196/23458.
Summary: This research study looked at automated machine learning to create algorithms to predict a patient's chances of surviving Covid-19 infection, looking at a variety of variables including vital signs, comorbidities, and biomarkers.
Anxiety levels among physician mothers during the COVID-19 pandemic. [Correspondence]
Linos E, Halley MC, Sarkar U, Mangurian C, Sabry H, Olazo K, Mathews KS, Diamond L (Psychiatry Service), Goyal MK, Linos E, Jagsi R.
Am J Psychiatry. 2021 Feb 1;178(2):203-204. doi: 10.1176/appi.ajp.2020.20071014.
Summary: After surveying the "Physician Moms Group" on Facebook, the authors note in this letter to the editor that anxiety among physician mothers is significantly higher during the pandemic than during normal times.
Interprofessional communication: Integrating evidence to enhance systems during a pandemic. [Article]
Cazeau N (Nursing).
Clin J Oncol Nurs. 2021 Feb 1;25(1):56-60. doi: 10.1188/21.CJON.56-60.
Summary: This paper reviews the communication models and technologies that can be used to enhance interprofessional communication among teams, with a particular focus on the unique challenges presented by the COVID-19 pandemic.
Emerging from COVID-19 pandemic: Provider perspective on use of neoadjuvant endocrine therapy (NET) in early stage hormone receptor positive breast cancer. [Meeting Abstract]
Park KU, Gregory ME, Lustberg MB, Bazan JG, Shen C, Rosenberg SM, Blinder VS (Psychiatry Service), Sharma P, Pusztai L, Partridge AH, Thompson A.
Cancer Res.. 2021 Feb;81(4 Suppl.). doi: 10.1158/1538-7445.SABCS20-SS2-05.
Summary: Results of a survey of 114 healthcare providers to evaluate patterns of care in early stage estrogen receptor positive breast cancer during the first months of the COVID-19 pandemic.
Impact of the COVID-19 pandemic on dermatology practice worldwide: Results of a survey promoted by the International Dermoscopy Society (IDS). [Article]
Conforti C, Lallas A, Argenziano G, Dianzani C, Di Meo N, Giuffrida R, Kittler H, Malvehy J, Marghoob AA (Dermatology Service), Soyer HP, Zalaudek I.
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021153. doi: 10.5826/dpc.1101a153.
Summary: A survey of 678 dermatologists in 52 countries found a decrease in the number of working days and skin cancer diagnoses, and an increase in telemedicine visits, during the pandemic.
Portable chest radiography as an exclusionary test for adverse clinical outcomes during the coronavirus disease 2019 pandemic. [Article]
Pagano A (Radiology), Finkelstein M, Overbey J, Steinberger S, Ellison T, Manna S, Toussie D, Cedillo M, Jacobi A, Gupta YS, Bernheim A, Chung M, Eber C, Fayad ZA, Concepcion J.
Chest. 2021 Jul;160(1):238-248. doi: 10.1016/j.chest.2021.01.053. Epub 2021 Jan 29.
Summary: This study looked at whether chest radiography can be used as an exclusionary test for adverse outcomes in patients with suspected Covid-19.
An autoantigen atlas from human lung HFL1 cells offers clues to neurological and diverse autoimmune manifestations of COVID-19. [Preprint]
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Jan 24. doi: 10.1101/2021.01.24.427965.
Summary: This preprint describes a COVID autoantigen atlas developed using proteins from human fetal lung fibroblast HFL11 cells. This autoantigenome information contributes to a detailed molecular map that can be used to investigate neurological and autoimmune manifestations of COVID-19.
Prevalence of Clostridioides difficile and other gastrointestinal pathogens in patients with COVID-19. [Article]
Laszkowska M (Medicine), Kim J, Faye AS, Joelson AM, Ingram M, Truong H, Silver ER, May B, Greendyke WG, Zucker J, Lebwohl B, Hur C, Freedberg DE.
Dig Dis Sci. 2021 Dec;66(12):4398-4405. doi: 10.1007/s10620-020-06760-y. Epub 2021 Jan 22.
Summary: In this study, 4973 hospitalized adult patients at two institutions were tested for COVID-19 and for gastrointestinal infections (from March 11 through April 28, 2020) in order to estimate the prevalence of co-infection with enteric pathogens of COVID-19 positive patients.
Human pre-implantation embryos are permissive to SARS-CoV-2 entry. [Preprint]
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Graduate Student), Hadjantonakis AK, Barnes FL, Zouves CG, Greene WC, Viotti M.
bioRxiv. 2021 Jan 21. doi: 10.1101/2021.01.21.427501.
Summary: This preprint investigates whether human pre-implantation embryos can be infected by SARS-CoV-2, something which is relevant to "natural human conceptions and assisted reproductive technologies during and after the COVID-19 pandemic."
Characterizing the anticancer treatment trajectory and pattern in patients receiving chemotherapy for cancer using harmonized observational databases: Retrospective study.
[Preprint]
Park RW, Jeon H, You SC, Kang SY, Seo SI, Warner JL, Belenkaya R (Health Informatics).
JMIR Med Inform. 2021 Apr 6;9(4):e25035. doi: 10.2196/25035. Epub 2021 Jan 20.
Summary: In this preprint, the authors present a technique to generate chemotherapy episodes to make data more discoverable so researchers can compare treatments for patients with cancer.
Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: An observational cohort study. [Article]
Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA (Medicine), Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL (Medicine).
Lancet Haematol. 2021 Mar;8(3):e185-e193. doi: 10.1016/S2352-3026(20)30429-4. Epub 2021 Jan 19.
Summary: This study analyzes data collected across multiple institutions by the Center for International Blood and Marrow Transplant Research (CIBMTR) using a special form created to capture COVID-19-related data on HSCT recipients between March 27, 2020 and Aug 12, 2020. The authors reported a "30 day survival from COVID-19 of only approximately 70%" in this patient group.
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. [Article]
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J, Lytras S, Czudnochowski N, Shah R, Meury M, Jesudason N, De Marco A, Li K, Bassi J, O'Toole A, Pinto D, Colquhoun RM, Culap K, Jackson B, Zatta F, Rambaut A, Jaconi S, Sreenu VB, Nix J, Zhang I (Graduate Studies), Jarrett RF, Glass WG (Computational and Systems Biology Program), Beltramello M, Nomikou K, Pizzuto M, Tong L, Cameroni E, Croll TI, Johnson N, Di Iulio J, Wickenhagen A, Ceschi A, Harbison AM, Mair D, Ferrari P, Smollett K, Sallusto F, Carmichael S, Garzoni C, Nichols J, Galli M, Hughes J, Riva A, Ho A, Schiuma M, Semple MG, Openshaw PJM, Fadda E, Baillie JK, Chodera JD (Computational and Systems Biology Program), The ISARIC4C Investigators, the COVID-19 Genomics UK (COG-UK) consortium, Rihn SJ, Lycett SJ, Virgin HW, Telenti A, Corti D, Robertson DL, Snell G.
Cell. 2021 Mar 4;184(5):1171-1187.e20. doi: 10.1016/j.cell.2021.01.037. Epub 2021 Jan 28.
Summary: This research article demonstrates how the Covid-19 mutation N439K has resistance to several of the monoclonal antibody treatments being used and reduces the activity of some the immune responses from persons who have recovered from Covid-19 infection. This research shows why ongoing molecular surveillance is necessary as vaccines and treatments are being developed.
Abdominal gastrointestinal imaging findings on computed tomography in patients with COVID-19 and correlation with clinical outcomes. [Article]
Horvat N (Radiology), Alves Pinto PV, Araujo-Filho JAB (Radiology), Santos JMMM, Dias AB, Miranda JA, de Oliveira CV, Barbosa CS, Morais TC, AN Assuncao Jr, Nomura CH, Cavalcante Viana PC.
Eur J Radiol Open. 2021;8:100326. doi: 10.1016/j.ejro.2021.100326. Epub 2021 Jan 18.
Summary: In this retrospective study, the authors studied abdominal imaging in 81 COVID-positive patients to study intestinal abnormalities and clinical outcomes.
Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients. [Article]
Remsik J (Human Oncology and Pathogenesis Program), Wilcox JA (Graduate Staff), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Human Oncology and Pathogenesis Program), Avila EK (Neurology), Santomasso B (Neurology), Boire A (Human Oncology and Pathogenesis Program).
Cancer Cell. 2021 Feb 8;39(2):276-283.e3. doi: 10.1016/j.ccell.2021.01.007. Epub 2021 Jan 16.
Summary: This research article details how cancer patients with Covid who exhibit neurological symptoms weeks after acute infection have increased inflammatory cytokines in the cerebrospinal fluid, which lead to long term neurological dysfunction. Their findings suggest that anti-inflammatory treatments should be used to manage neurological symptoms in Covid patients.
Outpatient clinical pharmacy practice in the face of COVID-19 at a cancer center in New York City. [Article]
Yerram P (Pharmacy), Thackray J (Pharmacy), Modelevsky LR (Pharmacy), Land JD (Pharmacy), Reiss SN (Pharmacy), Spatz KH (Pharmacy), Levoir AC (Pharmacy), Pak TK (Pharmacy), Dao PH (Pharmacy), Buege MJ (Pharmacy), DeRespiris LM (Pharmacy), Lau C (Pharmacy), Orozco JS (Pharmacy), Boparai M (Pharmacy), Koranteng LA (Pharmacy), Reichert KE (Pharmacy), Yan SQ (Pharmacy), Daukshus NP (Pharmacy), Mathew S (Pharmacy), Buie LW (Pharmacy), Tizon RF (Pharmacy), Freeswick S (Hospital Administration), Liu D (Pharmacy), Harnicar S (Pharmacy).
J Oncol Pharm Pract. 2021 Mar;27(2):389-394. doi: 10.1177/1078155220987625. Epub 2021 Jan 17.
Summary: MSK restructured its pharmacy services at the height of the pandemic in New York City, deploying six pharmacists to COVID-19 inpatient services for three months and using telemedicine technologies to allow those in outpatient settings to minimize on-site contact.
The COVID-19 pandemic - An opportune time to update medical licensing.
[Viewpoint]
Mullangi S (Graduate Staff), Agrawal M, Schulman K.
JAMA Intern Med. 2021 Mar 1;181(3):307-308. doi:10.1001/jamainternmed.2020.8710. Epub Jan 13.
Summary: This article highlights the need to adapt state licensure requirements for physicians to the new practice patterns that emerged during the pandemic. For example, the rise of telemedicine during the pandemic allowed physicians to care for patients located in different states. This change in practice calls for adjustments to the physician licesure state laws.
Federated Learning used for predicting outcomes in SARS-COV-2 patients. [Preprint]
Flores M, Dayan I, Roth H, Zhong A, Harouni A, Gentili A, Abidin A, Liu A, Costa A, Wood B, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan C, Xu D, Wu D, Huang E, Kitamura F, Lacey G, de Antônio Corradi GC, Shin HH (Radiology), Obinata H, Ren H, Crane J, Tetreault J, Guan J, Garrett J, Park JG, Dreyer K, Juluru K (Radiology), Kersten K, Rockenbach MABC, Linguraru M, Haider M, AbdelMaseeh M, Rieke N, Damasceno P, Cruz e Silva PM, Wang P, Xu S, Kawano S, Sriswasdi S, Park SY, Grist T, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon F, Gilbert F, Kaggie J, Li Q, Quraini A, Feng A, Priest A, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Diez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess C, Compas C, Bhatia D, Oermann E, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Keshava Murthy KN (Radiology), Fu LC, de Mendonca MRF, Fralick M, Kang MK, Adil M, Gangai N (Radiology), Vateekul P, Elnajjar P (Radiology), Hickman S, Majumdar S, McLeod S, Reed S, Graf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, de Lima Lavor V, Rakvongthai Y, Lee YR, Wen Y.
Res Sq. 2021 Jan 8;rs.3.rs-126892. doi: 10.21203/rs.3.rs-126892/v1. (Epub ahead of print)
Summary: Twenty institutions collaborated to train an artificial intelligence model to predict COVID patient oxygen requirements. This preprint has not yet been peer reviewed.
The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo. [Article]
Müller C, Obermann W, Karl N, Wendel HG (Cancer Biology and Genetics), Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J.
Antiviral Res. 2021 Feb;186:105012. doi: 10.1016/j.antiviral.2021.105012. Epub 2021 Jan 7.
Summary: Researchers found that a synthetic rocaglate molecule had antiviral effects against SARS-CoV-2 in human bronchial cells.
Introductions to the community: Early-career researchers in the time of COVID-19. [Voices]
Ganesh K (Molecular Pharmacology Program), Patel J, Orlova VV, Gifford C, Elias S, Vaughan A.
Cell Stem Cell. 2021 Jan 7;28(1):17-19. doi: 10.1016/j.stem.2020.12.014.
Summary: Six early-career researchers share how their experience of the COVID-19 pandemic has impacted their lab work and research.
Genitourinary medical oncology expert opinion survey regarding treatment management in the COVID-19 pandemic. [Article]
Sarfaty M (Graduate Staff), Feldman DR (Medicine), Morris MJ (Medicine), Motzer RJ (Medicine), Rathkopf DE (Medicine), Regazzi AM (Medicine), Iyer G (Medicine), Voss MH (Medicine), Bajorin DF (Medicine), Rosenberg JE (Medicine).
Clin Genitourin Cancer. 2021 Jun;19(3):e178-e183. doi: 10.1016/j.clgc.2020.12.002. Epub 2021 Jan 7.
Summary: The COVID-19 pandemic affected cancer care across all cancer types, including genitourinary cancers. This article reports the results of a survey sent to experts involved in the management of genitourinary cancers in Europe and North America. The survey was intended to collect information about the changes in practice patterns that occurred as a result of the pandemic. The results of the study will inform the genitourinary oncologist community about the effects of the pandemic in their field.
The state of melanoma: Emergent challenges and opportunities. [CCR Perspectives in Regulatory Science and Policy]
Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H, Aguirre-Ghiso JA, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB (Medicine), Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G..
Clin Cancer Res. 2021 May 15;27(10):2678-2697. doi: 10.1158/1078-0432.CCR-20-4092. Epub 2021 Jan 7.
Summary: This article is a Melanoma Research Foundation (MRF) report on the current progress and future directions for melanoma research, as well as prevention, diagnosis and management of melanoma.
Human stem cell models to study host-virus interactions in the central nervous system. [Review]
Harschnitz O (Developmental Biology), Studer L (Developmental Biology).
Nat Rev Immunol. 2021 Jul;21(7):441-453. doi: 10.1038/s41577-020-00474-y. Epub 2021 Jan 4.
Summary: In this review, the authors describe how human pluripotent stem cell technology can help understand viral infections of the human central nervous system.
Impact of telemedicine on patient satisfaction and perceptions of care quality in radiation oncology. [Article]
Shaverdian N (Radiation Oncology), Gillespie EF (Radiation Oncology), Cha E (Graduate Staff), Kim SY (Psychiatry Service), Benvengo S (Radiation Oncology), Chino F (Radiation Oncology), Kang JJ (Radiation Oncology), Li Y (Psychiatry Service), Atkinson TM (Psychiatry Service), Lee N (Radiation Oncology), Washington CM (Hospital Administration), Cahlon O (Physician in Chief), Gomez DR (Radiation Oncology).
J Natl Compr Canc Netw. 2021 Jan 4;19(10):1174-1180. doi: 10.6004/jnccn.2020.7687. Epub 2021 Jan 4
Summary: This study, conducted at Memorial Sloan Kettering Cancer Center, compared patient satisfaction with office visits in Radiation Oncology practice before the pandemic with telemedicine consultations during the pandemic (specifically, the first half of 2020). Patient preferences for office and telemedicine consulations and identified predictors of patient preferences for either of these types of visits were assessed.
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study. [Original report]
Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I (Surgery), Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar S, Vidya R, Bhangu AA, on behalf of the COVIDSurg Collaborative (Brown L (Graduate Staff) in group).
J Clin Oncol. 2021 Jan 1;39(1):66-78. doi: 10.1200/JCO.20.01933. Epub 2020 Oct 6.
Summary: This study analyzes pulmonary complication rates in elective cancer surgeries conducted in multiple centers internationally during the pandemic. Those centers were following surgical pathways.
Performance of severe acute respiratory syndrome coronavirus 2 real-time RT-PCR tests on oral rinses and saliva samples. [Article]
Babady NE (Laboratory Medicine), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti EV (Medicine), Aslam A (Infection Control), Diver M (Nursing), Sokoli D (Hospital Administration), Mason G (BAIC), Shah MK (Medicine), Korenstein D (Medicine), Kamboj M (Medicine).
J Mol Diagn. 2021 Jan;23(1):3-9. doi: 10.1016/j.jmoldx.2020.10.018. Epub 2020 Nov 17.
Summary: Testing for SARS-CoV-2 is an essential tool in the fight against the current pandemic. Swabs, such as oropharyngeal swabs (OPSs) and especially nasopharyngeal swabs (NPSs), are the most common specimen collection methods recommended for SARS but because of a few downsides there is a need for adding more testing methods. This study investigated the reliability of two other methods, self-collected oral rinses (ORs) and oropharyngeal saliva, as alternative sample types for the detection of SARS-CoV-2. The study found that oropharyngeal saliva could be an acceptable alternative.
Canakinumab as treatment for COVID-19-related pneumonia: A prospective case-control study. [Article]
Generali D, Bosio G, Malberti F, Cuzzoli A, Testa S, Romanini L, Fioravanti A, Morandini A, Pianta L, Giannotti G, Viola EM, Pier-Franceschi MG, Foramitti M, Tira RA, Zangrandi I, Chiodelli G, Machiavelli A, Cappelletti MR, Giossi A, De Giuli V, Costanzi C, Campana C, Bernocchi O, Sirico M, Zoncada A, Molteni A, Venturini S, Giudici F, Scaltriti M (Pathology), Pan A.
Int J Infect Dis. 2021 Mar;104:433-440. doi: 10.1016/j.ijid.2020.12.073. Epub 2020 Dec 29.
Summary: This study evaluated the efficacy and safety of the drug canakinumab in patients with moderate COVID-19-related pneumonia. The drug showed promise in decreasing the need for invasive mechanical ventilation in prevention of clinical deterioration of patients with COVID-19 pneumonia, leading to earlier hospital discharge and better prognosis.
The Radiation Oncology Education Collaborative Study Group 2020 spring symposium: Is virtual the new reality? [Article]
Nelson BA, Lapen K (Graduate Staff), Schultz O, Nangachiveettil J, Braunstein SE, Fernandez C, Fields EC, Gunther JR, Jeans E, Jimenez RB, Kharofa JR, Laucis A, Yechieli RL, Gillespie EF, Golden DW.
Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):315-321. doi: 10.1016/j.ijrobp.2020.12.026. Epub 2020 Dec 26.
Summary: This report shares the advantages and limits of conducting the 2020 ROECSG symposium virtually because of the pandemic. The authors' discussion will help with planning future scientific meetings.
A DKMS (German Bone Marrow Donor Center) view on cryopreservation of unrelated donor stem cell products during the COVID-19 pandemic. [Correspondence]
Schmidt AH, Buk D, Bernas SN, Mengling T, Neujahr E, van den Brink MRM (Medicine).
Am J Hematol. 2021 Mar 1;96(3):E91-E92. doi: 10.1002/ajh.26081. Epub 2020 Dec 24.
Summary: In this letter to the editor, the authors discuss cryopreservation of stem cell products from unrelated donors which has been used as a way to overcome the challenges associated with the Covid-19 pandemic but which also presents some challenges of its own, as often these products end up at risk of not being used for various reasons explained by the authors.
COVID-19 in pediatric survivors of childhood cancer and hematopoietic cell transplantation from a single center in New York City. [Article]
Jimenez-Kurlander L (Fellow), Antal Z (Pediatrics), DeRosa A (Pediatrics), Diotallevi D (Pediatrics), Pottenger E (Pediatrics), Wilson N (Pediatrics), Corcoran S (Medicine), Boulad F (Pediatrics), Friedman DN (Pediatrics).
Pediatr Blood Cancer. 2021 Mar;68(3):e28857. doi: 10.1002/pbc.28857. Epub 2020 Dec 23.
Summary: In this paper, the authors analyzed COVID-19 infections among pediatric survivors of childhood cancer followed at Memorial Sloan Kettering Cancer Center and concluded from their preliminary data that "childhood cancer survivors appear to be at relatively low risk for COVID-19 complications."
Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience. [Article]
Madhusoodhan PP, Pierro J, Musante J, Kothari P (Pediatrics), Gampel B, Appel B, Levy A, Tal A, Hogan L, Sharma A, Feinberg S, Kahn A, Pinchinat A, Bhatla T, Glasser CL, Satwani P, Raetz EA, Onel K, Carroll WL.
Pediatr Blood Cancer. 2021 Mar;68(3):e28843. doi: 10.1002/pbc.28843. Epub 2020 Dec 18.
Summary: In this 13-institution, multicenter, retrospective study, 578 pediatric oncology patients were tested for COVID-19, with 98 found to be positive, 73 of which were symptomatic. Their clinical and laboratory information was collected and analyzed, from which it was concluded that although COVID-related morbidity and mortality were low in pediatric oncology patients overall, they were higher than in the general pediatric population, with some subgroups more at risk for severe COVID disease.
Expanding the toolbox to combat a pandemic. [Comment]
Prockop SE (Pediatrics).
Blood. 2020 Dec 17; 136(25):2847-2848. doi: https://doi.org/10.1182/blood.2020009408.
Summary: This is a comment about an article published in Blood by Keller and colleagues. "Keller MD, Harris KM, Jensen-Wachspress MA, et al. SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein. Blood. 2020;136(25):2905-2917."
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. [Article]
Hoffmann HH, Sànchez-Rivera FJ (Cancer Biology and Genetics), Schneider WM, Luna JM, Soto-Feliciano YM, Ashbrook AW, Le Pen J, Leal AA, Ricardo-Lax I, Michailidis E, Hao Y, Stenzel AF, Peace A, Zuber J, Allis CD, Lowe SW (Cancer Biology and Genetics), MacDonald MR, Poirier JT, Rice CM.
Cell Host Microbe. 2021 Feb 10;29(2):267-280.e5. doi: 10.1016/j.chom.2020.12.009. Epub 2020 Dec 16.
Summary: In this article, the authors identified SARS-CoV-2 host proteins. They organized their results in a library to help develop possible COVID-19 drug treatments.
Hospital length of stay for patients with severe COVID-19: Implications for Remdesivir's value. [Research Letter]
Anderson MR, Bach PB (Health Policy & Outcomes), Baldwin MR.
Pharmacoecon Open. 2021 Mar;5(1):129-131. doi: 10.1007/s41669-020-00243-6. Epub 2020 Dec 14.
Summary: This study questions whether the 33% higher price of remdesivir charged to U.S. hospitals is justified. The price is based on the company's clinical trial finding that remdesivir reduces LOS by 4 days, however, in the cohort study reported in this research letter, "the median LOS was markedly shorter than the equivalent endpoint in the ACTT-1 trial (7 vs. 15 days)". This finding led the researchers to conclude that "36% could have their LOS potentially prolonged to complete therapy."
Identification of biological correlates associated with respiratory failure in COVID-19. [Article]
Oh JH (Medical Physics), Tannenbaum A, Deasy JO (Medical Physics).
BMC Med Genomics. 2020 Dec 11;13(1):186. doi: 10.1186/s12920-020-00839-1.
Summary: This study re-analyzed data, originally collected for a genome-wide association study (GWAS) of Italian and Spanish participants by an international consortium group, using gene ontology analysis and protein-protein interaction analysis, to determine which biological processes were most implicated in respiratory failure in COVID-19 patients.
Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks. [Article]
Schneider WM, Luna JM, Hoffmann HH, Sànchez-Rivera FJ (Cancer Biology and Genetics), Leal AA, Ashbrook AW, Le Pen J, Ricardo-Lax I, Michailidis E, Peace A, Stenzel AF, Lowe SW (Cancer Biology and Genetics), MacDonald MR, Rice CM, Poirier JT.
Cell. 2021 Jan 7;184(1):120-132.e14. doi: 10.1016/j.cell.2020.12.006. Epub 2020 Dec 9.
Summary: This article reports on a study into the cellular level of processes associated with SARS-CoV-2 and other coronavirus infections. It contributes to the knowledge base of the biology of coronavirus infections.
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. [Article]
Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A (Epidemiology and Biostatistics), Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Xu KH, Raabe MJ, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD (Epidemiology and Biostatistics), Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V.
Nat Commun. 2020 Dec 9;11:6319. doi: 10.1038/s41467-020-20139-7.
Summary: This analysis of 24 autopsy lung samples of patients who died of COVID supports two disease phases: one with high viral RNA and one with low or undetectable viral RNA. The authors believe these to be distinct disease phases rather than different forms of the disease.
Racial disparities in patients with coronavirus disease 2019 infection and gynecologic malignancy. [Article]
Lara OD, Smith MJ, Wang Y, O'Cearbhaill R (Medicine), Blank SV, Kolev V, Carr C, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Jee J, Fehniger J, Lee YC, Isani S, Liu M, Wright JD, Pothuri B.
Cancer. 2021 Apr 1;127(7):1057-1067. doi: 10.1002/cncr.33335. Epub 2020 Dec 9.
Summary: A retrospective, observational cohort study of 193 patients with gynecologic cancer and COVID-19 infection at eight New York City-area hospital systems, where Black patients had disproportionate rates of hospitalization and death than non-Black patients.
The role of androgen deprivation therapy on the clinical course of COVID-19 infection in men with prostate cancer. [Meeting Abstract]
Patel VG, Zhong X, Shah NJ (Medicine), Martina LP, Hawley J, Lin E, Gartrell BA, Febles VRA, Wise DR, Qin Q, Mellgard G, Nauseef JT, Green D, Vlachostergios PJ, Kwon D, Huang FW, Liaw BCH, Tagawa ST, Morris MJ (Medicine), Oh WK.
J Clin Oncol. 2021 Jan 20; 39(6 Suppl.): 41. doi: 10.1200/JCO.2021.39.6_suppl.41.
Summary: This ASCO meeting abstract presents the negative findings of a retrospective cohort study of 465 prostate cancer patients who were evaluated for SARS-COV-2 viral detection by PCR to determine whether the use of androgen deprivation therapy by patients prior to COVID-19 diagnosis offered protection against severe COVID illness.
American Society of Clinical Oncology road to recovery report: Learning From the COVID-19 experience to improve clinical research and cancer care. [Special Report]
Pennell NA, Dillmon M, Levit LA, Moushey EA, Alva AS, Blau S, Cannon TL, Dickson NR, Diehn M, Gonen M (Biostatistics & Epidemiology), Gonzalez MM, Hensold JO, Hinyard LJ, King T, Lindsey SC, Magnuson A, Marron J, McAneny BL, McDonnell TM, Mileham KF, Nasso SF, Nowakowski GS, Oettel KR, Patel MI, Patt DA, Perlmutter J, Pickard TA, Rodriguez G, Rosenberg AR, Russo B, Szczepanek C, Smith CB, Srivastava P, Teplinsky E, Thota R, Traina TA, Zon R, Bourbeau B, Bruinooge SS, Foster S, Grubbs S, Hagerty K, Hurley P, Kamin D, Phillips J, Schenkel C, Schilsky RL, Burris HA 3rd.
J Clin Oncol. 2021 Jan 10;39(2):155-169. doi: 10.1200/JCO.20.02953. Epub 2020 Dec 8.
Summary: This article reports on the new recommendations from the American Society of Clinical Oncology (ASCO), the world's leading professional organization for physicians who care for people with cancer. The new recommendations are based on evaluation of the COVID-19 pandemic experience and are aimed at improved patient access to high quality cancer research and cancer care delivery going forward.
SRLs in a global pandemic: An administrative perspective. [Editorial]
Auger J, Fletcher L, Frankowiak S, Grills G, Lemas MV, Mische S, Monteiro M, Peláez F, Tabarini D (General & Administration), Vinard A, White AN.
Cytometry A. 2021 Jan;99(1):19-21. doi: 10.1002/cyto.a.24263. Epub 2020 Dec 2.
Summary: This paper provides the perspectives and lessons learned of administrators of biomedical shared resource laboratories/research core facilities on a range of issues that have affected their facilities and operations during the COVID-19 pandemic. They provide guidance on business continuity planning and explain the importance of strong core contingency plans.
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic. [Article]
COVIDSurg Collaborative (Brown L (Graduate Staff), Ganly I (Surgery) in group).
Br J Surg. 2021 Jan;108(1):88-96. doi: 10.1093/bjs/znaa051.
Summary: An international cohort study of 8,784 adult patients undergoing elective cancer surgery to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications.
Thirty-day mortality among patients with SARS-CoV-2 infection undergoing active antitumoral therapy. [Meeting Abstract]
Wong K (Graduate Staff), Lazo K (Graduate Staff), Mogilevskaya Y (Graduate Staff), Tan M (Medicine), Feinstein MB (Medicine).
Am J Respir Crit Care Med. 2021; 203:A3812. doi: 10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A3812.
Summary: A retrospective study of 1,770 cancer patients who tested positive for COVID-19 between March 2020 and May 2020 at Memorial Sloan Kettering Cancer Center, with authors noting results suggest short-term mortality among patients receiving immunotherapy may be higher than those receiving chemotherapy alone.
Outcomes of patients with hematologic malignancies and COVID-19: A report from the ASH Research Collaborative Data Hub. [Article]
Wood WA, Neuberg DS, Thompson JC, Tallman MS (Medicine), Sekeres MA, Sehn LH, Anderson KC, Goldberg AD (Medicine), Pennell NA, Niemeyer CM, Tucker E, Hewitt K, Plovnick RM, Hicks LK.
Blood Adv. 2020 Dec 8;4(23):5966-5975. doi: 10.1182/bloodadvances.2020003170.
Summary: This article refers to a global public tool, ASH Research Collaborative (ASH RC) COVID-19 Registry, created to compile the data on COVID-19 in patients with leukemia and other blood cancers. The article describes the outcomes and the patterns of coronavirus disease progression as discerned from this data.
Proton therapy treatment & research amid COVID-19. [News]
Simone CB 2nd (Radiation Oncology).
Oncology Times. 2020 Dec 5;42(23):1,6,9. doi: 10.1097/01.COT.0000724652.36050.46.
Summary: This article describes the success of the New York Proton Center in adjusting to working during the COVID-19 pandemic and the steps taken for the resumption of research activities, such as clinical trials, in preparation for the postpandemic reality.
Dermatologic surgery during the COVID-19 pandemic: Experience of a large academic center. [Research Letter]
Tee MW, Stewart C, Aliessa S (Medicine), Polansky M, Shah K, Petukhova T, Rossi A (Medicine), Lipner SR, Minkis K.
J Am Acad Dermatol. 2021 Apr;84(4):1094-1096. doi: 10.1016/j.jaad.2020.12.003. Epub 2020 Dec 5.
Summary: A letter to the editor presenting COVID safety measures taken during surgery at Weill Cornell Dermatology.
Decreased severity and incidence of SARS-CoV-2 infection in younger patients with bone marrow failure: Description of 4 clinical cases. [Preprint]
Castillo P, Boulad F (Pediatrics), Bhatia M, Arnold S, Lipton J, Wang W, Farrar J, Black V, Bennett C, Shimamura A, Kurre P, Vlachos A.
Authorea. 2020 Dec 2. doi: 10.22541/au.160689244.41003643/v1.
Summary: A survey of 29 institutions identified only four pediatric patients with bone marrow failure (BMF) who tested positive for COVID, or 0.3% of the total surveyed BMF patient population. All four patients had mild disease. This preprint has not been peer reviewed.
The hidden curve behind COVID-19 outbreak: The impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying - The head and neck cancer model. [Preprint]
Matos LL, Forster CHQ, Marta GN, Castro G Jr, Ridge JA, Hirata D, Miranda-Filho A, Hosni A, Sanabria A, Gregoire V, Patel SG (Surgery), Fagan JJ, D'Cruz AK, Licitra L, Mehanna H, Hao SP, Psyrri A, Porceddu S, Galloway TJ, Golusinski W, Lee NY (Radiation Oncology), Shiguemori EH, Matieli JE, Shiguemori APAC, Diamantino LR, Schiaveto LF, Leão L, Castro AF, Carvalho AL, Kowalski LP.
ResearchSquare. 2020 Dec 2. doi: 10.21203/rs.3.rs-119756/v1.
Summary: The authors used a model of head and neck squamous cell carcinoma progression to estimate the increased mortality burden of the pandemic on cancer patients. This preprint has not been peer reviewed.
Gastrointestinal endoscopy during the coronavirus pandemic in the New York area: Results from a multi-institutional survey. [Article]
Mahadev S, Aroniadis OC, Barraza LH, Agarunov E, Smith MS, Goodman AJ, Benias PC, Buscaglia JM, Gross SA, Kasmin F, Cohen J, Carr-Locke DL, Greenwald D, Mendelsohn R (Medicine), Sethi A, Gonda TA, (on behalf of NYSGE research committee).
Endosc Int Open. 2020 Dec;8(12): E1865-E1871. doi: 10.1055/a-1264-7599. Epub 2020 Nov 27.
Summary: A survey of 11 endoscopy units in the New York area found an overall pandemic-related decline in procedural volume and a general agreement of which situations indicated urgent endoscopic procedures during the pandemic. The 11 units reported notably different pre-procedural COVID testing policies.
Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer. [Research Letter]
Aydillo T, Gonzalez-Reiche AS, Aslam S, van de Guchte A, Khan Z, Obla A, Dutta J, van Bakel H, Aberg J, García-Sastre A, Shah G (Medicine), Hohl T (Medicine), Papanicolaou G (Medicine), Perales MA (Medicine), Sepkowitz K (Physician in Chief), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
N Engl J Med. 2020 Dec 24;383(26):2586-2588. doi: 10.1056/NEJMc2031670. Epub 2020 Dec 1.
Summary: Cell cultures from 20 immunocompromised patients with Covid-19 found that stem cell transplant or CAR-T cell therapy recipients can shed SARS-CoV-2 virus for at least two months.
Skin cancer management during the COVID-19 pandemic. [Commentary]
Thomas J, Rossi AM (Medicine).
Cutis. 2020 Dec;106(6):E4-E8. doi: 10.12788/cutis.0146.
Summary: These recommendations for dermatologists recommend following National Comprehensive Cancer Network and European Society for Medical Oncology guidelines to reduce COVID transmission risk while treating skin cancer patients.
Trust in the age of COVID-19. [Editorial]
Breitbart W (Psychiatry Service).
Palliat Support Care. 2020 Dec;18(6):634-635. doi: 10.1017/S1478951520001364.
Summary: In this letter, the author shares his opinion on trust in the time of the COVID-19 pandemic. He states how crucial it is for the healthcare workforce to "recognize that trust needs to be restored."
Bridging the divide between physicians and administrators during COVID-19.
[Commentary]
Mullangi S (Graduate Fellow), Diamond R, Patel KK.
Am J Manag Care. 2020 Dec;26(12):499-500. doi: 10.37765/ajmc.2020.88497.
Summary: This article reflects on the tensions that Covid-19 brought about between physicians and administrators and ways in which solutions can be found to remedy them. The three key points are transparancy in leadership, leadership to make sustainable investments in the community, and financial alignment between administrators and the front line workers.
Oncology-inspired treatment options for COVID-19. [Research Article]
Pillarsetty N (Radiology), Carter LM (SKI Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2020 Dec;61(12):1720-1723. doi: 10.2967/jnumed.120.249748. Epub 2020 Jul 17.
Summary: Researchers used a human antibody that binds to SARS-CoV-2 in a proof of concept study, concluding that molecularly targeting the virus is a potential therapeutic approach.
Impact of the COVID pandemic on gynaecological cancer surgery -- Results from the Covidsurg gynaecological cancer international study. [Meeting Abstract]
Sundar SS, Leung E, Khan T, Glasbey J, Abu-Rustum N (Surgery), Chiva LM, Fagotti A, Fujiwara K, Ghebre R, Gultekin M, Konney T, Ng J, Pareja R, Seenivasagam RK, Sehouli J, Shylasree T, Bhangu A, Fotopoulou C, Covidsurg Cancer Collaborators.
Int J Gynecol Cancer. 2020 Dec;30 (Suppl 4): A123-A124. doi: 10.1136/ijgc-2020-ESGO.218.
Summary: This multi-center study looks at the impact of COVID on gynecological cancer surgery. As described in this conference abstract, surgical delays and change in type of surgery occurred relatively frequently, while COVID-related adverse surgical outcomes were low.
Telemedicine blood pressure monitoring after anti-GD2 monoclonal antibody immunotherapy during the COVID-19 pandemic. [Meeting Abstract]
Glincher R (Pediatrics), Cheung NK (Pediatrics), Kasper C (Pediatrics), Scoppetuolo LA (Pediatrics), Modak S (Pediatrics).
Pediatr Blood Cancer. 2020 Dec;67 (Suppl 4): S116. doi: 10.1002/pbc.28742.
Summary: A conference abstract about remotely monitoring blood pressure post-immunotherapy during the pandemic in order to detect the potential onset of adverse treatment effects.
COVID-19 in pediatric hematology and oncology patients in New York City. [Meeting Abstract]
Gampel B, Troullioud Lucas A (Graduate Fellow), Broglie L, Gartrell-Corrado R, Lee M, Levine J, Orjuela-Grimm M, Satwani P, Glade Bender J (Pediatrics), Roberts S (Pediatrics).
Pediatr Blood Cancer. 2020 Dec;67 (Suppl 4): S36. doi: 10.1002/pbc.28742.
Summary: This conference abstract describes 19 hematology, oncology and hematopoietic cell transplant pediatric patients who tested positive for COVID. Most had mild symptoms similar to children without cancer.
Fractional SIR epidemiological models. [Article]
Taghvaei A, Georgiou TT, Norton L (Office of the Pres & CEO), Tannenbaum A.
Sci Rep. 2020 Nov 30;10:20882. doi: 10.1038/s41598-020-77849-7.
Summary: The authors recommend a change to epidemiological models to better represent transmission dynamics.
Clonal hematopoiesis is associated with risk of severe COVID-19. [Preprint]
Bolton KL, Koh Y, Foote MB (Graduate Fellow), Im H, Jee J (Graduate Fellow), Sun CH, Safonov A (Medicine), Ptashkin R (Pathology), Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M (Collaborative Research Centers), Derkach A (Biostat/Epidemiology), Gedvilaite E (Pathology), Tkachuk KA (Medicine), Braunstein LZ (Radiation Oncology), Gao T (Collaborative Research Centers), Papaemmanuil E (Biostat/Epidemiology), Babady E (Laboratory Medicine), Pessin MS (Laboratory Medicine), Kamboj M (Medicine), Diaz LA Jr (Medicine), Ladanyi M (Pathology), Rauth MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V (Medicine), Offit K (Medicine), Norton L (Office of the Pres & CEO), Berger MF (Pathology), Levine RL (Human Oncology & Pathogenesis), Kim SE, Kim NJ, Zehir A (Pathology).
medRxiv. 2020 Nov 27. doi: 10.1101/2020.11.25.20233163v1.
Summary: A study of 515 patients from Memorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia found that patients with clonal hematopoiesis were more likely to have severe COVID infections, along with an increased risk of other infections. This preprint has not been peer reviewed.
The rocaglate CR-31-B (-) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo. [Preprint]
Müller C, Obermann W, Karl N, Wendel HG (Cancer Biology and Genetics), Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J.
bioRxiv. 2020 Nov 24. doi: 10.1101/2020.11.24.389627.
Summary: Researchers found that a synthetic rocaglate molecule had antiviral effects against SARS-CoV-2 in human bronchial cells. This preprint has not been peer reviewed.
Experiences from the epicenter: Professional impact of the COVID-19 pandemic on genetic counselors in New York. [Article]
Bergstrom KL, Brander TE, Breen KE (Medicine), Naik H.
Am J Med Genet C Semin Med Genet. 2021 Mar;187(1):28-36. doi: 10.1002/ajmg.c.31855. Epub 2020 Nov 23.
Summary: In this study conducted in New York State, the authors anonymously surveyed 165 genetic counselors to assess the impact of the Covid-19 pandemic on their services. The article highlights the rapid shift to telegenetics and future recommendations, such as implementing a hybrid model.
Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction. [Letter]
Fu W, Chen Y, Wang K, Hettinghouse A, Hu W (Human Oncology & Pathogenesis Program), Wang JQ, Lei ZN, Chen ZS, Stapleford KA, Liu CJ.
Protein Cell. 2021 Jul;12(7):586-591. doi: 10.1007/s13238-020-00803-w. Epub 2020 Nov 18..
Summary: In this letter to the editor, the authors present how they developed an Elisa assay and identified from the assay three FDA-approved drugs that may help with treating Covid-19.
Language and health equity during COVID-19: Lessons and opportunities. [Commentary]
Ortega P, Martínez G, Diamond L (Psychiatry Service).
J Health Care Poor Underserved. 2020 Nov;31(4):1530-1535. doi: 10.1353/hpu.2020.0114.
Summary:In this commentary, the authors highlight three critical steps to implement during and beyond the pandemic to decrease linguistic minority communities' health disparities.
Performance of SARS-CoV-2 real-time RT-PCR tests on oral rinses and saliva samples. [Article]
Babady NE (Laboratory Medicine), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti EV (Medicine), Aslam A (Infection Control), Diver M (Nursing), Sokoli D (Hospital Administration), Mason G (BAIC), Shah MK (Medicine), Korenstein D (Medicine), Kamboj M (Medicine).
J Mol Diagn. 2021 Jan;23(1):3-9. doi: 10.1016/j.jmoldx.2020.10.018. 2020 Nov 17.
Summary: Between April and May 2020, the researchers compared COVID screening methods in MSK employees who were either showing symptoms or who had known disease exposure. They found SARS-CoV-2 detection from posterior oropharyngeal saliva, but not from oral rinses or mouthwashes, equivalent to detection from nasopharyngeal swabs.
Choosing wisely during the COVID-19 pandemic: Optimising outpatient cancer care while conserving resources with a new algorithm to report automated ANC results. [Correspondence]
Fenelus M (Laboratory Medicine), Graham T (Laboratory Medicine), Golden R (Laboratory Medicine), Bautista JL (Laboratory Medicine), So RJ (Laboratory Medicine), Plante N (Laboratory Medicine), Peerschke EIB (Laboratory Medicine).
J Clin Pathol. 2021 Mar;74(3):202-204. doi: 10.1136/jclinpath-2020-207114. Epub 2020 Nov 16.
Summary: This study determined if and how a streamlined system of only testing absolute neutrophil counts (ANC), instead of full blood counts, helped to decrease patient wait times, staffing, and resources in patients undergoing chemotherapy.
Physiology of cardiomyocyte injury in COVID-19. [Preprint]
Siddiq MM, Chan AT (Medicine), Miorin L, Yadaw AS, Beaumont KG, Kehrer T, White KM, Cupic A, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Martinez P, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R.
medRxiv. 2020 Nov 13. doi: 10.1101/2020.11.10.20229294.
Summary: In this preprint, a publication not yet peer-reviewed, the authors use clinical data from patients and results from experiences conducted in the lab to study how Covid-19 might affect the heart.
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium. [Article]
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Negretti NM, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Vanderbilt COVID-19 Consortium Cohort, Human Cell Atlas Biological Network (Pe'er D (Computational and Systems Biology Program) in group), Kropski JA, Sucre JMS.
J Clin Invest. 2021 Jan 4;131(1):e140766. doi: 10.1172/JCI140766. Epub 2020 Nov 12.
Summary: The authors researched whether genes involved in a person's susceptibility to SARS-COV-2 change their expression during development, and if this might impact the growing seriousness of COVID-19 over the age span.
Cardiovascular care of the oncology patient during COVID-19: An expert consensus document from the ACC Cardio-Oncology and Imaging Councils. [Article]
Baldassarre LA, Yang EH, Cheng RK, DeCara JM, Dent S, Liu JE (Medicine), Rudski LG, Storm JB, Thavendiranathan P, Barac A, Zaha VG, Bucciarelli-Ducci C, Ellahham S, Deswal A, Lenneman C, Villarraga HR, Blaes AH, Ismail-Khan R, Ky B, Leja MJ, Scherrer-Crosbie M.
J Natl Cancer Inst. 2021 May 4;113(5):513-522. doi: 10.1093/jnci/djaa177.
Summary: A consensus statement on cardiovascular care for cardio-oncology patients during the pandemic.
Remote training of SRL users and staff in a global pandemic. [SRL Communication]
Daniels K (Research Facilities), Conway A, Gardner R (Research Facilities), Martinez L, Price KM, Schneider S, Sheridan R, Srivastava J, Thornton S.
Cytometry A. 2021 Jan;99(1):42-50. doi: 10.1002/cyto.a.24262. Epub 2020 Nov 18.
Summary: This article describes challenges to personnel training experienced by Shared Resource Laboratories (SRLs), which are technologically advanced research laboratory facilities at academic and research institutions, during the COVID-19 epidemic, and provides an overview of remote training platforms used.
Racial disparities in patients with COVID-19 infection and gynecologic malignancy. [Meeting Abstract]
Lara O, Smith M, Wang Y, O'Cearbhaill R (Medicine), Blank S, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Jee J (Graduate Fellow), Isani S, Liu M, Wright J, Pothuri B.
Int J Gynecol Cancer. 2020 Nov 1;30(Supp. 3):A54. doi: 10.1136/ijgc-2020-ESGO.96.
Summary: Data from 8 New York-area hospital systems showed that Black patients with gynecologic cancer and COVID-19 were more likely to require hospitalization than non-Black patients.
Inflammatory markers in gynecologic oncology patients hospitalized with COVID-19. [Meeting Abstract]
Smith M, Lara O, O'Cearbhaill R (Medicine), Sutter M, Knisely A, McEachron J, Gabor L, Carr C, Blank S, Prasad-Hayes M, Frey M, Jee J (Graduate Fellow), Fehniger J, Lee YC, Isani S, Wright J, Pothuri B.
Int J Gynecol Cancer. 2020 Nov 1;30(Supp. 3):A120. doi: 10.1136/ijgc-2020-IGCS.253.
Summary: An evaluation of 86 patients with a history of gynecologic cancer who were hospitalized with COVID-19, with authors noting that inflammatory markers (ferritin and C-reactive protein) in these patients are associated with COVID-19 severity and can be used as prognostic markers.
Planned-use glucarpidase for outpatient high dose methotrexate (HD-MTX) administration in patients with CNS lymphoma (CNSL) during the COVID-19 pandemic. [Meeting Abstract]
Schaff L (Neurology), Lobbous M, Bozza A (Neurology), Carlow D, Nabors L, Grommes C (Neurology).
Neuro Oncol. 2020 Nov 1;22(Suppl. 2):ii25–ii26. doi: 10.1093/neuonc/noaa215.105.
Summary: This meeting abstract reports on the results of a small study (seven treaments administered to three patients) investigating the feasibility of using glucarpidase to make outpatient high dose methotrexate administration to CNS lymphoma patients possible during the COVID-19 pandemic.
Comparison of nasopharyngeal swabs and saliva samples for the detection of SARS-Cov-2 RNA. [Meeting Abstract]
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S37. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which eighty-seven paired NPS and saliva samples were collected) looking into the feasibility of using saliva as an alternative for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR) in order to overcome the lack of availability of nasopharyngeal swabs (NPS). Saliva was found to be an acceptable alternative sample for SARS-CoV-2 RNA detection by RT-PCR.
Comparison of oral rinses and nasopharyngeal swabs for the detection of SARS-CoV-2 RNA. [Meeting Abstract]
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S37-S38. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which 98 paired oral rinse and NPS samples were collected) looking into the feasibility of using oral rinse as an alternative for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR) in order to overcome the lack of availability of nasopharyngeal swabs. Oral rinses were not found to be a suitable alternative to nasopharyngeal swabs.
The evaluation of oropharyngeal swabs and saliva samples for the detection of SARS-CoV-2 RNA. [Meeting Abstract]
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S39. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which a total of 100 paired saliva and orophrayngeal swabs (OPS) samples were collected) looking into the feasibility of using saliva versus OPS for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR). Saliva was found to be superior to oropharyngeal swabs for detection of SARS-CoV-2 RNA.
Temporal spatial heterogeneity of immune response to SARS-CoV-2 lung infection. [Meeting Abstract]
Desai N, Ting D, Neyaz A, Szabolcs A, Shih A, Chen J, Thapar V, Nieman L, Solovyov A (Biostat/Epidemiology), Mehta A, Lieb D, Kulkarni A, Jaicks C, Pinto C, Monroe R, Danaher P, Gong J, Juric D, Chebib I, Greenbaum B (Biostat/Epidemiology), Rivera M, Hacohen N, Sholl L, Stone J, Ting D, Deshpande V.
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S33-S34. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on a study (of 89 pulmonary and extrapulmonary samples from 24 COVID-19 autopsies) that attempted to investigate the relationship between SARS-CoV-2 lung infection and the severity of pulmonary disease.
Love in the age of COVID-19. [Editorial]
Breitbart WS (Psychiatry Service).
Palliat Support Care. Oct;18(5):511-512. doi: 10.1017/S1478951520001145. Epub 2020 Nov 9.
Summary: In this editorial, the author reflects on what we can learn from death during the COVID-19 pandemic, hoping that it taught us that "passing love along is what we were born to do."
COVID Moonshot: Open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine learning. [Preprint]
The COVID Moonshot Consortium (Bruce Macdonald H (Computational and Systems Biology Program), Chodera J (Computational and Systems Biology Program), Rufa D (Graduate Studies), Wittmann M (Computational and Systems Biology Program), Boby ML (Graduate Studies), Glass WG (Computational and Systems Biology Program) in group.)
bioRxiv. 2020 Oct 30. doi: 10.1101/2020.10.29.339317.
Summary: A team of international scientists is working to develop antiviral drugs for COVID-19. They report on their methodologies for determining the structures of compounds in this preprint.
COVID-19 in pediatric survivors of childhood cancer and hematopoietic cell transplantation from a single-center in New York City. [Preprint]
Kurlander L (Pediatrics), Antal Z (Pediatrics), DeRosa A (Pediatrics), Diotallevi D (Pediatrics), Pottenger E (Pediatrics), Wilson N (Pediatrics), Corcoran S (Medicine), Boulad F (Pediatrics), Novetsky Friedman D (Pediatrics).
Authorea. 2020 Oct 29. doi: 10.22541/au.160396932.21022667/v1.
Summary: In this brief report, the authors did a retrospective study to determine the impact of COVID-19 infections on 321 childhood cancer survivors seen at Memorial Sloan Kettering between May 5 and September 10, 2020. Based on preliminary results, they report that pediatric survivors don't seem to be at high risk for COVID-19 complications.
Severe acute respiratory syndrome coronavirus 2 surveillance and exposure in the perioperative setting with universal testing and Personal Protective Equipment (PPE) policies. [Article]
Aslam A (Infection Control), Singh J (Infection Control), Robilotti E (Medicine), Chow K (Epidemiology Infectious Disease), Bist T (Medicine), Reidy-Lagunes D (Medicine), Shah M (Medicine), Korenstein D (Medicine), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2021 Nov 2;73(9):e3013-e3018. doi: 10.1093/cid/ciaa1607.
Summary: From a study conducted at MSKCC, this paper gives guidance on conducting pre-procedural COVID-19 testing. The article also highlights how critical personal protective equipment are in procedural settings.
Identification of immunohistochemical reagents for in situ protein expression analysis of coronavirus-associated changes in human tissues. [Article]
Szabolcs M, Sauter JL (Pathology), Frosina D (Pathology), Geronimo JA (Pathology), Hernandez E (Pathology), Selbs E, Rapkiewicz AV, Rekhtman N (Pathology), Baine MK (Graduate Fellow), Jäger E, Travis WD (Pathology), Jungbluth AA (Pathology).
Appl Immunohistochem Mol Morphol. 2021 Jan;29(1):5-12. doi: 10.1097/PAI.0000000000000878. Epub 2020 Oct 20.
Summary: SARS-CoV2 is known to cause severe pulmonary disease but may also involve other organs, making the proper assessment of virus-related pathomorphologic changes in specimens valuable for better understanding COVID-19 disease. This study investigated the usefulness of commercially available monoclonal antibodies for detecting viral antigens in standard archival pathological specimens.
Using simulation to develop solutions for ventilator shortages from the epicenter. [Brief Report]
Burnett GW, Shah A, Fried EA, Shah R (Anesthesiology), Lai CY, Levin M.
Simul Healthc. 2021 Feb;16(1):78-79. doi: 10.1097/SIH.0000000000000523. Epub 2020 Oct 20.
Summary: This brief report describes the work carried out by the Mount Sinai Department of Anesthesiology's Human Emulation, Education and Evaluation Lab for Patient Safety and Professional Study (HELPS) at the height of the COVID-19 pandemic in NYC. The authors make a strong case for the value of using the safe environment of simulation for testing devices and protocols before use on patients, especially during unprecedented emergency situations.
Important concerns over SARS-CoV-2 infection in children with cancer - Reply. [Letter]
Kung AL (Pediatrics), Mauguen A (Biostat/Epidemiology), Boulad F [Pediatrics].
JAMA Oncol. 2020 Dec;6(12):1980. doi: 10.1001/jamaoncol.2020.4767. Epub 2020 Oct 15.
Summary: In this reply, authors addressed concerns raised in a commentary regarding their recent Research Letter. One concern was related to the different types of pediatric cancer being pathophysiologically different, and another was related to observed sex differences.
Using automated-machine learning to predict COVID-19 patient survival: Identify influential biomarkers. [Preprint]
Ikemura K, Goldstein DY, Szymanski J, Bellin E, Stahl L, Yagi Y (Pathology), Saada M, Simone K, Gil MR.
medRxiv. 2020 Oct 14. doi: 10.1101/2020.10.12.20211086.
Summary: This pre-print article describes a novel use of automated machine learning to predict patient survival and mortality from COVID-19. The authors were also able to identify the most important biomarkers correlated with mortality.
Severe COVID-19: A multifaceted viral vasculopathy syndrome. [Article]
Magro CM, Mulvey J (Graduate Fellow), Kubiak J, Mikhail S, Suster D, Crowson AN, Laurence J, Nuovo G.
Ann Diagn Pathol. 2021 Feb;50:151645. doi: 10.1016/j.anndiagpath.2020.151645. Epub 2020 Oct 13.
Summary: This article contibutes to the knowledge of mechanisms causing a severe course of COVID-19 infection and lays the foundation for creating new therapies targeting those mechanisms.
Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019. [Article]
Magro C, Mulvey JJ (Graduate Fellow), Laurence J, Seshan S, Crowson AN, Dannenberg AJ, Salvatore S, Harp J, Nuovo GJ.
Hum Pathol. 2020 Dec;106:106-116. doi: 10.1016/j.humpath.2020.10.002. Epub 2020 Oct 12.
Summary: This study, conducted on 23 patients with COVID-19, investigated the possible complement activation of cutaneous and subcutaneous microvessels and SARS-CoV-2 docked protein within the endothelium.
Impact of the COVID-19 pandemic on telehealth research in cancer prevention and care: A call to sustain telehealth advances. [Commentary]
Park ER, Chiles C, Cinciripini PM, Foley KL, Fucito LM, Haas JS, Joseph AM, Ostroff JS (Psychiatry Service), Rigotti NA, Shelley DR, Taylor KL, Zeliadt SB, Toll BA; Smoking Cessation at Lung Examination (SCALE) Research Group.
Cancer. 2021 Feb 1;127(3):334-338. doi: 10.1002/cncr.33227. Epub 2020 Oct 13.
Summary: This commentary describes the history and barriers of telehealth and how the COVID-19 pandemic impacted telehealth and its use in clinical research.
The impact of the COVID-19 pandemic on surgical management of breast cancer: Global trends and future perspectives. [Article]
Rocco N, Montagna G (Graduate Staff), Di Micco R, Benson J, Criscitiello C, Chen L, Di Pace B, Colmenarejo AJE, Harder Y, Karakatsanis A, Maglia A, Mele M, Nafissi N, Ferreira PS, Taher W, Tejerina A, Vinci A, Nava M, Catanuto G.
Oncologist. 2021 Jan;26(1):e66-e77. doi: 10.1002/onco.13560. Epub 2020 Oct 21.
Summary: This paper reports on the findings of a panel of 12 breast surgeons and a Web-based poll created to investigate the changes in surgical practice due to the COVID-19 pandemic among breast surgeons from several countries worldwide.
Palliative nursing: The core of COVID-19 care. [Article]
Paice JA, Wholihan D, Dahlin C, Rosa WE (SKI Psychiatry/Counseling), Mazanec P, Long CO, Thaxton C, Greer K.
J Hosp Palliat Nurs. 2021 Feb;23(1):6-8. doi: 10.1097/NJH.0000000000000709. Epub 2020 Oct 12.
Summary: This article highlights the important role and scope of palliative nursing and how essential to care the palliative nurse is in the COVID-19 era.
Bronchoscopy and tracheostomy in the COVID-19 era. [Perspective]
Oberg CL, Beattie JA (Medicine), Folch EE.
Chest Physician. 2020 Oct 11;15(10):34-36.
Summary: A discussion of the use of bronchoscopy, tracheostomy, and other aerosol-generating procedures for asymptomatic, symptomatic, and critically ill COVID patients.
SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome. [Preprint]
Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP (Graduate Studies), Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD (Computational and Systems Biology Program), Bowman GR.
bioRxiv. 2020 Oct 7. doi: 10.1101/2020.06.27.175430.
Summary: This preprint describes how citizen scientists worldwide simulated protein folding to contribute to the understanding of SARS-CoV-2 and potential COVID treatments.
Online liver imaging course; Pivoting to transform radiology education during the SARS-CoV-2 pandemic. [Article]
Elsayes KM, Marks RM, Kamel S, Towbin AJ, Kielar AZ, Patel P, Chernyak V, Fowler KJ, Nassar S, Soliman MA, Kamaya A, Mendiratta-Lala M, Borhani AA, Fetzer DT, Fung AW, Do RKG (Radiology), Bashir MR, Lee J, Consul N, Olmsted R, Kambadakone A, Taouli B, Furlan A, Sirlin CB, Hsieh P.
Acad Radiol. 2021 Jan;28(1):119-127. doi: 10.1016/j.acra.2020.10.001. Epub 2020 Oct 6.
Summary: In the time of the COVID-19 pandemic, conferences and workshops have had to switch from in-person to online. This article reports on the successes and challenges of an online Online Liver Imaging Course (OLIC).
Supporting clinical decision-making during the SARS-CoV-2 pandemic through a global research commitment: The TERAVOLT experience. [Commentary]
Trama A, Proto C, Whisenant JG, Torri V, Cortellini A, Michielin O, Barlesi F, Dingemans AC, Van Meerbeeck J, Pancaldi V, Mazieres J, Soo RA, Leighl NB, Peters S, Wakelee H, Horn L, Hellmann M (Medicine), Wong SK, Garassino MC, Baena J.
Cancer Cell.2020 Nov 9;38(5):602-604. doi: 10.1016/j.ccell.2020.10.002. Epub 2020 Oct 5
Summary: This commentary details how a global collaboration for data collection within the Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) was instrumental in providing decision-making in thoracic cancer. The limits of the registry are also discussed.
Survey of cancer care providers' attitude toward care for older adults with cancer during the COVID-19 pandemic. [Article]
BrintzenhofeSzoc K, Krok-Schoen JI, Pisegna JL, MacKenzie AR, Canin B, Plotkin E, Boehmer LM, Shahrokni A (Medicine).
J Geriatr Oncol. 2021 Mar;12(2):196-205. doi: 10.1016/j.jgo.2020.09.028. Epub 2020 Oct 5.
Summary: This study looks at the attitudes and barriers toward the care of older adults with cancer during Covid-19.
Leveraging nurse practitioner capacities to achieve global health for all: COVID-19 and beyond.
[Opinion]
Rosa WE (SKI Psychiatry/Counseling), Fitzgerald M, Davis S, Farley JE, Khanyola J, Kwong J, Moreland PJ, Rogers M, Sibanda B, Turale S.
Int Nurs Rev. 2020 Dec;67(4):554-559. doi: 10.1111/inr.12632. Epub 2020 Oct 2.
Summary: This paper makes a case for why Nurse Practitioners (NPs) are currently under-utilized across the globe and argues that their capacities/skills should be better leveraged at all levels and that - especially in the face of a global pandemic - nurse practitioner scopes of practice should be expanded across nations.
Scholarly publishing in the wake of COVID-19. [Editorial]
Miller RC, Tsai CJ (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):491-495. doi: 10.1016/j.ijrobp.2020.06.048. Epub 2020 Sep 2.
Summary: This communication piece discusses how the Covid-19 pandemic and subsequent need to quickly disseminate scientific literature across the globe impacted scholarly communication and publishing.
Social isolation: Managing psychological distress in hospitalized patients during the COVID-19 pandemic. [Article]
Cazeau N (Ld - Advanced Practice Providers).
Clin J Oncol Nurs. 2020 Oct 1;24(5):472-474. doi: 10.1188/20.CJON.472-474.
Summary: This article discusses the importance of assessing and managing the psychological distress of cancer inpatients receiving treatment, particularly during the COVID-19 pandemic, when social isolation may be exacerbated by visitation restrictions.
Community in the time of COVID-19. [Perspective]
Sheridan L (Neurology).
Rehabil Oncol. 2020 Oct;38(4):141-142. doi: 10.1097/01.REO.0000000000000234.
Summary: Laura Sheridan, PT, DPT, CLT, the president of the Academy of Oncologic Physical Therapy, shares her perspective on how community and support of one another has been an important constant throughout the COVID-19 pandemic and will continue to be so in the rapidly changing healthcare landscape.
A concern about survival time as an endpoint in coronavirus disease 2019 clinical trials. [Research Letter]
Tan KS (Biostat/Epidemiology).
Clin Trials. 2020 Oct;17(5):505-506. doi: 10.1177/1740774520946026. Epub 2020 Aug 20.
Summary: In this article, the author highlights the importance of adapting statistical methods to analyze survival in Covid-19 clinical trials.
Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus. [Article]
Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N (Radiation Oncology), Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS.
Radiother Oncol. 2020 Oct;151:314-321. doi: 10.1016/j.radonc.2020.04.019. Epub 2020 Jul 27.
Summary: Joint recommendations from the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) offer guidance for radiation oncologists treating head and neck cancer (HNC) on how to proceed with radiation procedures during the COVID-19 pandemic.
Natural killer cell responses to emerging viruses of zoonotic origin.
[Review]
Diaz-Salazar C (Immunology), Sun JC (Immunology).
Curr Opin Virol. 2020 Oct;44:97-111. doi: 10.1016/j.coviro.2020.07.003.
Summary: This article describes how natural killer (NK) cells play a critical role in the early anti-viral response of nearly all emerging viruses, including Covid-19.
Identification of biological correlates associated with respiratory failure in COVID-19. [Preprint]
Oh JH (Medical Physics), Tannenbaum A, Deasy JO (Medical Physics).
medRxiv. 2020 Sep 30. doi: 10.1101/2020.09.29.20204289.
Summary: This preprint re-analyzed data, originally collected for a genome-wide association study (GWAS) of Italian and Spanish participants by an international consortium group, using gene ontology analysis and protein-protein interaction analysis to determine which biological processes were most implicated in respiratory failure in COVID-19 patients.
Clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in COVID-19 patients with a moderate to high pre-test probability of PE. [Short Communication]
Das JP (Radiology), Yeh R (Radiology), Schöder H (Radiology).
Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):794-799. doi: 10.1007/s00259-020-05043-y. Epub 2020 Sep 22.
Summary: This paper describes a study that included 33 patients and investigated the utility of using Q-SPECT/CT as an "imaging modality for diagnosing PE in COVID-19 patients with a medium to high probability of PE."
Experiences of healthcare providers of older adults with cancer during the COVID-19 pandemic. [Article]
Krok-Schoen JL, Pisegna JL, BrintzenhofeSzoc K, MacKenzie AR, Canin B, Plotkin E, Boehmer LM, Shahrokni A (Medicine).
J Geriatr Oncol. 2021 Mar;12(2):190-195. doi: 10.1016/j.jgo.2020.09.021. Epub 2020 Sep 18.
Summary: This article examines the experiences and challenges of healthcare providers to care for older adults with cancer during Covid-19.
Inflammatory leptomeningeal cytokines mediate delayed COVID-19 encephalopathy.
[Preprint]
Remsik J (Human Oncology and Pathogenesis Program), Wilcox JA (Graduate Fellow), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Pathology), Avila EK (Neurology), Santomasso B (Neurology), Boire A (Neurology).
medRxiv. 2020 Sept 18. doi: 10.1101/2020.09.15.20195511.
Summary: This preprint (not yet confirmed by peer-review) reports on the "first series to demonstrate an increase in pro-inflammatory CSF cytokines" in cancer patients with moderate and severe COVID-19 infections "who subsequently developed moderate to severe neurologic symptoms" in the weeks following respiratory illness, suggesting that "neurologic toxicity associated with COVID-19 is biochemically similar to CAR T cell neurotoxicity."
Reevaluating chronic opioid monitoring during and after the COVID-19 pandemic. [Commentary]
Rao PN, Jotwani R, Joshi J, Gulati A (Anesthesiology), Mehta N.
Pain Manag. 2020 Nov;10(6):353-358. doi: 10.2217/pmt-2020-0063. Epub 2020 Sep 18.
Summary: This commentary explores what remote opioid management by pain management providers looks like in the time of the COVID-19 pandemic and the considerations that should be made "in an attempt to further mitigate risks of both COVID-19 exposure and opioid misuse."
Behavioral changes without respiratory symptoms as a presenting sign of COVID-19 encephalitis. [Case Report]
Rebeiz T, Lim-Hing K, Khazanehdari S, Rebeiz K (Radiology).
Cureus. 2020 Sep 15;12(9):e10469. doi: 10.7759/cureus.10469.
Summary: This case report describes a febrile patient without respiratory symptoms who presented to the emergency department due to isolated behavioral disturbances and was diagnosed with COVID-19 encephalitis after evaluation.
Complement and coagulation: Key triggers of COVID-19-induced multiorgan pathology. [Commentary]
Ghebrehiwet B, Peerschke EI (Laboratory Medicine).
J Clin Invest. 2020 Nov 2;130(11):5674-5676. doi: 10.1172/JCI142780. Epub 2020 Sept 14.
Summary: A commentary on an article identifying factors behind a circulatory immune process that can be brought on by COVID-19.
Progression to fibrosing diffuse alveolar damage in a series of 30 minimally invasive autopsies with COVID-19 pneumonia in Wuhan, China. [Article]
Li Y, Wu J, Wang S, Li X, Zhou J, Huang B, Luo D, Cao Q, Chen Y, Chen S, Ma L, Peng L, Pan H, Travis WD (Pathology), Nie X.
Histopathology. 2021 Mar;78(4):542-555. doi: 10.1111/his.14249. Epub 2020 Nov 11.
Summary: An autopsy study of COVID-19 patients to determine the clinical course related to and patterns of damaged lung tissue.
Respiratory management of adult patients with acute respiratory distress syndrome due to COVID-19. [Commentary]
Makkar P (Graduate Fellow), Pastores SM (Anesthesiology).
Respirology. 2020 Nov;25(11):1133-1135. doi: 10.1111/resp.13941. Epub 2020 Sept 14.
Summary: This commentary describes the various respiratory management strategies for Covid-19 patients with acute respiratory distress syndrome (ARDS).
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. [Preprint]
Li F, Han M, Dai P, Xu W, He J, Tao X, Wu Y, Tong X, Xia X, Guo W, Zhou Y, Li Y, Zhu Y, Zhang X, Liu Z, Aji R, Cai X, Li Y, Qu D, Chen Y (Medicine), Jiang S, Wang Q, Ji H, Xie Y, Sun Y, Lu L, Gao D.
bioRxiv. 2020 Sept 12. doi: 10.1101/2020.09.11.293035.
Summary: The authors assess whether the prostate cancer drug enzalutamide could be used to treat COVID-19 patients. Use in a mouse model found inconclusive results. This is a preprint and has not yet been peer reviewed.
Cardio-oncology care in the era of the coronavirus disease 2019 (COVID-19) pandemic: An International Cardio-Oncology Society (ICOS) statement. [Review Article]
Lenihan D, Carver J, Porter C, Liu JE (Medicine), Dent S, Thavendiranathan P, Mitchell JD, Nohria A, Fradley MG, Pusic I, Stockerl-Goldstein K, Blaes A, Lyon AR, Ganatra S, López-Fernández T, O'Quinn R, Minotti G, Szmit S, Cardinale D, Alvarez-Cardona J, Curigliano G, Neilan TG, Herrmann J.
CA Cancer J Clin.2020 Nov;70(6):480-504. doi: 10.3322/caac.21635. Epub 2020 Sep 10.
Summary: This review provides an overview of the implications of Covid-19 on cardio-oncology and outlines modifications such as a shift towards using cardiac biomarkers and focused CV imaging to minimize risk of Covid-19 infection without impacting the care of CVD in patients being treated for cancer.
Measures of infection prevention and incidence of SARS-CoV-2 infections in cancer patients undergoing radiotherapy in Germany, Austria and Switzerland. [Review]
Matuschek C, Fischer JC, Combs SE, Fietkau R, Corradini S, Zänker K, Bölke E, Djiepmo-Njanang FJ, Tamaskovics B, Fischer JE, Stuschke M, Pöttgen C, Förster R, Zwahlen DR, Papachristofilou A, Ganswindt U, Pelka R, Schneider EM, Feldt T, Jensen BEO, Häussinger D, Knoefel WT, Kindgen-Milles D, Pedoto A (Anesthesiology), Grebe O, van Griensven M, Budach W, Haussmann J.
Strahlenther Onkol. 2020 Dec;196(12):1068-1079. doi: 10.1007/s00066-020-01681-1. Epub 2020 Sep 10.
Summary: The authors analyzed 106 responses to a survey sent to radiation oncology institutions in Germany, Austria, and Switzerland. Cancer treatments, often on modified schedules, continued with the implementation of additional safety measures.
Rapid deployment of virtual mind-body interventions during the COVID-19 outbreak: Feasibility, acceptability, and implications for future care. [Commentary]
Trevino KM (Psychiatry Service), Raghunathan N (Medicine), Latte-Naor S (Integrative Medicine), Polubriaginof FCG (Health Informatics), Jensen C (Chief Digital Officer and Head of Technology), Atkinson TM (Psychiatry Service), Emard N (Integrative Medicine), Seluzicki CM (Integrative Medicine), Ostroff JS (Psychiatry Service), Mao JJ (Integrative Medicine).
Support Care Cancer. 2021 Feb;29(2):543-546. doi: 10.1007/s00520-020-05740-2. Epub 2020 Sep 9.
Summary: This article describes the rapid deployment of remotely delivered mind-body therapies and services to patients with cancer. The study found high utilization and satisfaction with the virtual services.
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation. [Article]
Shah GL (Medicine), DeWolf S (Graduate Fellow), Lee YJ (Medicine), Tamari R (Medicine), Dahi PB (Medicine), Lavery JA (Biostat/Epidemiology), Ruiz J (Medicine), Devlin SM (Biostat/Epidemiology), Cho C (Medicine), Peled JU (Medicine), Politikos I (Medicine), Scordo M (Medicine), Babady NE (Laboratory Medicine), Jain T (Graduate Fellow), Vardhana S (Medicine), Daniyan AF (Medicine), Sauter CS (Medicine), Barker JN (Medicine), Giralt SA (Medicine), Goss C (Laboratory Medicine), Maslak P (Laboratory Medicine), Hohl TM (Medicine), Kamboj M (Medicine), Ramanathan L (Laboratory Medicine), van den Brink MR (Medicine), Papadopoulos E (Medicine), Papanicolaou G (Medicine), Perales MA (Medicine).
J Clin Invest. 2020 Dec 1:130(12):6656-6667. doi: 10.1172/JCI141777. Epub 2020 Sep 8.
Summary: In this study, the authors report favorable clinical outcomes for COVID-19-positive patients who received cellular therapies (Allo, Auto, or CAR T therapy). Their research will help other transplant centers with decision-making.
Breast cancer patients' response to COVID-19-related imaging and treatment delays: An online forum analysis. [Case Study]
Zhang Z, Ojutiku O, Mango VL (Radiology).
J Am Coll Radiol. 2021 Jan;18(1 Pt A):71-74. doi: 10.1016/j.jacr.2020.09.027. Epub 2020 Sep 7.
Summary: This case study qualitatively analyzed all posts on the COVID-19 forum on breastcancer.org to identify patient concerns in response to COVID-19.
PI3K/mTOR and topoisomerase inhibitors with potential activity against SARS-CoV-2 infection. [Preprint]
White JR, Foote MB (Graduate Fellow), Jee J (Graduate Fellow), Argilés G (SKI Medicine), Wan JCM (SKI Medicine), Diaz LA Jr (Medicine).
medRxiv. 2020 Sep 3. doi: 10.1101/2020.09.02.20186783.
Summary: This preprint reports on a data evaluation effort at Memorial Sloan Kettering Cancer Center to find possible therapeutic agents for preventing COVID-19 infection. The statistical analysis study identified two classes of therapeutic agents that have a potential to play a preventative role by affecting ACE2, our gene associated with SARS-CoV-2 infection.
Considerations for use of hematopoietic growth factors in patients with cancer related to the COVID-19 pandemic. [Guidelines]
Griffiths EA, Alwan LM, Bachiashvili K, Brown A, Cool R, Curtin P, Geyer MB (Medicine), Gojo I, Kallam A, Kidwai WZ, Kloth DD, Kraut EH, Lyman GH, Mukherjee S, Perez LE, Rosovsky RP, Roy V, Rugo HS, Vasu S, Wadleigh M, Westervelt P, Becker PS.
J Natl Compr Canc Netw. 2020 Sep 1;1-4. doi: 10.6004/jnccn.2020.7610.
Summary: Hematopoietic cell growth factors are agents known to support proliferation and differentiation of blood cells. They are used in cancer care in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes. As with other cancer-related therapeutics the use of these agents in the time of the COVID-19 pandemic needed adjustments. This article reports on the National Comprehensive Cancer Network (NCCN) recommendations for adjustments in the use of these agents in the time of the COVID-19 pandemic, to ensure optimal care in the face of multiple new factors the pandemic brought in.
Temporal evolution of tomographic findings of pulmonary infection in COVID-19. [Letter]
Araujo-Filho JAB (SKI Radiology), Sawamura MVY, Teixeira FB, Apanavicius A, Costa AN.
Einstein (Sao Paulo). 2020 Oct 2;18:eCE5974. doi: 10.31744/einstein_journal/2020CE5974.
Summary: This letter to the editor describes using chest CT imaging for long- term prognosis and follow-up of Covid-19.
No talent left behind: A silver lining for diversity in radiation oncology in the post-coronavirus disease 2019 (COVID-19) era. [Editorial]
Kamran SC, Yerramilli D (Radiation Oncology), Vapiwala N.
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):472-474. doi: 10.1016/j.ijrobp.2020.05.055. Epub 2020 Sep 2.
Summary: This opinion piece discusses diversity in the context of how the Covid-19 pandemic may shape how and whom enters into radiation oncology residency in the coming years.
Radiation oncologist perceptions of telemedicine from consultation to treatment planning: A mixed-methods study. [Editorial]
Zhang H, Cha EE (Graduate Student), Lynch K (Psychiatry/Counseling), Cahlon O (Radiation Oncology), Gomez DR (Radiation Oncology), Shaverdian N (Radiation Oncology), Gillespie EF (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):421-429. doi: 10.1016/j.ijrobp.2020.07.007. Epub 2020 Sep 2.
Summary: This study looks at the views of radiation oncologists on telemedicine at MSKCC. The study found that for the most part physicians found telemedicine to be a positive experience and the focus should be on increasing access to care for patients limited by location and financial constraints.
Inflammatory markers in gynecologic oncology patients hospitalized with COVID-19 infection. [Article]
Smith M, Lara OD, O'Cearbhaill R (Medicine), Knisely A, McEachron J, Gabor L, Carr C, Blank S, Prasad-Hayes M, Frey M, Jee J (Graduate Fellow), Fehniger J, Wang Y, Lee YC, Isani S, Wright JD, Pothuri B.
Gynecol Oncol.2020 Dec;159(3):618-622. doi: 10.1016/j.ygyno.2020.09.036. Epub 2020 Sep 25.
Summary: This article assessed a variety of inflammatory markers to see if any were predictive of COVID-19 in gynecological cancer patients. They found that ferritin, procalcitonin, and CRP may have prognostic value, as well as elevated white blood cell count, lactate, and creatinine at admission, whereas D-dimers were not found to be predictive of severe COVID-19 infection.
Preprints during the COVID-19 pandemic: Public health emergencies and medical literature. [Perspective]
Guterman EL, Braunstein LZ (Radiation Oncology).
J Hosp Med. 2020 Oct;15(10):634-636. doi: 10.12788/jhm.3491. Epub 2020 Sept 23.
Summary: This perspective piece details the advantages and disadvantages of preprints in the context of the speed of COVID-19 literature being produced and provides recommendations for improving the preprint server system.
Abdominopelvic CT findings in patients with novel coronavirus disease 2019 (COVID-19). [Article]
Goldberg-Stein S, Fink A, Paroder V (Radiology), Kobi M, Yee J, Chernyak V.
Abdom Radiol (NY). 2020 Sep;45(9):2613-2623. doi: 10.1007/s00261-020-02669-2.
Summary: According to this study, 57% of Covid-19-positive patients yielded positive findings on CT scans of the abdomen and pelvis. The hope is that this study will better be able to reveal why some Covid-19 patients experience abdominal symptoms and some do not.
Defining COVID-19 outcomes in thoracic cancer patients: TERAVOLT (Thoracic cancERs international coVid 19 cOLlaboraTion). [Meeting Abstract]
Baena Espinar J, Torri V, Whisenant J, Hirsch FR, Rogado J, de Castro Carpeño J, Halmos B, Ceresoli GL, Gomez Rueda A, Tiseo M, Felip E, Majem Tarruella M, Monnet I, Tapan U, Wakelee H, Huang LC, Garassino MC, Peters S, Horn L, Hellmann M (Medicine).
Ann Oncol. 2020 Sept;31(Suppl 4):S1204-S1205. doi: 10.1016/j.annonc.2020.08.2316.
Summary: This abstract describes a global consortium of outcomes of COVID-19 infection in thoracic malignancies. It identified COVID-19 risk factors for increased mortality in these patients, such as age, smoking status, cancer stage, and need for steroids.
COVID-19 in patients with lung cancers in New York City. [Meeting Abstract]
Luo J (Graduate Fellow), Rizvi H (Collaborative Research Centers), Preeshagul IR (Medicine), Egger JV (Collaborative Research Centers), Hoyos D (Biostat/Epidemiology), Bandlamudi C (Collaborative Research Centers), Donoghue MTA (Collaborative Research Centers), Luksza M, Greenbaum BD (Biostat/Epidemiology), Wolchok JD (Human Oncology & Pathogenesis Program), Kris MG (Medicine), Hellmann MD (Medicine).
Clin Cancer Res. 2020 Sep;26(18 Suppl.). doi: 10.1158/1557-3265.COVID-19-IA04.
Summary: While it became clear that cancer patients with COVID-19 were especially vulnerable to a severe course of COVID-19, it raised questions as to whether these vulnerabilities were related predominantly to patient characteristics or to cancer and cancer treatments. The research on specific treatment for lung cancer established that patient-related characteristics influence the severity of COVID-19 rather than cancer treatment. This conclusion will be instrumental for optimal decision making on treatment of these patients.
Data harmonization for COVID-19 and cancer research registries. [Meeting Abstract]
Belenkaya R (Health Informatics), Watson A (Health Informatics), Bethusamy S (Health Informatics), Patel M (Health Informatics), Sandler T (Health Informatics), Schwartz J (Health Informatics), Park J (Health Informatics), Dobbins M (Health Informatics), Maloy M (Health Informatics), Lam M (Health Informatics), Bahadur N (Health Informatics), Philip J (Health Informatics).
Clin Cancer Res. 2020 Sep;26(18 Suppl.). doi: 10.1158/1557-3265.COVID-19-PO-061.
Summary: The research data on Covid-19 in cancer patients generated during the pandemic is abundant and complex and it is recorded in multiple institutional and cross-institutional registries. It became a challenge to technically reconcile Covid-19 and cancer research registries built on different standards. To address the need, MSKCC created a framework for ensuring compatibility of Covid-19 and cancer research registries.
Symptoms of anxiety, depression and self-care behaviors during the COVID-19 pandemic in the general population. [Article]
Galindo-Vázquez O, Ramírez-Orozco M, Costas-Muñiz R (Psychiatry Service), Mendoza-Contreras LA, Calderillo-Ruíz G, Meneses-García A.
Gac Med Mex. 2020;156(4):298-305. doi: 10.24875/GMM.20000266.
Summary: This article studied the impact of COVID-19 on anxiety, depression, and self-care behaviors. The results were analyzed from online surveys answered by 1508 participants.
Comment on "Screening of asymptomatic surgical patients for SARS-CoV-2: The Covid19 Subcommittee of the Operating Room Executive Committee." [Brief Clinical Report]
Kamboj M (Medicine), Pessin M (Laboratory Medicine), Barber T (Surgery), The COVID19 Subcommittee of the O.R. Executive Committee at Memorial Sloan Kettering, (Ardizzone L (Anesthesiology), Drebin J (Surgery), Fischer G (Anesthesiology), Jewell E (Surgery), Laudone V (Surgery), Levine M (Hospital Administration), Linder J (Hospital Administration), Simon B (Josie Robertson Surgery Center), Stromblad C (Strategy and Innovation), Tabar V (Neurosurgery), Weiser M (Surgery), Yee SJ (Nursing) in group).
Ann Surg. 2020 Sep 1;272(3):e243. doi: 10.1097/SLA.0000000000004101.
Summary: This commentary describes a protocol for preoperative assessment of patients for Covid-19 to minimize risk of conducting surgery on Covid-positive patients.
Anti-SARS-CoV-2 antibody response in patients with chronic lymphocytic leukemia. [Letter]
Roeker LE (Medicine), Knorr DA (Medicine), Pessin MS (Laboratory Medicine), Ramanathan LV (Laboratory Medicine), Thompson MC (Graduate Fellow), Leslie LA, Zelenetz AD (Medicine), Mato AR (Medicine).
Leukemia. 2020 Nov;34(11):3047-3049. doi: 10.1038/s41375-020-01030-2. Epub 2020 Aug 27.
Summary: This letter to the editor describes decreased antibody and immune response in immunocompromised patients with CLL, with implications in vaccine success rates in these patients.
Challenges faced by women in radiology during the pandemic - A summary of the AAWR Women's Caucus at the ACR 2020 Annual Meeting. [Editorial]
Esfahani SA, Lee A (Graduate Fellow), Hu JY, Kelly M, Magudia K, Everett C, Szabunio M, Ackerman S, Spalluto LB.
Clin Imaging. 2020 Dec;68:291-294. doi: 10.1016/j.clinimag.2020.08.016. Epub 2020 Aug 28.
Summary: This article details the challenges of women in radiology due to the Covid-19 pandemic and subsequent changes to work/life needs.
The global impact of COVID-19 on gastrointestinal endoscopy units: An international survey of endoscopists. [Article]
Alboraie M, Piscoya A, Tran QT, Mendelsohn RB (Medicine), Butt AS, Lenz L, Alavinejad P, Emara MH, Samlani Z, Altonbary A, Monged A, Lemmers A, Sudovykh I, Ho DQD, Ghazanfar S, Kamau E, Iqbal S, Tan DMY, Liao WC, Vignesh S; "The Global Endo-COVID working group".
Arab J Gastroenterol. 2020 Sep;21(3):156-161. doi: 10.1016/j.ajg.2020.08.008. Epub 2020 Aug 26.
Summary: A survey of 163 endoscopists in 48 countries found significant COVID-related declines in endoscopic procedures and a need to improve training on the use of personal protective equipment.
Uninterrupted continuous and intermittent nebulizer therapy in a COVID-19 patient using sequential vibratory mesh nebulizers: A case report. [Case Report]
Elnadoury O, Beattie J (Medicine), Lubinsky AS.
J Aerosol Med Pulm Drug Deliv. 2020 Dec;33(6):357-360. doi: 10.1089/jamp.2020.1636. Epub 2020 Aug 25.
Summary: This case report describes how to deliver continuous and intermittent nebulizer treatment without interruption in patients infected with SARS-CoV2 using two Aerogen vibratory mesh nebulizers.
Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning. [Preprint]
Navlakha S, Morjaria S (Medicine), Perez-Johnston R (Radiology), Zhang A, Taur Y (Medicine).
medRxiv. 2020 Aug 23. 20179838; doi: https://doi.org/10.1101/2020.08.23.20179838.
Summary: This preprint describes the creation and use of an artificial intelligence tool for predicting COVID-19 severity in cancer patients at Memorial Sloan Kettering Cancer Center.
The cancer nurse as primary palliative care agent during COVID-19. [Editorial]
Rosa WE (SKI Psychiatry/Counseling), Finlayson CS (Nursing), Ferrell BR.
Cancer Nurs. 2020 Nov/Dec;43(6):431-432. doi: 10.1097/NCC.0000000000000886. Epub 2020 Aug 19.
Summary: This editorial highlights the amplified role of cancer nurses as primary palliative care agents in the unprecedented time of COVID-19. The authors note their inestimable value as "educational resources to support the delivery of primary palliative care."
Frequency, associated risk factors, and characteristics of COVID-19 among healthcare personnel in a Spanish health department. [Article]
Algado-Sellés N, Gras-Valentí P, Chico-Sánchez P, Mora-Muriel JG, Soler-Molina VM, Hernández-Maldonado M, Lameiras-Azevedo AS, Jiménez-Sepúlveda NJ, Gómez-Sotero IL, Villanueva-Ruiz CO, Barrenengoa-Sañudo J, Fuster-Pérez M, Cánovas-Javega S, Cerezo-Milan P, Monerris-Palmer M, Esclapez A, Cartagena-Llopis L, García-Rivera C, Martínez-Tornero I, Nadal-Morante V, Merino-Lucas E, Rodriguez-Diaz JC, Vidal-Catala I, Llorens-Soriano P, San Inocencio D, Gil-Carbonell J, Montiel-Higuero I, Sánchez-Vela P (Human Oncology and Pathogenesis Program), Sánchez-Payá J.
Am J Prev Med. 2020 Dec;59(6):e221-e229. doi: 10.1016/j.amepre.2020.07.014. Epub 2020 Aug 18.
Summary: An observational study of 3,900 healthcare personnel in a Spanish health department who showed symptoms or were in contact with a COVID-19 patient between March 2, 2020 and April 19, 2020.
Predictors of health insurance, life insurance, and retirement savings among NYC's immigrant taxi and for-hire vehicle drivers. [Article]
Gany F (Psychiatry Service), Mirpuri S (Psychiatry Service), Kim SY (Psychiatry Service), Narang B (Psychiatry Service), Ramirez J (Psychiatry Service), Roberts-Eversley N (Psychiatry Service), Ocampo A (Psychiatry Service), Aragones A (Psychiatry Service), Leng J (Psychiatry Service).
J Community Health. 2020 Dec;45(6):1098-1110. doi: 10.1007/s10900-020-00903-y. Epub 2020 Aug 17.
Summary: Results of a survey of 422 taxi and for-hire vehicle drivers in the New York City metropolitan area to examine health and financial planning behaviors, including the impact of COVID-19.
The effect of neutropenia and filgrastim (G-CSF) in cancer patients with COVID-19 infection. [Preprint]
Morjaria S (Medicine), Zhang AW, Kaltsas A (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Operation Excellence), Predmore J (Ld - Advanced Practice Providers), Perez-Johnston R (Radiology), Jee J (Graduate Fellow), Perales MA (Medicine), Daniyan AF (Medicine), Taur Y (Medicine), Mailankody S (Medicine).
medRxiv. 2020 Aug 15. doi: 10.1101/2020.08.13.20174565.
Summary: The study looked at hospitalized cancer patients with neutropenia (a condition that commonly affects cancer patients and is treated with recombinant human granulocyte colony-stimulating factor, G-CSF, filgrastim) who also had COVID-19 infection. The retrospective study found that neutropenia did not affect the course of COVID-19 infection in such patients but CSF administration did. The authors recommended exercising caution and weighing risks vs benefits of SCF treatment of neutropenic patients with COVID-19 infection. This preprint has not been peer reviewed.
Chemotherapy and COVID-19 outcomes in patients with cancer. [Article]
Jee J (Graduate Fellow), Foote MB (Graduate Fellow), Lumish M (Graduate Fellow), Stonestrom AJ (Graduate Fellow), Wills B (Graduate Fellow), Narendra V (Graduate Fellow), Avutu V (Graduate Fellow), Murciano-Goroff YR (Graduate Fellow), Chan JE (Medicine), Derkach A (Biostat/Epidemology), Philip J (Health Informatics), Belenkaya R (Health Informatics), Kerpelev M (Information Systems), Maloy M (Health Informatics), Watson A (Health Informatics), Fong C (Collaborative Research Centers), Janjigian Y (Medicine), Diaz LA Jr (Medicine), Bolton KL (Medicine), Pessin MS (Laboratory Medicine).
J Clin Oncol. 2020 Oct 20;38(30):3538-3546. doi: 10.1200/JCO.20.01307. Epub 2020 Aug 14.
Summary: In this retrospective study, the authors analyzed the influence of receiving anti-cancer treatments and other cancer-related features on the severity of COVID-19.
Recommendations for testing and treating outpatient cancer patients in the era of COVID-19. [Guidelines]
Reidy-Lagunes D (Medicine), Saltz LB (Medicine), Postow M (Medicine), Scordo M (Medicine), Moskowitz A (Medicine), Tew W (Medicine), Zamarin D (Medicine), Redelman-Sidi G (Medicine).
J Natl Cancer Inst. 2021 Jul;113(7):820-822. doi: 10.1093/jnci/djaa111. Epub 2020 Aug 14.
Summary: This article reports guidelines for COVID-19 patients receiving anti-cancer treatment (chemotherapy, targeted therapy, or immunotherapy). An MSK task force wrote those guidelines and hopes it will be useful to oncologists in other institutions.
Results and impact of intensive SARS-CoV-2 testing in a high volume, outpatient radiation oncology clinic in a pandemic hotspot. [Preprint]
McBride SM (Radiation Oncology), Bundick K (Radiation Oncology), Hubbeling H (Graduate Staff), Freret M (Graduate Staff), Modlin LA (Graduate Staff), Kamboj M (Medicine), Cahlon O (Radiation Oncology), Gomez DA (Radiation Oncology).
medRxiv. 2020 Aug 14. doi: 10.1101/2020.08.11.20172551.
Summary: The study reported on the efforts by the Memorial Sloan Kettering Cancer Center for reducing interruptions in radiation therapy during the COVID-19 pandemic. The Department of Radiation Oncology implemented PCR testing of outpatients coming for treatment along with antibody testing later into the pandemic. These departmental efforts, combined with following the statewide pandemic fighting policies, helped prevent interruptions in radiotherapy treatment that could have jeopardized the treatment's efficacy during the pandemic. This preprint has not been peer reviewed.
Face masks: Benefits and risks during the COVID-19 crisis. [Review]
Matuschek C, Moll F, Fangerau H, Fischer JC, Zänker K, van Griensven M, Schneider M, Kindgen-Milles D, Knoefel WT, Lichtenberg A, Tamaskovics B, Djiepmo-Njanang FJ, Budach W, Corradini S, Häussinger D, Feldt T, Jensen B, Pelka R, Orth K, Peiper M, Grebe O, Maas K, Gerber PA, Pedoto A (Anesthesiology), Bölke E, Haussmann J.
Eur J Med Res. 2020 Aug 12;25(1):32. doi: 10.1186/s40001-020-00430-5.
Summary: This review of available literature found that wearing face masks that cover the nose and mouth are effective at interrupting airborne infections in the community. This review highlights the protectiveness of certain types of face masks in defined risk groups as well as their risks.
Hospital length of stay for severe COVID-19: Implications for Remdesivir's value. [Preprint]
Anderson MR, Bach PB (Center for Health Policy and Outcomes), Baldwin MR.
medRxiv. 2020 Aug 12. doi: 10.1101/2020.08.10.20171637.
Summary: The retrospective study looked at the impact of the drug Remdesivir (that received emergency use authorization for treatment of severe COVID-19) on the length of stay of inpatients with severe COVID-19 infection and found that, contrary to the expectations, the use of Remdesivir did not reduce the length of stay in the studied population. This preprint has not been peer reviewed.
Oncologic immunomodulatory agents in patients with cancer and COVID-19. [Preprint]
Jee J (Graduate Fellow), Stonestrom AJ (Graduate Fellow), Devlin S (Biostat/Epidemiology), Nguyentran T (Ld - Advanced Practice Providers), Wills B (Graduate Staff), Narendra V (Graduate Fellow), Foote MB (Graduate Staff), Lumish M (Graduate Staff), Vardhana S (Medicine), Pastores SM (Anesthesiology), Korde N (Medicine), Patel D (Medicine), Horwitz S (Medicine), Scordo M (Medicine), Daniyan A (Medicine).
medRxiv. 2020 Aug 12. doi: 10.1101/2020.08.11.20145458.
Summary: This preprint provides a retrospective investigation of the effects of oncologic immunomodulatory agents on the 820 cancer patients diagnosed with SARS-CoV-2 at Memorial Sloan Kettering Cancer Center up to June 2, 2020.
Development and validation of a surgical prioritization and ranking tool and navigation aid for head and neck cancer (SPARTAN-HN) in a scarce resource setting: Response to the COVID-19 pandemic. [Article]
de Almeida JR, Noel CW, Forner D, Zhang H, Nichols AC, Cohen MA (Surgery), Wong RJ (Surgery), McMullen C, Graboyes EM, Divi V, Shuman AG, Rosko AJ, Lewis CM, Hanna EY, Myers J, Paleri V, Miles B, Genden E, Eskander A, Enepekides DJ, Higgins KM, Brown D, Chepeha DB, Witterick IJ, Gullane PJ, Irish JC, Monteiro E, Goldstein DP, Gilbert R.
Cancer. 2020 Nov 15;126(22):4895-4904. doi: 10.1002/cncr.33114. Epub 2020 Aug 11.
Summary: This study defines an algorithm to fairly and consistently triage head and neck cancer patients that require surgery.
Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19. [Article]
Laurence J, Mulvey JJ (Graduate Fellow), Seshadri M, Racanelli A, Harp J, Schenck EJ, Zappetti D, Horn EM, Magro CM.
Clin Immunol. 2020 Oct;219:108555. doi: 10.1016/j.clim.2020.108555. Epub 2020 Aug 6.
Summary: This article reports on the effects of the administration of the anti-C5 monoclonal antibody eculizumab to three critically ill COVID-19 patients who had failed to respond to multiple other interventions, including steroids, remdesivir, and tociluzimab.
Rethinking clinical trials reform during the COVID-19 pandemic. [Viewpoint]
Nabhan C, Choueiri TK, Mato AR (Medicine).
JAMA Oncol. 2020 Sep;6(9):1327-1329. doi: 10.1001/jamaoncol.2020.3142. Epub 2020 Aug 6.
Summary: This viewpoint article details how Covid-19 has caused a significant change to how clinical trials are conducted, including telemedicine and virtual support for trial participants, laboratory tests and procedures done in clinics not affiliated with the trial, the speed of recruitment into trials, and the focus on patient-reported outcomes. These are all changes that can shape how clinical trials are conducted in a post-Covid world to improve access to and impact of clinical trials.
Consensus statement on the management of Waldenström macroglobulinemia patients during the COVID-19 pandemic. [Expert Opinion]
Talaulikar D, Advani RH, Branagan AR, Buske C, Dimopoulos MA, D'Sa S, Kersten MJ, Leblond V, Minnema MC, Owen RG, Palomba ML (Medicine), Tedeschi A, Trotman J, Varettoni M, Vos JM, Treon SP, Kastritis E, Castillo JJ.
HemaSphere. 2020 Aug; 4(4): e433. doi: 10.1097/HS9.0000000000000433.
Summary: The International Workshop on Waldenström Macroglobulinemia (IWWM) Treatment Recommendations Panel provides answers to help guide patient therapy during the pandemic.
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium. [Preprint]
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Hackett A, Koval M, Guttentag SH, Blackwell TS, Vanderbilt COVID-19 Consortium Cohort, Webber SA, Banovich NE, Kropski JA, Sucre JMS, HCA Lung Biological Network.
medRxiv. 2020 Aug 3. doi: 10.1101/2020.05.22.111187.
Summary: In this preprint, researchers use a mouse model of SARS-COV-2 to determine how lung development impacts disease susceptibility.
CT colonography's role in the COVID-19 pandemic: A safe(r), socially distanced total colon examination. [Perspective]
Moreno CC, Yee J, Ahmed FS, Barish MA, Brewington C, Dachman AH, Gollub MJ (Radiology), Kim DH, McFarland E, Pickhardt PJ, Reddy S, Zalis M, Chang KJ.
Abdom Radiol (NY). 2021 Feb;46(2):486-490. doi: 10.1007/s00261-020-02674-5. Epub 2020 Aug 3.
Summary: The favorable procedural profile of CT colonography (CTC) for colorectal cancer screening is described in this paper as it may be a reasonable alternative to optical colonoscopy during the COVID-19 pandemic.
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. [Preprint]
Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A (Biostat/Epidemiology), Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD (Biostat/Epidemiology), Hacohen N, Lagana SM, Rivera MN, Sholl, LM, Stone JR, Ting DT, Deshpande V.
medRxiv. 2020 Aug 2. doi: 10.1101/2020.07.30.20165241.
Summary: This preprint contributes to the knowledge of the pathology of pulmonary disease associated with Covid-19 infection.
Cancer therapy and treatments during COVID-19 era. [Review]
Akula SM, Abrams SL, Steelman LS, Candido S, Libra M, Lerpiriyapong K (Research Facilities), Cocco L, Ramazzotti G, Ratti S, Follo MY, Martelli AM, Blalock WL, Piazzi M, Montalto G, Cervello M, Notarbartolo M, Basecke J, McCubrey JA.
Adv Biol Regul. 2020 Aug;77:100739. doi: 10.1016/j.jbior.2020.100739.
Summary: This article provides a summary of the impact of COVID-19 on patients with different types of cancer and their treatments, as well as, the potential repurposing of various drugs/agents to minimize or treat COVID-19 disease.
Commentary: Echoes of war. [Commentary]
Rocco G (Surgery).
J Thorac Cardiovasc Surg. 2020 Aug;160(2):594-595. doi: 10.1016/j.jtcvs.2020.03.130. Epub 2020 Apr 10.
Summary: This commentary by MSK thoracic surgeon Dr. Gaetano Rocco discusses how early reports of the pandemic from China and Italy should inform surgical care in New York, the new epicenter of COVID at the time of publication.
How we manage patients with chronic lymphocytic leukemia during the SARS-CoV-2 pandemic. [Expert Opinion]
Rossi D, Shadman M, Condoluci A, Brown JR, Byrd JC, Gaidano G, Hallek M, Hillmen, P, Mato A (Medicine), Montserrat E, Ghia P.
HemaSphere. 2020 Aug; 4(4): e432. doi: 10.1097/HS9.0000000000000432.
Summary: Cancer patients with Covid-19 are especially vulnerable to infection and their treatment during the pandemic has to be reviewed and revised in that new light. This article provides expert opinion, based on literature review, on treatment adjustments needed for patients with Chronic Lymphocytic Leukemia at the time of the pandemic.
Providing equitable care to patients with limited dominant language proficiency amid the COVID-19 pandemic. [Editorial]
Diamond LC (Psychiatry), Jacobs EA, Karliner L.
Patient Educ Couns.2020 Aug;103(8):1451-1452. doi: 10.1016/j.pec.2020.05.028.
Summary: This editorial highlights the health care disparities experienced disproportionately by populations who are limited English proficient (LEP), exacerbated during the COVID-19 pandemic. It outlines steps for more clear communication that can be taken to provide equitable care to LEP populations and help contain the spread of COVID-19.
COVID-19 outcomes of patients with gynecologic cancer in New York City. [Article]
Lara OD, O'Cearbhaill RE (Medicine), Smith MJ, Sutter ME, Knisely A, McEachron J, Gabor LR, Jee J, Fehniger JE, Lee YC, Isani SS, Wright JD, Pothuri B.
Cancer. 2020 Oct 1;126(19):4294-4303. doi: 10.1002/cncr.33084. Epub 2020 Jul 30.
Summary: Cancer patients that also have COVID-19 may be affected by this infection in a different way than the general population. The interplay between Covid-19 infection and various cancer treatments is an important factor in patients' severity of infection, its complications, and survival. This article reports a study which compiled data on patients with gynecologic cancers in multiple NYC hospitals. The study found that the immunotherapy treatments negatively affect the infection severity and patient survival while cancer chemotherapy and surgery don't. These findings inform treatment decisions that also allow for continuing chemotherapy and surgery. Further evaluation of immunotherapy for cancer patients with Covid-19 is needed and caution should be exercised during the pandemic.
COVID-19: A multidisciplinary review. [Review]
Chams N, Chams S, Badran R, Shams A, Araji A (Radiology), Raad M, Mukhopadhyay S, Stroberg E, Duval EJ, Barton LM, Hajj Hussein I.
Front Public Health. 2020 Jul 29;8:383. doi: 10.3389/fpubh.2020.00383.
Summary: This is a comprehensive review of what we have learned about the novel coronavirus and the infection it causes (up to July 2020, the time of this article's publication). It covers the whole spectrum of COVID-19 including timeline, origins, how the virus is transmitted, epidemiology, clinical symptoms, disease course and complications, treatments that emerged, etc.
Guidelines for COVID-19 management in hematopoietic cell transplantation and cellular therapy recipients. [Practice Guidelines]
Waghmare A, Abidi MZ, Boeckh M, Chemaly RF, Dadwal S, El Boghdadly Z, Kamboj M (Medicine), Papanicolaou GA (Medicine), Pergam SA, Shahid Z.
Biol Blood Marrow Transplant. 2020 Nov;26(11):1983-1994. doi: 10.1016/j.bbmt.2020.07.027. Epub 2020 Jul 28.
Summary: Guidelines for the diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplantation and cellular therapy recipients, produced using available data and the expert opinion of the American Society for Transplantation and Cellular Therapy Infectious Diseases Special Interest Group members.
Real-world issues and potential solutions in HCT during the COVID-19 pandemic: Perspectives from the WBMT and the CIBMTR's Health Services and International Studies Committee. [Practice Guidelines]
Algwaiz G, Aljurf M, Koh M, Horowitz MM, Ljungman P, Weisdorf D, Saber W, Kodera Y, Szer J, Jawdat D, Wood WA, Brazauskas R, Lehmann L, Pasquini MC, Seber A, Lu PH, Atsuta Y, Riches M, Perales MA (Medicine), Worel N, Okamoto S, Srivastava A, Chemaly RF, Cordonnier C, Dandoy CE, Wingard JR, Kharfan-Dabaja MA, Hamadani M, Majhail NS, Waghmare AA, Chao N, Kröger N, Shaw B, Mohty M, Niederwieser D, Greinix H, Hashmi SK; WBMT and the CIBMTR Health Services and International Studies Committee.
Biol Blood Marrow Transplant. 2020 Dec;26(12):2181-2189. doi: 10.1016/j.bbmt.2020.07.021. Epub 2020 Jul 24.
Summary: The Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee collaborated to write these worldwide guidelines on Hematopoietic Cell Transplantation in the times of COVID-19.
The differing pathophysiologies that underlie COVID-19 associated perniosis and thrombotic retiform purpura: A case series. [Article]
Magro C, Mulvey JJ (Laboratory Medicine), Laurence J, Sanders S, Crowson N, Grossman M, Harp J, Nuovo G.
Br J Dermatol. 2021 Jan;184(1):141-150. doi: 10.1111/bjd.19415. Epub 2020 Jul 22.
Summary: The authors compare two skin manifestations of COVID, one that arises in mild disease and one in severe illness, and the distinct immune responses behind them.
Summary of COVID-19 clinical practice adjustments across select institutions. [Letter to the Editor]
Schultz L, Link MP, Rheingold S, Hawkins DS, Dome JS, Wickiser J, Kung AL (Pediatrics), Henderson TO, Aftandilian C.
Pediatr Blood Cancer. 2020 Nov;67(11):e28411. doi: 10.1002/pbc.28411. Epub 2020 Jul 19.
Summary: This letter to the editor details physician recommendations from six academic pediatric hematology/oncology programs for caring for immunocompromised pediatric patients who are at higher risk of infection.
Outcomes of COVID-19 in patients with CLL: A multicenter, international experience. [Clinical Trials and Observations]
Mato AR (Medicine), Roeker LE (Medicine), Lamanna N, Allan J, Leslie LA, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs RW, Ahn IE, Pu JJ, Isaac K, Barr PM, Ujjani C, Geyer MB (Medicine), Berman E, Zelenetz AD (Medicine), Malakhov N, Furman RR, Koropsak M, Bailey N, Hansson L, Perini GF, Ma S, Ryan CE, Wiestner A, Portell CA, Shadman M, Chong EA, Brander DM, Sundaram S, Seddon AN, Seymour E, Patel M, Martinez-Calle N, Munir T, Walewska R, Broom A, Walter HS, El-Sharkawi D, Parry H, Wilson MR, Patten PE, Hernández-Rivas JÂ, Miras F, Fernàndez Escalada N, Ghione P (Graduate Fellow), Nabhan C, Lebowitz S (Outpatient Operations), Bhavsar EB, López-Jiménez J, Naya D, Garcia-Marco JA, Skånland SS, Cordoba R, Eyre TA.
Blood. 2020 Sep 3;136(10):1134-1143. doi: 10.1182/blood.2020006965. Epub 2020 Jul 20.
Summary: This study of nearly 200 chronic lymphocytic leukemia patients with symptomatic COVID infections found that patients requiring hospitalization had high mortality rates.
Cancer did not stay home for COVID-19. [Editorial]
Levine RL (Human Oncology & Pathogenesis).
Sci Adv. 2020 Sep 10;6(37):eabd7487. doi: 10.1126/sciadv.abd7487. Epub 2020 Jul 17.
Summary: Dr. Ross Levine delineates the challenges COVID-19 has brought to cancer care and research in this editorial.
Oncology-inspired treatment options for COVID-19. [Brief Communication]
Pillarsetty N (Radiology), Carter L (Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2020 Dec;61(12):1720-1723. doi: 10.2967/jnumed.120.249748. Epub 2020 Jul 17.
Summary: In this article, the authors explore using radiotherapy developed for cancer therapy as a potential co-treatment for COVID-19.
Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. [Review]
Battisti NML, Mislang AR, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrió RG, Stauder R, Soto-Perez-de-Celis E, Jaklitsch M, Williams GR, O'Hanlon S, Alam M, Cairo C, Colloca G, Gil LA Jr, Sattar S, Kantilal K, Russo C, Lichtman SM (Medicine), Brain E, Kanesvaran R, Wildiers H.
J Geriatr Oncol. 2020 Nov;11(8):1190-1198. doi: 10.1016/j.jgo.2020.07.008. Epub 2020 Jul 16
Summary: In this article, experts from the International Society of Geriatric Oncology (SIOG) wrote cancer care recommendations for older patients during a pandemic.
When a cancer patient tests positive for Covid-19. [Article]
Majeed J (Ld-Advanced Practice Providers), Garcia J (Nursing), Holland J (Nursing), Daly B (Medicine), Robson ME (Medicine), Reidy-Lagunes D (Medicine).
Harvard Business Review 2020 Jul 16.
Summary: This article reports on the successes and challenges of an MSKCC program that remotely monitors cancer patients who test positive to Covid-19. The program involves five digital platforms.
Drug repurposing commonly against dengue virus capsid and SARS-CoV-2 nucleocapsid: An in silico approach. [Preprint]
Mukherjee D, Kumar R (Molecular Biology), Ray U.
ChemRxiv. 2020 Jul 15. doi: 10.1101/2020.07.30.20165241.
Summary: This preprint identifies five drugs approved for other diseases that bind to both COVID-19 and Dengue virus.
Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. [Article]
Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A (Radiation Oncology), Rodrigues GB, Schild SE, Senan S, Simone CB II (Radiation Oncology), Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D.
Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):631-640. doi: 10.1016/j.ijrobp.2020.05.012.
Summary: : A consensus statement of 32 experts in lung cancer recommend adhering to guidelines for recommended practice. For patients positive for Covid-19 it's recommended to postpone or interrupt radiation therapy. In a severe pandemic scenario, patients should be triaged based on a variety of factors.
The American College of Surgeons responds to COVID-19. [Special Article]
Rusch VW (Surgery), Wexner SD, in collaboration with the American College of Surgeons COVID-19 Communications Committee, Board of Regents, and Officers.
J Am Coll Surg. 2020 Oct;231(4):490-496. doi: 10.1016/j.jamcollsurg.2020.06.020. Epub 2020 Jul 14.
Summary: This article describes the efforts made by the American College of Surgeons and its multiple divisions to support medical professionals in addressing the challenges presented by the COVID-19 pandemic. These efforts also included support to cancer programs by creating guidelines on managing cancer patients during the pandemic.
Clinical trial design in the era of COVID-19. [Editorial]
Begg CB (Biostat/Epidemiology), Gonen M (Biostat/Epidemiology), Heitjan DF.
Clin Trials. 2020 Oct;17(5):465-466. doi: 10.1177/1740774520940230. Epub 2020 Jul 10.
Summary: This editorial highlights three articles published in volume 17, issue 5, of the journal "Clinical Trials," dedicated to the important aspects of experimental research in a pandemic such as COVID-19. The articles highlighted by the editors provide an overview of the health care response to the COVID-19 pandemic in a historical perspective, discuss what COVID-19 clinical trials should focus on, and discuss the suitability of traditional clinical research design during special situations such as the COVID-19 pandemic.
Digestive manifestations in patients hospitalized with COVID-19. [Preprint]
Elmunzer BJ, Spitzer RL, Foster LD, Merchant AA, Howard EF, Patel VA, West MK, Qayad E, Nustas R, Zakaria A, Piper MS, Taylor JR, Jaza L, Forbes N, Chau M, Lara LF, Papachristou GI, Volk ML, Hilson LG, Zhou S, Kushnir VM, Lenyo AM, McLeod CG, Amin S, Kuftinec GN, Yadav D, Fox C, Kolb JM, Pawa S, Pawa R, Canakis A, Huang C, Jamil LH, Aneese AM, Glamour BK, Smith ZL, Hanley KA, Wood J, Patel HK, Shah JN, Agarunov E, Sethi A, Evan L. Fogel EL, McNulty G, Haseeb A, Trieu JA, Dixon RE, Yang JY, Mendelsohn RB (Medicine), Calo D (Medicine), Aroniadis OC, LaComb JF, Scheiman JM, Sauer BG, Dang DT, Piraka CR, Shah ED, Pohl H, Tierney WM, Mitchell S, Condon A, Lenhart A, Dua KS, Kanagala VS, Kamal A, Singh VK, Pinto-Sanchez MI, Hutchinson JM, Kwon RS, Korsnes SJ, Singh H, Solati Z, Deshpande AR, Rockey DC, Alford TB, Durkalski V, the North American Alliance for the Study of Digestive Manifestations of COVID-19.
medRxiv. 2020 Jul 9. doi: 10.1101/2020.07.07.20143024.
Summary: This preprint compiles evidence on the presence and severity of gastrointestinal problems in patients with COVID-19.
Rapid scaling up of telehealth treatment for tobacco-dependent cancer patients during the COVID-19 outbreak in New York City. [Article]
Kotsen C (Psychiatry Service), Dilip D (Psychiatry Service), Carter-Harris L (Psychiatry Service), O'Brien M (Psychiatry Service), Witlock CW (Psychiatry Service), de Leon-Sanchez S (Psychiatry Service), Ostroff JS (Psychiatry Service).
Telemed J E Health.2021 Jan;27(1):20-29. doi: 10.1089/tmj.2020.0194. Epub 2020 Jul 9.
Summary: This article describes Memorial Sloan Kettering Cancer Center's successful transitioning from in-person smoking cessation counseling, to telehealth treatment for tobacco dependent cancer patients during COVID-19 pandemic.
The 3 B's of cancer care amid the COVID-19 pandemic crisis: "Be safe, be smart, be kind" - A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer. [Commentary]
Kang JJ (Radiation Oncology), Wong RJ (Surgery), Sherman EJ (Medicine), Rybkin A (Radiation Oncology), McBride SM (Radiation Oncology), Riaz N (Radiation Oncology), Tsai CJ (Radiation Oncology), Yu Y (Radiation Oncology), Chen L (Radiation Oncology), Zakeri K (Radiation Oncology), Gelblum DY (Radiation Oncology), Gillespie EF (Radiation Oncology), Cohen MA (Surgery), Cracchiolo JR (Surgery), Ganly I (Surgery), Patel S (Surgery), Singh B (Surgery), Boyle JO (Surgery), Roman BR (Surgery), Morris LG (Surgery), Shaha AR (Surgery), Dunn LA (Medicine), Ho AL (Medicine), Fetten JV (Medicine), Shah JP (Surgery), Pfister DG (Medicine), Lee NY (Radiation Oncology).
Cancer. 2020 Sep 15;126(18):4092-4104. doi: 10.1002/cncr.33031. Epub 2020 Jul 8.
Summary: MSK's treatment for head and neck cancer during the COVID pandemic followed the best available evidence while expanding telemedicine utilization.
Insights into pathogenesis of fatal COVID-19 pneumonia from histopathology with immunohistochemical and viral RNA studies. [Article]
Sauter JL (Pathology), Baine MK (Graduate Fellow), Butnor KJ, Buonocore DJ (Pathology), Chang JC (Pathology), Jungbluth AA (Pathology), Szabolcs MJ, Morjaria S (Medicine), Mount SL, Rekhtman N (Pathology), Selbs E, Sheng ZM, Xiao Y, Kleiner DE, Pittaluga S, Taubenberger JK, Rapkiewicz AV, Travis WD (Pathology).
Histopathology. 2020 Dec;77(6):915-925. doi: 10.1111/his.14201. Epub 2020 Jul 2.
Summary: This article describes post-mortem pathology findings from patients who died of Covid-19 pneumonia, including the wide spectrum of progression from rapid to prolonged disease course.
'Case of the Month' from Memorial Sloan Kettering Cancer Center, New York, NY, USA: Managing newly diagnosed metastatic testicular germ cell tumor in a COVID-19 positive patient. [Case Report]
Almassi N (Graduate Fellow), Mulhall JP (Surgery), Funt SA (Medicine), Sheinfeld J (Surgery).
BJU Int. 2020 Sep;126(3):333-335. doi: 10.1111/bju.15157. Epub 2020 Aug 18.
Summary: A case report of a patient whose surgery was postponed due to a positive COVID screening test and the disease management considerations that followed.
Crowdsourcing drug discovery for pandemics. [Correspondence]
Chodera J (Computational and Systems Biology Program), Lee AA, London N, von Delft F.
Nat Chem. 2020 Jul;12(7):581. doi: 10.1038/s41557-020-0496-2. Epub 2020 Jun 18.
Summary: This letter to the editor describes the creation of Moonshot COVID, an international consortium of scientists being funded through charity grants and crowdfunding to quickly and easily develop antiviral drugs to treat Covid-19 disease.
An inflammatory leptomeningeal signature in cancer patients with neurologic manifestations of COVID-19. [Meeting Abstract]
Wilcox JA (Neurology), Remsik J (Human Oncology and Pathogenesis Program), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Pathology), Avila E (Neurology), Sontomasso B (Neurology), Boire A (Neurology).
Cancer Res. 2020 Jul 1; 81(13 Suppl.). doi: 10.1158/1538-7445.AM2021-703.
Summary: A prospective evaluation of 18 cancer patients with confirmed SARS-CoV-2 infection and subsequent neurologic manifestations, with authors noting that findings suggest a potential role for anti-inflammatory treatments with these patients.
Regulating inspiratory pressure to individualise tidal volumes in a simulated two-patient, one-ventilator system. [Correspondence]
Chen GH (Medical Physics), Hellman S (Anesthesiology), Irie T (Anesthesiology), Downey RJ (Surgery), Fischer GW (Anesthesiology).
Br J Anaesth. 2020 Oct;125(4):e366-e368. doi: 10.1016/j.bja.2020.06.043. Epub 2020 June 30.
Summary: A serious complication of COVID-19 infection is acute respiratory distress syndrome and ventilators are used to address this condition. The high number of such cases at the time of the pandemic caused ventilator shortages which were sometimes solved by providing a single ventilator to more than one patient at the same time, presenting several challenges. This article reports on finding a technical solution to these challenges.
The international response to the coronavirus disease (2019) COVID-19 pandemic in radiation oncology. [Opinion]
Wang E, Tsai CJ (Radiation Oncology), Miller RC.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):523-524. doi: 10.1016/j.adro.2020.06.015. Epub 2020 Jun 29.
Summary: This article serves as an introduction to a special issue of the Society for Radiation Oncology's Advances in Radiation Oncology. It describes the evolution of topics and manuscript submissions as the practice of radiation oncology around the world has been impacted in response to the COVID-19 pandemic.
COVID-19 disease in New York City pediatric hematology and oncology patients. [Letter]
Gampel B, Troullioud Lucas AG (Graduate Fellow), Broglie L, Gartrell-Corrado RD, Lee MT, Levine J, Orjuela-Grimm M, Satwani P, Glade-Bender J (Pediatrics), Roberts SS (Pediatrics).
Pediatr Blood Cancer. 2020 Sep; 67(9): e28420. doi: 10.1002/pbc.28420. Epub 2020 Jun 26.
Summary: This letter to the editor describes the experience of two pediatric oncology departments in NYC (MSK and NYP) with Covid-19, including demographics and clinical characteristics of patients tested, and the clinical characteristics and impacts of the patients who tested positive.
Adrenal vascular changes in COVID-19 autopsies. [Article]
Iuga AC, Marboe CC, Yilmaz MM, Lefkowitch JH, Gauran C (Anesthesiology), Lagana SM.
Arch Pathol Lab Med. 2020 Oct;144(10):1159-1160. doi: 10.5858/arpa.2020-0248-LE. Epub 2020 Jun 24.
Summary: This article reports on the "pathological findings in the adrenal glands of the first five post-mortem examinations of patients with COVID-19 diagnosed on clinical grounds with confirmatory real-time polymerase chain reaction testing of nasopharyngeal swab." The authors consider the potential role of adrenal function in the pathogenesis of COVID-19 disease.
Determinants of COVID-19 disease severity in patients with cancer. [Letter]
Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Mead PA (Medicine), Rolling T (SKI Medicine), Perez-Johnston R (Radiology), Bernardes M (Graduate Fellow), Bogler Y (Graduate Fellow), Caldararo M (Graduate Fellow), Figueroa CJ (Medicine), Glickman MS (Immunology), Joanow A (Ld - Advanced Practice Providers), Kaltsas A (Medicine), Lee YJ (Medicine), Lucca A (Emp Health & Wellness), Mariano A (Ld - Advanced Practice Providers), Morjaria S (Medicine), Nawar T (Graduate Fellow), Papanicolaou GA (Medicine), Predmore J (Ld - Advanced Practice Providers), Redelman-Sidi G (Medicine), Schmidt E (Ld - Advanced Practice Providers), Seo SK (Medicine), Sepkowitz K (Physician in Chief), Shah MK (Medicine), Wolchok JD (Human Oncology & Pathogenesis Pgm), Hohl TM (Medicine), Taur Y (Medicine), Kamboj M (Medicine).
Nat Med. 2020 Aug;26(8):1218-1223. doi: 10.1038/s41591-020-0979-0. Epub Jun 24.
Summary: This article adds to the characterization of COVID-19 in patients with cancer as it reports the most extensive single-institution experience in patients with cancer from the epicenter of the US outbreak, describing outcomes on COVID-19-associated respiratory compromise and including a full 30-d follow-up for reporting primary study outcomes and death rates.
Missed opportunities on emergency remdesivir use. [Viewpoint]
Sarpatwari A, Kaltenboeck A (Biostat/Epidemiology), Kesselheim AS.
JAMA. 2020 Jul 28;324(4):331-332. doi: 10.1001/jama.2020.11932. Epub 2020 Jun 24
Summary: This editorial expresses concerns about the emergency-use authorization of remdesivir for COVID: a lack of robust monitoring of drug safety and effectiveness and pricing issues.
The alleviation of suffering during the COVID-19 pandemic. [Editorial]
Rosa WE, Ferrell BR, Applebaum AJ (Psychiatry Service).
Palliat Support Care. 2020 Aug;18(4):376-378. doi: 10.1017/S1478951520000462. Epub 2020 Jun 23
Summary: This editorial article delineates the types of mental suffering brought on by COVID and discusses how palliative care practices can inform responses to these challenges.
Bereavement care in the wake of COVID-19: Offering condolences and referrals. [Editorial]
Lichtenthal WG (Psychiatry Service), Roberts KE (SKI Psychiatry/Counseling), Prigerson HG.
Ann Intern Med. 2020 Nov 17;173(10):833-835. doi: 10.7326/M20-2526. Epub 2020 Jun 23.
Summary: In the challenging time of COVID-19, the article gives physicians direction to assess the need for a mental health provider referral for bereaved family members. The authors also offer guidance to communicate condolences.
Peptide receptor Radionuclide Therapy (PRRT) during the COVID-19 pandemic: Are there any concerns? [Editorial]
Bodei L (Radiology), Bergsland EK, de Herder WK, Ferone D, Hicks RJ, Hope TA, Kunikowska JA, Pavel M, Reidy-Lagunes DL (Medicine), Siveke J, Strosberg JR, Dittmer U, Herrmann K.
J Nucl Med. 2020 Aug;61(8):1094-1095. doi: 10.2967/jnumed.120.249136. Epub 2020 Jun 23
Summary: The authors discuss the risk factors for COVID-19 severity with regard to peptide receptor radionuclide therapy (PRRT), providing suggestions for monitoring the association of PRRT and COVID-19, as well as, clinical recommendations.
Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: Results from a nationwide online survey. [Article]
Paffenholz P, Peine A, Hellmich M, Paffenholz SV (GSK Graduate Student), Martin L, Luedde M, Haverkamp M, Roderburg C, Marx G, Heidenreich A, Trautwein C, Luedde T, Loosen SH.
Emerg Microbes Infect. 2020 Dec;9(1):1590-1599. doi: 10.1080/22221751.2020.1785951. Epub 2020 Jun 23.
Summary: This article reports the results of an online survey addressed to medical professionals in Germany to measure the COVID-19 pandemic impact. The results outline differences between subgroups, such as ambulatory centers versus university hospitals.
Validation of a digital pathology system including remote review during the COVID-19 pandemic. [Article]
Hanna MG (Pathology), Reuter VE (Pathology), Ardon O (Pathology), Kim D, Sirintrapun SJ (Pathology), Schüffler PJ (Collaborative Research Centers), Busam KJ (Pathology), Sauter JL (Pathology), Brogi E (Pathology), Tan LK (Pathology), Xu B (Pathology), Bale T (Pathology), Agaram NP (Pathology), Tang LH (Pathology), Ellenson LH (Pathology), Philip J (Health Informatics), Corsale L (Pathology), Stamelos E (Pathology), Friedlander MA (Regulatory Affairs), Ntiamoah P (Pathology), Labasin M (Pathology), England C (Hospital Administration), Klimstra DS (Pathology), Hameed M (Pathology).
Mod Pathol. 2020 Nov;33(11):2115-2127. doi: 10.1038/s41379-020-0601-5. Epub 2020 Jun 22.
Summary: This randomized, prospective study is the first validation of a digital pathology system from a remote non-CLIA (Clinical Laboratory Improvement Amendments) certified facility. Researchers found a major concordance rate of 100% comparing remote review and reporting of whole slide images to conventional microscopy.
A metastatic tumor is no different to a viral pandemic: Lessons learnt from COVID-19 may teach us to change the PRRT paradigm. [Editorial]
Paganelli G, Bodei L (Radiology), Modlin I.
Eur J Nucl Med Mol Imaging. 2020 Sep;47(10):2223-2226. doi: 10.1007/s00259-020-04904-w. Epub 2020 Jun 20.
Summary: This Editorial article is an emotional appeal to the Oncologist, Radiologist and Endocrinologist communities to compare the process of Peptide Receptor RadioTherapy (PRRT) acceptance and implementation with the deficiencies of COVID-19 pandemic response and to make PRRT implementation process efficient based on lessons learned from the COVID-19 pandemic.
A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids. [Short Article]
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW (Developmental Biology), Harschnitz O (Developmental Biology), Redmond D, Houghton S, Liu C, Naji A, Ciceri G (Developmental Biology), Guttikonda S (Graduate Studies), Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L (Developmental Biology), Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S.
Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. doi: 10.1016/j.stem.2020.06.015. Epub 2020 Jun 19.
Summary: The article presents a platform of cell and organoid derivatives from human pluripotent stem cells (hPSCs) to study tissue tropism. The authors underline that models are needed to understand how human cells respond to SARS-CoV-2 infection.
Implications for design and analyses of oncology clinical trials during the COVID-19 pandemic. [Viewpoint]
Moskowitz CS (Biostat/Epidemiology), Panageas KS (Biostat/Epidemiology).
JAMA Oncol. 2020 Sep;6(9):1326-1327. doi: 10.1001/jamaoncol.2020.2370 Epub 2020 Jun 18.
Summary: In this viewpoint, the authors discuss best practices for clinical trials reporting and design. They also advise adapting designs when developing a new clinical trial.
Rapid clearing of aerosol in an intubation box by vacuum filtration. [Correspondence]
Hellman S (Medical Physics), Chen GH (Anesthesiology), Irie T (Anesthesiology).
Br J Anaesth. 2020 Sep;125(3):e296-e299. doi: 10.1016/j.bja.2020.06.017. Epub 2020 Jun 18.
Summary: This letter to the editor describes a tool developed by the authors to filter droplets and aerosols during aerosol-generating procedures.
Responding to the Challenges of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Perspectives from the Association for Molecular Pathology Infectious Disease Subdivision Leadership. [Perspective]
Nolte FS, Babady NE (Laboratory Medicine), Buchan BW, Capraro GA, Graf EH, Leber AL, McElvania E, Yao JDC.
J Mol Diagn. 2020 Aug;22(8):968-974. doi: 10.1016/j.jmoldx.2020.06.003. Epub 2020 Jun 18.
Summary: In the era of pandemics, including Covid-19, laboratories are crucial as laboratory results make a foundation for subsequent care. Yet laboratories are facing many challenges in such times including regulatory, logistical, and supply-chain challenges. This article outlines the ways clinical laboratories addressed these challenges and offers recommendations for conducting laboratory work during the current pandemic.
Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: Recommendations from a panel of international experts. [Viewpoint]
Zeidan AM, Boddu PC, Patnaik MM, Bewersdorf JP, Stahl M (Graduate Fellow), Rampal RK (Medicine), Shallis R, Steensma DP, Savona MR, Sekeres MA, Roboz GJ, DeAngelo DJ, Schuh AC, Padron E, Zeidner JF, Walter RB, Onida F, Fathi A, DeZern A, Hobbs G, Stein EM (Medicine), Vyas P, Wei AH, Bowen DT, Montesinos P, Griffiths EA, Verma AK, Keyzner A, Bar-Natan M, Navada SC, Kremyanskaya M, Goldberg AD (Medicine), Al-Kali A, Heaney ML, Nazha A, Salman H, Luger S, Pratz KW, Konig H, Komrokji R, Deininger M, Cirici BX, Bhatt VR, Silverman LR, Erba HP, Fenaux P, Platzbecker U, Santini V, Wang ES, Tallman MS (Medicine), Stone RM, Mascarenhas J.
Lancet Haematol. 2020 Aug;7(8):e601-e612. doi: 10.1016/S2352-3026(20)30205-2. Epub 2020 Jun 18.
Summary: This article presents recommendations from a group of international experts from major cancer institutions and academic medical centers in the U.S.A., Europe, and Australia on different aspects of managing patients with hematological cancers adjusted for specific circumstances of the Covid-19 pandemic.
Innovation in cancer care delivery in the era of COVID-19. [Editorial]
Mullangi S, Schleicher SM, Aviki EM (Surgery).
JCO Oncol Pract. 2020 Nov; 16(11):718-719. doi: 10.1200/OP.20.00336. Epub 2020 Jun 17.
Summary: Cancer centers had to adapt their care delivery models because of COVID-19. The authors describe three changes that they hope will stay: Eliminate Low-Value Care, Offer Patient-Centered Substitutes, and Justify Start-Up Costs for Technology Adoption.
Coronavirus Disease 2019 as an opportunity to move toward transdisciplinary palliative care. [Letter]
Rosa WE, Anderson E, Applebaum AJ (Psychiatry Service), Ferrell BR, Kestenbaum A, Nelson JE (Medicine).
J Palliat Med. 2020 Oct;23(10):1290-1291. doi: 10.1089/jpm.2020.0306. Epub 2020 Jun 16.
Summary: This letter to the editor discusses how Covid-19 gives an opportunity to push all healthcare workers to support palliative care and deliver palliative care in a unified framework.
COVID-19 in patients with lung cancer. [Article]
Luo J (GME Medicine), Rizvi H (Collaborative Research Centers), Preeshagul IR (Medicine), Egger JV (Collaborative Research Centers), Hoyos D (Biostat/Epidemiology), Bandlamudi C (Collaborative Research Centers), McCarthy CG (Collaborative Research Centers), Falcon CJ (Collaborative Research Centers), Schoenfeld AJ (Medicine), Arbour KC (Medicine), Chaft JE (Medicine), Daly RM (Medicine), Drilon A (Medicine), Eng J (Medicine), Iqbal A (Medicine), Lai WV (Medicine), Li BT (Medicine), Lito P (Medicine), Namakydoust A (Medicine), Ng K (Medicine), Offin M (Medicine), Paik PK (Medicine), Riely GJ (Medicine), Rudin CM (Medicine), Yu HA (Medicine), Zauderer MG (Medicine), Donoghue MTA, Luksza M, Greenbaum BD (Biostat/Epidemiology), Kris MG (Medicine), Hellmann MD (Medicine).
Ann Oncol. 2020 Oct;31(10):1386-1396. doi:10.1016/j.annonc.2020.06.007. Epub 2020 Jun 17.
Summary: While the current pandemic demonstrated an increased severity of Covid-19 infection course in lung cancer patients, the study reported in this article established that this severity is a result of patient characteristics and behaviors that were the risk factors for lung cancer (e.g., smoking status and chronic obstructive pulmonary disease) rather than cancer itself.
Immune-checkpoint inhibitors for cancer therapy in the COVID-19 era. [Perspective]
Maio M, Hamid O, Larkin J, Covre A, Altomonte M, Calabrò L, Vardhana SA (Medicine), Robert C, Ibrahim R, Anichini A, Wolchok JD (Human Oncology & Pathogenesis Program), Di Giacomo AM.
Clin Cancer Res. 2020 Aug 15;26(16):4201-4205. doi: 10.1158/1078-0432.CCR-20-1657.2020. Epub 2020 Jun 15.
Summary: The authors recommend continuing with immune checkpoint inhibitor immunotherapy during the pandemic and adhering to strict COVID screening practices for these patients.
COVID-19 infections and outcomes in patients with multiple myeloma in New York City: A cohort study from five academic centers. [Article]
Hultcrantz M (Medicine), Richter J, Rosenbaum C, Patel D (Medicine), Smith E (Medicine), Korde N (Medicine), Lu S (Medicine), Mailankody S (Medicine), Shah U (Medicine), Lesokhin A (Medicine), Hassoun H (Medicine), Tan C (Medicine), Maura F (Medicine), Derkacs A (Biostat/Epidemiology), Diamond B (Medicine), Rossi A, Pearse RN, Madduri D, Chari A, Kaminetsky D, Braunstein M, Gordillo C, Davies F, Jagannath S, Niesvizky R, Lentzsch S, Morgan G, Landgren O (Medicine).
medRxiv. 2020 Jun 11. doi: 10.1016/j.jgo.2020.04.010.
Summary: Researchers studied a cohort of patients with multiple myeloma and related diseases at five large New York City institutions. Risk factors for more severe COVID symptoms tracked with those documented in the general population. The authors make recommendations for cancer treatment and COVID risk reduction during the pandemic.
Management of patients with acute leukemia during the COVID-19 outbreak: practical guidelines from the acute leukemia working party of the European Society for Blood and Marrow Transplantation. [Perspective]
Brissot E, Labopin M, Baron F, Bazarbachi A4, Bug G, Ciceri F, Esteve J, Giebel S, Gilleece MH, Gorin NC, Lanza F, Peric Z, Ruggeri A, Sanz J, Savani BN, Schmid C, Shouval R (Graduate Fellow), Spyridonidis A, Versluis J, Nagler A, Mohty M.
Bone Marrow Transplant. 2021 Mar;56(3):532-535. doi: 10.1038/s41409-020-0970-x. Epub 2020 Jun 11.
Summary: These working group guidelines recommend in-hospital practices to reduce COVID infection among patients with leukemia, along with best practices for screening, treatment, and clinical trial participation.
The future of pathology: What can we learn from the COVID-19 pandemic? [Editorial]
Williams BJ, Fraggetta F, Hanna MG (Pathology), Huang R, Lennerz J, Salgado R, Sirintrapun SJ (Pathology), Pantanowitz L, Parwani A, Zarella M, Treanor DE.
J Pathol Inform. 2020 Jun 9;11:15. doi: 10.4103/jpi.jpi_29_20.
Summary: This editorial emphasizes the importance of Digital Pathology, and its advantages over classic laboratory techniques, highlighted by the COVID-19 pandemic.
Use of a portable computed tomography scanner for chest imaging of COVID-19 patients in the urgent care at a tertiary cancer center. [Technical Note]
Bates DDB (Radiology), Vintonyak A (Radiology), Mohabir R (Radiology), Mahmood U (Medical Physics), Soto P (Radiology), Groeger JS (Medicine), Ginsberg MS (Radiology), Gollub MJ (Radiology).
Emerg Radiol.2020 Dec;27(6):597-600. doi: 10.1007/s10140-020-01801-5. Epub 2020 Jun 9
Summary: This article describes how MSK's urgent care used a portable CT scanner to get chest images of patients for evaluation of Covid-19.
Preserve junior faculty in biomedical sciences during and after the pandemic. [Editorial]
Avasthi P, Neill US (General & Administration), Pollack Porter KM, Weeraratna AT.
Nat Med. 2020 Jul;26(7):1003-1004. doi: 10.1038/s41591-020-0943-z. Epub 2020 Jun 8.
Summary: Challenges to research scientists are great during the pandemic, and even greater for those trying to get their foot in the door as junior researchers. This commentary urges funders to extend grant times and institutions to accommodate and evaluate researchers with pandemic-related challenges at the forefront of the review.
When to operate, hesitate and reintegrate: Society of Gynecologic Oncology surgical considerations during the COVID-19 pandemic. [White Paper]
Fader AN, Huh WK, Kesterson J, Pothuri B, Wethington S, Wright JD, Bakkum-Gamez JN, Soliman PT, Sinno AK, Leitao M (Surgery), Martino MA, Karam A, Rossi E, Brown J, Blank S, Burke W, Goff B, Yamada SD, Uppal S, Dowdy SC.
Gynecol Oncol. 2020 Aug;158(2):236-243. doi: 10.1016/j.ygyno.2020.06.001. Epub 2020 Jun 6.
Summary: Society of Gynecologic Oncology recommendations for when to operate and when to delay gynecologic cancer surgery during the COVID pandemic.
COVID-19 impact on early career investigators: a call for action. [Commentary]
Levine RL (Human Oncology & Pathogenesis Program), Rathmell WK.
Nat Rev Cancer. 2020 Jul;20(7):357-358.2020. doi: 10.1038/s41568-020-0279-5. Epub 2020 Jun 5.
Summary: In this commentary, the authors discuss how the COVID-19 pandemic has impacted research, and they lay out initiatives to help early career researchers through a variety of innovations.
Recommendations to leverage the palliative nursing role during COVID-19 and future public health crises. [Article]
Rosa WE, Gray TF, Chow K (Ld-Advanced Practice Providers), Davidson PM, Dionne-Odom JN, Karanja V, Khanyola J, Kpoeh JDN, Lusaka J, Matula ST, Mazanec P, Moreland PJ, Pandey S (Ld - Advanced Practice Providers), de Campos AP, Meghani SH.
J Hosp Palliat Nurs. 2020 Aug;22(4):260-269. doi: 10.1097/NJH.0000000000000665. Epub 2020 Jun 5.
Summary: This article provides recommendations for palliative care nurses and other healthcare providers to ensure that their optimal value is realized and leveraged during Covid-19 and future public health crises.
Training oncologists in the time of COVID -19. [Commentary]
Shoushtari A (Medicine), Choudhury N (Graduate Fellow).
Oncologist. 2020 Jul;25(7):546-547. doi: 10.1634/theoncologist.2020-0373. Epub 2020 Jun 2.
Summary: This commentary emphasizes the importance of prioritizing the training of the next generation of oncologists even during the COVID-19 pandemic.
Life and death in the age of COVID-19. [Editorial]
Breitbart WS (Psychiatry Service).
Palliative & Supportive Care. 2020 June;18(3):252-253. doi: 10.1017/S1478951520000334.
Summary: In this editorial, Dr. William Breitbart, Chair of the Department of Psychiatry and Behavioral Sciences at MSKCC, reflects on life and death in this unprecedented time of COVID-19.
Management of primary skin cancer during a pandemic: Multidisciplinary recommendations. [Commentary]
Baumann BC, MacArthur KM, Brewer JD, Mendenhall WM, Barker CA (Radiation Oncology), Etzkorn JR, Jellinek NJ, Scott JF, Gay HA, Baumann JC, Manian FA, Devlin PM, Michalski JM, Lee NY, Thorstad WL1 Wilson LD, Perez CA, Miller CJ.
Cancer. 2020 Sep 1;126(17):3900-3906. doi: 10.1002/cncr.32969. Epub 2020 Jun 1.
Summary: This commentary describes recommendations for weighing pros and cons of early or delayed interventions for localized skin cancers. For most patients at higher risk of serious Covid-related illness or death, the risk of Covid generally outweighs the benefits of early skin cancer treatment.
Overcoming the COVID-19 crisis and planning for the future. [Editorial]
LoGiudice SH (Strategy & Innovation), Liebhaber A (Strategy & Innovation), Schöder H (Radiology).
J Nucl Med. 2020 Aug;61(8):1096-1101. doi: 10.2967/jnumed.120.250522. Epub 2020 Jun 1
Summary: In this article, the authors address how healthcare organizations and health systems can approach some of the uncertainties that have arisen due to the COVID-19 pandemic and adjust their planning and strategy development accordingly.
Less can be more when targeting interleukin-6-mediated cytokine release syndrome in coronavirus disease 2019. [Commentary]
Betts BC, Young, JW (Medicine).
Critical Care Explorations 2020 Jun; 2(6);pe0138. doi: 10.1097/CCE.0000000000000138.
Summary: This commentary details evidence that selecting targeted Il-6 blockades are more effective than broad nonselective blockades at combating cytokine release syndrome. Cytokine release syndrome is a major trigger of Covid-19 mortality.
Standardized adult-gerontology acute care nurse practitioner point-of-care ultrasound training: A new perspective in the age of a pandemic. [Commentary]
Chen LL (Ld-Advanced Practice Providers).
J Am Assoc Nurse Pract. 2020 Jun;32(6):416-418. doi: 10.1097/JXX.0000000000000448.
Summary: This perspective article describes training on point-of-care ultrasounds, as they provide a key role in managing critically ill patients in isolation due to Covid-19.
Scoring system to triage patients for spine surgery in the setting of limited resources: Application to the COVID-19 pandemic and beyond. [Article]
Sciubba DM, Ehresman J, Pennington Z, Lubelski D, Feghali J, Bydon A, Chou D, Elder BD, Elsamadicy AA, Goodwin CR, Goodwin ML, Harrop J, Klineberg E, Laufer I (Neurosurgery), Lo SL, Neuman BJ, Passias PG, Protopsaltis T, Shin JH, Theodore N, Witham TF, Benzel EC.
World Neurosurg. 2020 Aug; 140: e373-e380. doi: 10.1016/j.wneu.2020.05.233. Epub 2020 May 29.
Summary: The authors describe a quantitative urgency scoring system that was generated to guide the triage and prioritizing of spine surgery cases in resource-limited settings, both during the COVID pandemic and post-COVID period.
Management of cardiovascular disease during coronavirus disease (COVID-19) pandemic. [Article]
Ganatra S, Dani SS, Shah S, Asnani A, Neilan TG, Lenihan D, Ky B, Barac A, Hayek SS, Leja M, Herrmann J, Thavendiranathan P, Fradley M, Bang V, Shreyder K, Parikh R, Patel R, Singh A, Brar S, Guha A, Gupta D (Medicine), Mascari P, Patten R, Venesy D, Nohria A, Resnic FS.
Trends Cardiovasc Med. 2020 Aug; 30(6): 315-325. doi: 10.1016/j.tcm.2020.05.004. Epub 2020 May 28.
Summary: From a review of the published literature, the authors provide a list of recommendations for the management of patients with cardiovascular disease in the time of COVID-19.
Treating the SARS-CoV-2-positive patient with cancer: A proposal for a pragmatic and transparent ethical process. [Commentary]
Perni S, Milligan MG, Saraf A, Vivenzio T, Marques A, Baker MA, Kosak T, Bartlett S, Physic MA, Batchelder MR, McBride S (Radiation Oncology), Bredfeldt J, Cail DW, Kearney MC, Whitehouse C, Orio P, Walsh G, Haas-Kogan DA, Martin NE.
Cancer. 2020 Sep 1;126(17):3896-3899. doi: 10.1002/cncr.32962. Epub 2020 May 28.
Summary: In this commentary, the authors describe the creation and implementation of a multidisciplinary treatment prioritization committee and its ethical and transparent decision-making processes that could be applicable to other oncologic settings.
Weight-based dosing of pembrolizumab every 6 weeks in the time of COVID-19. [Viewpoint]
Goldstein DA, Ratain MJ, Saltz LB. (Medicine).
JAMA Oncol. 2020 Nov;6(11):1694-1695. doi: 10.1001/jamaoncol.2020.2493. Epub 2020 May 27.
Summary: In this viewpoint, the authors present a solution to adjust pembrolizumab dosing regimen to decrease patients' financial burden. This new dosage would also reduce their risk of exposure to COVID-19.
Tocilizumab not associated with increased infection risk after CAR T - Implications for COVID-19? [Letter]
Frigault MJ, Nikiforow S, Mansour M, Hu ZH, Horowitz MM, Riches M, Hematti P, Turtle CJ, Zhang MJ, Perales MA (Medicine), Pasquini MC.
Blood. 2020 Jul 2;136(1):137-139. doi: 10.1182/blood.2020006216. Epub 2020 May 26.
Summary: In this letter, the authors report their findings on the risk of infections following tocilizumab use for chimeric antigen receptor T-cell (CAR-T)-mediated cytokine release syndrome (CRS).
Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung. [Preprint]
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Koval M, Guttentag SH, Blackwell TS, Vanderbilt COVID-19 Consortium Cohort, Webber SA, Banovich NE, Kropski JA, Sucre JMS, HCA Lung Biological Network.
bioRxiv. 2020 May 22. doi: https://doi.org/10.1101/2020.05.22.111187.
Summary: This preprint (which has not yet been confirmed by peer-review) reports on a mouse research study that looked at how viral entry-factors are regulated differently at different stages of lung development which may explain the biology behind why children appear to be less susceptible to SARS-CoV-2.
COVID-19 in New York City pediatric hematology and oncology patients. [Preprint]
Gartrell-Corrado RD, Gampel B, Troullioud Lucas AG (Pediatrics), Broglie L, Lee MT, Levine J, Orjuela-Grimm M, Satwani P, Glade-Bender J (Pediatrics), Roberts SS (Pediatrics).
Lancet. 2020 May 22. doi: 10.2139/ssrn.3582825.
Summary: This paper reports on the effect of COVID-19 disease on pediatric hematology, oncology and hematopoietic stem cell transplant (HCT) patients. The study included 19 out of 174 patients that tested positive for COVID-19, the majority of which were found to have mild disease that did not not require inpatient care.
ILROG emergency guidelines for radiation therapy of hematological malignancies during the COVID-19 pandemic. [Guidelines]
Yahalom J (Radiation Oncology), Dabaja BS, Ricardi U, Ng A, Mikhaeel NG, Vogelius IR, Illidge TM, Qi S, Wirth A, Specht L.
Blood. 2020 May 21;135(21):1829-1832. doi: 10.1182/blood.2020006028.
Summary: The International Lymphoma Radiation Oncology Group (ILROG) is a recognized international organization of radiation oncologists which produces guidelines for radiation therapy in blood cancers. In this article ILROG presents guidelines for radiation therapy practice adjusted to the complexities caused by the COVID-19 pandemic.
Plans to reactivate gastroenterology practices following the COVID-19 pandemic: A survey of North American Centers. [Article]
Kushnir VM, Berzin TM, Elmunzer BJ, Mendelsohn RB (Medicine), Patel V, Pawa S, Smith ZL, Keswani RN; North American Alliance for the Study of Digestive Manefestations of COVID-19.
Clin Gastroenterol Hepatol. 2020 Sep;18(10):2287-2294.e1. doi: 10.1016/j.cgh.2020.05.030. Epub 2020 May 21.
Summary: In this study, 123 gastroenterology practices located in North America answered to a survey designed by the authors to identify reactivation barriers and strategies during the COVID-19 pandemic.
AHPBA Webinar about Covid-19: Lessons learned responding to a pandemic. [Commentary]
Cleary S, D'Angelica M (Surgery), Demartines N, Doyle MB, Kent T, Pawlik TM.
HPB (Oxford). 2020 Aug;22(8):1135-1138. doi: 10.1016/j.hpb.2020.04.019. Epub 2020 May 20.
Summary: This commentary provides a summary of an international webinar help by the leadership of the Americas Hepato-Pancreato-Biliary Association (AHPBA) on lessons learned during the COVID-19 pandemic. A link to the full webinar is available in the commentary.
Laboratory-proven asymptomatic SARS-CoV-2 (COVID-19) infection on 18F-FDG PET/CT. [Image]
Krebs S (Radiology), Petkovska I (Radiology), Ho AL (Medicine), Ulaner GA (Radiology).
Clin Nucl Med. 2020 Aug;45(8):654-655. doi: 10.1097/RLU.0000000000003141. Epub 2020 May 19.
Summary: This case report describes a cancer patient in an outpatient setting whose COVID-19 infection diagnosis was made during a cancer imaging procedure which involved imaging of the lungs, along with other body regions. This accidental finding of COVID-19-related pneumonia in a cancer patient without Covid-19 symptoms stresses the necessity to test outpatient cancer patients, even those not displaying COVID symptoms, for the presence of coronavirus during COVID-19 pandemics.
North American Neuroendocrine Tumor Society guide for neuroendocrine tumor patient health care providers during COVID-19. [Editorial]
Bergsland EK, Halperin DM, Dillon JS, Dasari NA, Kunz PL, Soares HP, Pryma D, Bodei L (Radiology), Hope T, Soulen MC, Mailman J, Howe JR.
Pancreas. 2020 Jul; 49(6): 723-728. doi: 10.1097/MPA.0000000000001561. Epub 2020 May 19.
Summary: This editorial article presents suggestions from the North American Neuroendocrine Tumor Society (NANETS) on adjustments to the care of patients with neuroendocrine cancers in the time of the COVID-19 pandemic aimed at decreasing risk of infection transmission to patients and health care professionals.
Promoting health equity in the era of COVID-19. [Clinical Practice Statement]
Farley JH, Hines J, Lee NK, Brooks SE, Nair N, Brown CL (Surgery), Doll KM, Sullivan EJ, Chapman-Davis E.
Gynecol Oncol.2020 Jul;158(1):25-31. doi: 10.1016/j.ygyno.2020.05.023. Epub 2020 May 19
Summary: This article is a Clinical Practice Statement by the Society of Gynecologic Oncology (SGO) aimed at striving for greater socioeconomic equality in providing care for patients in the time of the COVID-19 pandemic. The article describes psychological factors of inequality, such as biases, and describes what constitutes socioeconomic disparities in healthcare including those related to income and race, and how they were exacerbated by the COVID-19 pandemic. The challenges and solutions related to cancer care, and gynecologic oncology in particular, are described.
Granulocyte-colony stimulating factor in COVID-19: Is it stimulating more than just the bone marrow? [Correspondence]
Nawar T (Graduate Fellow), Morjaria S (Medicine), Kaltsas A (Medicine), Patel D (Quality & Safety), Perez-Johnston R (Radiology), Daniyan AF (Medicine), Mailankody S (Medicine), Parameswaran R (Medicine).
Am J Hematol. 2020 Aug;95(8):E210-E213. doi: 10.1002/ajh.25870. Epub 2020 May 17.
Summary: In this Letter to the Editor, the authors express concerns related to administering a Granulocyte-colony stimulating factor (GCSF) which is routinely given to cancer patients for prevention of neutropenia, during the Covid-19 pandemic. The concerns arose from 3 cases of administering GCSF for neutropenia to cancer patients who also had COVID-19. In all probability, this was the first report describing the course of COVID-19 infection in selected cancer patients who received GCSF for neutropenic fever in the United States.
American Association for Thoracic Surgery: Maintaining the mission during the COVID-19 pandemic. [Article]
Moon MR, Jones DR (Surgery), Adams DH, Starnes VA.
J Thorac Cardiovasc Surg. 2020 Sep;160(3):737-739. doi: 10.1016/j.jtcvs.2020.05.022. Epub 2020 May 16
Summary: In the time of COVID-19 pandemic many scientific activities were disrupted. This affected the activities of scholarly and professional societies, American Association for Thoracic Surgery (AATS) being one of them. Thus, the Association's 100th Annual Meeting could not be held in a physical setting. However, recognizing the importance of professional exchange between surgeons from 70 countries which would contribute significantly to the advancements in the field, this important forum was modified to be held virtually. The article also briefly outlines the early history of AATS which corresponded to the time of great world catastrophes.
COVID-19 in children with cancer in New York City. [Research Letter]
Boulad F (Pediatrics), Kamboj M (Medicine), Bouvier N (SKI Pediatrics), Mauguen A (Biostat/Epidemiology), Kung AL (Pediatrics).
JAMA Oncol. 2020 Sep;6(9):1459-1460. doi: 10.1001/jamaoncol.2020.2028. Epub 2020 May 13.
Summary: In this study, 178 children with cancer showed similar rates of COVID infection and mortality as children in the general population.
Impact of PD-1 blockade on severity of COVID-19 in patients with lung cancers. [Research Brief]
Luo J (Graduate Fellow), Rizvi H (Collaborative Research Centers), Egger JV (Collaborative Research Centers), Preeshagul IR (Medicine), Wolchok JD (Human Oncology & Pathogenesis Program), Hellmann MD (Medicine).
Cancer Discov. Cancer Discov. 2020 Aug;10(8):1121-1128. doi: 10.1158/2159-8290.Cd-20-0596. Epub 2020 May 12.
Summary: The authors found that a small sample of lung cancer patients who had previously received PD-1 blockade immune therapy did not experience statistically significant increased COVID symptom severity, but smoking history did make an impact.
Clinical and radiographic presentations of COVID-19 among patients receiving radiation therapy for thoracic malignancies. [Teaching Case]
Samson P, Ning MS, Shaverdian N (Radiation Oncology), Shepherd AF (Radiation Oncology), Gomez DR (Radiation Oncology), McGinnis GJ, Nitsch PL, Chmura S, O'Reilly MS, Lee P, Chang JY, Robinson C, Lin SH.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):700-704. doi: 10.1016/j.adro.2020.04.020. Epub 2020 May 11.
Summary: A case series of how COVID-19 presented in three lung cancer patients receiving radiation therapy.
Advanced head and neck surgery training during the COVID-19 pandemic. [Article]
Givi B, Moore MG, Bewley AF, Coffey CS, Cohen MA (Surgery), Hessel AC, Jalisi S, Kang S, Newman JG, Puscas L, Shindo M, Shuman A, Thakkar P, Weed DT, Chalian A.
Head Neck. 2020 Jul;42(7):1411-1417. doi: 10.1002/hed.26252. Epub 2020 May 8.
Summary: In this study, authors surveyed head and neck fellows and accredited program directors to assess the impact of COVID-19 on head and neck surgical training. They conclude that "current trainees appear well-positioned to achieve expertise before entering practice."
Cancer and coronavirus disease 2019 (COVID-19)-Facing the "C Words." [Opinion]
Shah UA (Medicine).
JAMA Oncol. 2020 Sep 1;6(9):1330-1331. doi: 10.1001/jamaoncol.2020.1848. Epub 2020 May 7.
Summary: In this opinion piece, an MSK oncologist and cancer survivor who was diagnosed with Hodgkin lymphoma during her fellowship training, reflects on being diagnosed with COVID-19.
Emerging trends in COVID-19 treatment: Learning from inflammatory conditions associated with cellular therapies. [Review Article]
Cancio M (Pediatrics), Ciccocioppo R, Rocco PRM, Levine BL, Bronte V, Bollard CM, Weiss D, Boelens JJ (Pediatrics), Hanley PJ.
Cytotherapy. 2020 Sep;22(9):474-481. doi: 10.1016/j.jcyt.2020.04.100. Epub 2020 May 7.
Summary: This article discusses the inflammatory conditions that arise both as a side effect of certain therapies used in oncology (such as cellular therapies and stem cell transplantation), and as a result of Covid-19 infection. The authors suggest that therapeutic approaches used in managing such complications may be applicable in management of Covid-19 patients.
The heterogeneous landscape and early evolution of pathogen-associated CpG and UpA dinucleotides in SARS-CoV-2. [Preprint]
di Gioacchino A, Ŝulc P, Komarova AV, Greenbaum BD (Biostat/Epidemiology), Monasson R, Cocco S.
bioRxiv. 2020 May 06. doi: https://doi.org/10.1101/2020.05.06.074039
Summary: This preprint looks at the genetics of the virus that causes COVID-19, specifically at the rate and drivers of its mutation.
Need for caution in the diagnosis of radiation pneumonitis in the COVID-19 pandemic. [Research Letter]
Shaverdian N (Radiation Oncology), Shepherd AF (Radiation Oncology), Rimner A (Radiation Oncology), Wu AJ (Radiation Oncology), Simone CB (Radiation Oncology), Gelblum DY (Radiation Oncology), Gomez DR (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):617-620. doi: 10.1016/j.adro.2020.04.015. Epub 2020 May 5.
Summary: This research letter reports on four patients presenting radiation pneumonitis' symptoms during the time of COVID-19. The authors recommend COVID-19 testing before starting high-dose corticosteroids.
Determinants of severity in cancer patients with COVID-19 illness. [Preprint]
Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Mead PA (Medicine), Rolling T (SKI Medicine), Perez-Johnston R (Radiology), Bernardes M (Graduate Fellow), Bogler Y (Graduate Fellow), Caldararo M (Graduate Fellow), Figueroa CJ (Medicine), Glickman MS (Immunology), Joanow A (Ld - Advanced Practice Providers), Kaltsas A (Medicine), Lee YJ (Medicine), Lucca A (Emp Health & Wellness), Joanow A (Ld - Advanced Practice Providers), Mariano AR (Ld - Advanced Practice Providers), Morjaria S (Medicine), Nawar T (Graduate Fellow), Papanicolaou GA (Medicine), Predmore J (Ld - Advanced Practice Providers), Redelman-Sidi G (Medicine), Schmidt E (Ld - Advanced Practice Providers), Seo SK (Medicine), Sepkowitz K (Physician in Chief), Shah MK (Medicine), Wolchok JD (Human Oncology & Pathogenesis Pgm), Hohl TM (Medicine), Taur Y (Medicine), Kamboj M (Medicine).
medRxiv. 2020 May 04. doi: https://doi.org/10.1101/2020.05.04.20086322.
Summary: This preprint studies outcomes in 423 patients with cancer hospitalized for COVID-related symptoms. It found age (over 65) and immune checkpoint inhibitor therapy to be risk factors for disease severity and hospitalization.
Effectivity of a programme for the control & prevention of COVID-19 healthcare-associated infections in a Spanish academic hospital. [Preprint]
Gras-Valentí P, Mora-Muriel JG, Chico-Sánchez P, Algado-Sellés N, Soler-Molina VM, Hernández-Maldonado M, Sánchez-Vela P (Human Oncology & Pathogenesis Program), et al.
Bull World Health Organ. 4 May 2020. doi: http://dx.doi.org/10.2471/BLT.20.263384.
Summary: This study of healthcare worker exposure to COVID recommends the continuous wearing of surgical masks in both patient and staff areas of the hospital.
Leveraging technology for remote learning in the era of COVID-19 and social distancing: Tips and resources for pathology educators and trainees. [Article]
Mukhopadhyay S, Booth AL, Calkins SM, Doxtader EE, Fine SW (Pathology), Gardner JM, Gonzalez RS, Mirza KM, Jiang XS.
Arch Pathol Lab Med. 2020 Sep 1;144(9):1027-1036. doi: 10.5858/arpa.2020-0201-ED. Epub 2020 May 4.
Summary: This article is a guide for pathologists and pathologists-in-training. It provides a curated list of online resources for virtual learning, specifically in pathology, with a focus on anatomic pathology.
Nuclear medicine operations in the times of COVID 19: Strategies, precautions and experiences. [Commentary]
Czernin J, Fanti S, Meyer PT, Allen-Auerbach M, Hacker M, Sathekge M, Hicks R, Scott AM, Hatazawa J, Yun M, Schöder H (Radiology), Bartenstein P, Herrmann K.
J Nucl Med. 2020 May 01;61(5):626-629. doi: 10.2967/jnumed.120.245738.
Summary: In this editorial, 11 teams from hospitals in Europe, Australia, Africa, and the United States share their experience as well as their strategies to contain the coronavirus from spreading.
Management of CLL patients early in the COVID-19 pandemic: An international survey of CLL experts. [Correspondence]
Koffman B, Mato A (Medicine), Byrd JC, Danilov A, Hedrick B, Ujjani C, Roeker L (Graduate Fellow), Stephens DM, Davids MS, Pagel JM, Shadman M.
Am J Hematol. 2020 Aug;95(8):E199-E203. doi: 10.1002/ajh.25851. Epub 2020 Apr 30.
Summary: This correspondence reports on the results of a survey of a cohort of chronic lymphocytic leukemia (CLL) experts who were asked "questions about experts' base-line information and their recommendations on isolation, testing and CLL management in patients with CLL and COVID-19".
The many faces of the anti-COVID immune response. [Perspective]
Vardhana SA (Medicine), Wolchok JD (Human Oncology & Pathogenesis Program).
J Exp Med. 2020 Apr 30;217(6). doi: 10.1084/jem.20200678.
Summary: In this article, the authors "explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity."
Modifying practices in GI oncology in the face of COVID-19: Recommendations from expert oncologists on minimizing patient risk. [Article]
Lou E, Beg S, Bergsland E, Eng C, Khorana A, Kopetz , Lubner S, Saltz L (Medicine), Shankara V, Zafar SY.
JCO Oncol Pract.2020 Jul;16(7):383-388. doi: 10.1200/OP.20.00239. Epub 2020 Apr 30
Summary: A group of expert oncologists in the field of GI oncology summarize recommendations for adapting/changing practices in response to the COVID-19 pandemic, and carefully consider the costs versus benefits to patients when modifying treatment and practice.
BTK inhibitors in cancer patients with COVID19: "The winner will be the one who controls that chaos" (Napoleon Bonaparte). [Perspective]
Chong EA, Roeker L (Graduate Fellow), Shadman M, Davids MS, Schuster SJ, Mato A (Medicine).
Clin Cancer Res. 2020 Jul 15;26(14):3514-3516. doi: 10.1158/1078-0432.CCR-20-1427. Epub 2020 Apr 28.
Summary: The authors discuss the benefits and risks of continuing to treat with BTK inhibitors patients with chronic lymphocytic leukemia (CLL) and B-cell lymphomas who get infected with COVID-19. The pros and cons of BTKi discontinuation for patients are considered.
Could BCG be used to protect against COVID-19? [Comment]
Redelman-Sidi G (Medicine).
Nat Rev Urol. 2020 Jun 01. doi: 10.1038/s41585-020-0325-9. Epub 2020 Apr 27.
Summary: The author comments on clinical studies that are trying to determine whether BCG vaccination could protect humans against COVID-19 infection. Discussed are data from a non-peer-reviewed publication and the trials in progress, while important questions are considered about how this will impact bladder cancer patients who have been or will be treated with BCG.
Thyroid surgery during COVID-19 pandemic: Principles and philosophies. [Article]
Shaha AR (Surgery).
Head Neck. 2020 Jun;42(6):1322-1324. doi: 10.1002/hed.26198. Epub 2020 Apr 27.
Summary: A surgeon shares his clinical observations/philosophy of managing patients with thyroid cancer during the COVID-19 pandemic and describes some issues to be considered in the decision-making process when determining if patients require thyroid surgery urgently or not.
Analysis of complement deposition and viral RNA in placentas of COVID-19 patients. [Article]
Mulvey JJ (Graduate Fellow), Magro CM, Ma LX, Nuovo GJ, Baergen RN.
Ann Diagn Pathol. 2020 Jun;46:151530. doi: 10.1016/j.anndiagpath.2020.151530. Epub 2020 Apr 25.
Summary: This article reports on the placental pathology of five full-term babies that were delivered from COVID-19 infected patients without significant morbidity or mortality to the mothers or their newborns.
Impact of the COVID-19 pandemic on endoscopy practice: Results of a cross-sectional survey from the New York metropolitan area. [Letter to the Editor]
Mahadev S, Aroniadis OS, Barraza L, Agarunov E, Goodman AJ, Benias PC, Buscaglia JM, Gross SA4, Kasmin FE, Cohen JJ, Carr-Locke DL, Greenwald DA, Mendelsohn RB (Medicine), Sethi A, Gonda TA; NYSGE research committee.
Gastrointest Endosc. 2020 Sep;92(3):788-789. doi: 10.1016/j.gie.2020.04.047. Epub 2020 Apr 25.
Summary: Endoscopists from hospitals across the New York metropolitan area report on the results of a survey of 69 endoscopists, administered with the support of the New York Society of Gastroenterological Endoscopy, that collected "information regarding demographics, case volume, personal protective equipment (PPE) use, and endoscopist exposure to COVID-19."
Emergency changes in international guidelines on treatment for head and neck cancer patients during the COVID-19 pandemic. [Editorial]
Chaves ALF, Castro AF, Marta GN, Junior GC, Ferris RL, Giglio RE, Golusinski W, Gorphe P, Hosal S, Leemans CR, Magné N, Mehanna H, Mesía R, Netto E, Psyrri A, Sacco AG, Shah JP (Surgery), Simon C, Vermorken JB, Kowalski LP.
Oral Oncol. 2020 Aug;107:104734. doi: 10.1016/j.oraloncology.2020.104734. Epub 2020 Apr 24.
Summary: General guidelines/recommendations meant to assist multidisciplinary teams around the world make diagnosis and treatment decisions for HNSCC patients, while they take into consideration the constraints and epidemiological characteristics of their local situation.
The impact of COVID-19 on head and neck surgery, education, and training. [Article]
Shah JP (Surgery).
Head Neck. 2020 Jun;42(6):1344-1347. doi: 10.1002/hed.26188. Epub 2020 Apr 25.
Summary: In these trying times of COVID-19, renowned Head and Neck Surgeon, Dr. Jatin Shah, considers the question "how do we conduct our day-to-day activities, and plan to retain our robust education and training programs, to educate and train the next generation of head and neck surgeons?" and discusses "embracing technology and alternative means" to deal with these challenges.
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. [Brief Communication]
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL; HCA Lung Biological Network (Pe'er D (Computational and Systems Biology Program) in group).
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
Summary: An investigation of how the virus that causes COVID-19 binds to a person's cells, and how genetic expression in cells throughout the body impacts this process and disease transmission.
Current knowledge and research priorities in the digestive manifestations of COVID-19. [Article]
Aroniadis OC, DiMaio CJ, Dixon RE, Elmunzer BJ, Kolb JM, Mendelsohn RB (Medicine), Singal AG, Ordiah CO, Rockey DC, Spitzer RL, Tierney WM, Wani S, Yadav D.
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1682-1684. doi: 10.1016/j.cgh.2020.04.039. Epub 2020 Apr 22.
Summary: The authors review what is known about the gastrointestinal impact of COVID-19.
Management of locally advanced rectal cancer during the COVID-19 pandemic: A necessary paradigm change at Memorial Sloan Kettering Cancer Center. [Opinion]
Romesser PB (Radiation Oncology), Wu AJ (Radiation Oncology), Cercek A (Medicine), Smith JJ (Surgery), Weiser M (Surgery), Saltz L (Medicine), Garcia-Aguilar J (Surgery), Crane CH (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):687-689. doi: 10.1016/j.adro.2020.04.011. Epub 2020 Apr 22.
Summary: MSK practitioners detail how COVID-19 changed the standard of care for rectal cancer patients at the hospital.
Donning a new approach to the practice of gastroenterology: Perspectives from the COVID-19 pandemic epicenter. [Article]
Sethi A, Swaminath A, Latorre M, Behin DS, Jodorkovsky D, Calo D (Medicine), Aroniadis O, Mone A, Mendelsohn RB (Medicine), Sharaiha RZ, Gonda TA, Khanna LG, Bucobo JC, Nagula S, Ho S, Carr-Locke DL, Robbins DH; New York Society for Gastrointestinal Endoscopy (NYSGE).
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1673-1681. doi: 10.1016/j.cgh.2020.04.032. Epub 2020 Apr 21.
Summary: Gastroenterologists from New York City-area hospitals discuss how COVID-19 impacted their practice.
Perspectives from the Cancer and Aging Research Group: Caring for the vulnerable older patient with cancer and their caregivers during the COVID-19 crisis in the United States. [Article]
Mohile S, Dumontier C, Mian H, Loh KP, Williams GR, Wildes TM, Boyd K, Ramsdale E, Pyne S, Magnuson A, Tew W (Medicine), Klepin HD, Dale W, Shahrokni A (Medicine).
J Geriatr Oncol. 2020 Jun;10(6):779-782. doi: 10.1016/j.jgo.2020.04.010. Epub 2020 Apr 10.
Summary: Recommendations from the Cancer and Aging Research Group on how to safely treat older patients with cancer.
Thoracic radiation therapy during COVID-19: Provisional guidelines from a comprehensive cancer center within a pandemic epicenter. [Opinion]
Wu AJ (Radiation Oncology), Rimner A (Radiation Oncology), Shepherd AF (Radiation Oncology), Gelblum DY (Radiation Oncology), Shaverdian N (Radiation Oncology), Yorke E (Medical Physics), Simone CB (Radiation Oncology), Gomez DR (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):603-607 doi: 10.1016/j.adro.2020.04.008. Epub 2020 Apr 20.
Summary: The article presents MSK's provisional guidelines for providing radiation treatment to patients with lung and other thoracic cancers during the COVID-19 pandemic.
Tracheostomy during SARS-CoV -2 pandemic: Recommendations from the New York Head and Neck Society. [Article]
Miles BA, Schiff B, Ganly I (Surgery), Ow T, Cohen E, Genden E, Culliney B, Mehrotra B, Savona S, Wong RJ (Surgery), Haigentz M, Caruana S, Givi B, Patel K, Hu K.
Head Neck. 2020 Jun;42(6):1282-1290. doi: 10.1002/hed.26166. Epub 2020 Apr 17.
Summary: The New York Head and Neck Society provides guidance on performing tracheostomy procedures for patients with COVID-19.
Modified routine cardiac imaging surveillance of adult cancer patients and survivors during the COVID-19 pandemic. [Viewpoint]
Calvillo-Argüelles O., Abdel-Qadir H, Ky B, Liu JE (Medicine), Lopez-Mattei JC, Amir E, Thavendiranathan P.
JACC CardioOncol. 2020 Jun;2(2):345-349. doi: 10.1016/j.jaccao.2020.04.001. Epub 2020 Apr 16.
Summary: Guidance on when to provide cardiac surveillance imaging to cancer patients and cancer survivors taking anthracyclines and trastuzumab.
The case for masks - health care workers can benefit, too. [Article]
Kaltenboeck A (Biostat/Epidemiology), Rajkumar SV.
Mayo Clin Proc. 2020 Jun 01;95(6):1132-1134. doi: Epub 2020 Apr 15.
Summary: The authors recommend that everyone who works at or enters a healthcare organization wear a mask, regardless of patient contact.
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. [Article]
Magro C, Mulvey JJ (Graduate Fellow), Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J.
Transl Res. 2020 Jun;220:1-13. doi: 10.1016/j.trsl.2020.04.007. Epub 2020 Apr 15
Summary: The researchers compared the pathology of COVID-19 to the more familiar acute respiratory distress syndrome.
COVID-19 in the cancer patient. [Article]
Yeoh CB (Anesthesiology), Lee KJ, Rieth EF (Anesthesiology), Mapes R, Tchoudovskaia A (Anesthesiology), Fischer GW (Anesthesiology), Tollinche LE (Anesthesiology).
Anesthesia & Analgesia 2020 Jul;131(1):16-23. doi: 10.1213/ANE.0000000000004884. Epub 2020 Apr 15.
Summary: This review article looks at how COVID-19 impacts cancer patients and how to proceed with cancer surgeries in light of these considerations.
Pediatric endoscopy in the era of Coronavirus disease 2019: A North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper. [Position Paper]
Walsh CM, Fishman DS, Lerner DG; NASPGHAN Endoscopy and Procedures Committee (Queliza K (Pediatrics) in group).
J Pediatr Gastroenterol Nutr. 2020 Jun;70(6):741-750. doi: 10.1097/MPG.0000000000002750. Epub 2020 Apr 14.
Summary: The North American Society for Pediatric Gastroenterology, Hepatology & Nutrition offers guidance on how to safely offer endoscopy services to children during the pandemic.
Practice recommendations for risk-adapted head and neck cancer radiation therapy during the COVID-19 pandemic: an ASTRO-ESTRO consensus statement. [Article]
Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N (Radiation Oncology), Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS.
Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):618-627. doi: 10.1016/j.ijrobp.2020.04.016. Epub 2020 Apr 14.
Summary: Joint recommendations from the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) offer guidance on how to proceed with radiation procedures during the COVID-19 pandemic.
Cancer surgery and COVID19. [Editorial]
COVID19 Subcommittee of the O.R. Executive Committee at Memorial Sloan Kettering, Ardizzone L (Anesthesiology), Barber T (Surgery), Drebin J (Surgery), Fischer G (Anesthesiology), Jewell E (Surgery), Laudone V (Surgery), Levine M (Hospital Administration), Linder J (Hospital Administration), Simon B (Josie Robertson Surgery Center), Stromblad C (Strategy and Innovation), Tabar V (Neurosurgery), Weiser M (Surgery), Yee SJ (Nursing).
Ann Surg Oncol. 2020 Jun;27(6):1713-1716. doi: 10.1245/s10434-020-08462-1. Epub 2020 Apr 13.
Summary: This Editorial article describes cancer surgery practice at the time of the Covid-19 pandemic at the Memorial Sloan Kettering Cancer Center. It outlines the challenges faced and the solutions found. The insights from this leading cancer dedicated institution could be helpful for any institution which conducts surgeries in cancer patients.
Chimeric Antigen Receptor T cell therapy during the COVID-19 pandemic. [Article]
Bachanova V, Bishop MR, Dahi P (Medicine), Dholaria B, Grupp SA, Hayes-Lattin B, Janakiram M, Maziarz RT, McGuirk JP, Nastoupil LJ, Oluwole OO, Perales MA (Medicine), Porter DL, Riedell PA.
Biol Blood Marrow Transplant. 2020 Jul;26(7):1239-1246. doi: 10.1016/j.bbmt.2020.04.008. Epub 2020 Apr 14.
Summary: Chimeric antigen receptor (CAR) T-cell therapy is currently one of the most promising immune therapies for blood cancers. This article presents consensus recommendations from the CAR T-cell Consortium (a group formed by researchers from 8 U.S. academic institutions), on multiple aspects of using this treatment at the time of the Covid-19 pandemic. The recommendations for institutions which treat patients with CAR T-cell therapy are formatted as questions and answers.
TMPRSS2 and COVID-19: Serendipity or opportunity for intervention? [Article]
Stopsack KH (SKI Medicine), Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW (Medicine).
Cancer Discov. 2020 Jun;10(6):779-782. doi: 10.1158/2159-8290.CD-20-0451. Epub 2020 Apr 10
Summary: Covid-19 pandemic statistics have shown gender inequality in susceptibility to the coronavirus infection. It appears that men are more susceptible than women. This article discusses the role of a specific gene, involved both in viral infection and cancer processes, which could be a potential culprit in the increased male susceptibility to coronavirus and influenza infections and a potential target for treatments to fight this susceptibility.
Management of cancer surgery cases during the COVID-19 pandemic: Considerations. [Editorial]
Bartlett DL, Howe JR, Chang G, Crago A (Surgery), Hogg M, Karakousis G, Levine E, Maker A, Mamounas E, McGuire K, Merchant N, Shibata D, Sohn V, Solorzano C, Turaga K, White R, Yang A, Yoon S, Society of Surgical Oncology.
Ann Surg Oncol. 2020 Jun;27(6):1717-1720. doi: 10.1245/s10434-020-08461-2. Epub 2020 Apr 8.
Summary: This Editorial article presents the Society of Surgical Oncology's cumulation of expert recommendations on the optimal surgical practice changes in the time of the COVID-19 pandemic. The recommendations are given for surgical management of different types of cancer.
Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. [Article]
Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A (Radiation Oncology), Rodrigues GB, Schild SE, Senan S, Simone CB II (Radiation Oncology), Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D.
Radiother Oncol. 2020 May;146:223-229. doi: 10.1016/j.radonc.2020.04.001. Epub 2020 Apr 6.
Summary: A consensus statement of 32 experts in lung cancer recommend adhering to guidelines for recommended practice. For patients positive for Covid-19 it's recommended to postpone or interrupt radiation therapy. In a severe pandemic scenario, patients should be triaged based on a variety of factors.
Sustainable social distancing through facemask use and testing during the Covid-19 pandemic. [Preprint]
Chowell G, Chowell D (Human Oncology & Pathogenesis Program), Roosa K, Dhillon R, Srikrishna D.
medRxiv. 2020 April 6. doi:10.1101/2020.04.01.20049981
Summary: This preprint article describes a model in which the pandemic may be controlled through a combination of robust testing, treatment, self-isolation, along with social distancing measures and wearing face masks.
Breast radiotherapy therapy under COVID-19 pandemic resource constraints -- approaches to defer or shorten treatment from a Comprehensive Cancer Center in the United States. [Review]
Braunstein LZ (Radiation Oncology), Gillespie EF (Radiation Oncology), Hong L (Medical Physics), Xu A (Radiation Oncology), Bakhoum SF (Radiation Oncology), Cuaron J (Radiation Oncology), Mueller B (Radiation Oncology), Cahlon O (Radiation Oncology), Powell S (Radiation Oncology), Khan AJ (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug; 5(4): 582-588. doi: 10.1016/j.adro.2020.03.013. Epub 2020 Apr 1.
Summary: The MSKCC Breast radiation department advises omitting radiation therapy in favorable subgroups of breast cancer patients and accelerating or abbreviating regimens for others. Hypofractionated approaches are shown to be safe and effective.
Palliative radiation for oncologic emergencies in the setting of COVID-19: Approaches to balancing risks and benefits. [Opinion]
Yerramilli D (Radiation Oncology), Xu AJ (Radiation Oncology), Gillespie EF (Radiation Oncology), Shepherd AF (Radiation Oncology), Beal K (Radiation Oncology), Gomez D (Radiation Oncology), Yamada J (Research and Technology Management), Tsai J (Radiation Oncology), Yang J (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):589-594 doi: 10.1016/j.adro.2020.04.001. 2020 Jul-Aug;5(4):589-594. Epub 2020 Apr 1.
Summary: The authors state that abbreviated courses of palliative radiation during the Covid-19 pandemic can best maximize benefits to metastatic cancer patients and reduce risks of viral transmission.
Prostate cancer radiation therapy recommendations in response to COVID-19. [Article]
Zaorsky NG, Yu JB, McBride SM (Radiation Oncology), Dess RT, Jackson WC, Mahal BA, Chen R, Choudhury A, Henry A, Syndikus I, Mitin T, Tree A, Kishan AU, Spratt DE.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):659-665. doi: 10.1016/j.adro.2020.03.010 Epub 2020 Apr 1.
Summary: Recommendations from the National Comprehensive Cancer Network risk group for prostate cancer advise a reduction of resources for all stages of prostate cancer. Telemedicine, consultations, and return visits can be delayed one to six months until there are more resources and staff, and treatment can be delayed for low risk until safe, and for unfavorable or high risk neoadjuvant hormone therapy for four to six months.
Rationale for prolonged corticosteroid treatment in the acute respiratory distress syndrome caused by coronavirus disease 2019. [Commentary]
Villar J, Confalonieri M, Pastores, S (Anesthesiology), Meduri GU.
Crit Care Expl 2020 Apr 1; 2(4):e0111. doi: 10.1097/CCE.0000000000000111.
Summary: Recommendations for corticosteroids for Covid-19-associated acute respiratory distress syndrome. Based on the current lack of strong evidence, the authors advise that it is unethical to deny the administration of corticosteroids to Covid-19 ARDS patients experiencing severe cytokine storm.
COVID-19 pandemic related concerns of Latino cancer patients: Perspectives of mental health providers from US and Latin America. [Meeting Abstract]
Costas-Muniz R (Psychiatry Service), Montana F, Ruda-Santolaria L, Sanchez-Ramirez JC, Torres-Blasco N, Castro EM, Esenarro L, Galindo-Vazquez O, Breitbart WS (Psychiatry Service), Claros M (Psychiatry Service), Narang B (Psychiatry Service), Gany F (Psychiatry Service).
Ann Behav Med. 2020 Apr;55(Suppl. 1):S123. doi: 10.1093/abm/kaab020.
Summary: Results of an online survey of mental health providers offering services to Latino or Hispanic cancer patients in the United States, Latin America, and Spain, specifically their perspective of the concerns and needs of these patients during the COVID-19 pandemic.
Delivery of mental health services to Latino cancer patients during the COVID-19 pandemic in Latin America and United States. [Meeting Abstract]
Costas-Muniz R (Psychiatry Service), Galindo-Vazquez O, Montana F, Ruda-Santolaria L, Sanchez-Ramirez JC, Torres-Blasco N, Castro EM, Esenarro L, Claros M (Psychiatry Service), Narang B (Psychiatry Service), Breitbart WS (Psychiatry Service), Gany F (Psychiatry Service).
Ann Behav Med. 2020 Apr;55(Suppl. 1):S133. doi: 10.1093/abm/kaab020.
Summary: Results of an online survey of mental health providers offering services to Latino or Hispanic cancer patients in the United States, Latin America, and Spain, specifically their professional background, clinical productivity, and delivery of mental health services during the COVID-19 pandemic.
My risk and your risk: Perceived personal versus other risk as influences on actions to prevent Covid-19 infections. [Meeting Abstract]
Kiviniemi MT, Hay JL (Psychiatry Service), Waters EA, Orom HA.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S547. doi: 10.1093/abm/kaab020.
Summary: This abstract from the 2021 Annals of Behavioral Medicine meeting reports on a survey of 410 American adults on the perception of their own risk versus the risk to other people.
Risk perception research in the era of Covid-19: A multi-faceted investigation. [Meeting Abstract]
Waters EA, Peters E, Kiviniemi MT, Tuman M (SKI Psychiatry/Counseling), Hay JL (Psychiatry Service), Orom HA.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S547. doi: 10.1093/abm/kaab020.
Summary: This abstract from the 2021 Annals of Behavioral Medicine meeting introduces the symposium's risk perception research presenters and their topics.
The US failure to control the Covid-19 epidemic has a Whiteness problem. [Meeting Abstract]
Orom HA, Waters EA, Hay JL (Psychiatry Service), Tuman M (SKI Psychiatry/Counseling), Kiviniemi MT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S548. doi: 10.1093/abm/kaab020.
Summary: This conference abstract discusses the results of a survey on COVID-19 beliefs and prevention completed by a representative sample of the U.S. adults in June 2020. The respondents' breakdown by race, and the impact of different racial groups attitudes towards COVID-19 prevention on the course of the pandemic, is discussed.
Cultural influences on perceptions of risk for Covid-19. [Meeting Abstract]
Tuman M (SKI Psychiatry/Counseling), Hay JL (Psychiatry Service), Schofield E (Psychiatry Service), Orom HA, Waters EA, Kiviniemi MT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S548. doi: 10.1093/abm/kaab020.
Summary: This conference abstract reports on the results of a survey on COVID-19 risk perception completed by a sample of U.S. adults in June 2021. The research was aimed at establishing whether any correlation existed between beliefs prioritizing hierarchical social order, and individualism (beliefs prioritizing autonomy) and perception of infectious disease risks.
Coping in the era of Covid: Lessons learned and adapted. [Meeting Abstract]
Rowland JH, Goyal N, Applebaum AJ (Psychiatry Service), Coons HLT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S596. doi: 10.1093/abm/kaab020.
Summary: This conference abstract describes the agenda for a clinical expert discussion panel on the unique challenges that faced cancer patients, caregivers and cancer care providers, as well as lessons learned and innovative modifications to providing care that can be incorporated into post-pandemic practice and improve future cancer care delivery.
Safety recommendations for evaluation and surgery of the head and neck during the COVID-19 pandemic. [Special Communication]
Givi B, Schiff BA, Chinn SB, Clayburgh D, Iyer NG, Jalisi S, Moore MG, Nathan CA, Orloff LA, O'Neill JP, Parker N, Zender C, Morris LGT (Surgery), Davies L.
JAMA Otolaryngol Head Neck Surg. 2020 Jun 01;146(6):579-584. doi: 10.1001/jamaoto.2020.0780. Epub 2020 Mar 31.
Summary: This report identifies safety recommendations for clinicians performing head and neck procedures and surgeries during the Covid-19 pandemic.
COVID-19 pneumonia: What is the role of imaging in diagnosis? [Letter to the Editor]
Araujo-Filho JAB (SKI Radiology), Sawamura MVY, Costa AN, Cerri GG, Nomura CH.
J Bras Pneumol. 2020 Mar 27;46(2):e20200114. doi: 10.36416/1806-3756/e20200114
Summary: This letter describes that CT scans should not be used to diagnose asymptomatic Covid-19 patients, but can be considered in hospitalized or symptomatic cases of potential Covid-19 pneumonia, but that Covid-19 diagnostic tests should always be used to confirm a positive Covid-19 diagnosis.
Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of diagnostic testing for SARS-CoV-2/COVID-19. [Editorial]
Patel R, Babady E (Laboratory Medicine), Theel ES, Storch GA, Pinsky BA, St George K, Smith TC, Bertuzzi S.
mBio. 2020 Mar 26;11(2). doi: 10.1128/mBio.00722-20
Summary: A report describing the use and value of the two types of Covid-19 tests, viral RNA tests and serology tests, and how to leverage these tests to address the pandemic.
U.S. ICU resource availability for COVID-19. [Report]
Halpern NA (Anesthesiology), Tan KS (Biost/Epidemiology), SCCM Ventilator Taskforce.
SCCM. 2020 Mar 25.
Summary: This blog post describes the availability of critical care resources in the US in order to care for the surge in Covid-19 patients.
Efforts to reduce the impacts of COVID-19 outbreak on radiation oncology in Taiwan. [Opinion]
Chen YL, Hsu FM, Tsai CJ (Radiation Oncology), Cheng JCH.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):534-537. doi: 10.1016/j.adro.2020.03.005. Epub 2020 Mar 17.
Summary: This opinion piece details the steps that Taiwan has taken to provide uninterrupted radiation oncology services throughout the Covid-19 pandemic.
SARS-CoV-2 entry genes are most highly expressed in nasal goblet and ciliated cells within human airways. [Preprint]
Sungnak W, Huang Ni, Becavin C, Berg M, HCLA Lung Biological Network (Pe'er D (Computational and Systems Biology Program) in group).
arXiv.org. 2020 Mar 13. arXiv:2003.06122 [q-bio.CB].
Summary: This preprint article describes how the expression of genes that are coronavirus receptors are found in large amounts in the nasal passages. This could explain why nasal respiratory transmission is so significant.
Interim guidelines for COVID-19 management in hematopoietic cell transplant and cellular therapy patients. [Guidelines]
Waghmare A, Boeckh M, Chemaly RF, Dadwal SS, Papanicolaou GA (Medicine), Pergam S.
American Society for Transplantation and Cellular Therapy (ASTCT) 2020 March 9. Version 1.1.
Summary: This document is intended as a guide for diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplant (HCT) and cellular therapy patients. It does not cover specific infection prevention policies and procedures.
Management of multiple myeloma during COVID-19 pandemic. [Review]
Jethava YS, Fonseca R, Landgren O (Laboratory Medicine).
Leuk Res Rep. 2020; 14: 100212. doi: 10.1111/bjd.19415.
Summary: The authors recommend best practices for caring for multiple myeloma patients during the COVID pandemic.
Works: Last updated: 2022-12-29
Adames A (Nursing), Briody P (Nursing), Brown S (Nursing), Ford J (Nursing), Tolda C (Nursing), Barton-Burke M (Nursing).
Asia Pac J Oncol Nurs. 2022 Dec 28;100182. doi: 10.1016/j.apjon.2022.100182. Online ahead of print.
Summary: Results of two virtual focus groups to examine the impact of telehealth on radiation oncology nursing care at a comprehensive cancer care center during the COVID-19 pandemic, specifically between March and August 2020.
Applebaum AJ (Psychiatry Service), Sannes T, Mitchell HR, McAndrew NS, Wiener L, Knight JM, Nelson AJ, Gray TF, Frank PM, Lahijani SC, Pozo-Kaderman C, Rueda-Lara M, Miran DM, Landau H (Medicine), Amonoo HL.
Transplant Cell Ther. 2022 Dec 23;S2666-6367(22)01841-3. doi: 10.1016/j.jtct.2022.12.014. Online ahead of print.
Summary: Background and recommendations for supporting and preparing caregivers delivering home-based care to hematopoietic cell transplantation (HCT) patients, informed by the COVID-19 pandemic.
Pisegna JL, BrintzenhofeSzoc K, Shahrokni A (Medicine), Canin B, Plotkin E, Boehmer LM, Chien L, Malone MV, MacKenzie AR, Krok-Schoen JL.
Support Care Cancer. 2022 Dec 23;31(1):78. doi: 10.1007/s00520-022-07544-y.
Summary: Results of a survey of 271 multidisciplinary healthcare providers to examine the differences in cancer care for older adults between urban and suburban/rural settings during COVID-19.
Shadman M, Liu C, Eakle K, Hiew HJ, Biondo JML, Ghia P, Mato AR (Medicine).
Hemasphere. 2022 Dec 20;7(1):e811. doi: 10.1097/HS9.0000000000000811. eCollection 2023 Jan.
Summary: A prospective review of 27 studies of patients with chronic lymphocytic leukemia, with each study including serology results for 20 or more patients, to evaluate COVID-19 vaccination response in this population.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T (Immunology), Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X; CoV-Contact Cohort, Covid HGE, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard C, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL.
Science. 2022 Dec 20;eabo3627. doi: 10.1126/science.abo3627. Online ahead of print.
Summary: A study of 558 patients with multisystem inflammatory syndrome in children (MIS-C) from the international COVID Human Genetic Effort (CHGE) cohort, as this is a rare and severe condition that can follow benign COVID-19 infection.
Liu K, Hwang J (Graduate Medical Education), Chesteen K, Huth H, Zhu Y, Mixon A, Tillman S, Misra S, Karlekar M.
J Palliat Med. 2022 Dec;25(12):1844-1849. doi: 10.1089/jpm.2022.0006. Epub 2022 Sep 14.
Summary: Results of an observational retrospective study of 123 adult patients with confirmed COVID-19 who received a palliative care consultation and were hospitalized between April 6, 2020 and August 26, 2020.
Lee VH, Adham M, Ben Kridis W, Bossi P, Chen MY, Chitapanarux I, Gregoire V, Hao SP, Ho C, Ho GF, Kannarunimit D, Kwong DL, Lam KO, Lam WKJ, Le QT, Lee AW, Lee NY (Radiation Oncology), Leung TW, Licitra L, Lim DW, Lin JC, Loh KS, Lou PJ, Machiels JP, Mai HQ, Mesia R, Ng WT, Ngan RK, Tay JK, Tsang RK, Tong CC, Wang HM, Wee JT.
Lancet Oncol. 2022 Dec;23(12):e544-e551. doi: 10.1016/S1470-2045(22)00505-8.
Summary: Consensus recommendations from 33 international experts on nasopharyngeal carcinoma in the context of COVID-19 or similar future pandemics or settings.
Yan J (Infection Control), Steiger SN (Pharmacy), Kodama R (Infectious Disease Service), Fender J (Infection Control), Tan C (Pharmacy), Laracy J (Medicine), Cohen N (Pharmacy), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Seo SK (Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 Nov 29;ciac916. doi: 10.1093/cid/ciac916. Online ahead of print.
Summary: Results of an observational study of 156 patients who received sotrovimab at Memorial Sloan Kettering Cancer Center in New York City during the BA.1 Omicron surge of the pandemic.
Harrell Shreckengost CS, Foianini JE, Moron Encinas KM, Tola Guarachi H, Abril K, Amin D, Berkowitz D, Castater CA, Douglas JM, Grant AA, Khullar OV, Lane AN, Lin A, Niroula A, Nizam A, Rashied A, Reitz AW, Roser SM, Spychalski J, Arap SS, Bento RF, Ciaralo PPD, Imamura R, Kowalski LP, Mahmoud A, Mariani AW, Menegozzo CAM, Minamoto H, Montenegro FLM, Pêgo-Fernandes PM, Santos J Jr, Utiyama EM, Sreedharan JK, Kalchiem-Dekel O (Medicine), Nguyen J, Dhamsania RK, Allen K, Modzik A, Pathak V, White C, Blas J, Talal El-Abur I, Tirado G, Yánez Benítez C, Weiser TG, Barry M, Boeck M, Farrell M, Greenberg A, Miller P, Park P, Camazine M, Dillon D, Smith RN.
Crit Care Explor. 2022 Nov 21;4(11):e0796. doi: 10.1097/CCE.0000000000000796. eCollection 2022 Nov.
Summary: Results of an international multi-institute retrospective cohort study of 549 hospitalized COVID-19 patients to compare outcomes in those who underwent tracheostomy within 14 days of intubation versus more than 14 days after intubation.
Lewicka M (Psychiatry & Behavioral Sciences), Hay JL (Psychiatry and Behavioral Sciences), Waters EA, Schofield E (Psychiatry & Behavioral Sciences), Orom H, Kiviniemi MT.
J Prev (2022). 2022 Nov 17. doi: 10.1007/s10935-022-00715-x. Online ahead of print.
Summary: Results of a study of 410 adults in the United States to examine associations between worldview orientations and six facets of risk for COVID-19.
Romano K (Nursing), Rodrigue D (Nursing).
Nurse Leader. 2022 Nov 16. doi: 10.1016/j.mnl.2022.10.002. Epub ahead of print.
Summary: A description of how nurse leaders modified traditional orientation methods in response to the COVID pandemic and staff turnover, with examples of quotes from preceptees and preceptors.
Gonzalez AA, Olsen EL, Killeen SZ, Blair RV, Seshan SV, Jaimes EA (Medicine), Roy CJ, Prieto MC.
J Med Primatol. 2022 Nov 15. doi: 10.1111/jmp.12626. Online ahead of print.
Summary: A case report that describes the measurements of soluble urokinase plasminogen activator receptor in an African green monkey infected with SARS-CoV-2, with authors noting findings suggest elevated levels of this receptor may be associated with renal dysfunction and pathology in the context of COVID-19.
Bradic M (Collaborative Research Centers), Taleb S, Thomas B, Chidiac O, Robay A, Hassan N, Malek J, Ait Hssain A, Abi Khalil C.
J Transl Med. 2022 Nov 12;20(1):526. doi: 10.1186/s12967-022-03737-5.
Summary: A study of 133 patients with acute respiratory distress syndrome (100 COVID-19 patients and 33 non-COVID-19 controls) to assess if COVID-19 infection could be complicated by this syndrome.
Tiutan T (Medicine), Wallins JS (Medicine), Brown S (Biostat/Epidemiology), Gonen M (Biostat/Epidemiology), Korenstein D (Medicine).
Clin Chem Lab Med. 2022 Nov 11;61(2):339-348. doi: 10.1515/cclm-2022-0366. Print 2023 Jan 27..
Summary: A retrospective study of 209 cancer patients hospitalized with COVID-19 who had procalcitonin recorded on admission in order to evaluate the utility of procalcitonin in predicting disease severity and death from COVID-19 in this population.
Kwok G, Reese S, Dugad S (SKI Psychiatry/Counseling), Donovan KA, Tsui J, Sahler OJZ, Levonyan-Radloff K, Barnett ME (Psychiatry Service), Manne S, Ohman-Strickland P, Devine KA.
J Adolesc Young Adult Oncol. 2022 Nov 11. doi: 10.1089/jayao.2022.0113. Online ahead of print.
Summary: Results of a survey of 144 patients aged 18-39 who were recently diagnosed with and being treated for cancer, with responses evaluated to understand factors associated with COVID-19 vaccine uptake and intention.
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Robilotti EV (Medicine), Kamboj M (Medicine), Babady NE (Laboratory Medicine).
Sci Rep. 2022 Nov 8;12(1):18968. doi: 10.1038/s41598-022-21564-y.
Summary: Results of a study to investigate the detection accuracy of the spike gene target failure genomic signature for Alpha and Omicron variants by analyzing positive SARS-CoV-2 samples tested on a widely used, commercial test between December 2020 and July 2022.
Lewicka M (Psychiatry Service), Hamilton JG (Psychiatry Service), Waters EA, Orom H, Schofield E, Kiviniemi MT, Kanetsky PA, Hay JL (Psychiatry Service).
J Behav Med. 2022 Nov 5;1-11. doi: 10.1007/s10865-022-00374-7. Online ahead of print.
Summary: Results of a survey of 343 participants who were enrolled in skin cancer prevention intervention studies to examine associations between social COVID-19 exposure and psychological functioning.
Bakouny Z, Labaki C, Grover P, Awosika J, Gulati S, Hsu CY, Alimohamed SI, Bashir B, Berg S, Bilen MA, Bowles D, Castellano C, Desai A, Elkrief A, Eton OE, Fecher LA, Flora D, Galsky MD, Gatti-Mays ME, Gesenhues A, Glover MJ, Gopalakrishnan D, Gupta S, Halfdanarson TR, Hayes-Lattin B, Hendawi M, Hsu E, Hwang C, Jandarov R, Jani C, Johnson DB, Joshi M, Khan H, Khan SA, Knox N, Koshkin VS, Kulkarni AA, Kwon DH, Matar S, McKay RR, Mishra S, Moria FA, Nizam A, Nock NL, Nonato TK, Panasci J, Pomerantz L, Portuguese AJ, Provenzano D, Puc M, Rao YJ, Rhodes TD, Riely GJ (Medicine), Ripp JJ, Rivera AV, Ruiz-Garcia E, Schmidt AL, Schoenfeld AJ, Schwartz GK, Shah SA, Shaya J, Subbiah S, Tachiki LM, Tucker MD, Valdez-Reyes M, Weissmann LB, Wotman MT, Wulff-Burchfield EM, Xie Z, Yang YJ, Thompson MA, Shah DP, Warner JL, Shyr Y, Choueiri TK, Wise-Draper TM; COVID-19 and Cancer Consortium.
JAMA Oncol. 2022 Nov 3. doi: 10.1001/jamaoncol.2022.5357. Online ahead of print.
Summary: A cohort study of 12,046 patients with cancer and COVID-19, with authors noting that findings suggest patients with baseline immunosuppression as well may experience worse outcomes when treated with immunotherapy or non-immunotherapy systemic anticancer therapy.
Nguyenla X, Wehri E, Van Dis E, Biering SB, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang X, Jockusch S, Tao C, Chien M, Xie W, Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Russo JJ, Ju J, Näär AM, Stanley S, Schaletzky J.
Sci Rep. 2022 Nov 2;12(1):18506. doi: 10.1038/s41598-022-21034-5.
Summary: Results of a study to identify compounds that act synergistically with remdesivir, which the authors note is the only FDA-approved therapeutic for COVID-19, in preventing SARS-CoV-2 replication.
Parekh de Campos A, Levoy K, Pandey S (Ld-Advanced Practice Providers), Wisniewski R (Ld-Advanced Practive Providers), DiMauro P, Ferrell BR, Rosa WE (Psychiatry Service).
Am J Nurs. 2022 Nov 1;122(11):40-45. doi: 10.1097/01.NAJ.0000897124.77291.7d.
Summary: An editorial that explores how the COVID-19 pandemic has shown the need for palliative care education and training, especially amongst nurses.
Mullangi S (Graduate Staff), Aviki EM (Surgery), Hershman DL.
JAMA Oncol. 2022 Dec 1;8(12):1736-1738. doi: 10.1001/jamaoncol.2022.4543. Epub 2022 Oct 27.
Summary: This is a viewpoint that uses data from the American Society of Clinical Oncology’s COVID-19 in Oncology Registry to study the association of various factors with cancer treatment delays among a cohort of patients who tested positive for SARS-CoV-2.
Khawaja F, Papanicolaou G (Medicine), Dadwal S, Pergam SA, Wingard JR, Boghdadly ZE, Abidi MZ, Waghmare A, Shahid Z, Michaels L, Hill JA, Kamboj M (Medicine), Boeckh M, Auletta JJ, Chemaly RF.
Transplant Cell Ther. 2022 Oct 20;S2666-6367(22)01705-5. doi: 10.1016/j.jtct.2022.10.010. Online ahead of print.
Summary: A guidance document in the form of frequently asked questions that is based on current knowledge about COVID-19 vaccination in hematopoietic cell transplantation and chimeric antigen receptor T-cell recipients.
Belkhatir Z, Estépar RSJ, Tannenbaum AR (Medical Physics).
Comput Med Imaging Graph. 2022 Dec;102:102129. doi: 10.1016/j.compmedimag.2022.102129. Epub 2022 Oct 19.
Summary: A guidance document in the form of frequently asked questions that is based on current knowledge about COVID-19 vaccination in hematopoietic cell transplantation and chimeric antigen receptor T-cell recipients.
Yang N (SKI Medicine), Garcia A, Meyer C, Tuschl T, Merghoub T (Human Oncology and Pathogenesis Program), Wolchok JD (Human Oncology and Pathogenesis Program), Deng L (Medicine).
NPJ Vaccines. 2022 Oct 19;7(1):120. doi: 10.1038/s41541-022-00542-5.
Summary: Results of a study to explore the potential of a virus as a cancer or SARS-CoV-2 vaccine adjuvant to create a stronger immune response in those being vaccinated.
van den Puttelaar R, Lansdorp-Vogelaar I, Hahn AI (Biostat/Epidemiology), Rutter CM, Levin TR, Zauber AG (Biostat/Epidemiology), Meester RGS.
Cancer Epidemiol Biomarkers Prev. 2022 Oct 10;EPI-22-0544. doi: 10.1158/1055-9965.EPI-22-0544. Online ahead of print.
Summary: Results of a study to predict the impact of COVID-19 pandemic-related delays in screening and diagnosis on colorectal cancer–related outcomes.
Han Y, Tan L, Zhou T (Research Facilities), Yang L, Carrau L, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D; NYSCF Global Stem Cell Array Team, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A (Research Facilities), Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T, Chen S.
Cell Stem Cell. 2022 Oct 6;29(10):1475-1490.e6. doi: 10.1016/j.stem.2022.09.008.
Summary: A description of a screening strategy to link human genetics with viral infectivity using human-induced pluripotent stem cells (hiPSC), with SARS-CoV-2 infection discussed.
Widman AJ (Medicine), Cohen B, Park V (Pharmacy), McClure T (Infection Control), Wolchok J (HOPP), Kamboj M (Medicine).
J Natl Compr Canc Netw. 2022 Oct;20(10):1134-1138. doi: 10.6004/jnccn.2022.7048.
Summary: Results of an electronic health record analysis of 408 cancer patients receiving immune checkpoint inhibition therapy who were vaccinated for COVID-19 between January 16 and March 27, 2021 to see whether this vaccination increases susceptibility to immune-related adverse events.
Fiore MC, Smith SS, Adsit RT, Bolt DM, Conner KL, Bernstein SL, Eng OD, Lazuk D, Gonzalez A, Jorenby DE, D'Angelo H, Kirsch JA, Williams B, Nolan MB, Hayes-Birchler T, Kent S, Kim H, Piasecki TM, Slutske WS, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew JP, McMahan G, Rolland B, Tindle HA, Warren GW, An LC, Boyd AD, Brunzell DH, Carrillo V, Chen LS, Davis JM, Dilip D (SKI Medicine), Ellerbeck EF, Iturrate E, Jose T, Khanna N, King A, Klass E, Newman M, Shoenbill KA, Tong E, Tsoh JY, Wilson KM, Theobald WE, Baker TB.
PLoS One. 2022 Sep 28;17(9):e0274571. doi: 10.1371/journal.pone.0274571. eCollection 2022.
Summary: Results of a study of 104,590 hospitalized adult COVID-19 patients to characterize changes in mortality, intubation, and intensive care unit admission rates during the first 20 months of the pandemic.
Rausen MS (Anesthesiology), Nahass TA (Graduate Staff), Halpern NA (Anesthesiology).
J Intensive Care Med. 2022 Dec;37(12):1662-1666. doi: 10.1177/08850666221126648. Epub 2022 Sep 21.
Summary: A description of the experience of deploying Omnitool, a novel remote ventilator management control technology, for use with intensive care unit patients in the latter half of 2020 during the COVID-19 pandemic.
Dunbar S, Babady E (Laboratory Medicine), Das S, Moore C.
Front Cell Infect Microbiol. 2022 Sep 20;12:1031436. doi: 10.3389/fcimb.2022.1031436. eCollection 2022.
Summary: An editorial of the experiences of various diagnostic laboratories and manufacturers during the COVID-19 pandemic.
Babady NE (Laboratory Medicine), Burckhardt RM, Krammer F, Moore PL, Enquist LW.
mBio. 2022 Oct 26;13(5):e0222322. doi: 10.1128/mbio.02223-22. Epub 2022 Sep 20.
Summary: An opinion piece on COVID-19 that looks at designing networks to systematically assess variants, connecting laboratory and clinical data, global data sharing, and becoming more proactive in responding to pathogens.
Jiang J (Medical Physics), Tyagi N (Medical Physics), Tringale K (Graduate Staff), Crane C (Radiation Oncology), Veeraraghavan H (Medical Physics).
Med Image Comput Comput Assist Interv. 2022 Sep;13434:556-566. doi: 10.1007/978-3-031-16440-8_53. Epub 2022 Sep 16.
Summary: This conference paper describes an image modeling method developed with 3,643 computed tomography scans arising from head and neck, lung, and kidney cancers as well as COVID-19.
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Developmental Biology), Hadjantonakis AK (Developmental Biology), Coates A, Barnes FL, Zouves CG, Greene WC, Viotti M.
Sci Rep. 2022 Sep 14;12(1):15451. doi: 10.1038/s41598-022-18906-1.
Summary: A study of human embryos preimplantation to explore the factors required for SARS-CoV-2 entry into cells, with findings confirming that these embryos at the blastocyst stage are susceptible to SARS-CoV-2 infection.
DeWolf S (Medicine), Laracy JC (Medicine), Perales MA (Medicine), Kamboj M (Medicine), van den Brink MRM (Medicine), Vardhana S (Medicine).
Immunity. 2022 Oct 11;55(10):1779-1798. doi: 10.1016/j.immuni.2022.09.006. Epub 2022 Sep 13.
Summary: A review of SARS-CoV-2 immunologic vulnerability and how understanding the natural history of viral infections in these high-risk populations can improve prevention and treatment strategies.
Elsakka A (Graduate Staff), Yeh R (Radiology), Das J (Radiology).
Semin Nucl Med. 2023 Jan;53(1):98-106. doi: 10.1053/j.semnuclmed.2022.09.002. Epub 2022 Sep 22.
Summary: A review of the role of molecular imaging techniques in evaluating thoracic and extra-thoracic manifestations of COVID-19 and assessing post-acute COVID-19 syndrome.
Dioverti V, Boghdadly ZE, Shahid Z, Waghmare A, Abidi M, Pergam S, Boeckh M, Dadwal S, Kamboj M (Medicine), Seo S (Medicine), Chemaly RF, Papanicolaou GA (Medicine).
Transplant Cell Ther. 2022 Dec;28(12):810-821. doi: 10.1016/j.jtct.2022.09.002. Epub 2022 Sep 11.
Summary: An update to the 2020 guidelines for the diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplantation and cellular therapy recipients, produced using available data and the expert opinion of the American Society for Transplantation and Cellular Therapy (ASTCT) Infectious Diseases Special Interest Group members.
Wagner MJ, Hennessy C, Beeghly A, French B, Shah DP, Croessmann S, Vilar-Compte D, Ruiz-Garcia E, Ingham M, Schwartz GK, Painter CA, Chugh R, Fecher L, Park C, Zamulko O, Trent JC, Subbiah V, Khaki AR, Tachiki L, Nakasone ES, Loggers ET, Labaki C, Saliby RM, McKay RR, Ajmera A, Griffiths EA, Puzanov I, Tap WD (Medicine), Hwang C, Tejwani S, Jhawar SR, Hayes-Lattin B, Wulff-Burchfield E, Kasi A, Reuben DY, Nagaraj G, Joshi M, Polimera H, Kulkarni AA, Esfahani K, Kwon DH, Paoluzzi L, Bilen MA, Durbin EB, Grivas P, Warner JL, Davis EJ.
Cancers (Basel). 2022 Sep 5;14(17):4334. doi: 10.3390/cancers14174334.
Summary: A retrospective cohort study of 281 patients with sarcoma and COVID-19 reported to the COVID-19 and Cancer Consortium (CCC19) registry between March 17, 2020 and September 30, 2021.
Santos PMG (Graduate Staff), Dee EC (Graduate Staff), Deville C Jr.
JAMA Health Forum. 2021 Sep 3;2(9):e212579. doi: 10.1001/jamahealthforum.2021.2579.
Summary: With the inequities exposed by the COVID-19 pandemic as a backdrop, this is a viewpoint of three areas that are needed to confront the harms of anti-Asian sentiment on Asian American health: disaggregation and genetic ancestry in medical research, cultural humility in clinical practice, and workforce diversity.
Soto-Perez-de-Celis E, Mislang AR, Hernández-Favela CG, Russo C, Colloca G, Williams GR, O'Hanlon S, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Gironés-Sarrió R, Stauder R, Jaklitsch M, Cairo C, Gil LA Jr, Alam M, Sattar S, Kantilal K, Loh KP, Lichtman SM (Medicine), Brain E, Wildiers H, Kanesvaran R, Battisti NML.
J Geriatr Oncol. 2022 Sep;13(7):1054-1057. doi: 10.1016/j.jgo.2022.07.005. Epub 2022 Jul 15.
Summary: Updated recommendations from the International Society of Geriatric Oncology (SIOG) building on their initial set from 2021 regarding COVID-19 vaccinations among older adults with cancer.
Stavrou E, Qiu J, Zafar A, Tramontano AC, Isakoff S, Winer E, Schrag D (Medicine), Manz C.
JCO Oncol Pract. 2022 Sep;18(9):e1447-e1453. doi: 10.1200/OP.22.00072. Epub 2022 Jun 7.
Summary: Results of an electronically administered survey of 51 breast medical oncology clinicians to evaluate their perspectives on the use of telemedicine for outpatient breast cancer care, given its rise during the COVID-19 pandemic.
Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ (Graduate Staff), Harp J, Ahamed J, Magro C.
Am J Pathol. 2022 Sep;192(9):1282-1294. doi: 10.1016/j.ajpath.2022.05.006. Epub 2022 May 28.
Summary: An investigator-initiated, prospective case series of 21 patients (15 with severe/critical COVID-19 and six with mild/moderate COVID-19) who had cutaneous punch biopsy specimens collected between April 1, 2020 and December 31, 2020 at a single institution.
Shi R, Zhang H, Morris Q (Computational and Systems Biology Program).
J Am Med Inform Assoc. 2022 Sep 1;ocac160. doi: 10.1093/jamia/ocac160. Online ahead of print.
Summary: Using COVID-19 as an example, the authors present PAN-cODE, an artificial intelligence method to forecast daily increases in pandemic infections and mortality. Such forecasting facilitates informed policy decisions on the introduction of non-pharmaceutical interventions to reduce infection spread.
Levoy K, Foxwell A, Rosa WE (Psychiatry Service).
Curr Opin Support Palliat Care. 2022 Sep 1;16(3):94-101.
Summary: This review article synthesizes evidence from individual studies on changes to palliative care delivery during the COVID-19 pandemic, and the implications of these changes in Oncology Nursing practice going forward.
Wang JM, Henry C, Lynch KA (Psychiatry Service), Nisa NA, Basabe NC, Hernández R (Psychiatry Service), Lubetkin EI.
Int J Community Wellbeing. 2022 Aug 23;1-19. doi: 10.1007/s42413-022-00180-8.
Summary: The researchers examined community-based organizations (CBO) and employee perceptions of COVID-19’s impact on CBO health-related services. The CBOs participating in this study were located in Upper Manhattan, New York City (serving East Harlem, Central Harlem, Morningside Heights and Hamilton Heights, and Washington Heights and Inwood).
Lambert B, Stopard IJ, Boroujeni A (Pathology), Mendoza R, Zuretti A.
PLoS One. 2022 Aug 18;17(8):e0272442. doi: 10.1371/journal.pone.0272442. eCollection 2022.
Summary: The authors used a mathematical model to quantify the mortality risk in patients hospitalized for COVID-19. The study was conducted across two hospitals in New York: State University of New York (SUNY) Downstate Health Sciences University and Maimonides Medical Center.
Nolan MB, Piasecki TM, Smith SS, Baker TB, Fiore MC, Adsit RT, Bolt DM, Conner KL, Bernstein SL, Eng OD, Lazuk D, Gonzalez A, Hayes-Birchler T, Jorenby DE, D'Angelo H, Kirsch JA, Williams BS, Kent S, Kim H, Lubanski SA, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle HA, Warren GW, Abu-El-Rub N, An LC, Boyd AD, Brunzell DH, Carrillo VA, Chen LS, Davis JM, Deshmukh VG, Dilip D (SKI Medicine), Goldstein A, Ha PK, Iturrate E, Jose T, Khanna N, King A, Klass E, Lui M, Mermelstein RJ, Poon C (DigITs), Tong E, Wilson KM, Theobald WE, Slutske WS.
Cancer Epidemiol Biomarkers Prev. 2022 Aug 15;EPI-22-0500. doi: 10.1158/1055-9965.EPI-22-0500. Online ahead of print.
Summary: This article reports on a study that uses the electronic health record data of over 100,000 adult hospitalized patients with COVID-19, obtained from 21 United States health systems from February 2020 through September 2021. The findings demonstrate that cancer patients with COVID-19 were at risk of severe COVID-19 outcomes (mitigated to a degree by prior COVID-19 vaccination), while past history of cancer was not associated with such risk.
Klima M, Yazdi AK, Li F, Chau I, Hajian T, Bolotokova A, Kaniskan HU, YHan Y, Wang K (Chemical Biology), Li D (Chemical Biology), Luo M (Chemical Biology), Jin J, Boura E, Vedadi M.
Protein Science. 2022; 31( 9):e4395. https://doi.org/10.1002/pro.4395.
Summary: This article presents research on the crystal struture of SARS-CoV-2 that may help in the development of more potent antiviral therapeutics against coronaviruses.
Noy A (Medicine), Vardhana SA (Medicine).
Haematologica. 2022 Dec 1;107(12):2988-2989. doi: 10.3324/haematol.2022.281484. Epub Aug 11.
Summary: This case study reports on the immune response and efficacy of vaccination in a cancer patient with a history of chemotherapy treatment. The patient contracted COVID-19 shortly after beginning chemotherapy, and received several rounds of vaccination with SARS-CoV-2 mRNA vaccine six months following treatment.
Steffanoni S, Calimeri T, Laurenge A, Fox CP, Soussain C, Grommes C (Neurology), Tisi MC, Boot J, Crosbie N, Visco C, Arcaini L, Chaganti S, Sassone MC, Alencar A, Armiento D, Romano I, Dietrich J, Itchaki G, Bruna R, Fracchiolla NS, Arletti L, Venditti A, Booth S, Musto P, Hoang Xuan K, Batchelor TT, Cwynarski K, Ferreri AJM.
Br J Haematol. 2022 Nov;199(4):507-519. doi: 10.1111/bjh.18396. Epub 2022 Aug 9.
Summary: The authors studied the presentation, management, and outcomes in patients with primary central nervous system lymphoma and SARS-CoV-2 infection.
Silverberg JI, Zyskind I, Naiditch H, Zimmerman J, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Rosenberg AZ.
PLoS One. 2022 Aug 4;17(8):e0271310. doi: 10.1371/journal.pone.0271310. eCollection 2022.
Summary: In this longitudinal observational study conducted before Covid-19 vaccines' availability, the authors studied chronic COVID-19 symptoms among 390 adults from 5 U.S. states.
Robilotti EV (Medicine), Whiting K (Biostat/Epidemiology), Lucca A (Employee Health), Poon C (DigITs), Jani K (Laboratory Medicine), McMillen T (Laboratory Medicine), Freeswick S (Pharmacy), Babady NE (Laboratory Medicine), Seshan VE (Biostat/Epidemiology), Kamboj M (Medicine).
Clin Microbiol Infect. 2022 Dec;28(12):1624-1628. doi: 10.1016/j.cmi.2022.07.017. Epub 2022 Aug 3.
Summary: In this retrospective study, the authors compared the effectiveness of receiving two doses of mRNA vaccines versus three doses in 21,557 healthcare workers employed at MSKCC. The study looked at the data from December 15, 2020 to January 15, 2022.
Gammon R, Katz LM, Strauss D, Rowe K, Menitove J, Benjamin RJ, Goel R, Borge D (Laboratory Medicine), Reichenberg S, Smith R.
Transfus Med. 2022 Aug 2. doi: 10.1111/tme.12896. Online ahead of print.
Summary: This article describes challenges in blood donation and banking during the COVID-19 pandemic in the United States, the ways the blood community addressed those challenges, and lessons learned for the future.
Laracy JC (Medicine), Kamboj M (Medicine), Vardhana SA (Medicine).
Curr Opin Infect Dis. 2022 Aug 1;35(4):271-279. doi: 10.1097/QCO.0000000000000841. Epub 2022 Jul 5.
Summary: The article describes the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 infection in patients with blood cancers.
Mussetti A, Peric Z, Figueroa C (Medicine).
Curr Opin Infect Dis. 2022 Aug 1;35(4):295-301. doi: 10.1097/QCO.0000000000000843. Epub 2022 Jul 5.
Summary: A review of how telemedicine is being used in hematology via studies published before and during the COVID-19 pandemic.
Orsini EM, Sacha GL, Han X, Wang X, Duggal A, Rajendram P (Anesthesiology).
Acute Crit Care. 2022 Aug;37(3):312-321. doi: 10.4266/acc.2022.00136. Epub 2022 Aug 29.
Summary: A retrospective, observational case-control study of 900 adult patients critically ill with COVID-19 admitted to the intensive care units of the Cleveland Clinic Health System between March 15, 2020 and August 31, 2020.
Horvat JV (Radiology), Sevilimedu V (Biostat/Epidemiology), Becker AS (Radiology), Perez-Johnston R (Radiology), Yeh R (Radiology), Feigin KN (Radiology).
Eur Radiol. 2022 Aug;32(8):5752-5758. doi: 10.1007/s00330-022-08655-0. Epub 2022 Mar 5.
Summary: A retrospective cohort study of 357 patients who underwent breast magnetic resonance imaging (MRI) following COVID-19 vaccination between January 22, 2021 and March 21, 2021.
Gebert RR (SKI Psychiatry/Counseling), Behrens MR (SKI Psychiatry/Counseling), Loschiavo MJ (SKI Psychiatry/Counseling).
Palliat Support Care. 2022 Jul 28;1-2. doi: 10.1017/S1478951522000943. Online ahead of print.
Summary: An editorial that describes the moral distress and challenges faced by psychosocial oncology clinical research staff within the COVID-19 pandemic.
Baldwin-Medsker A (Health Informatics), Skwira-Brown A.
Clin J Oncol Nurs. 2022 Jul 25;26(4):374-382. doi: 10.1188/22.CJON.374-382.
Summary: A review of how the COVID-19 pandemic changed clinical oncology practice and impacted digital health technologies in oncology care.
Cazeau N (Advanced Practice Providers), Palazzo M (Advanced Practice Providers), Savani M, Shroff RT.
Clin J Oncol Nurs. 2022 Jul 25;26(4):367-373. doi: 10.1188/22.CJON.367-373.
Summary: A review of current knowledge via research studies that looked to the COVID-19 vaccine immune response of immunosuppressed patients with hematologic and solid tumor malignancies.
Johnson W (Medicine), Kalvin H (Biostat/Epidemiology), Panageas K (Biostat/Epidemiology), Nicodemus J (Medicine), Cathcart E (Medicine), Lin YH (HOPP), Hosszu K (Pediatrics), Lee C, Hamlin P (Medicine), Horwitz S (Medicine), Intlekofer A (Medicine), Joffe E (SKI Medicine), Kumar A (Medicine), Batlevi C (Medicine), Matasar M (Medicine), Moskowitz A (Medicine), Noy A (Medicine), Palomba M (Medicine), Salles G (Medicine), Straus D (Medicine), von Keudell G (Human Resources), Zelenetz A (Medicine), Boelens JJ (Pediatrics), Babady NE (Laboratory Medicine), Maslak P (Laboratory Medicine), Wolchok JD (HOPP), Vardhana S (Medicine).
Research Square. 2022 Jul 18; doi: https://doi.org/10.21203/rs.3.rs-1836295/v1.
Summary: A preprint of a two-arm, single-institution phase II study of N-acetylcysteine in 42 patients with severe COVID-19 admitted to Memorial Sloan Kettering Cancer Center between May 2020 and April 2021.
Behr GG (Radiology), Raphael JP, Price AP (Radiology), Pandit-Taskar N (Radiology).
Clin Imaging. Clin Imaging. 2022 Oct;90:1-4. doi: 10.1016/j.clinimag.2022.07.002. Epub 2022 Jul 11.
Summary: A retrospective review of 48 pediatric patients with documented COVID-19 who had undergone one or more imaging studies between March 2020 and December 2020 at Memorial Sloan Kettering Cancer Center.
García-Gutiérrez V, Breccia M, Jabbour E, Mauro M (Medicine), Cortes JE.
J Hematol Oncol. 2022 Jul 11;15(1):90. doi: 10.1186/s13045-022-01309-0.
Summary: This review, written by international experts, uses clinically relevant case studies to discuss three major scenarios often seen in the treatment of chronic myeloid leukemia (CML) in the chronic phase, and also "addresses global challenges commonly faced by hematologists treating patients with CML during the COVID-19 pandemic."
Wu JTY, de la Hoz MAA, Kuo PC, Paguio JA, Yao JS, Dee EC (Graduate Staff), Yeung W, Jurado J, Moulick A, Milazzo C, Peinado P, Villares P, Cubillo A, Varona JF, Lee HC, Estirado A, Castellano JM, Celi LA.
J Digit Imaging. 2022 Dec;35(6):1514-1529. doi: 10.1007/s10278-022-00674-z. Epub 2022 Jul 5.
Summary: This study reports on an international, multi-center effort that originated at MIT. Retrospective data was used to develop COVID-19 mortality prediction models using the "best machine learning practices for clinical model development." These models were then tested but found to perform differently across different institutions, clinical settings, and populations.
Harrington CA (SKI Surgery), Hsu M (Epidemiology & Biostatistics), Tan KS (Epidemiology & Biostatistics), Medina B (Graduate Staff), Boerner T (SKI Surgery), Adusumilli PS (Surgery), Bains MS (Surgery), Bott MJ (Surgery), Isbell JM (Surgery), Park BJ (Surgery), Sihag S (Surgery), Rusch VW (Surgery), Jones DR (Surgery), Rocco G (Surgery), Molena D (Surgery). Ann Surg. 2022 Jul 4. doi: 10.1097/SLA.0000000000005525. Online ahead of print.
Summary: This single-institution study used patient characteristics and outcomes data from a 4-month period (March-June) in 2019 compared to data from that period in 2020, as well as survey data, to examine how the COVID-19 pandemic affected care for patients undergoing thoracic surgery for cancer, particularly with respect to the adoption of telemedicine.
Hohl SD, Shoenbill KA, Taylor KL, Minion M, Bates-Pappas GE (SKI Psychiatry/Counseling), Hayes RB, Nolan MB, Simmons VN, Steinberg MB, Park ER, Ashing K, Beneventi D, Cox LS, Goldstein AO, King A, Kotsen C (Psychiatry Service), Presant CA, Sherman SE, Sheffer CE, Warren GW, Adsit RT, Bird JE, D'Angelo H, Fiore MC, Nguyen CVT, Pauk D, Rolland B, Rigotti NA.
Nicotine Tob Res. 2022 Jul 2;ntac160. doi: 10.1093/ntr/ntac160. Online ahead of print.
Summary: This article reports how 34 centers participating in tobacco cessation treatments adapted to the changes needed because of COVID-19. As a result, they had to shift to telehealth services rapidly. The centers are National Cancer Institute (NCI)-designated cancer centers participating in NCI's Cancer Center Cessation Initiative.
Mullangi S (Graduate Staff), Aviki EM (Surgery), Chen Y (Biostatistics & Epidemiology), Robson M (Medicine), Hershman DL.
JAMA Netw Open. 2022 Jul 1;5(7):e2224296. doi: 10.1001/jamanetworkopen.2022.24296.
Summary: A cohort study of 3,028 patients within the American Society of Clinical Oncology COVID-19 Oncology Data Registry, with authors noting that findings suggest some health disparities may have been exacerbated during the COVID-19 pandemic as an effect of cancer treatment delay.
Glance LG, Dick AW, Shippey E, McCormick PJ (Anesthesiology), Dutton R, Stone PW, Shang J, Lustik SJ, Lander HL, Gosev I, Joynt Maddox KE.
JAMA Netw Open. 2022 Jul 1;5(7):e2222360. doi: 10.1001/jamanetworkopen.2022.22360.
Summary: A cross-sectional study of 2,950,147 adults undergoing major surgery to compare changes in mortality in this population across insurance types, with authors noting that findings suggest the early phase of the COVID-19 pandemic was not associated with increases in insurance-based disparities.
Popowitch EB, Kaplan S (Laboratory Medicine), Wu Z (Laboratory Medicine), Tang YW (Laboratory Medicine), Miller MB.
Microbiol Spectr. 2022 Jun 29;e0124822. doi: 10.1128/spectrum.01248-22. Online ahead of print.
Summary: In this article, the authors compare the accuracy of 3 tests for detecting non-COVID-19 respiratory pathogens such as rhinovirus/enterovirus or influenza.
Fotopoulou C, Khan T, Bracinik J, Glasbey J, Abu-Rustum N (Surgery), Chiva L, Fagotti A, Fujiwara K, Ghebre R, Gutelkin M, Konney TO, Ng J, Pareja R, Seenivasagam RK, Sehouli J, Surappa S, Bhangu A, Leung E, Sundar S; CovidSurg Gynecological cancer collaborators.
Am J Obstet Gynecol. 2022 Nov;227(5):735.e1-735.e25. doi: 10.1016/j.ajog.2022.06.052. Epub 2022 Jun 30.
Summary: The CovidSurg-Cancer Consortium studied the impact of COVID-19 on delaying surgeries for gynecologic cancer. The prospective cohort study was conducted internationally in 227 centers.
Steinberger S, Finkelstein M, Pagano A (Radiology), Manna S, Toussie D, Chung M, Bernheim A, Concepcion J, Gupta S, Eber C, Dua S, Jacobi AH.
Clin Imaging. 2022 Oct;90:71-77. doi: 10.1016/j.clinimag.2022.06.014. Epub 2022 Jun 28.
Summary: A retrospective study of 363 patients with COVID-19 between March 1, 2020 and April 8, 2020, with authors noting barotrauma is a frequent complication of mechanically ventilated COVID-19 patients and those with barotrauma have a higher rate of pneumothorax and an increased risk of death.
Gordon A (Medicine), Rotemberg V (Medicine), Love D (Medicine), Kurtansky NR (Medicine), Pagel D (Medicine), Mones J (Medicine).
Telemed J E Health. 2022 Jun 28. doi: 10.1089/tmj.2021.0531. Online ahead of print.
Summary: This article analyzed the use of asynchronous provider-to-provider communications at Memorial Sloan Kettering Cancer Center during the COVID-19 pandemic from January to December 2020. Asynchronous communications are conducted via portal messages or interprofessional e-consults.
Rosa WE (Psychiatry Service), Roberts KE, Schlak AE, Applebaum AJ (Psychiatry Service), Breitbart WS (Psychiatry Service), Kantoff EH (Psychiatry Service), Pessin H (Psychiatry Service), Lichtenthal WG (Psychiatry Service).
Int J Environ Res Public Health. 2022 Jun 25;19(13):7801. doi: 10.3390/ijerph19137801.
Summary: This article discusses how Meaning-Centered Psychotherapy, an intervention developed initially to help cancer patients, could be adapted to assist with healthcare providers' burnout and distress.
Rosa WE (Psychiatry Service), Lynch KA (Psychiatry Service), Hadler RA, Mahoney C (Human Resources), Parker PA (Psychiatry Service).
Transl Behav Med. 2022 Jun 18;ibac044. doi: 10.1093/tbm/ibac044. Online ahead of print.
Summary: In this study, the authors interviewed 11 palliative specialists from diverse roles, such as "social workers, pharmacists, chaplaincy services, physicians, and advanced practice providers," providing telehealth care. The participants shared their experience with telepalliative care, reporting on challenges and facilitators.
Sayman HB, Toplutas KN, Tunick J, Aras O (Radiology).
Nucl Med Rev Cent East Eur. 2022;25(2):127-128. doi: 10.5603/NMR.a2022.0026. Epub 2022 Jun 14.
Summary: The authors present imaging using lung 99mTc-Vitamin C SPECT/CT from two patients. Those images may help identify lung damage and its potential progression.
Feinberg J (Graduate Staff), Sonoda Y (Surgery).
Oncologist. 2022 Jun 8;27(6):428-429. doi: 10.1093/oncolo/oyac044.
Summary: This is a commentary on telehealth specific to the oncologic field. It discusses its impact on patient outcomes, quality of patient care, cost, access, and future role.
Bjerre Real C (Graduate Staff), Dhawan V (Anesthesiology), Sharma M (Psychiatry Service), Seier K (Biostatistics/Epidemiology), Tan KS (Biostatistics/Epidemiology), Matsoukas K (Medical Library), Maloy M (Health Informatics), Voigt L (Anesthesiology), Alici Y (Psychiatry Service), Chawla S (Anesthesiology).
J Acad Consult Liaison Psychiatry. 2022 Nov-Dec;63(6):539-547. doi: 10.1016/j.jaclp.2022.05.005. Epub 2022 Jun 2.
Summary: This retrospective cohort single-center study looked at 70 critically ill cancer patients with a confirmed COVID-19 diagnosis over a ~4 month period early in the pandemic (3/1/2020-7/10/2020) to evaluate their delirium frequency and outcomes. Results showed this study population had a high incidence of delirium and patients with delirium had higher hospital and ICU stays and ventilation days, however, no statistically significant difference in hospital mortality. Also, patients being administered cancer-directed therapies were less likely to be positive for delirium.
Freise NF, Kivel M, Grebe O, Meyer C, Wafaisade B, Peiper M, Zeus T, Schmidt J, Neuwahl J, Jazmati D, Luedde T, Bölke E, Feldt T, Jensen BEO, Bode J, Keitel V, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Knoefel WT, Schneider M, Gerber PA, Pedoto A (Anesthesiology), Häussinger D, van Griensven M, Rezazadeh A, Flaig Y, Kirchner J, Antoch G, Schelzig H, Matuschek C.
Eur J Med Res. 2022 Jun 2;27(1):80. doi: 10.1186/s40001-022-00695-y.
Summary: This paper reports on "a case series of eight consecutive patients with cardiac side effects after inoculation of either the first or the second dose of a mRNA vaccine against SARS-CoV-2." Study participants were young and healthy with no pre-vaccination cardiac history, however, study results suggested that "cardiac adverse events such as myocarditis or pericarditis shortly after SARS-CoV-2 mRNA vaccination are rare but possible and occur particularly in male patients."
Dien Bard J, Babady NE (Laboratory Medicine).
Clin Lab Med. 2022 Jun;42(2):147-160. doi: 10.1016/j.cll.2022.02.007. Epub 2022 Mar 8.
Summary: This review paper describes the important role that molecular testing methods have played in the COVID-19 pandemic and discusses the challenges encountered and how these can be avoided in the future.
Lyudovyk O (SKI Epidemiology), Kim JY, Qualls D (Graduate Staff), Hwee MA (HOPP), Lin YH (HOPP), Boutemine SR (Medicine), Elhanati Y (SKI Epidemiology/Biostatistics), Solovyov A (SKI Epidemiology/Biostatistics), Douglas M (Ld-Advanced Practice Providers), Chen E, Babady NE (Laboratory Medicine), Ramanathan L (Laboratory Medicine), Vedantam P (Research Facilities), Bandlamudi C (Collaborative Research Centers), Gouma S, Wong P (Research Facilities), Hensley SE, Greenbaum B (Biostatistics/Epidemiology), Huang AC, Vardhana SA (Medicine).
Cancer Cell. 2022 Jul 11;40(7):738-753.e5. doi: 10.1016/j.ccell.2022.05.013. Epub 2022 May 30.
Summary: This important study analyzed cellular and humoral immune responses in 103 cancer patients with prior COVID-19 infection (based on SARS-CoV-2 positive PCR test, between March 1, 2020 and January 20, 2021) to establish whether B and CD4+ T cell immunity are key factors associated with delayed viral infection clearance and incidence of prolonged COVID-19 disease.
Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ (Graduate Staff), Harp J, Ahamed J, Magro C.
Am J Pathol. 2022 May 28;S0002-9440(22)00149-3. doi: 10.1016/j.ajpath.2022.05.006. Online ahead of print.
Summary: This paper reports on an investigator-initiated, single institution prospective case series that included COVID-19 patient cohorts (between April 1, 2020 and December 31, 2020). The finding supports “the hypothesis that these microvascular changes may be a unique characteristic of COVID-19 ARDS versus other forms of ARDS” and may “refine the approach to predicting COVID-19 progression and intervening in its advance.”
Maki KR (Pharmacy), Steiger SN (Pharmacy), Su Y (SKI Medicine), Boumiza A (Medicine), Tan CA (Pharmacy), Kerpelev M (Information Systems), Seo SK (Medicine), Cohen N (Pharmacy).
Infect Control Hosp Epidemiol. 2022 May 26;1-25. doi: 10.1017/ice.2022.129. Online ahead of print.
Summary: This observational study looked at hospitalized cancer patients with COVID-19 and bacterial co-infections. The results of this study can inform antibiotics use in this patient population.
Badalov E, Blackler L (Ethics), Scharf AE (Ethics), Matsoukas K (Medical Library), Chawla S (Anesthesiology), Voigt LP (Anesthesiology), Kuflik A.
Int J Equity Health. 2022 May 24;21(1):76. doi: 10.1186/s12939-022-01629-0.
Summary: The article focuses on the effects of socioeconomic disparities on COVID-19 pandemic outcomes among vulnerable populations.
Siotos C, Ferraro J, Horen SR, Siotou K, Lopez J (Graduate Staff), Dorafshar AH.
Aesthetic Plast Surg. 2022 Dec;46(6):3111-3116. doi: 10.1007/s00266-022-02944-1. Epub 2022 May 20.
Summary: The study compared industry payments to plastic surgeons before and during the COVID-19 pandemic and found that the pandemic had a significant impact on such payments.
Rodino KG, Peaper DR, Kelly BJ, Bushman F, Marques A, Adhikari H, Tu ZJ, Marrero Rolon R, Westblade LF, Green DA, Berry GJ, Wu F, Annavajhala MK, Uhlemann AC, Parikh BA, McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Babady NE (Laboratory Medicine), Hahn AM, Koch RT, Grubaugh ND; Yale SARS-CoV-2 Genomic Surveillance Initiative, Rhoads DD.
J Clin Microbiol. 2022 Jun 15;60(6):e0060022. doi: 10.1128/jcm.00600-22. Epub 2022 May 18.
Summary: This article describes a particular indicator of a SARS-CoV-2 variant (Omicron BA.2.12.1) with both high diagnostic sensitiviy and specificity, that may provide a method for rapid detection of the variant.
Stuver R (Graduate Staff), Shah GL (Medicine), Roeker LE (Medicine), Mato AR (Medicine), Batlevi CL (Medicine), Chung DJ (Medicine), Doddi S (Laboratory Medicine), Falchi L (Medicine), Gyurkocza B (Medicine), Hamilton A (Medicine), Lin YH (Medicine), Jakubowski AA (Medicine), Joffe E (Medicine), Landau HL (Medicine), Lin RJ (Medicine), Mailankody S (Medicine), Palomba ML (Medicine), Park JH (Medicine), Perales MA (Medicine), Ponce DM (Medicine), Ramanathan LV (Laboratory Medicine), Salles GA (Medicine), Scordo M (Medicine), Seo SK (Medicine), Shah UA (Medicine), Stein EM (Medicine), Straus D (Medicine), Usmani SZ (Medicine), Young JW (Medicine), Zelenetz AD (Medicine), Noy A (Medicine), Vardhana SA (Medicine).
Cancer Cell. 2022 2022 Jun 13;40(6):590-591. doi: 10.1016/j.ccell.2022.05.007. Epub 2022 May 16.
Summary: This letter reports on a randomized clinical trial involving patients with hematological malignancies, a population especially vulnerable to COVID-19. The experimental group was treated with AZD7442, the combined monoclonal product AZD7442/Evusheld (tixagevimab-cilgavimab) that has been granted emergency use authorization (EUA). The drug was developed and studied before emergence of the Omicron variant. The trial showed reduced activity of the substance against the Omicron strain. The trial results, however, support the 300 mg dose of AZD7442 pre-exposure prophylaxis.
Manci R (Graduate Staff), Nazir ZH (Graduate Staff), Marghoob AA (Medicine), Cordova M (Medicine).
JAAD Int. 2022 May 16. doi: 10.1016/j.jdin.2022.05.009. Online ahead of print.
Summary: In this study an imaging optical techique called Reflectance Confocal Microscopy (RCM) was used to track skin changes following COVID-19 vaccination with mRNA vaccines (Pfizer and Moderna). The study was conducted in a small sample of subjects and the findings should be viewed as secondary to local immune response to the vaccine. The methodology used may pave a way to identify potential vaccine non-responders.
Rosa WE (SKI Psychiatry), Lynch KA (Psychiatry), Hadler RA, Mahoney C (Psychiatry), Parker PA (Psychiatry).
Am J Hosp Palliat Care. 2022 May 15;10499091221101883. doi: 10.1177/10499091221101883.
Summary: This study explored the experiences of a multidisciplinary palliative care team delivering telepalliative care for oncology inpatients during the peak of the COVID-19 pandemic in New York City. The interviews conducted in the course of the study identified clinician distress as a primary experience stemming from the challenges of the situation. Participants provided detailed recommendations to improve telepalliative care delivery for hospitalized oncology patients in the future.
Scarci M, Raveglia F, Bortolotti L, Benvenuti M, Merlo L, Petrella L, Cardillo G, Rocco G (Surgery).
Semin Thorac Cardiovasc Surg. Summer 2022;34(2):726-732. doi: 10.1053/j.semtcvs.2021.03.038. Epub 2021 May 11.
Summary: This multicenter study (4 northern Italian medical centers) looked at the impact of COVID-19 on thoracic surgical patients, exploring the postoperative and recovery time (~ 90 days) outcomes of 107 patients who underwent lung resection from December 2019 to March 2020, twelve of which developed COVID-19 disease. Patients who developed COVID disease symptoms were at a possible higher risk of death, and factors such as BMI, smoking history, DLCO/VA%, number of resected segments and duration of surgery possibly put thoracic surgical patients at greater risk to develop COVID.
Laracy JC (Medicine), Robilotti EV (Medicine), Yan J (Infection Control), Lucca A (Employee Health & Wellness), Aslam A (Infection Control), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Infect Control Hosp Epidemiol. 2022 May 4;1-3. doi: 10.1017/ice.2022.105. Online ahead of print.
Summary: During the omicron surge of COVID-19 in December 2021-January 2022, healthcare professionals at MSK were more likely to have asymptomatic disease at the time of diagnosis compared to those who had COVID from May to October 2021. The most common symptoms were sore throat and cough.
Bliss JW, Lavery JA (Biostat/Epidemiology), Underwood WP (Medicine), Chun SS (Medicine), Fickera GA (Research Service Centers), Lee CP (Medicine), Corcoran S (Medicine), Maloy MA (Health Informatics), Polubriaginof FC (Health Informatics), Kelly DW (Information Systems), Scott JM (Medicine), Boutros PC, Moskowitz CS (Biostatistics & Epidemiology), Jones LW (Medicine).
Cancer Epidemiol Biomarkers Prev. 2022 May 4;31(5):1036-1042. doi: 10.1158/1055-9965.EPI-21-1186.
Summary: Self questionnaires of a mixed sample of cancer patients and survivors suggest that moderate exercise may lessen the risk of COVID-19 diagnosis compared to a more sedentary lifestyle, but does not impact disease severity.
Shah NJ (Medicine), Patel VG, Zhong X, Pina L, Hawley JE, Lin E, Gartrell BA, Febles VA, Wise DR, Qin Q, Mellgard G, Joshi H, Nauseef JT, Green DA, Vlachostergios PJ, Kwon DH, Huang F, Liaw B, Tagawa S, Kantoff P (Medicine), Morris MJ (Medicine) , Oh WK.
JNCI Cancer Spectr. 2022 May 2;6(3):pkac035. doi: 10.1093/jncics/pkac035.
Summary: This retrospective cohort multicenter study (7 US medical centers) looked at prostate cancer patients (inpatient and outpatient) with a confirmed COVID-19 diagnosis over a 3 month period early in the pandemic (3/1/2020-5/31/2020). Clinical data was collected on 465 patients and analyzed but no statistically significant relationship was found to exist between androgen deprivation therapy use and more severe COVID-19 illness outcomes.
Glance LG, Chandrasekar EK, Shippey E, Stone PW, Dutton R, McCormick PJ (Anesthesiology), Shang J, Lustik SJ, Wu IY, Eaton MP, Dick AW.
JAMA Netw Open. 2022 May 2;5(5):e2213527. doi: 10.1001/jamanetworkopen.2022.13527.
Summary: The Centers for Medicare & Medicaid Services (CMS) forced hospitals to stop performing nonessential surgeries during the first wave of COVID-19 in the United States. This study of nearly 3.5 million patients across 719 hospitals found that racial minority groups were not disproportionately impacted by the moratorium.
Papa N, Roberts MJ, Perera M (Surgery)
ANZ J Surg. 2022 May;92(5):950-952. doi: 10.1111/ans.17646. Epub 2022 Apr 2.
Summary: This paper explores trends in prostate cancer screening and surgery volume in Australia from January 2020 through December 2021 and compares those rates to the preceding 10 years.
Yeoh CB (Anesthesiology), Seier KP (Biostat/Epidemiology), Francis J (Surgery), Abramson DH (Surgery), Tan KS (Biostat/Epidemiology), Tollinche LE (Anesthesiology).
JOJ Ophthalmol. 2022 Apr;9(2):555757. doi: 10.19080/jojo.2022.09.555757. Epub 2022 Apr 26.
Summary: A retrospective cross-sectional observational study of all Reporting to Improve Safety and Quality (RISQ) corneal injury reports at Memorial Sloan Kettering Cancer Center between January 1, 2015 and April 30, 2021, with authors noting an increased incidence in perioperative corneal injuries during the COVID-19 pandemic.
van Nijnatten TJA, Jochelson MS (Radiology), Lobbes MBI.
Eur J Radiol. 2022 Apr 30;152:110334. doi: 10.1016/j.ejrad.2022.110334. Online ahead of print.
Summary: Lymph node abnormalities resulting from COVID-19 vaccinations often have different characteristics from those caused by cancer. Still, any suspicious lymph nodes on the same side as breast cancer call for biopsy.
Schluter C, Fefer M, Lee G, Alty IG, Dee EC (Graduate Staff).
J Cancer Educ. 2022 Apr 25;1-5. doi: 10.1007/s13187-022-02140-4. Epub ahead of print.
Summary: Online health information relating to COVID-19 and cancer was found to be of good quality but received readability scores significantly above the recommended grade level 6.
Migliacci J (Research and Technology Management), Rodavitch A (Research and Technology Management), Riely G (Medicine), Sabbatini P (Medicine), Houston C (Research and Technology Management), Hanley S (Research and Technology Management).
Contemp Clin Trials. 2022 Jun;117:106760. doi: 10.1016/j.cct.2022.106760. Epub 2022 Apr 20.
Summary: This article describes the creation of a COVID-19 Research Committee at MSK that reviewed research protocols with the aim of minimizing bottlenecks, reducing redundancies, and boosting transparency through an internal portal.
Olshen AB, Garcia A, Kapphahn KI, Weng Y, Vargo J, Pugliese JA, Crow D, Wesson PD, Rutherford GW, Gonen M (Biostat/Epidemiology), Desai M.
J Clin Transl Sci. 2022 Apr 19;6(1):e59. doi: 10.1017/cts.2022.389. eCollection 2022.
Summary: A method for predicting hospitalizations from COVID-19 two to four weeks from the time of prediction, evaluated on San Francisco Bay Area hospitalizations.
Chen M, Mohd Said N, Mohd Rais NC, Ho F, Ling N, Chun M, Ng YS, Eng WN, Yao Y, Korc-Grodzicki B (Medicine), Pang A.
J Geriatr Oncol. 2022 Apr 13;S1879-4068(22)00080-7. doi: 10.1016/j.jgo.2022.04.006. Epub ahead of print.
Summary: Nearly 85 percent of a cohort of 250 patients aged 65 and above of the National University Cancer Institute, Singapore (NCIS) were satisfied with a hybrid telemedicine care model.
Rubenstein RN (SKI Surgery), Stern CS (Surgery), Plotsker EL (SKI Surgery), Haglich K (Surgery), Tadros AB (Surgery), Mehrara BJ (Surgery), Matros E (Surgery), Nelson JA (Surgery).
J Surg Oncol. 2022 Aug;126(2):205-213. doi: 10.1002/jso.26889. Epub 2022 Apr 12.
Summary: Using the National Surgical Quality Improvement Program, the authors show that during the first year of the Covid-19 pandemic there was an 11% decline in breast cancer surgeries.
Min JY, Simmons W, Banerjee S, Wang F, Williams N, Zhang Y, Reese AB, Mushlin AI, Flory JH (Medicine).
Diabetes Obes Metab. 2022 Apr 4. doi: 10.1111/dom.14704. Epub ahead of print.
Summary: In the retrospective study, the authors examined antidiabetic drugs' effect on Covid-19 infections and adverse outcomes. 30,747 patients were included in the study.
McGary LHF (GSK Graduate Student), Vardhana SA (Medicine).
Cancer Discov. 2022 Apr 1;12(4):892-894. doi: 10.1158/2159-8290.CD-22-0080.
Summary: In this spotlight, the authors comment on the article published by Fahrner et al. titled "The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals."
Harvey RD, Begue A (Ld-Advanced Practice Providers), Raine C, Yabroff R.
J Adv Pract Oncol. 2022 Apr;13(3):198-201. doi: 10.6004/jadpro.2022.13.3.2. Epub 2022 May 23.
Summary: Journal of the Advanced Practitioner in Oncology Live Virtual 2021 panelists' perspectives of the COVID-19 pandemic and how to respond to future crises that may impact cancer patients and practices.
Haynes RM, Sirintrapun SJ (Pathology), Gao J, McKenzie AJ.
Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-7. doi: 10.1200/EDBK_349671.
Summary: A description of how the COVID-19 pandemic impacted cancer clinical trials at Memorial Sloan Kettering Cancer Center, the Sarah Cannon Research Institute, the U.S. Food and Drug Administration Oncology Center of Excellence, and for a patient diagnosed with early-stage breast cancer.
Chow R, Simone CB (Radiation Oncology), Prsic EH, Shin HJ.
Ann Palliat Med. 2022 Jul;11(7):2285-2290. doi: 10.21037/apm-21-2797. Epub 2022 Mar 30..
Summary: The authors of this paper underwent a cost-effectiveness study on using statins to treat patients hospitalized with Covid-19. They conclude that additional randomized controlled trials should be done on statins as they appear to be cost-effective candidates.
Wang JY, Zhang W, Roehrl VB, Roehrl MW, Roehrl MH (Pathology).
Front Immunol. 2022 Mar 24;13:831849. doi: 10.3389/fimmu.2022.831849. eCollection 2022.
Summary: This article describes a COVID autoantigen atlas developed from the proteins from human fetal lung fibroblast HFL11 cells. This autoantigenome information contributes to a detailed molecular map that can be used to investigate neurological and autoimmune manifestations of COVID-19.
Vardhana S (Medicine), Baldo L, Morice WG 2nd, Wherry EJ.
Sci Immunol. 2022 May 20;7(71):eabo1303. doi: 10.1126/sciimmunol.abo1303. Epub 2022 May 20.
Summary: In this viewpoint, the authors describe how a better understanding of T-cell response and detection would help with a future public health plan of action toward COVID-19.
Bethea TN, Zhai W, Zhou X, Ahles TA (Psychiatry Service), Ahn J, Cohen HJ, Dilawari AA, Graham DMA, Jim HSL, McDonald BC, Nakamura ZM, Patel SK, Rentscher KE, Root J (Psychiatry Service), Saykin AJ, Small BJ, Van Dyk KM, Mandelblatt JS, Carroll JE.
Cancer Med. 2022 Sep;11(17):3352-3363. doi: 10.1002/cam4.4682. Epub 2022 Mar 22.
Summary: In this paper, the authors analyzed if older women with breast cancers and women without cancer had a similar response to lack of sleep because of the Covid-19 pandemic.
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Developmental Biology), Hadjantonakis AK (Developmental Biology), Coates A, Barnes FL, Zouves CG, Greene WC, Viotti M.
bioRxiv. 2022 Mar 18. doi: https://doi.org/10.1101/2021.01.21.427501
Summary: In this preprint paper, which is not yet peer-reviewed, the authors assess if human embryos could be susceptible to Covid-19 infection.
Horvat JV (Radiology), Sevilimedu V (Biostatistics & Epidemiolgy), Becker AS (Radiology), Perez-Johnston R (Radiology), Yeh R (Radiology), Feigin KN (Radiology).
Eur Radiol. 2022 Mar 5. doi: 10.1007/s00330-022-08655-0. Epub ahead of print.
Summary: In this retrospective cohort study, 357 patients who underwent breast MRI following COVID-19 vaccination (between January 22, 2021 to March 21, 2021) were studied to assess the frequency of ipsilateral axillary adenopathy. It was concluded that adenopathy is a frequent event that can last 4-8 weeks after the second vaccine dose and therefore longer follow-up periods were favored for patients without a current ipsilateral breast cancer diagnosis.
Klugman M, Patil S (Biostatistics & Epidemiology), Gany F (Psychiatry), Blinder V (Psychiatry).
Work. 2022;71(4):815-823. doi: 10.3233/WOR-211095. Epub 2022 Mar 3.
Summary: In this study looking at the workplace environment of essential workers, data on a cohort of 563 women who underwent breast cancer treatment between 2010-2018 was analyzed based on whether they were essential or non-essential workers and other characteristics. Researchers compared job benefits and perceptions of workplace environment between groups and one of the study findings was that non-union essential workers were more vulnerable in terms of workplace protections.
Zhou G, Burnett GW, Shah RS (Anesthesiology), Lai CY, Katz D, Fried EA.
Simul Healthc. 2022 Oct 1;17(5):336-342. doi: 10.1097/SIH.0000000000000644. Epub 2022 Mar 4.
Summary: This techical report describes the creation of a cough and particle simulator to test personal protective equipment from droplets and aerosols.
Morjaria S (Medicine), Zhang AW, Kaltsas A (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Operation Excellence), Predmore J (Ld - Advanced Practice Providers), Perez-Johnston R (Radiology), Jee J (Graduate Fellow), Perales MA (Medicine), Daniyan AF (Medicine), Taur Y (Medicine), Mailankody S (Medicine).
Clin Infect Dis. 2022 Mar 1;74(4):567-574. doi: 10.1093/cid/ciab534.
Summary: The study looked at hospitalized cancer patients with neutropenia (a condition that commonly affects cancer patients and is treated with recombinant human granulocyte colony-stimulating factor, G-CSF, filgrastim) who also had COVID-19 infection. The retrospective study found that neutropenia did not affect the course of COVID-19 infection in such patients but CSF administration did. The authors recommended exercising caution and weighing risks vs benefits of SCF treatment of neutropenic patients with COVID-19 infection.
Avutu V (Medicine), Monga V, Mittal N, Saha A, Andolina JR, Bell DE, Fair DB, Flerlage JE, Frediani JN, Heath JL, Kahn JM, Reichek JL, Super L, Terao MA, Freyer DR, Roth ME.
JCO Oncol Pract. 2022 Mar;18(3):224-231. doi: 10.1200/OP.21.00554. Epub 2021 Dec 14.
Summary: This consensus statement by the Children’s Oncology Group (COG) AYA Responsible Investigator (RI) Network "reviews opportunities to use technology to optimize AYA trial enrollment and study conduct, as well as considerations for widespread implementation of these practices," something which became more relevant due to the COVID-19 pandemic when communication technology was more rapidly adopted.
Di Gioacchino A, Legendre R, Rahou Y, Najburg V, Charneau P, Greenbaum BD (Biostatistics & Epidemiology), Tangy F, van der Werf S, Cocco S, Komarova AV.
RNA. 2022 Mar;28(3):277-289. doi: 10.1261/rna.078969.121. Epub 2021 Dec 22.
Summary: This article presents the development of a new bioinformatics tool, the sgDI-tector to detect sgRNA expression levels in COVID-19.
Wang JY, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
J Transl Autoimmun. 2022;5:100147. doi: 10.1016/j.jtauto.2022.100147. Epub 2022 Feb 25.
Summary: This article describes a model of how viral infections, and specifically SARS-Cov-2 infection, can lead to autoimmune disease. The authors identified a database of over 700 candidate autoantigens that can be further investigated in regards to the large number of auto-immune-related adverse events due to COVID-19.
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W (Structural Biology), Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J.
Commun Biol. 2022 Feb 22;5(1):154. doi: 10.1038/s42003-022-03101-9.
Summary: This study provides further evidence to the use of combination drugs that work against SARS-Cov-2 polymerase and exonuclease to provide better therapeutic responses for effective COVID-19 treatment.
Greene L (Medicine), Uwishema O, Nicholas A, Kapoor A, Berjaoui C, Adamolekun E, Khoury C, Yagoub FEAM, Onyeaka H.
Afr J Emerg Med. 2022 Feb 21. doi: 10.1016/j.afjem.2022.02.004. Epub ahead of print.
Summary: This commentary describes how one of the affects of the COVID-19 pandemic has been the reallocation of attention and resources from other diseases and outbreaks that are often significantly more fatal, such as the Crimean-Congo Haemorrhagic Fever outbreak in Africa.
Min JY, Williams N, Simmons W, Banerjee S, Wang F, Zhang Y, Reese AB, Mushlin AI, Flory JH (Medicine).
Diabet Med. 2022 May;39(5):e14815. doi: 10.1111/dme.14815. Epub 2022 Feb 28..
Summary: This research examined the association between the risk of COVID-19 hospitalization in diabetic patients with higher baseline HbA1c. Diabetic patients with poor glucose control are at significantly increased risk for hospitalization from COVID-19 and healthcare providers should be providing increased preventative efforts in these patients.
Neuberger M, Jungbluth A (Pathology), Irlbeck M, Streitparth F, Burian M, Kirchner T, Werner J, Rudelius M, Knösel T.
Infection. 2022 Oct;50(5):1111-1120. doi: 10.1007/s15010-022-01769-z. Epub 2022 Feb 18.
Summary: In this retrospective study, the authors show that 8% of critically ill COVID-19 patients could develop a duodenal infection as an adverse event of COVID-19 infection.
Turco F, Armstrong A, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E, Efstathiou J, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ (Medicine), et al.
Eur Urol. 2022 2022 Jul;82(1):6-11. doi: 10.1016/j.eururo.2022.02.010. Epub 2022 Feb 17.
Summary: In this correspondence, the authors report on experts' advanced prostate cancer management recommendations during the COVID-19 pandemic after attending the Advanced Prostate Cancer Consensus Conference 2021.
Roman A (Nursing), Pineiro AV (Nursing).
J Nurses Prof Dev. 2022 Feb 17. doi: 10.1097/NND.0000000000000868. Epub ahead of print.
Summary: This article describes how nursing communication and communication skills training are vital during times of crisis such as during the COVID-19 pandemic, and how the pandemic impacted the design of a communication skills training program.
Elkrief A, Hennessy C, Kuderer NM, Rubinstein SM, Wulff-Burchfield E, Rosovsky RP, Vega-Luna K, Thompson MA, Panagiotou OA, Desai A, Rivera DR, Khaki AR, Tachiki L, Lynch RC, Stratton C, Elias R, Batist G, Kasi A, Shah DP, Bakouny Z, Cabal A, Clement J, Crowell J, Dixon B, Friese CR, Fry SL, Grover P, Gulati S, Gupta S, Hwang C, Khan H, Kim SJ, (Ld-Advanced Practice Providers), Klein EJ, Labaki C, McKay RR, Nizam A, Pennell NA, Puc M, Schmidt AL, Shahrokni A (Medicine), Shaya JA, Su CT, Wall S, Williams N, Wise-Draper TM, Mishra S, Grivas P, French B, Warner JL, Wildes TM
Lancet Healthy Longev. 2022 Feb 14. doi: 10.1016/S2666-7568(22)00009-5. Epub ahead of print.
Summary: This observational study aimed at quantifying the association of a novel geriatric risk index, comprising patient age and other parameters, with COVID-19 severity and outcomes. The index was found to be able to help clinicians in identifying older adults most at risk for severe COVID-19.
Satyanarayana G, Enriquez KT, Sun T, Klein EJ, Abidi M, Advani SM, Awosika J, Bakouny Z, Bashir B, Berg S, Bernardes M (Graduate Staff), Egan PC, Elkrief A, Feldman LE, Friese CR, Goel S, Gomez CG, Grant KL, Griffiths EA, Gulati S, Gupta S, Hwang C, Jain J, Jani C, Kaltsas A (Medicine), Kasi A, Khan H, Knox N, Koshkin VS, Kwon DH, Labaki C, Lyman GH, McKay RR, McNair C, Nagaraj G, Nakasone ES, Nguyen R, Nonato TK, Olszewski AJ, Panagiotou OA, Puc M, Razavi P, Robilotti EV (Medicine), Santos-Dutra M, Schmidt AL, Shah DP, Shah SA, Vieira K, Weissmann LB, Wise-Draper TM, Wu U, Wu JT, Choueiri TK, Mishra S, Warner JL, French B, Farmakiotis D.
Open Forum Infect Dis. 2022 Feb 14;9(3):ofac037. doi: 10.1093/ofid/ofac037. eCollection 2022 Mar.
Summary: This study identified factors associated with the risk of coinfection in cancer patients with COVID-19 with other infections (bacterial, viral and fungal). Clinical and laboratory indicators can guide antimicrobial therapy, which may improve clinical outcomes.
Kiviniemi MT, Orom H, Hay JL (Psychiatry), Waters EA.
BMC Public Health. 2022 Feb 14;22(1):298. doi: 10.1186/s12889-022-12649-4.
Summary: In this study, the authors surveyed 410 participants to assess if political affiliation impacted risk perception regarding COVID-19. They found that people affiliated with the Republican party were most likely to have a lower perceived risk for themselves and others and less likely to engage in preventive behavior toward COVID-19.
Kleber J (Nursing).
Clin J Oncol Nurs. 2022 Feb 1;26(1):120. doi: 10.1188/22.CJON.120.
Summary: A brief column discussing challenges with sourcing sufficient single-use personal protective equipment and the environmental concerns with its disposal, along with innovative patient care strategies that resulted when more carefully considering its use.
Whisenant JG, Baena J, Cortellini A, Huang LC, Lo Russo G, Porcu L, Wong SK, Bestvina CM, Hellmann MD (Medicine), Roca E, Rizvi H (Collaborative Research Centers), Monnet I, Boudjemaa A, Rogado J, Pasello G, Leighl NB, Arrieta O, Aujayeb A, Batra U, Azzam AY, Unk M, Azab MA, Zhumagaliyeva AN, Gomez-Martin C, Blaquier JB, Geraedts E, Mountzios G, Serrano-Montero G, Reinmuth N, Coate L, Marmarelis M, Presley CJ, Hirsch FR, Garrido P, Khan H, Baggi A, Mascaux C, Halmos B, Ceresoli GL, Fidler MJ, Scotti V, Métivier AC, Falchero L, Felip E, Genova C, Mazieres J, Tapan U, Brahmer J, Bria E, Puri S, Popat S, Reckamp KL, Morgillo F, Nadal E, Mazzoni F, Agustoni F, Bar J, Grosso F, Avrillon V, Patel JD, Gomes F, Ibrahim E, Trama A, Bettini AC, Barlesi F, Dingemans AM, Wakelee H, Peters S, Horn L, Garassino MC, Torri V.
J Thorac Oncol. J Thorac Oncol. 2022 May;17(5):661-674. doi: 10.1016/j.jtho.2021.12.015. Epub 2022 Feb 1.
Summary: An international study of 1,491 patients from 18 countries found that COVID outcomes for patients with thoracic cancers depended on seven main factors, including age, cancer stage, and whether or not the patient developed pneumonia.
Lo Gullo R (Radiology), Cloutier Lambert C, Lin O (Pathology), Jochelson MS (Radiology), D'Alessio D (Radiology).
Breast Cancer Res Treat. 2022 Feb;191(3):677-683. doi: 10.1007/s10549-021-06473-4. Epub 2022 Jan 11.
Summary: This retrospective study looked at 222 patients being screened for suspicious lymphadenopathy to analyze the accuracy of fine-needle aspiration biopsy alone versus fine-needle aspiration biopsy combined with other tools such as flow cytometry.
Freise NF, Kivel M, Grebe O, Meyer C, Wafaisade B, Peiper M, Zeus T, Schmidt J, Neuwahl J, Jazmati D, Luedde T, Bölke E, Feldt T, Jensen BEO, Bode J, Keitel V, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Knoefel WT, Schneider M, Gerber PA, Pedoto A (Anesthesiology), et al.
Research Square. 2021 Dec 28; doi: 10.21203/rs.3.rs-1157175/v1.
Summary: This retrospective study looked at eight patients who came to the hospital with cardiac symptoms following the first or second COVID vaccination. This is a preprint article, not yet peer-reviewed.
Chen Y (Biostat/Epidemiology), Fei W, Wang Q, Zeng D, Wang Y.
Adv Neural Inf Process Syst. 2021 Dec;34:27747-27760.
Summary: Proposed models and methods to assist public health decision-making and the clinical management of COVID-19 patients.
Yurdaisik I, Demiroz AS, Oz AB, Akker M, Agirman A, Aksoy SH, Nurili F (Radiology).
Cureus. 2021 Dec 27;13(12):e20734. doi: 10.7759/cureus.20734.
Summary: This study reports on postmortem biopsies aimed at evaluating histopathologic changes in major organs of deceased COVID-19 patients.
Di Gioacchino A, Legendre R, Rahou Y, Najburg V, Charneau P, Greenbaum BD (Biostat/Epidemiology), Tangy F, van der Werf S, Cocco S, Komarova AV.
RNA. 2021 Dec 22;rna.078969.121. doi: 10.1261/rna.078969.121. (Epub ahead of print.)
Summary: This article reports on the development of a bioinformatics tool to be used in the study of the molecular mechanisms of SARS-CoV-2.
Lynch KA (Psychiatry Service), Green A (Medicine), Saltz L (Medicine), Epstein AS (Medicine), Romano DR (Medicine), Vera J (Psychiatry Service), Nelson JE (Medicine).
JCO Oncol Pract. 2022 May;18(5):e669-e676. doi: 10.1200/OP.21.00585. Epub 2021 Dec 22.
Summary: Eighteen physicians were surveyed to share their experience as oncologists providing care during the 2020 COVID-19 surge. The authors hope to give guidance for future pandemics.
Kim SJ (Ld-Advanced Practice Providers), Fessele KL (Nursing), Tin AL (Biostat/Epidemiology), Malling C (SKI Psychiatry), Litchfield H (Medicine), Korc-Grodzicki B (Medicine), Shahrokni A. (Medicine)
J Geriatr Oncol. 2022 May;13(4):416-419. doi: 10.1016/j.jgo.2021.12.014. Epub 2021 Dec 21.
Summary: This study underscored the importance of frailty screening in the care management of older Covid-19 patients with cancer.
Trinidad J, Gabel CK, Bonomo L, Cartron A, Chand S, Coburn W, Daveluy S, Davis M, DeNiro KL, Guggina LM, Han JJ, Hennessy K, Hoffman M, Katz K, Keller JJ, Kim SJ, Konda S, Lake E, Lincoln FN, Lo JA, Markova A (Medicine), Marvin EK, Micheletti RG, Newman S, Nutan F, Nguyen CV, Pahalyants V, Patel J, Rahnama-Moghadam S, Rambhatla PV, Riegert M, Reingold RE (Graduate Student), Robinson DB, Rrapi R, Sartori-Valinotti JC, Seminario-Vidal L, Sharif-Sidi Z, Smogorzewski J, Spaccarelli N, Stewart JR, Tuttle SD, Ulrich MN, Wanat KA, Xia FD, Kaffenberger B, Kroshinsky D.
J Eur Acad Dermatol Venereol. 2022 May;36(5):e323-e325. doi: 10.1111/jdv.17898. Epub 2022 Jan 20.
Summary: This retrospective multi-center study, conducted from March to June 2020, assessed the utility of tele-dermatology in inpatient consultations.
Govindarajan R, Vu AN, Salas RME, Miller AM (Neurology), Sandness DJ, Said RR, Southerland AM, Fernandez A, Romano S, Sennott BJ, Patino-Murillas J, Soni M; AAN Undergraduate Education Subcommittee and Education Committee.
Neurology. 2021 Dec 17;10.1212/WNL.0000000000013222. doi: 10.1212/WNL.0000000000013222. (Epub ahead of print.)
Summary: The Covid-19 pandemic changed the ways medical schools offered clerkships, or clinical experience, to medical students as part of their curricula. This article discusses different methods of virtual instruction, hybrid models of clerkship training, and implementation challenges in Neurology clerkship settings.
Maruthur M (Medicine), Lee E (Medicine), Dusza S (Medicine), Nehal K (Medicine), Rossi A. (Medicine)
Dermatol Surg. 2022 Feb 1;48(2):187-190. doi: 10.1097/DSS.0000000000003352. Epub Dec 14.
Summary: The article reports on the results of an online survey on telemedicine adoption distrubuted to the American College of Mohs Surgeons. The survey responses demonstrated that the Covid-19 pandemic triggered the use of telemedicine in managing patients undergoing Mohs surgery and identified the most common uses, barriers, and future plans for telemedicine in this settings.
Lambert B, Stopard IJ, Momeni-Boroujeni A (Graduate Fellow), Mendoza R, Zuretti A.
medRxiv. 2021 Dec 8. doi: 10.1101/2021.11.12.21266248.
Summary: This preprint describes a study of patients in two hospitals in NYC: SUNY Downstate Health Sciences University and Maimonides Medical Center. The researchers undertook quantifying the mortality risk associated not only with static data (e.g. demographics and patient history) but also with dynamic factors, such as changes in biomarkers, throughout hospitalisation.
Lara OD, Smith M, Wang Y, O'Cearbhaill RE (Medicine), Blank SV, Kolev V, Carr C, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Cohen S, Fehniger J, Lee YC, Isani S, Liu M, Wright JD, Pothuri B.
Gynecol Oncol. 2022 Feb;164(2):304-310. doi: 10.1016/j.ygyno.2021.12.004. Epub 2021 Dec 7.
Summary: This article offers an update on COVID-19 outcomes among patients with gynecologic cancers in New York City during the initial surge of COVID-19. The data came from 8 NYC area hospital systems between March and June 2020.
Ruiz ES, Veldhuizen IJ (SKI Medicine), Abdullah A, Rossi A (Medicine), Nehal KS (Medicine), Schmults C, Waldman A, Lee EH (Medicine).
J Am Acad Dermatol. 2022 Oct;87(4):878-880. doi: 10.1016/j.jaad.2021.11.052. Epub 2021 Dec 4.
Summary: In this letter to the editor, the authors report the results of their study on cancer patients worrying about their skin cancer versus worrying about surgery delays caused by COVID-19.
Rognvaldsson S, Eythorsson E, Thorsteinsdottir S, Vidarsson B, Onundarson PT, Agnarsson BA, Sigurdardottir M, Thorsteinsdóttir I, Olafsson I, Runolfsdottir HL, Helgason D, Emilsdottir AR, Agustsson AS, Bjornsson AH, Kristjansdottir G, Thordardottir AR, Indridason OS, Jonsson A, Gislason GK, Olafsson A, Steingrimsdottir H, Kampanis P, Hultcrantz M (Medicine), Durie BGM, Harding S, Landgren O, Palsson R, Love TJ, Kristinsson SY.
Blood Cancer J. 2021 Dec 1;11(12):191. doi: 10.1038/s41408-021-00580-7.
Summary: In this cohort study of 75,422 Icelandic patients, the authors studied the impact of monoclonal gammopathy of undetermined significance (MGUS) on being infected with COVID-19 and the severity of the disease. MGUS is a precursor of multiple myeloma.
Yeh R (Radiology), Elsakka A (Fellow), Wray R (Radiology), Perez Johnston R (Radiology), Gangai NC (Radiology), Yarmohammadi H (Radiology), Schoder H (Radiology), Pandit-Taskar N (Radiology).
Clin Imaging.. 2021 Dec;80:262-267. doi: 10.1016/j.clinimag.2021.08.002. Epub 2021 Aug 8.
Summary: Researchers retrospectively read FDG PET/CT scans from 31 patients and had a SARS-CoV-2 detection rate of 41.9%. Patients with FDG PET/CT-detectable infection were more likely to be symptomatic and hospitalized.
Lee CY (Medicine), Shah MK (Medicine), Hoyos D (Biostat/Epidemiology), Solovyov A (Biostat/Epidemiology), Douglas M (Medicine), Taur Y (Medicine), Maslak PG (Laboratory Medicine), Esther Babady N (Laboratory Medicine), Greenbaum B (Biostat/Epidemiology), Kamboj M (Medicine), Vardhana SA (Medicine).
Cancer Discov. 2022 Jan;12(1):62-73. doi: 10.1158/2159-8290.CD-21-1033. Epub 2021 Nov 9.
Summary: The article describes persistent symptomatic COVID-19 infection in patients with lymphoid malignancies. It identifies B-cell depletion as the key immunologic driver of persistent infection and demonstrates viral evolution in these patients.
Kozak KE (Leukemia Service), Ouyang L (Ld - Advanced Practice Providers), Derkach A (Biostat/Epidemiology), Sherman A (Leukemia Service), McCall SJ (Ld - Advanced Practice Providers), Famulare C (Collaborative Research Centers - PIC Directed), Chervin J (Collaborative Research Centers - PIC Directed), Daley RJ (Pharmacy), Morjaria S (Medicine), Mauro MJ (Medicine), Rampal RK (Medicine).
Leukemia. 2021 Dec;35(12):3578-3580. doi: 10.1038/s41375-021-01457-1. Epub 2021 Nov 5.
Summary: This letter to the editor describes the study on the SARS-CoV-2 mRNA vaccines antibody response in patients with certain hematologic malignancies, specifically in patients with Philadelphia-chromosome positive and negative Myeloproliferative Neoplasms (MPNs).
Bryan A, Tatem K, Diuguid-Gerber J, Cooke C, Romanoff A (SKI Surgery), Choudhury N, Scanlon M, Kishore P, Sydney E, Masci J, Bakshi P, Pemmasani S, Davis NJ, Maru D.
BMJ Open. 2021 Nov 3;11(11):e053158. doi: 10.1136/bmjopen-2021-053158.
Summary: This paper reports on the results of serological testing of 19,107 staff members (from 30 April to 30 June, 2020) employed at New York City Health and Hospitals (NYC H+H) who also responded to a survey to assess demographic and occupational factors associated with serostatus. The findings showed a "seropositivity rate of 29% during the first wave of the COVID-19 epidemic" and that the "risk of exposure varied significantly by employee demographics, occupation and work location."
Cancer Center Cessation Initiative Telehealth Working Group: Rigotti NA, Taylor KL, Beneventi D, King A, Kotsen C (Psychiatry Service), Fleisher L, Goldstein AO, Park ER, Sherman SE, Steinberg MB, Albert DA, Sanderson Cox L, Hayes RB, Hohl SD, Sheffer CE, Shoenbill KA, Simmons VN, Warren GW, Adsit R, Minion M, Pauk D, Rolland B.
J Natl Compr Canc Netw. 2021 Nov;19(Suppl_1):S21-S24. doi: 10.6004/jnccn.2021.7092.
Summary: This article describes how the shift to virtual telehealth services prompted by the COVID-19 pandemic occured in three healthcare institutions: Memorial Sloan Kettering Cancer Center, MD Anderson Cancer Center and the University of Chicago, and explores future avenues of investigation to advance telehealth for tobacco cessation treatment in cancer care.
Sarkar RR (Graduate Staff), Wu AJ (Radiation Oncology), Reyngold M (Radiation Oncology), Cuaron JJ (Radiation Oncology), Zinovoy M (Radiation Oncology), Hajj C (Radiation Oncology), Pappou E (Surgery), Segal N (Medicine), Yaeger R (Medicine), Wei IH (Surgery), Widmar M (Surgery), Weiser M (Surgery), Paty P (Surgery), Cercek A (Medicine), Smith JJ (Surgery), Saltz L (Medicine), Garcia-Aguilar J (Surgery), Crane CH (Radiation Oncology), Romesser PB (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e73-e74. doi: 10.1016/j.ijrobp.2021.07.434.
Summary: This study investigated whether short-course radiation therapy (SCRT) as part of total neoadjuvant therapy (TNT) is safe and feasible for patients by following a cohort of 42 patients who were treated with SCRT during an institutional COVID-19 pandemic mandate (from March to June of 2020), when all patients undergoing radiation therapy for locally advanced rectal cancer were treated with SCRT. The findings suggest that a watch-and-wait (WW) strategy after SCRT-TNT is feasible, but more long-term research is needed to establish oncologic safety.
Kang JJ (Radiation Oncology), Wu Y(Radiation Oncology), Rybkin A (Radiation Oncology), Yu Y (Radiation Oncology), Chen L (Radiation Oncology), Zakeri K (Radiation Oncology), McBride S (Radiation Oncology), Riaz N (Radiation Oncology), Tsai CJ (Radiation Oncology), Gelblum D (Radiation Oncology), Wong RJ (Surgery), Sherman E (Medicine), Pfister DG (Medicine), Lee NY (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e412. doi: 10.1016/j.ijrobp.2021.07.1185.
Summary: By comparing a cohort of new patients early in the Covid pandemic (March 17, 2020-July 2020) versus a historical, contemporary pre-Covid patient cohort (November 2019-March 16, 2020), the study authors were able to evaluate if "early oropharyngeal cancer (OPC) outcomes with radiation therapy (RT) were affected" by Covid pandemic-related practice changes. Although "no difference in early 6 month outcomes" between cohorts were found, important clinical trends were identified that may not be favorable to long-term outcomes.
Gunther JR, Yang JC, Hajj C (Radiation Oncology), Ng AK, Brady JL, Cheng S, Levis M, Qi S, Mikhaeel G, Ricardi U, Illidge T, Turin A, Knafl M, Specht L, Dabaja B, Yahalom J (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e308-e309. doi: 10.1016/j.ijrobp.2021.07.961.
Summary: This multi-center study that included ninety-three patients with hematologic malignancies from 4 institutions (114 RT courses), evaluated the preliminary efficacy and toxicity of novel hypofractionated radiation therapy regimens that were adopted during the Covid pandemic (1/1/2020 to 8/31/2020) according to guidelines published by the International Lymphoma Radiation Oncology Group (ILROG). The preliminary findings showed "low rates of acute toxicity and reasonable short-term treatment efficacy" but longer follow-up and further control group analysis is needed and forthcoming.
Hajj C (Radiation Oncology), Lee J (Radiation Oncology), Fregonese B (Radiation Oncology), Imber BS (Radiation Oncology), Wijetunga NA (Graduate Staff), Yang JC, Casey DL (Graduate Staff), Yahalom J (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e306. doi: 10.1016/j.ijrobp.2021.07.956.
Summary: This study evaluates a single center's experience adopting emergency guidelines published by the International Lymphoma Radiation Oncology Group (ILROG) to support hypofractionation across multiple dose regimens for 36 non-Hodgkin lymphoma patients. The group reported that early response rates to the one dose regimen (adopted between March 30, 2020 through November 30, 2020 due to the Covid-19 pandemic) are similar but that "longer term follow-up is required to confirm the durability of these results."
Cuaron JJ (Radiation Oncology), Gillespie EF (Radiation Oncology), Shaverdian N (Radiation Oncology), Benvengo S (Radiation Oncology), Washington CM (Hospital Administration), Cahlon O (Radiation Oncology), Gomez DR (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S111. doi: 10.1016/j.ijrobp.2021.07.256.
Summary: This paper reports on the experience of 192 patients (treated at 208 sites) who - after the pandemic restrictions were relaxed - opted for fully remote management via telemedicine. The safety data that was prospectively collected and the data from patient satisfaction surveys (administered before, during, and after treatment) showed that "treatment with fully remote providers is safe and feasible" and that there was high patient satisfaction.
Savitt AG, Manimala S, White T, Fandaros M, Yin W, Duan H, Xu X, Geisbrecht BV, Rubenstein DA, Kaplan AP, Peerschke EI (Laboratory Medicine), Ghebrehiwet B.
Front Immunol. 2021 Nov 5;12:767347. doi: 10.3389/fimmu.2021.767347. eCollection 2021.
Summary: In this paper, the researchers analyzed four major proteins from the genome of SARS-CoV-2 to understand if they were all involved in triggering the life-threatening cytokine storm.
Schmidt AL, Tucker MD, Bakouny Z, Labaki C, Hsu CY, Shyr Y, Armstrong AJ, Beer TM, Bijjula RR, Bilen MA, Connell CF, Dawsey SJ, Faller B, Gao X, Gartrell BA, Gill D, Gulati S, Halabi S, Hwang C, Joshi M, Khaki AR, Menon H, Morris MJ (Medicine), Puc M, Russell KB, Shah NJ (Medicine), Sharifi N, Shaya J, Schweizer MT, Steinharter J, Wulff-Burchfield EM, Xu W, Zhu J, Mishra S, Grivas P, Rini BI, Warner JL, Zhang T, Choueiri TK, Gupta S, McKay RR.
JAMA Netw Open. 2021 Nov;4(11):e2134330. doi: 10.1001/jamanetworkopen.2021.34330.
Summary: This study investigated whether being on androgen deprivation therapy (ADT) is associated with decreased rate of 30-day mortality from COVID-19 among patients with prostate cancer. Findings based on a cohort of 1106 male patients did "not support the hypothesis that ADT may be useful in reducing the mortality or severity of SARS-CoV-2 infection" as no statistically significant difference was observed, however, ongoing prospective trials will further explore the potential role for ADT in affecting the course or outcomes of COVID-19 infection.
Pastuszak AW, Patel DP, Jenkins LC, Hsieh TC, Yafi FA, Mumford SL, Mulhall JP (Surgery), Hotaling JM.
J Sex Med. 2022 Jan;19(1):1-4. doi: 10.1016/j.jsxm.2021.10.003. Epub 2021 Oct 30.
Summary: In the expert opinion, the authors report on quality issues from papers published during the COVID-19 pandemic. They specifically looked at research papers on the topic of male sexual and reproductive medicine, but their findings could apply to other fields.
Perez-Johnston R (Radiology), Araujo-Filho J (SKI Radiology), Mckenney AS (Graduate Staff), Gangai N (Radiology), Plodkowski AJ (Radiology), Liu CC (Radiology), Sawan P (Radiology), Taur Y (Medicine), Morjaria SM (Medicine), Ginsberg MS (Radiology).
Eur Radiol. 2022 Apr;32(4):2661-2671. doi: 10.1007/s00330-021-08341-7. Epub 2021 Oct 30.
Summary: In this retrospective study of 627 COVID-19-positive cancer patients, the researchers looked at the results of chest radiographs to analyze if there is an association with COVID-19 adverse outcomes in cancer patients.
Nath SS (Urgent Care Center), Yadav NU (Medicine), Derkach A (Biost/Epidemiology), Perez-Johnston R (Radiology), Tachiki L, Maguire K (Nursing), Babar A (Urgent Care Center), Maloy MA (Health Informatics), Klotz A (Medicine), Jee J (Graduate Staff), Taur Y (Medicine), Chawla S (Anesthesiology), Babady E (Laboratory Medicine), Khaki AR, Madeleine MM, Grivas P, Henning DJ, Aaltonen L, Lyman GH, Groeger J (Medicine).
Cancer Invest. 2021 2022 Jan;40(1):17-25. doi: 10.1080/07357907.2021.1985134. Epub 2021 Oct 28.
Summary: This retrospective analysis followed 255 adult patients with a history of cancer who presented to Memorial Sloan Kettering Cancer Center (MSKCC) urgent care center (UCC) with concurrent COVID-19 infection (from March 1, 2020 to May 31, 2020) to try to identify "vital signs, labs, and imaging at presentation" that can help predict outcomes and "have implications in triage and disposition planning in the urgent care and emergency settings."
Siddiq MM, Chan AT (Medicine), Miorin L, Yadaw AS, Beaumont KG, Kehrer T, Cupic A, White KM, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Sebra R, Martinez P, Prabha S, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Albrecht RA, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R.
J Virol. 2022 Jan 26;96(2):e0106321. doi: 10.1128/JVI.01063-21. Epub 2021 Oct 20.
Summary: This article reports on a study which explored how COVID-19 affects heart heatlh, specifically cardiomyocytes (cardiac muscle cells), of people without a history of heart disease.
Breen KE (Medicine), Tuman M (SKI Psychiatry), Bertelsen CE (Strategy and Innovation), Sheehan M (Medicine), Wylie D (Medicine), Fleischut MH (Medicine), Offit K (Medicine), Stadler ZK (Medicine), Salo-Mullen (Medicine) EE, Hamilton JG (Psychiatry Service).
JCO Oncol Pract. 2022 Apr;18(4):e462-e471. doi: 10.1200/OP.21.00301. Epub 2021 Oct 15..
Summary: This study surveyed 380 patients during the first 6 months of the pandemic (March-August 2020) about their experiences and preferences regarding their cancer genetic counseling clinic appointments provided as telehealth visits. Overall findings illustrated "that as the pandemic progressed, patients expressed less concern regarding the quality of telehealth care and an increasing preference for and satisfaction with telehealth."
D'Agnillo F, Walters KA, Xiao Y, Sheng ZM, Scherler K, Park J, Gygli S, Rosas LA, Sadtler K, Kalish H, Blatti CA 3rd, Zhu R, Gatzke L, Bushell C, Memoli MJ, O'Day SJ, Fischer TD, Hammond TC, Lee RC, Cash JC, Powers ME, O'Keefe GE, Butnor KJ, Rapkiewicz AV, Travis WD (Pathology), Layne SP, Kash JC, Taubenberger JK.
Sci Transl Med. 2021 Nov 17;13(620):eabj7790. doi: 10.1126/scitranslmed.abj7790.
Summary: This article reports on the molecular, immunological, and pathological findings of a study of lung autopsy samples from 18 patients with fatal COVID-19 that may support the "development of relevant disease markers and urgently needed therapeutics."
Ricardo-Lax I, Luna JM, Thao TTN, Le Pen J, Yu Y, Hoffmann HH, Schneider WM, Razooky BS, Fernandez-Martinez J, Schmidt F, Weisblum Y, Trüeb BS, Berenguer Veiga I, Schmied K, Ebert N, Michailidis E, Peace A, Sánchez-Rivera FJ (Cancer Biology and Genetics), Lowe SW (Cancer Biology and Genetics), Rout MP, Hatziioannou T, Bieniasz PD, Poirier JT, MacDonald MR, Thiel V, Rice CM.
Science. 2021 Nov 26;374(6571):1099-1106. doi: 10.1126/science.abj8430. Epub 2021 Oct 14.
Summary: The authors created a system that allows for the study of SARS-CoV-2, including the development of new therapeutics, without the need for high-level biocontainment.
Robilotti E (Medicine), Whiting K (Biostat/Epidemiology), Lucca A (Employee Health & Wellness), Poon C (DigITs), Guest R (Human Resources), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Solovyov A (SKI Epidemiology & Biostatistics), Kelson S (Health Informatics), Browne K (Nursing), Freeswick S (Hospital Administration), Hohl TM (Medicine), Korenstein D (Medicine), Ruchnewitz D, Lässig M, Łuksza M, Greenbaum B (Biostat/Epidemiology), Seshan VE (Biostat/Epidemiology), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 Aug 24;75(1):e774-e782. doi: 10.1093/cid/ciab886. Epub 2021 Oct 13.
Summary: This study explored SARS CoV-2 infection in vaccinated and unvaccinated healthcare professionals during an 8 months follow-up period after the initial COVID-19 vaccine rollout. Researchers investigated the effectiveness and durability of the vaccine in the context of new variants of the virus.
Bolton KL, Koh Y, Foote MB (Graduate Fellow), Im H, Jee J (Graduate Fellow), Sun CH, Safonov A (Medicine), Ptashkin R (Pathology), Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M (Collaborative Research Centers), Derkach A (Biostat/Epidemiology), GedvilaiteE (Pathology), Tkachuk KA (Medicine), Wiley BJ, Chan IC, Braunstein LZ (Radiation Oncology), Gao T (Collaborative Research Centers), Papaemmanuil E (Biostat/Epidemiology), Babady NE (Laboratory Medicine), Pessin MS (Laboratory Medicine), Kamboj M (Medicine), Diaz LA Jr (Medicine), Ladanyi M (Pathology), Rauh MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V (Medicine), Offit K (Medicine), Norton L (Office of the Pres & CEO), Berger MF (Pathology), Levine RL (Human Oncology & Pathogenesis), Kim ES, Kim NJ, Zehir A (Pathology).
Nat Commun. 2021 Oct 13;12:5975. doi: 10.1038/s41467-021-26138-6.
Summary: This study used the sequencing data of CH (Clonal hematopoiesis)-associated genes and Covid-19 infection data of two patient cohorts: one composed of patients with solid tumors treated at MSK and the other of previously healthy individuals without cancer who were hospitalized for Covid-19 between January and April 2020 at four tertiary hospitals in South Korea (KoCH cohort). The results suggested that there is a relationship between CH and risk of different types of severe infections, including risk of severe Covid-19.
Shah N (Medicine), Dahi PB (Medicine), Ponce DM (Medicine), Sauter CS (Medicine), Shaffer BC (Medicine), Chung DJ (Medicine), Politikos I (Medicine), Lin RJ (Medicine), Giralt SA (Medicine), Papanicolaou G (Medicine), Ramanathan LV (Medicine), Perales MA (Medicine), Kamboj M (Medicine), Shah GL (Medicine), Gyurkocza B (Medicine).
Transplant Cell Ther. 2022 Jan;28(1):55.e1-55.e5. doi: 10.1016/j.jtct.2021.10.004. Epub 2021 Oct 11.
Summary: A retrospective study of 15 patients with past COVID-19 infections finds that subsequent hematopoietic cell transplantations can be performed safely.
Olshen AB, Garcia A, Kapphahn KI, Weng Y, Wesson PD, Rutherford GW, Gonen M (Biostat/Epidemiology), Desai M.
medRxiv. 2021 Oct 9. doi: 10.1101/2021.10.08.21264785.
Summary: This preprint describes a model for predicting hospitalizations from COVID in the San Francisco area two to four weeks ahead of time. It has not been peer reviewed.
Taya M, Paroder V (Radiology), Redelman-Sidi G (Medicine), Gangai N (Radiology), Golia Pernicka JS (Radiology), Gollub MJ (Radiology), Javed-Tayyab S (Radiology), Petkovska I (Radiology), Bates DDB (Radiology).
Emerg Radiol. 2021 Dec;28(6):1087-1096. doi: 10.1007/s10140-021-01986-3. Epub 2021 Oct 3.
Summary: This retrospective cross-sectional study conducted at a tertiary oncologic center looked at the contrast-enhanced CT of the abdomen and pelvis of 63 patients with COVID-19. The most common new imaging abnormality found in this study's cohort was "features of gastric or bowel thickening, followed by small volume ascites, gallbladder distention, and isolated cases of pancreatitis and portal vein thrombosis."
Anabaraonye N, Tsai CJ (Radiation Oncology), Saeed H, Chino F (Radiation Oncology), Ekpo E, Ahuja S, Garcia O, Miller RC.
Adv Radiat Oncol. 2021 Nov 18;7(2):100845. doi: 10.1016/j.adro.2021.100845.
Summary: This letter compares gender and other data points for all articles published by the journal Advances in Radiation Oncology between its inception in December 2015 and the end of February 2020 and between March 1, 2020 and May 31, 2020 when the COVID-19 pandemic in North America began, with authors noting nonsenior female researchers participated less in article publishing during the latter time period.
Rosa WE (SKI Psychiatry), Downing J, Ferrell BR, Grant L, Matula ST, Pandey S, Sey-Sawo J, Sowe M, Upvall M.
Int J Palliat Nurs. 2021 Oct 2;27(8):410-416. doi: 10.12968/ijpn.2021.27.8.410.
Summary: This article explores how global nursing partnerships improved palliative care during the COVID pandemic.
Goffredo P (Graduate Staff), Sun M, Jensen C, Trudel J, Madoff R, Lowry A, Gaertner, W.
Dis Colon Rectum. 2021 Oct 1;64(10):1163-1166. doi: 10.1097/DCR.0000000000002193.
Summary: Researchers found that virtual interviews and visits slightly changed the importance of several factors for colon and rectal surgery (CRS) fellowship applicants. Compared to those with in-person meetings, those with the virtual process were less swayed by location and more concerned with a fellowship site's online presence and post-fellowship careers of alumni.
Miller R, Anabaraonye N, Tsai J (Radiation Oncology), Saeed H, Chino F (Radiation Oncology), Garcia O, Ekpo E, Ahuja S, Lauro C.
J Am J Clin Oncol. 2021 Oct 1; 44(10); doi:10.1097/COC.0000000000000862.
Summary: The authors of this conference abstract (P107) found that early career female first authorship declined in the journal ASTRO Advances in Radiation Oncology during the early pandemic compared to the pre-pandemic rate.
Ackerman B, Keane C, Beaver JA, Kluetz PG, Rivera D, Paliwal P, Singh H, Mpofu P, Amiri-Kordestani L, Baxi SS (Medicine).
Journal of Clinical Oncology. 2021 Oct;39(28 Suppl.) doi: 10.1200/JCO.2020.39.28_suppl.227.
Summary: This meeting abstract finds that early breast cancer diagnoses declined in April and May 2020 compared to March 2020, a decline not present in a 2019 cohort. Those diagnosed February-June 2020 were more likely than those diagnosed the year before to have systemic therapy as their primary treatment.
Fischer JC, Schmidt AG, Bölke E, Uhrberg M, Keitel V, Feldt T, Jensen B, Häussinger D, Adams O, Schneider EM, Balz V, Enczmann J, Rox J, Hermsen D, Schulze-Bosse K, Kindgen-Milles D, Knoefel WT, van Griensven M, Haussmann J, Tamaskovics B, Plettenberg C, Scheckenbach K, Corradini S, Pedoto A (Anesthesiology), Maas K, Schmidt L, Grebe O, Esposito I, Ehrhardt A, Peiper M, Buhren BA, Calles C, Stöhr A, Lichtenberg A, Freise NF, Lutterbeck M, Rezazadeh A, Budach W, Matuschek C.
Eur J Med Res. 2021 Sep 16;26:107. doi: 10.1186/s40001-021-00560-4.
Summary: This exploratory observational study followed 157 adult COVID-19 convalescent patients to try to better understand the immune mechanisms underlying the variability in COVID-19 clinical courses by identifying immunogenetic background characteristics and evaluating whether they are associated with reduced or increased severity of the disease. Results showed that "severity of the disease seems to be strongly associated with the AB0 blood group allele status of the patients."
Dayan I, Roth HR, Zhong A, Harouni A, Gentili A, Abidin AZ, Liu A, Costa AB, Wood BJ, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan P, Xu D, Wu D, Huang E, Kitamura FC, Lacey G, de Antônio Corradi GC, Nino G, Shih HH (Radiology), Obinata H, Ren H, Crane JC, Tetreault J, Guan J, Garrett JW, Kaggie JD, Park JG, Dreyer K, Juluru K (Radiology), Kersten K, Rockenbach MABC, Linguraru MG, Haider MA, AbdelMaseeh M, Rieke N, Damasceno PF, E Silva PMC, Wang P, Xu S, Kawano S, Sriswasdi S, Park SY, Grist TM, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon YJ, Quraini A, Feng A, Priest AN, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Díez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess CP, Compas C, Bhatia D, Oermann EK, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Keshava Murthy KN (Radiology), Fu LC, de Mendonça MRF, Fralick M, Kang MK, Adil M, Gangai N (Radiology), Vateekul P, Elnajjar P (Radiology), Hickman S, Majumdar S, McLeod SL, Reed S, Gräf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, de Lavor VL, Rakvongthai Y, Lee YR, Wen Y, Gilbert FJ, Flores MG, Li Q.
Nat Med. 2021 Oct;27(10):1735-1743. doi: 10.1038/s41591-021-01506-3. Epub 2021 Sep 15.
Summary: In this study, data from 20 institutions worldwide was used to train artificial intelligence models using a method called federated learning to predict the future oxygen requirements of symptomatic patients with COVID-19. The authors believe that "it provides a powerful proof-of-concept of the feasibility of using FL for fast and collaborative development of needed AI models in healthcare."
Dilawari A, Rentscher KE, Zhai W, Zhou X, Ahles TA (Psychiatry Service), Ahn J, Bethea TN, Carroll JE, Cohen HJ, Graham DA, Jim HSL, McDonald B, Nakamura ZM, Patel SK, Root JC (Psychiatry Service), Small BJ, Saykin AJ, Tometich D, Van Dyk K, Mandelblatt JS.
Breast Cancer Res Treat. 2021 Nov;190(2):287-293. doi: 10.1007/s10549-021-06362-w. Epub 2021 Sep 13.
Summary: This study investigated the types and factors associated with medical care disruptions experienced by participants in a longitudinal cohort of non-metastatic breast cancer survivors (aged 60–98) across five US regions. The study showed that there was a high rate of disruptions for this cohort during the first 6 months of the pandemic and that "psychosocial factors were associated with care disruptions."
Tamari R (Medicine), Politikos I (Medicine), Knorr DA (Medicine), Vardhana SA (Medicine), Young, JC (Medicine), Marcello LT (Medicine), Doddi S (Laboratory Medicine), Delvin SM (Epidemiology and Biostatistics), Ramanathan LV (Laboratory Medicine), Pessin MS (Labaratory Medicine), Dunn E (Nursing), Palazzo M (Nursing), Bravo CD (Collaborative Research), Papanicolaou GA (Medicine), Kamboj M (Medicine), Perales MA (Medicine), Chung DJ (Medicine), Shah GL (Medicine).
Blood Cancer Discov. 2020 Sep 13; 2(6). doi: 10.1158/2643-3230.BCD-21-0142.
Summary: The immune response to mRNA COVID vaccines in 217 cancer patients receiving cellular therapies was high. The timing of vaccination after treatment impacted the response.
Chung DJ (Medicine), Shah GL (Medicine), Delvin SM (Epidemiology and Biostatistics), Ramanathan LV (Laboratory Medicine), Doddi S (Laboratory Medicine), Pessin MS (Labaratory Medicine), Hoover E (Medicine), Marcello LT (Medicine), Young, JC (Medicine), Boutemine SR (Medicine), Serrano E (Medicine), Sharan S (Medicine), Momotaj S (Medicine), Margetich L (Medicine), Bravo CD (Collaborative Research), Papanicolaou GA (Medicine), Kamboj M (Medicine), Mato AR (Medicine), Roeker LE (Medicine), Hultcrantz M (Medicine), Mailankody S (Medicine), Lesokhin AM (Medicine), Vardhana SA (Medicine), Knorr DA (Medicine).
Blood Cancer Discov. 2020 Sep 13; 2(6). doi: 10.1158/2643-3230.BCD-21-0139.
Summary: A cohort of 551 leukemia, lymphoma, and multiple myeloma patients showed suppressed responses to COVID-19 vaccination compared to healthy controls.
Yamada C, Hofmann JC, Witt V, Gupta GK (Laboratory Medicine), Winters JL, The ASFA COVID-19 Taskforce.
J Clin Apher.. J Clin Apher. 2021 Dec;36(6):878-881. doi: 10.1002/jca.21939. Epub 2021 Sep 12.
Summary: The American Society for Apheresis (ASFA) Task Force's report mapping out the issues and considerations that should be made when apheresis procedures are requested in the COVID-19 pandemic to ensure "efficient and optimum use of apheresis resources."
Bunzli S, O'Brien P, Aston W, Ayerza MA, Chan L, Cherix S, de Las Heras J, Donati D, Eyesan U, Fabbri N (Surgery), Ghert M, Hilton T, Idowu OK, Imanishi J, Puri A, Rose P, Sabah D, Turcotte R, Weber K, Dowsey MM, Choong PFM.
BMJ Open. 2021 Sep 2;11(9):e047175. doi: 10.1136/bmjopen-2020-047175.
Summary: A survey of 18 sarcoma surgeons from 14 countries led to the development of a COVID-informed decision-making framework for patient care.
Wu JTY, de la Hoz MAA, Kuo PC, Paguio JA, Yao JS, Dee EC (Graduate Staff), Yeung W, Jurado J, Moulick A, Milazzo C, Peinado P, Villares P, Cubillo A, Varona JF, Lee HC, Estirado A, Castellano JM, Celi LA.
arXiv.org. 2021 Sep 1. arXiv:2109.02439 [cs.LG].
Summary: The authors used machine learning to create a COVID-19 mortality prediction model, taking data from electronic health records and chest X-rays. This preprint has not been peer reviewed.
Smeltzer M, Bunn B, Choi YS, Coate L, Corona-Cruz J, Drilon A (Medicine), Duma N, Edelman M, Fidler MJ, Gadgeel S, Goto Y, Herbst R, Hesdorffer M, Higgins K, Labdi B, Leal T, Liu S, Mazotti J, Novello S, Patel S.
J Thorac Oncol. 2021 Sept 1; 16(10); doi:10.1016/j.jtho.2021.08.093.
Summary: This conference abstract looked at how telehealth was used during the COVID-19 pandemic and how it impacts thoracic cancer care.
Singh A, Garg A, Mandlik D, Vander Poorten V, Patel SG (Surgery), O'Neill JP, Spriano G, Shaha A (Surgery), Chaturvedi P, Cernea C, Shah J (Surgery).
J Surg Oncol. 2021 Sep;124(4):476-482. doi: 10.1002/jso.26571. Epub 2021 Jun 9.
Summary: This paper reports on a cross-sectional self-reported QOL assessment administered between July and September 2020 to 979 individuals (from 53 countries), including surgeons, physicians, dentists, and nurses who see patients with head and neck diseases. Factors that adversely influenced the QOL of head and neck healthcare workers during the early period of the COVID pandemic were characterized.
Bottino F, Tagliente E, Pasquini L (Radiology), Napoli AD, Lucignani M, Figà-Talamanca L, Napolitano A.
J Pers Med. 2021 Sep;11(9):893. doi: 10.3390/jpm11090893.
Summary: This systematic review of the literature aims to describe the current machine learning techniques that are being used to predict mortality in COVID patients, summarizing the different models being used and the data and clinical features that they are considering making their prediction assessments.
Pan D (Medicine), Ip A, Zhan S, Wasserman I, Snyder DJ, Agathis AZ, Shamapant N, Yang JY, Pai A, Mazumdar M, Poor H.
Heart Lung. Sep-Oct 2021;50(5):618-621. doi: 10.1016/j.hrtlng.2021.04.010. Epub 2021 May 27.
Summary: This retrospective study looked at pre-hospitalization use of antiplatelet medications (a class of anti-thrombotic drugs such as Aspirin, etc.) in a sample of patients hospitalized with COVID-19 infection in March-April 2020. The study found that although patients on antiplatelet drugs were older and had more comorbidities, severity of COVID-19 disease course was not significantly different between users and non-users of antiplatelet drugs.
Vignesh S, Butt AS, Alboraie M, Costa Martins B, Piscoya A, Tran QT, Yew DTM, Ghazanfar S, Alavinejad P, Kamau E, Verma AM, Mendelsohn RB (Medicine), Khor C, Moss A, Liao DWC, Huang CS, Tsai FC.
Clin Endosc. 2021 Sep;54(5):678-687. doi: 10.5946/ce.2021.140. Epub 2021 Sep 30.
Summary: This study surveyed teaching faculty in gastroenterology training programs on how the COVID-19 pandemic impacted their training programs and various aspects of endoscopy training.
Budahi A (Laboratory Medicine), Vickerie S (Laboratory Medicine), Ahmed S, Bakker T (Information Systems), Venditti CJ (Laboratory Medicine), Pessin MS (Laboratory Medicine), Adem P (Laboratory Medicine).
Transfusion.2021 Sep;61 Suppl 3:1A-272A. doi: 10.1111/trf.16620.
Summary: A review of blood product utilization and transfusion reaction reports of cancer patients with COVID-19, with authors noting this population requires a significant commitment of resources from the transfusion service.
Orom H, Allard NC, Kiviniemi MT, Hay JL (Psychiatry Service), Waters EA, Schofield E (Psychiatry Service), Thomas SN, Tuman M.
J Racial Ethn Health Disparities. 2022 Oct;9(5):1807-1817. doi: 10.1007/s40615-021-01117-1. Epub 2021 Aug 30.
Summary: A June 2020 survey of 50,000 adults in the United States found that Black and Latinx participants were more likely than whites to perceive COVID-19 as a higher risk and to take precautionary measures, like social distancing and masking, to prevent its spread.
Lee CY (Medicine), Shah MK (Medicine), Hoyos D (Biostat/Epidemiology), Solovyov A (Biostat/Epidemiology), Douglas M (Medicine), Taur Y (Medicine), Maslak PG (Laboratory Medicine), Esther Babady N (Laboratory Medicine), Greenbaum B (Biostat/Epidemiology), Kamboj M (Medicine), Vardhana SA (Medicine).
medRxiv. 2021 Aug 29. doi: 10.1101/2021.08.25.21262417.
Summary: A study of 382 patients with lymphomas and COVID-19 diagnoses found that 13.9% of the surviving 368 patients still showed persistent COVID symptoms 30 days after testing positive. This preprint has not been peer reviewed.
Esther Babady N (Laboratory Medicine), Cohen B, McClure T, Chow K, Caldararo M (Graduate Fellow), Jani K (Laboratory Medicine), McMillen T (Laboratory Medicine), Taur Y (Medicine), Shah M (Medicine), Robilotti E (Medicine), Aslam A (Infection Control), Kamboj M (Medicine).
Infect Control Hosp Epidemiol. 2022 Oct;43(10):1413-1415. doi: 10.1017/ice.2021.378. Epub 2021 Aug 27.
Summary: A retrospective study of 105 cancer patients with COVID-19 infections found that patients with hematological cancers took longer to clear the infection and were likely infectious for longer than patients with solid tumors.
Hoff NP, Freise N, Schmidt AG, Firouzi-Memarpuri P, Reifenberger J, Luedde T, Böelke E, Meller S, Homey B, Feldt T, Ole Jensen BE, Keitel V, Schmidt L, Maas K, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Buhren BA, Knoefel WT, Schneider M, Gerber PA, Pedotoa A (Anesthesiology), Häussinger D, Grebe O, van Griensven M, Braun SA, Salzmann S, Rezazadeh A, Matuschek C.
Eur J Med Res. 2021 Aug 25;26:98. doi: 10.1186/s40001-021-00557-z.
Summary: Delayed skin reactions, appearing days after the first or second dose of the Moderna vaccine, are rare, benign, and treatable with topical glucocorticosteroids or oral antihistamines.
Schiaffino S, Pinker K (Radiology), Magni V, Cozzi A, Athanasiou A, Baltzer PAT, Camps Herrero J, Clauser P, Fallenberg EM, Forrai G, Fuchsjäger MH, Helbich TH, Kilburn-Toppin F, Kuhl CK, Lesaru M, Mann RM, Panizza P, Pediconi F, Pijnappel RM, Sella T, Thomassin-Naggara I, Zackrisson S, Gilbert FJ, Sardanelli F.
Insights Imaging.. 2021 Aug 20;12:119. doi: 10.1186/s13244-021-01062-x.
Summary: The European Society of Breast Imaging (EUSOBI)'s recommendations for breast imaging and COVID vaccination to prevent unnecessary imaging and procedures resulting from COVID vaccine-related enlarged lymph nodes.
Foote MB (Graduate Fellow), White JR, Jee J (Graduate Fellow), Argilés G (SKI Medicine), Wan JCM (SKI Medicine), Rousseau B (SKI Medicine), Pessin MS (Laboratory Medicine), Diaz LA Jr (Medicine).
JAMA Oncol. 2021 Nov 1;7(11):1686-1691. doi: 10.1001/jamaoncol.2021.3585. Epub 2021 Aug 19.
Summary: Cancer patients on mTOR/PI3K inhibitors and antimetabolites showed reduced SARS-CoV-2 positivity rates than those treated with other therapies.
Peerschke EI (Laboratory Medicine), Valentino A (Laboratory Medicine), So RJ (Laboratory Medicine), Shulman S (Laboratory Medicine), Ravinder (Laboratory Medicine).
Front Immunol. 2021 Aug 18;12:716361. doi: 10.3389/fimmu.2021.716361.
Summary: Researchers evaluated certain plasma markers in cancer patients and found that COVID-19 increased complement activation, the stimulation of plasma proteins that can lead to inflammatory reactions.
Siegler JE, Boreskie PE, Strowd R, Rook R, Goss A, Al-Mufti F, Rossow B, Miller A (Neurology), Chamberlain A, London Z, Hurley J, Geocadin R, Richie M, Isaacson R, Rybinnik I, Chan TM.
Neurol Sci. 2021 Nov;42(11):4437-4445. doi: 10.1007/s10072-021-05549-9. Epub 2021 Aug 12.
Summary: This study looked at academic neurology-themed podcasts, and whether the COVID-19 pandemic impacted the utilization of these podcasts. The study found that there was no significant increase in downloads during the early months of the pandemic, but that more general and other subspecialty podcasts would be analyzed.
Hossain S (Anesthesiology), Pastores SM (Anesthesiology).
Crit Care Med.. 2021 Aug 11. doi: 10.1097/CCM.0000000000005291. (Epub ahead of print).
Summary: This editorial reviews a recent systematic review of COVID-19 patients with acute respiratory distress syndrome (ARDS) and how COVID-19 ARDS differs from classical ARDS. The review discussed in this editorial found that barotrauma, or the development of pneumothorax or pneumomediastinum, was a defining feature of COVID-19 ARDS. The authors of this editorial raise the question of whether baratrauma is unique to COVID-19 ARDS, or simply a marker for severe disease.
Thom B (Medicine), Benedict C, Friedman DN (Pediatrics), Watson SE, Zeitler MS, Chino F (Radiation Oncology).
Cancer. 2021 Dec 1;127(23):4481-4491. doi: 10.1002/cncr.33823. Epub 2021 Aug 5.
Summary: This study used a survey to look at the financial situation of young adult cancer survivors in the COVID-19 pandemic. The study found that the pandemic significantly worsened cancer-related financial toxicity and overall financial hardship in this category of patients and led to test or treatment skipping and other such behaviors that jeopardized survivorship care and health outcomes.
Wang JY, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Aug 4. doi: 10.1101/2021.07.30.454526.
Summary: This study investigates the connections between viral infections, such as COVID-19, and autoimmune disease.
Chow K (Infection Control), Aslam A (Infection Control), McClure T (Infection Control), Singh J (Infection Control), Burns J (Nursing), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Lucca A (Employee Health & Wellness), Bubb T (Infection Control), Robilotti E (Medicine), Babady E (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2022 May 3;74(9):1579-1585. doi: 10.1093/cid/ciab670. Epub 2021 Jul 30.
Summary: This study aimed at assessing the risk of hospital SARS-Cov-2 infection included hospitalized cancer patients not sick with COVID-19 at admission but diagnosed with coronavirus during their hospitalization. The study found that there was low risk of getting infected in the inpatient setting.
Pirovano G (SKI Radiology), Ordonez AA, Jain SK, Reiner T (Radiology), Carroll LS, Pillarsetty NVK (Radiology).
Nucl Med Biol. 2021 Jul-Aug;98-99:69-75. doi: 10.1016/j.nucmedbio.2021.05.002.
Summary: The authors of this report used their experience with radiolabeled antibodies for oncology applications to develop a SARS-CoV-2 detection system based on "the combination of a specific radiolabeled antibody and a separation membrane."
Roeker LE (Medicine), Eyre TA, Thompson MC (Graduate Staff), Lamanna N, Coltoff A, Davids MS, Baker P, Leslie LA, Rogers KA, Allan JN, Cordoba R, Lopez-Garcia A, Antic D, Pagel JM, Martinez-Calle N, Garcia-Marco JA, Hernández-Rivas JÁ, Miras F, Coombs CC, Österborg A, Seddon AN, López-Jiménez J, Wilson MR, El-Sharkawi D, Wojenski D, Ma S, Munir T, Valenciano S, Seymour E, Barr PM, Pu JJ, Patten PE, Perini GF, Huntington SF, Parry H, Sundaram S, Skarbnik AP, Kamdar M, Jacobs RW, Walter HS, Walewska R, Broom A, Lebowitz S (Medicine), Isaac K, Portell CA, Ahn IE, Ujjani C, Shadman M, Skånland SS, Chong EA, Mato AR (Medicine).
Blood. 2021 Nov 4;138(18):1768-1773. doi: 10.1182/blood.2021011841.Epub 2021 Jul 23.
Summary: In this retrospective study, investigators from 45 centers studied the case fatality rate in patients with chroniclymphocytic leukemia (CLL) diagnosed with COVID-19. The study found that the overall trend in case fatality rate for CLL patients is similar to the improved overall survival observed for patients with COVID-19 in the general population.
Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W (Structural Biology), Patel DJ (Structural Biology), Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J.
bioRxiv. 2021 Jul 21. doi: 10.1101/2021.07.21.453274.
Summary: This preprint reports on the identification of two hepatitis C NS5A inhibitors (Pibrentasvir and Ombitasvir) as potential drugs to work in combination with current treatments such as Remdesivir, to reduce the viral RNA replication of SARS-CoV-2. This preprint descibes a potential combination therapy for treatment of COVID-19.
Silverberg JI, Zyskind I, Naiditch H, Zimmerman J, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Rosenberg AZ..
J Allergy Clin Immunol Pract. 2021 Sep;9(9):3331-3338.e2. doi: 10.1016/j.jaip.2021.06.046. Epub 2021 Jul 15.
Summary: This research paper surveyed 9507 adults to look at the association between COVID-19 symptoms and the antibody response.
Cheung CK, Tucker-Seeley R, Davies S, Gilman M (AYA Psychiatry), Miller KA, Lopes G, Betz GD, Katerere-Virima T, Helbling LE, Thomas BN, Lewis MA.
Future Oncol. 2021 Jul 15. doi: 10.2217/fon-2020-1213. (Epub ahead of print)
Summary: This review describes how the COVID-19 pandemic was a catalyst to expose the long-standing racial crises against Blacks and Asians, and how anti-Black and anti-Asian racism impacts healthcare. The authors describe how adolescent and young adult (AYA) oncology researchers must protect young BIPOC cancer patients' exploitation, and how to provide ethical and effective methods of patient engagement and research that is antiracist.
Wilson BN (Graduate Staff), Aleisa A (Graduate Staff), Menzer C (SKI Medicine), Rossi AM (Medicine).
JAAD Case Rep. JAAD Case Rep. 2021 Sep;15:26-29. doi: 10.1016/j.jdcr.2021.07.004. Epub 2021 Jul 15.
Summary: This case report describes a novel treatment for facial atrophy and depigmentation in a COVID-19 patient who was in prone position. The authors used a Co2 laser delivery system of the drug bimatoprost and microneedling to achieve repigmentation of the facial skin.
Tevaarwerk AJ, Chandereng T, Osterman T, Arafat W, Smerage J, Polubriaginof FCG (Health Informatics), Heinrichs T, Sugalski J, Martin DB.
JCO Oncol Pract. 2021 Sep;17(9):e1318-e1326. doi: 10.1200/OP.21.00195. Epub 2021 Jul 15.
Summary: With the COVID-19 pandemic accelerating the adoption of telemedicine, this National Comprehensive Cancer Network survey of >1000 oncologists from 26 institutions to investigate the providers' assessment of telemedicine used with cancer patients. The survey results suggested that respondents viewed telemedicine "as safe and effective for cancer care within certain clinical scenarios" and demonstrated "an ongoing role for telemedicine in oncology."
Starr TN, Czudnochowski N, Liu Z, Zatta F, Park YJ, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG (Computational and Systems Biology), Zhang I (Graduate Student), Dingens AS, Bowen JE, Tortorici MA, Walls AC, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Dillen J, Tucker H, Bassi J, Silacci-Fregni C, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota E, Abdelnabi R, Foo SC, Cameroni E, Stumpf S, Croll TI, Nix JC, Havenar-Daughton C, Piccoli L, Benigni F, Neyts J, Telenti A, Lempp FA, Pizzuto MS, Chodera JD (Computational and Systems Biology), Hebner CM, Virgin HW, Whelan SPJ, Veesler D, Corti D, Bloom JD, Snell G.
Nature. 2021 Sep 2;597(7874):97-102. doi: 10.1038/s41586-021-03807-6. Epub 2021 Jul 14.
Summary: This article describes how antibodies are used to neutralize the SARS-CoV-2 virus by targing their receptor-binding domain. The data reported shows how these antibodies work, and how this research can be used for therapeutics against both SARS-CoV-2 infection as well as potential future pandemics.
Su C, Zhang Y, Flory JH (Medicine), Weiner MG, Kaushal R, Schenck EJ, Wang F.
NPJ Digit Med. 2021 Jul 14;4:110. doi: 10.1038/s41746-021-00481-w.
Summary: This retrospective study looked at nearly 15,000 COVID-19 patients in NYC in the early surge of the pandemic. The authors identified four biologically distinct subphenotypes, and these subphenotypes were highly predictive of clinical outcomes. For one subphenotype (IV) it was found that mortality was highly correlated to social determinants of health, specifically age, comorbidities, and clinical manifestation of disease. The findings provide a more complete understanding of how COVID-19 impacts different populations.
Koch E, Villanueva F, Marchetti MA (Medicine), Abarzúa Á, Cárdenas C, Castro JC, Dominguez F, Droppelmann K, Droppelmann N, Galindo H, León A, Madrid J, Molgó M, Mondaca S, Montero P, Uribe P, Villaseca MA, Vinés E, Navarrete-Dechent C.
J Eur Acad Dermatol Venereol. 2021 Nov;35(11):e735-e737. doi: 10.1111/jdv.17522. Epub 2021 Jul 26.
Summary: This letter to the editor describes a retrospective study from January 2019 through March 2021 from Chile that showed a 31% decrease in melanoma diagnoses each month during the pandemic, compared to the control year. The authors describe how skin cancer screening is still a vital cancer prevention tool and that delays in diagnosis due to the pandemic lead to increased stage at diagnosis and increased mortality rates.
Harrington CA (Surgery), Molena D (Surgery).
Semin Thorac Cardiovasc Surg. 2021 Jul 13;S1043-0679(21)00322-1. doi: 10.1053/j.semtcvs.2021.07.010. (Epub ahead of print).
Summary: In this commentary, the authors report that cancer surgery for esophageal cancer, esophagectomy, should not be postponed during a pandemic.
Hasan AN (Pediatrics).
Image-Guided Management of COVID-19 Lung Disease. 2020 Jul 10. doi: 10.1007/978-3-030-66614-9_10.
Summary: This book chapter describes how COVID-19 can lead to severe respiratory disease, the clinical course of the disease, clinical symptoms and signs, clinical assessments, and therapies to treat respiratory disease from COVID-19 infection.
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Jul 7. doi: 10.1101/2021.07.05.451199.
Summary: In this preprint, the authors studied autoantigens from human Jurkat T-cells. This study allows growing the autoantigens database to better understand post-Covid syndromes, such as autoimmune effects.
Medjeral-Thomas NR, Troldborg A, Hanse AG, Pihl R (Chemical Biology Program), Clarke CL, Peters JE, Thomas DC, Willicombe M, Palarasah Y, Botto M, Pickering MC, Thiel S.
Oxf Open Immunol. 2021 Jul 7;2(1):iqab014. doi: 10.1093/oxfimm/iqab014. eCollection 2021.
Summary: This study measured and compared the level of protease inhibitors in hemodialysis patients infected with COVID-19 and non-infected patients. The authors observed different inhibitors' levels. Therefore additional studies are needed to understand the mechanisms.
COVIDSurg Collaborative (Ganly I (Surgery), Brown L (Graduate Staff) in group).
Br J Surg. 2021 Jul 6;znab183. doi: 10.1093/bjs/znab183. (Epub ahead of print).
Summary: This large international study used artificial intelligence to create a COVIDsurg Morality Score, a predictive score for mortality in surgical patients infected with SARS-CoV-2. The study concluded that it would be safe to restart the wide range of elective surgeries for patients for whom the score predicts low risk.
da Ponte G, Ouakinin S, Breitbart W (Psychiatry Service).
J Acad Consult Liaison Psychiatry. . 2021 Nov-Dec;62(6):669-670. doi: 10.1016/j.jaclp.2021.06.004. Epub 2021 Jul 6.
Summary: In this letter to the editor, the authors comment on a recently published letter “The role of religious and spiritual aid in quarantine hospitalization due to SARS-CoV-2” and highlight that Meaning Centered Psychotherapy may help non-religious as well as religious patients.
Kamboj M (Medicine).
Lancet Haematol. 2021 Jul 2;S2352-3026(21)00197-6. doi: 10.1016/S2352-3026(21)00197-6. (Epub ahead of print).
Summary: This comment discusses the article "Immunogenicity of the BNT162b2 COVID-19 mRNA vaccine and early clinical outcomes in patients with haematological malignancies in Lithuania: a national prospective cohort study," where the authors study the response to COVID-19 mRNA vaccines for patients with haematological malignancies.
Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K (Chemical Biology Program), Li D (Chemical Biology Program), Liu J, Smil D, Luo M (Chemical Biology Program), Jin J, Fish PV, Brown PJ, Vedadi M.
SLAS Discov. 2021 Oct;26(9):1200-1211. doi: 10.1177/24725552211026261. Epub 2021 Jul 1.
Summary: In this article, the authors describe the development of an assay to screen S-adenosylmethionine (SAM) competitive MTase inhibitors and SAM analogs with the hope of developing future drugs against COVID-19.
Schenk EC, Potter TM, Cook C, Huffling K, Rosa WE (SKI Psychiatry/Counseling).
Am J Nurs. 2021 Jul 1;121(7):66-69. doi: 10.1097/01.NAJ.0000758540.26343.2e.
Summary: This article discusses how nurses can help with attaining the United Nations (UN) Sustainable Development Goal 11 (SDG-11), making "cities and human settlements inclusive, safe, resilient and sustainable."
Jonathan K (Medicine), Edwards C, Heelan K, Harwood C, Fearfield L.
Br J Dermatol.2021 Jul;185 Suppl 1:3-185. doi: 10.1111/bjd.20130.
Summary: This conference abstract looked at how teledermatology provided support to patients experiencing immune checkpoint inhibitor toxicity during the height of the COVID-19 pandemic.
Hill MV, Ross EA, Crawford D, Lai L, Turaga K, Grubbs EG, Mullen J, Dineen S, D'Angelica M (Surgery), Reddy S, Farma JM.
Am J Surg. 2021 Jul;222(1):99-103. doi: 10.1016/j.amjsurg.2020.11.007. Epub 2020 Nov 8.
Summary: This article examines the virtual experience of program directors and candidates via surveys during the 2020 Complex General Surgical Oncology interview season.
Elmunzer BJ, Spitzer RL, Foster LD, Merchant AA, Howard EF, Patel VA, West MK, Qayed E, Nustas R, Zakaria A, Piper MS, Taylor JR, Jaza L, Forbes N, Chau M, Lara LF, Papachristou GI, Volk ML, Hilson LG, Zhou S, Kushnir VM, Lenyo AM, McLeod CG, Amin S, Kuftinec GN, Yadav D, Fox C, Kolb JM, Pawa S, Pawa R, Canakis A, Huang C, Jamil LH, Aneese AM, Glamour BK, Smith ZL, Hanley KA, Wood J, Patel HK, Shah JN, Agarunov E, Sethi A, Fogel EL, McNulty G, Haseeb A, Trieu JA, Dixon RE, Yang JY, Mendelsohn RB (Medicine), Calo D (Medicine), Aroniadis OC, LaComb JF, Scheiman JM, Sauer BG, Dang DT, Piraka CR, Shah ED, Pohl H, Tierney WM, Mitchell S, Condon A, Lenhart A, Dua KS, Kanagala VS, Kamal A, Singh VK, Pinto-Sanchez MI, Hutchinson JM, Kwon RS, Korsnes SJ, Singh H, Solati Z, Willingham FF, Yachimski PS, Conwell DL, Mosier E, Azab M, Patel A, Buxbaum J, Wani S, Chak A, Hosmer AE, Keswani RN, DiMaio CJ, Bronze MS, Muthusamy R, Canto MI, Gjeorgjievski VM, Imam Z, Odish F, Edhi AI, Orosey M, Tiwari A, Patwardhan S, Brown NG, Patel AA, Ordiah CO, Sloan IP, Cruz L, Koza CL, Okafor U, Hollander T, Furey N, Reykhart O, Zbib NH, Damianos JA, Esteban J, Hajidiacos N, Saul M, Mays M, Anderson G, Wood K, Mathews L, Diakova G, Caisse M, Wakefield L, Nitchie H, Waljee AK, Tang W, Zhang Y, Zhu J, Deshpande AR, Rockey DC, Alford TB, Durkalski V; for the North American Alliance for the Study of Digestive Manifestations of COVID-19.
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1355-1365.e4. doi: 10.1016/j.cgh.2020.09.041. Epub 2020 Oct 1.
Summary: The authors studied gastrointestinal symptoms among 1992 patients hospitalized with COVID-19 and found that most symptoms were mild and not an indicator of the severity of the disease.
Laszkowska M (Medicine), Faye AS, Kim J, Truong H, Silver ER, Ingram M, May B, Ascherman B, Bartram L, Zucker J, Sobieszczyk ME, Abrams JA, Lebwohl B, Freedberg DE, Hur C6.
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1402-1409.e1. doi: 10.1016/j.cgh.2020.09.037. Epub 2020 Sep 30.
Summary: This retrospective study looked at gastrointestinal (GI) symptoms among 2804 hospitalized patients with COVID-19. The authors observed that patients with GI symptoms had less severe COVID-19 disease.
Stahl M (Graduate Fellow), Narendra V (Graduate Fellow), Jee J (Graduate Fellow), Derkach A (Biostat/Epidemiology), Maloy M (Health Informatics), Geyer MB (Medicine), Mato AR (Medicine), Roeker LE (Medicine), Tallman MS (Medicine), Shah GL (Medicine), Daniyan A (Medicine), Goldberg AD (Medicine).
Leuk Lymphoma. 2021 Aug;62(8):1940-1948. doi: 10.1080/10428194.2021.1885664. Epub 2021 Jun 28.
Summary: This research article found that patients with hematological cancers were at significantly higher risk for poorer outcomes when diagnosed with Covid-19. They found that a diagnosis of AML, active treatment in the previous 3 months, neutropenia within 7 days prior to and within 28 days after Covid-19 diagnosis, or more than 3 comorbidities, all increased odds of death.
Frank MO, Blachere NE, Parveen S, Hacisuleyman E, Fak J, Luna JM, Michailidis E, Wright S, Stark P, Campbell A, Foo A, Sakmar TP, Huffman V, Bergh M, Goldfarb A, Mansisidor A, Patriotis AL, Palmquist KH, Poulton N, Leicher R, Vargas CDM, Duba I, Hurley A, Colagreco J, Pagane N, Orange DE, Mora K, Rakeman JL, Fowler RC, Fernandes H, Lamendola-Essel MF (SKI Medicine), Didkovsky N, Silvera L, Masci J, Allen M, Rice CM, Darnell RB.
PLoS One. 2021 Jun 25;16(6):e0252949. doi: 10.1371/journal.pone.0252949. eCollection 2021.
Summary: The authors report their results in this study on validating a PCR-based saliva assay, the Darnell Rockefeller University Laboratory (DRUL) saliva assay, in a preschool program setting.
Morjaria S (Medicine), Nouovini R (Medicine), Sirintrapun SJ (Pathology).
J Appl Lab Med. J Appl Lab Med. 2021 Nov 1;6(6):1688-1693. doi: 10.1093/jalm/jfab078. Epub 2021 Nov 9.
Summary: This article presents a COVID-19 testing framework based on thought experiments used for four frequently encountered community scenarios.
Seban RD, Champion L, Yeh R (Radiology), Schwartz LH, Dercle L.
Eur J Nucl Med Mol Imaging. 2021 Oct;48(11):3351-3352. doi: 10.1007/s00259-021-05468-z. Epub 2021 Jun 23.
Summary: In this letter to the editor, the authors report on the potential theranostic value of [18F]-FDG PET in the era of RNA vaccination.
Rentscher KE, Zhao X, Small BJ, Cohen HJ, Dilawari AA, Patel SK, Bethea TN, Van Dyk KM, Nakamura ZM, Ahn J, Zhai W, Ahles TA (Psychiatry Service), Jim HSL, McDonald BC, Saykin AJ, Root JC (Psychiatry Service), Graham DMA, Carroll JE, Mandelblatt JS.
Cancer. 2021 Oct 1;127(19):3671-3679. doi: 10.1002/cncr.33687. Epub 2021 Jun 23.
Summary: This original article describes the impact of Covid-19 loneliness and mental health on older breast cancer survivors, but found that both cancer survivors and women without cancer experienced similar changes to their mental health. They concluded that screening for loneliness is important for all older women at risk during the pandemic.
von Delft, Frank, Calmiano M, Chodera J (Computational and Systems Biology Program), Griffen E, Lee A, London N, Matviuk T, Perry B, Robinson M, von Delft A.
Nature. 2021 Jun 17;594:330-332. doi: 10.1038/d41586-021-01571-1.
Summary: In this comment, the authors report on a team assembled from Twitter called the COVID moonshot. One hundred fifty collaborators work on open drug-discovery research.
Thompson MA, Henderson JP, Shah PK, Rubinstein SM, Joyner MJ, Choueiri TK, Flora DB, Griffiths EA, Gulati AP, Hwang C, Koshkin VS, Papadopoulos EB (Medicine), Robilotti EV (Medicine), Su CT, Wulff-Burchfield EM, Xie Z, Yu PP, Mishra S, Senefeld JW, Shah DP, Warner JL.
JAMA Oncol. 2021 Jun 17. doi: 10.1001/jamaoncol.2021.1799. (Epub ahead of print)
Summary: This original research describes the potential benefit of convalescent plasma for patients with hematological cancer and Covid-19 infection.
Fischer JC, Schmidt AG, Boelke E, Uhrberg M, Keitel V, Feldt T, Jensen B, Häussinger D, Adams O, Schneider EM, Balz V, Enczmann J, Rox J, Hermsen D, Schulze-Bosse K, Kindgen-Milles D, Knoefel WT, van Griensven M, Haussmann J, Tamaskovics B, Plettenberg C, Scheckenbach K, Corradini S, Pedoto A (Anesthesiology), Maas K, Schmidt L, Grebe O, Esposito I, Erhardt A, Peiper M, Buhren BA, Calles C, Stöhr A, Lichtenberg A, Freise N, Lutterbeck M, Rezazadeh A, Budach W, Matuschek C.
Research Square. 2021 June 16. doi: 10.21203/rs.3.rs-600023/v1.
Summary: In this observatory study, the authors studied if specific HLA alleles in 157 adult COVID-19 patients could be associated with the severity of the disease.
Zhang WA, Morjaria S (Medicine), Kaltsas A (Medicine), Hohl TM (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Ld - Advanced Practice Providers), Predmore J, Perez-Johnston R (Radiology), Jee J (Graduate Staff), Daniyan AF (Medicine), Perales M (Medicine), Taur Y (Medicine).
Clin Infect Dis. 2021 Jun 10;ciab534. doi: 10.1093/cid/ciab534. (Epub ahead of print)
Summary: In this retrospective cohort study of 379 cancer patients infected with COVID-19, the authors study if the administration of filgrastim because of neutropenia impacted the severity of COVID
Singh A, Garg A, Mandlik D, Vander Poorten V, Patel SG (Surgery), O'Neill JP, Spirano G, Shaha A (Surgery), Chaturvedi P, Cernea C, Shah J (Surgery).
J Surg Oncol. 2021 Jun 9. doi: 10.1002/jso.26571. (Epub ahead of print)
Summary: This article reports on the results of an international survey on the quality of life among health practitioners caring for Head and Neck Cancer patients during the COVID-19 pandemic.
Emard N (SKI Integrative Medicine), Lynch KA (SKI Psychiatry/Counseling), Liou KT (Integrative Medicine), Atkinson T (Psychiatry Service), Green AK (Medicine), Daly B (Medicine), Trevino K (Psychiatry Service), Mao JJ (Integrative Medicine).
JMIR Cancer. 2021 Jun 8;7(2):e27384. doi: 10.2196/27384. Epub 2021 Jan 22.
Summary: This article reports on a study of 30 cancer patients who participated in a virtual mind-body program during the COVID-19 pandemic to determine the program's impact on the patients’ psychosocial well-being. It demonstrated the program's potential for addressing behavioral, psychological, and social challenges faced by cancer patients.
Feldman S (Graduate Staff), Liu J (Medicine), Steingart R (Medicine), Gupta D (Medicine).
Curr Treat Options Oncol. 2021 Jul; 22(7)58. doi: 10.1007/s11864-021-00855-y. Epub 2021 Jun 7.
Summary: This article describes how Covid-19 impacted training for cardio-oncology and how programs and trainees can adapt to the challenges.
LaPlant Q (Radiation Oncology), Thor M (Medical Physics), Shaverdian N (Radiation Oncology), Shin JY (Radiation Oncology), Gilbo P (Radiation Oncology), Luo J (Graduate Staff), Gomez DR (Radiation Oncology), Gelblum DY (Radiation Oncology).
Radiother Oncol. 2021 Jun 6;S0167-8140(21)06574-9. doi: 10.1016/j.radonc.2021.06.002.
Summary: This Letter to the Editor describes research conducted at Memorial Sloan Kettering Cancer Center aimed at establishing the possible impact of radiation therapy (RT) to cardiopulmonary structures on the outcomes of COVID-19 infection in cancer patients who underwent RT prior to contracting COVID-19. While some impact was found to be related to the risk of hospitalization due to COVID-19, the study did not find the increased risk of severe infection or death. The researchers conclude that, while cancer patients with a history of thoracic RT should be closely monitored, RT should continue to be used when treating cancer patients during the COVID-19 pandemic.
Daly B (Medicine), Lauria TS (Nursing), Holland JC (Nursing), Garcia J (Nursing), Majeed J (Ld-Advanced Practice Providers), Walters CB (Patient & Caregiver Engagement), Zablocki M (Strategy and Analytics), Chow K (Ld-Advanced Pratice Providers), Strachna O (Health Informatics), Giles CE (Ld-Advanced Practice Providers), Kelly MF (Ld-Advanced Practice Providers), Housen A (Ld-Advanced Practice Providers), Canavan M (Ld-Advanced Practice Provdiers), Maresca NM (Ld-Advanced Practice Providers), Baser R (Biostatistics & Epidemiology), Salvaggio R (Nursing), Robson ME (Medicine), Reidy-Lagunes DL (Medicine).
JCO Oncol Pract. 2021 Sep;17(9):e1278-e1285. doi: 10.1200/OP.21.00269. Epub 2021 Jun 4.
Summary: This study describes patient perspectives on remote monitoring at home of oncology patients for Covid-19 infections.
Oh D, Haffey P, Patel A, Gulati A (Anesthesiology).
Pain Med. 2021 Ju1;22(7):1642-1650. doi: 10.1093/pm/pnab163. Epub 2021 Jun 4.
Summary: This study looks at intravenous ketamine for cancer-related neuropathy. The study was conducted during the COVID-19 pandemic.
Rosa WE (SKI Psychiatry/Counseling), Levoy K, Battista V, Dahlin C, Thaxton C, Greer K.
J Hosp Palliat Nurs. 2021 Jun 2. doi: 10.1097/NJH.0000000000000773. (Epub ahead of print)
Summary: This article presents a step by step coaching process for nurses intended to mitigate psychological distress in health practitioners caused by mass bereavement during COVID-19 pandemic.
Papanicolaou GA (Medicine), Neofytos D.
Curr Opin Infect Dis. 2021 Aug 1;34(4):273-274. doi: 10.1097/QCO.0000000000000744.
Summary: This editorial describes how even during the Covid-19 pandemic patients were still receiving transplants, however Covid-19 presented significant challenges for patients post-transplant.
Gras-Valentí P, Mora-Muriel JG, Chico-Sánchez P, Algado-Sellés N, Soler-Molina VM, Hernández-Maldonado M, Lameiras-Azevedo AS, Jiménez Sepúlveda NJ, Gómez Sotero IL, Villanueva-Ruiz CO, Barrenengoa-Sañudo J, Fuster-Pérez M, Cánovas-Jávega S, Cerezo-Milan P, Monerris-Palmer M, Llorens-Soriano P, Merino-Lucas E, Rodríguez-Diaz JC, Gil-Carbonell J, Sánchez-Martínez R, Pastor-Cesteros R, Mena-Esquivias L, Galiana-Ivars M, Jaime-Sánchez FA, Margarit-Ferri C, Gonzalez-deDios J, Lloret G, García-Alonso MA, Sánchez-Vela P (Human Oncology & Pathogenesis Program), Sánchez-Payá J.
J Patient Saf. 2021 Jun 1;17(4):323-330. doi: 10.1097/PTS.0000000000000852. Epub 2021 Apr 7.
Summary: This study of healthcare worker exposure to COVID recommended the continuous wearing of surgical masks in both patient and staff areas of the hospital.
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
J Autoimmun. 2021 Jun;120:102644. doi: 10.1016/j.jaut.2021.102644. Epub 2021 Apr 27.
Summary: The research reported in this article was aimed at exploring autoimmune symptoms caused by SARS-CoV-2 infection. The researchers created a comprehensive resource and atlas for the investigation of autoimmune sequelae of COVID-19 (“long COVID”). This is a second study resulting from this research with new contribution to the knowledge of the relationships between COVID infection and autoimmunity. This research and the atlas contributes to ongoing and future studies into the mechanisms of long-term autoimmune consequences after acute COVID.
Motzer J (Medicine), Jonasch EA, McGregor BA, Figlin RA.
Kidney Cancer J. 2021 Jun;19(2):42-47. doi: 10.52733/KCJ19n2-r1.
Summary: In this roundtable discussion, leading cancer experts from across the United States share their views on current changes, challenges and opportunities for delivering cancer care during the COVID-19 pandemic.
Bubb TN (Medicine), Haas JP.
Am J Infect Control. 2021 Jun;49(6 Suppl.): S8-S9. doi: 10.1016/j.ajic.2021.04.034.
Summary: This conference abstract reports on the results of a survey posted periodically on social media in the first half of 2020 and completed by specialized healthcare workers - Infection Preventionists (IPs) - from 16 US states and 4 countries, working predominantly in Acute Care. The reported experiences of IPs during the beginning of the pandemic included working long hours/overtime, shortages of protective equipment, stress and emotional exhaustion, etc. At the same time the survey respondents felt that their profession's standing was boosted.
Ferreri AJM, Steffanoni S, Calimeri T, Laurenge A, Fox CP, Soussain C, Grommes C (Neurology), Sassone MC, Touat M, Boot J, Crosbie N, Chaganti S, Dietrich J, Alencar A, Itchaki G, Hoang Xuan K, Batchelor T, Cwynarski K.
Hematol Oncol. 2021 Jun;39 (Suppl. 2):227-229. doi: 10.1002/hon.68_2880.
Summary: This conference abstract reports an international study of 50 patients with CNS lymphoma and concurrent COVID-19.
Moreira DC, Millen GC, Sands S (Psychiatry Service), Kearns PR, Hawkins DS.
Am Soc Clin Oncol Educ Book. 2021;41:1-10. doi: 10.1200/EDBK_321497.
Summary: The article is a review of the challenges and direct and collateral effects of the COVID-19 pandemic on the care of children with cancer. Reviewed are such aspects as the severity of COVID-19 in pediatric cancer patients, adaptation of health care delivery to the pandemic challenges, patient access to cancer diagnosis and care during the pandemic, impact on clinical trials in pediatric oncology, etc.
Croll TI, Diederichs K, Fischer F, Fyfe CD, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne AM (Graduate Studies), Reeves M, Richardson JS, Santoni G, Stäb S, Tronrud DE, von Soosten LC, Williams CJ, Thorn A.
Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7.
Summary: This article reports on the ongoing efforts of structural biology scientists in improving and deepening accumulated knowledge about the structures of SARS-CoV-2 proteins.
Rosa WE (SKI Psychiatry/Counseling).
Online J Issues Nurs. 2021 May 31;26(2). doi: 10.3912/OJIN.Vol26No02ManOS.
Summary: This overview describes the impact of the Covid-19 pandemic on nurses and the nursing profession.
Mendoza R, Saha N (Structural Biology), Momeni A, Gabutan E, Alawad M, Dehghani A, Diks J, Lin B, Wang D, Alshal M, Fyke W, Wang B, Himanen JP (Structural Biology), Premsrirut P, Nikolov DB (Structural Biology).
Heliyon. Heliyon. 2021 Jun;7(6):e07200. doi: 10.1016/j.heliyon.2021.e07200. Epub 2021 May 31.
Summary: This research article describes a potential pharmacological target for treating Covid-19-related inflammation.
Fisher CL, Wright KB, Hampton CN, Vasquez TS, Kastrinos A, Applebaum AJ (Psychiatry Service), Sae-Hau M, Weiss ES, Lincoln G, Bylund CL.
Transl Behav Med. 2021 May 25;11(5):1187-1197. doi: 10.1093/tbm/ibab021.
Summary: This article reports on the results of a survey of adult child caregivers caring for a parent diagnosed with a blood cancer during the COVID-19 pandemic. This study revealed the patterns of uncertainty caregivers experienced, and established the need for the supportive services to help caregivers provide care and deal with the psychological burden experienced during the global health crisis.
Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP (Graduate Studies), Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD (Computational and Systems Biology Program), Bowman GR.
Nat Chem. 2021 Jul;13(7):651-659. doi: 10.1038/s41557-021-00707-0. Epub 2021 May 24.
Summary: This paper reports on the efforts of over a million citizen scientists that participated in the Folding@home initiative to learn more about the SARS-CoV-2 protein structures and their conformational changes. They developed a "distributed computing project to create the first exascale computer and simulate 0.1 seconds of the viral proteome."
Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA (Human Oncology and Pathogenesis Program), Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE (Laboratory Medicine), Kumar A (Medicine), Widman AJ (Graduate Fellow), DeWolf S (Medicine), Boutemine SR (Medicine), Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, Maxwell KN, Reilly JP, Maslak PG (Laboratory Medicine), Vonderheide RH, Wolchok JD (Human Oncology and Pathogenesis Program), Hensley SE, Wherry EJ, Meyer NJ, DeMichele AM, Vardhana SA (Medicine), Mamtani R, Huang AC.
Nat Med. 2021 Jul;27(7):1280-1289. doi: 10.1038/s41591-021-01386-7. Epub 2021 May 20.
Summary: This study reports on a prospective observational cohort study of patients with cancer hospitalized with COVID-19 that found that CD8 T cells might influence recovery from COVID-19 when humoral immunity is deficient, suggesting that CD8 T cell responses to vaccination might provide protection in patients with hematologic cancer in this situation.
Morris A, McCorkindale W, The COVID Moonshot Consortium (Bruce Macdonald H (Computational and Systems Biology Program), Rufa D (Graduate Studies), Wittmann M (Computational and Systems Biology Program), Boby ML (Graduate Studies), Glass W (Computational and Systems Biology Program) in group), Drayman N, Chodera JD (Computational and Systems Biology Program), Tay S, London N, Lee AA. Chem Commun. 2021 Jun 18;57(48):5909-5912. doi: 10.1039/d1cc00050k. Epub 2021 May 6.
Summary: This paper reports on the work of researchers participating in the COVID Moonshot initiative and their use of machine learning to make predictions about chemical targets in their attempt to "develop patent-free antivirals with open science and open data."
Hoff NP, Freise N, Schmidt AG, Firouzi-Memarpuri P, JReifenberger J, Lüdde T, Boelke E, Meller S, Homey B, Torsten Feldt T, Ole Jensen BE, Keitel V, Schmidt L, Maas K, Haussmann J, Tamaskovics B, Budach W, Fischer JC, Buhren BA, Knoefel WT, Schneider M, Gerber PA, Pedotoa A (Anesthesiology), Häussinger D, Grebe O, van Griensven M, Braun SA, Salzmann S, Rezazadeh A, Matuschek C.
Research Square. 2021 May 13. doi: 10.21203/rs.3.rs-507024/v1.
Summary: This preprint reports on an analysis of patients with "COVID arm," a delayed skin reaction that has occurred in patients who received the mRNA-based COVID-19 vaccines. The authors concluded that although most cases resolve spontaneously, "topical glucocorticosteroids and oral anti histamines are effective in resolving the skin lesions and controlling symptoms."
Roeker LE (Medicine), Knorr DA (Medicine), Thompson MC (Graduate Fellow), Nivar M (Medicine), Lebowitz S (Outpatient Operations), Peters N (Outpatient Operations), Deonarine I Jr (Information Systems), Momotaj S (Medicine), Sharan S (Research Service Centers), Chanlatte V (Medicine), Hampton B (Medicine), Butala L (Nursing), Amato L (Nursing), Richford A (Nursing), Lunkenheimer J (Nursing), Battiato K (Nursing), Laudati C (Nursing), Mato AR (Medicine).
Leukemia. 2021 Sep;35(9):2703-2705. doi: 10.1038/s41375-021-01270-w. Epub 2021 May 13.
Summary: The study reported in this Letter to the Editor demonstrated the diminished immune response to SARS-CoV-2 mRNA vaccines in patients with chronic lymphocytic leukemia (CLL). Vaccination in patients with CLL may not have the same efficacy as in the general population, especially in patients receiving CLL-directed therapy
Jacob RP (Laboratory Medicine), Flynn J (Biostat/Epidemiology), Devlin SM (Biostat/Epidemiology), Maloy M (Health Informatics), Giralt SA (Medicine), Maslak P (Laboratory Medicine), O'Reilly RJ (Pediatrics), Tonon JA (Laboratory Medicine), Perales MA (Medicine), Avecilla ST (Laboratory Medicine), Cho C (Medicine).
Transplant Cell Ther. 2021 Aug;27(8):697.e1-697.e5. doi: 10.1016/j.jtct.2021.04.026. Epub 2021 May 13.
Summary: Since the COVID-19 pandemic has resulted in most medical centers using cryopreserved grafts for allogeneic hematopoietic cell transplantation, this single-center analysis of adult patients with hematologic malignancies who underwent allo-HCT with cryopreserved CD34-selected allo-HCT grafts is timely as it demonstrates that cryopreservation of CD34+ HPC grafts used in allo-HCT is a safe and practical option during COVID-19 times.
Choudhury NJ (Medicine), Riely GJ (Medicine), Sabbatini PJ (Physician in Chief), Hellmann MD (Medical Physics).
Cancer Cell. 2021 Jul 12;39(7):897-899. doi: 10.1016/j.ccell.2021.05.001. Epub 2021 May 7.
Summary: The authors of this Letter suggest applying the lessons and experience of conducting COVID-19 vaccine clinical trials to clinical cancer trials. They emphasize: increasing public trust in clinical research, increasing the understanding of the value of clinical trials (thus making the recruitment of volunteers speedier), simplifying clinical cancer trials design, increasing the transparency of clinical cancer trial protocols, and the efficient delivery of clinical trial results.
Crawford JM, Aguero-Rosenfeld ME, Aifantis I, Cadoff EM, Cangiarella JF, Cordon-Cardo C, Cushing M, Firpo-Betancourt A, Fox AS, Furuya Y, Hacking S, Jhang J, Leonard DGB, Libien J, Loda M, Mendu DR, Mulligan MJ, Nasr MR, Pecora ND, Pessin MS (Laboratory Medicine), Prystowsky MB, Ramanathan LV (Laboratory Medicine), Rauch MB, Riddell S, Roach K, Roth KA, Shroyer KR, Smoller BR, Spitalnik SL, Spitzer ED, Tomaszewski JE, Waltman S, Willis L, Sumer-King Z.
Acad Pathol. 2021 May 7. doi: 10.1177/23742895211006818.
Summary: Eleven academic medical institutions formed the New York State SARS-CoV-2 Testing Consortium in April 2020 to establish and improve communication at the height of the pandemic, and to create and share knowledge between the institutions and the state.
Grever M, Andritsos L, Banerji V, Barrientos JC, Bhat S, Blachly JS, Call T, Cross M, Dearden C, Demeter J, Dietrich S, Falini B, Forconi F, Gladstone DE, Gozzetti A, Iyengar S, Johnston JB, Juliusson G, Kraut E, Kreitman RJ, Lauria F, Lozanski G, Parikh SA, Park J (Medicine), Polliack A, Ravandi F, Robak T, Rogers KA, Saven A, Seymour JF, Tadmor T, Tallman MS (Medicine), Tam CS, Tiacci E, Troussard X, Zent C, Zenz T, Zinzani PL, Wörmann B.
Leukemia. 2021 Jul;35(7):1864-1872. doi: 10.1038/s41375-021-01257-7. Epub 2021 May 4.
Summary: This paper reports on the recommendations for the diagnosis and management of classic hairy cell leukemia (cHCL) that were updated to meet the concerns of and offer preventative measures for the COVID-19 pandemic. Since these patients are generally treated with first-line therapies that puts them in a state of prolonged immunosuppression, this increases their susceptibility to infections and the risk for a severe course of COVID-19.
Navlakha S, Morjaria S (Medicine), Perez-Johnston R (Radiology), Zhang A, Taur Y (Medicine).
BMC Infect Dis. 2021 May 4;21:391. doi: 10.1186/s12879-021-06038-2.
Summary: The authors developed and used a machine learning algorithm based on 267 clinical variables to identify cancer patients at high risk of severe COVID-19 outcomes.
De Luca A, Frusone F, Buzzacchino F, Amabile MI, Taffurelli M, Del Mastro L, Rutgers EJT, Sacchini V (Surgery), Caruso F, Minelli M, Fortunato L.
Eur J Surg Oncol. 2021 May 3;S0748-7983(21)00469-8. doi: 10.1016/j.ejso.2021.04.037. (Epub ahead of print)
Summary: This paper reports on a consenus conference on neoadjuvanr chemotherapy in breast cancer management which was held online due to the COVID-19 pandemic.
Afshar-Oromieh A, Prosch H, Schaefer-Prokop C, Bohn KP, Alberts I, Mingels C, Thurnher M, Cumming P, Shi K, Peters A, Geleff S, Lan X, Wang F, Huber A, Gräni C, Heverhagen JT, Rominger A, Fontanellaz M, Schöder H (Radiology), Christe A, Mougiakakou S, Ebner L.
Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2500-2524. doi: 10.1007/s00259-021-05375-3. Epub 2021 May 1.
Summary: A review of the role of imaging technologies in detecting 19 pathologies related to COVID-19.
Nagaraj G, Accordino MK, French B, Kuderer NM, Lyman GH, Stover DG, Blinder VS (Psychiatry Service), Schmidt AL, Shatsky RA, Grover P, Puc M, Hwang C, Wulff-Burchfield EM, Lewis MA, Menendez AG, Bilen MA, Warner JL, Lustberg MB, Shah DP.
Journal of Clinical Oncology. 2021 May 20;39(15 Suppl.). doi: 10.1200/JCO.2021.39.15_suppl.6500.
Summary: A study of 1,133 patients identified within the COVID-19 and Cancer Consortium registry who are in the United States, have invasive breast cancer, and received a laboratory-confirmed SARS-CoV-2 diagnosis between March 6, 2020 and February 4, 2021.
Shah DP, Shah P, Schmidt AL, Bakouny Z, Farmakiotis D, Abidi M, Rubinstein SM, Figueroa CJ (Medicine), Labaki C, Friese CR, Rathmann J, Hwang C, McKay RR, Park C, Puc M, Nagaraj G, French B, Warner JL, Shete S.
Journal of Clinical Oncology. 2021 May 20;39(15 Suppl.). doi: 10.1200/JCO.2021.39.15_suppl.6563.
Summary: A review of 7,289 adult cancer patients with laboratory-confirmed SARS-CoV-2 infection reported between March 16, 2020 and February 6, 2021 in the international COVID-19 and Cancer Consortium registry, with authors noting that the COVID-19-related lower respiratory tract disease rate is high and associated with worse mortality rates in cancer patients.
Rosa WE (SKI Psychiatry/Counseling), Karanja V, Kpoeh JDN, McMahon C, Booth J.
Nurs Educ Perspect. 2021 Apr 30. doi: 10.1097/01.NEP.0000000000000828. (Epub ahead of print)
Summary: The authors describe their experiences with a 90-minute Partners in Health teleconference with Liberian nurses on challenges and fears related to working during the pandemic.
Melms JC, Biermann J, Huang H, Wang Y, Nair A, Tagore S, Katsyv I, Rendeiro AF, Amin AD, Schapiro D, Frangieh CJ, Luoma AM, Filliol A, Fang Y, Ravichandran H, Clausi MG, Alba GA, Rogava M, Chen SW, Ho P, Montoro DT, Kornberg AE, Han AS, Bakhoum MF (Radiation Oncology), Anandasabapathy N, Suárez-Fariñas M, Bakhoum SF, Bram Y, Borczuk A, Guo XV, Lefkowitch JH, Marboe C, Lagana SM, Del Portillo A, Zorn E, Markowitz GS, Schwabe RF, Schwartz RE, Elemento O, Saqi A, Hibshoosh H, Que J, Izar B.
Nature. 2021 Jul;595(7865):114-119. doi: 10.1038/s41586-021-03569-1. Epub 2021 Apr 29.
Summary: By comparing samples from COVID-19-infected lungs to samples from control lungs, the researchers developed an atlas of lethal COVID-19 on a cellular level.
Moerdler S, Gampel B, Levine JM, Chou A, Madhusoodhan P, Oberg JA, Pierro J, Roberts SS (Pediatrics), Satwani P.
Pediatr Blood Cancer. 2021 Aug;68(8):e29088. doi: 10.1002/pbc.29088. Epub 2021 Apr 29.
Summary: The development of a pediatric hematology oncology fellows education initiative during the pandemic, especially a multi-institutional collaborative education series, promises to reshape curriculum and educational opportunities moving forward.
Ardon O (Pathology), Reuter VE (Pathology), Hameed M (Pathology), Corsale L (Pathology), Manzo A (Pathology), Sirintrapun SJ (Pathology), Ntiamoah P (Pathology), Stamelos E (Information Systems), Schueffler PJ (Collaborative Research Centers - PIC Directed), England C (Hospital Administration), Klimstra DS (Pathology), Hanna MG (Pathology).
Acad Pathol. 2021 Apr 28. doi: 10.1177/23742895211010276.
Summary: A description of how the pandemic impacted MSK's digital pathology workflow from March-June 2020.
Moya EM, Zamore C (SKI Psychiatry/Counseling), Perez LM, Tellez K (SKI Psychiatry/Counseling), Avila A, Aragones A (Psychiatry Service).
J Racial Ethn Health Disparities. 2022 Jun;9(3):1024-1029. doi: 10.1007/s40615-021-01041-4. Epub 2021 Apr 26.
Summary: A comparison of the impact of COVID-19 on low-income Mexican-born parents in New York City and El Paso, TX, including financial, mental health, and healthcare access repercussions.
Pillarsetty N (Radiology), Carter L (SKI Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2021 Jul 1;62(7):1020-1021. doi: 10.2967/jnumed.121.261950.
Summary: This article is an author's response to the comment on their Brief Communication “Oncology-Inspired Treatment Options for COVID-19” published in the Journal of Nuclear Medicine in July of 2020. The authors addressed the issues raised in the comment on their article.
Wingard JR, Ahn KW, Dandoy C, Perales MA (Medicine), Wood WA, Logan B, Riches M, Rizzo JD.
Transplant Cell Ther. 2021 Jul;27(7):533-539. doi: 10.1016/j.jtct.2021.04.008. Epub 2021 Apr 22.
Summary: This article reports on the recommendations, developed by The Center of International Blood and Marrow Transplantation Research (CIBMTR), for COVID-19 related adjustments for centers that perfrom hematopoietic cell transplantations.
Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Da Silva APD, Dias SDSG, da Silva CDS, Ferreira AC, Mattos M, Pão CRR, de Freitas CS, Soares VC, Hoelz LVB, Fernandes TVA, Branco FSC, Bastos MM, Boechat N, Saraiva FB, Ferreira MA, Jockusch S, Wang X, Tao C, Chien M, Xie W (Structural Biology), Patel D (Structural Biology), Garzia A, Tuschl T, Russo JJ, Rajoli RKR, Pedrosa CSG, Vitória G, Souza LRQ, Goto-Silva L, Guimarães MZ, Rehen SK, Owen A, Bozza FA, Bou-Habib DC, Ju J, Bozza PT, Souza TML.
J Antimicrob Chemother. 2021 Jun 18;76(7):1874-1885. doi: 10.1093/jac/dkab072. Epub 2021 Apr 21.
Summary: Identifying exisiting drugs that can be repurposed for use against SARS-Cov-2 became common during the COVID-19 pandemic. This article reports on the research into 2 such drugs, ofosbuvir and daclatasvir, that belong to the anti-HCV class of drugs. The laboratory research confirmed that the drugs in question have potential for treating COVID-19 infection but that further research is needed.
Chaudhuri D, Sasaki K, Karkar A, Sharif S, Lewis K, Mammen MJ, Alexander P, Ye Z, Lozano LEC, Munch MW, Perner A, Du B, Mbuagbaw L, Alhazzani W, Pastores SM (Anesthesiology), Marshall J, Lamontagne F, Annane D, Meduri GU, Rochwerg B.
Intensive Care Med. 2021 May;47(5):521-537. doi: 10.1007/s00134-021-06394-2. Epub 2021 Apr 19.
Summary: This systematic review of randomized controlled clinical trials (RCTs) on the use of corticosteroid drugs in COVID-19 and non-COVID-19 related acute respiratory distress syndrome (ARDS) found that the use of corticosteroids probably reduces mortality in patients with ARDS.
Herishanu Y, Avivi I, Aharon A, Shefer G, Levi S, Bronstein Y, Moshiashvili MM, Ziv-Baran T, Shorer Y, Scarfo L, Joffe E (Medicine), Perry C, Ghia P.
Blood. 2021 Jun 10;137(23):3165-3173. doi: 10.1182/blood.2021011568. Epub 2021 Apr 16.
Summary: About 40% of patients with chronic lymphocytic leukemia (66/167) showed an immune response to the Pfizer mRNA vaccine. Those who had a response tended to be younger, at an earlier disease stage, treatment naïve, or a year or more post-treatment.
Bryan AD, Tatem K, Diuguid-Gerber J, Cooke C, Romanoff A (SKI Surgery), Choudhury N, Scanlon M, Kishore P, Sydney E, Masci J, Bakshi P, Pemmasani S, Davis NJ, Maru D.
medRxiv. 2021 Apr 15. doi: 10.1101/2021.04.12.21255344.
Summary: Researchers determined the prevalence of SARS-CoV-2 antibodies among 727 New York City Health + Hospitals healthcare workers between April 30 and June 30, 2020. Black workers, workers with household COVID exposure, those living in Queens, Brooklyn and the Bronx, and those in non-clinical patient-facing roles were more likely to have positive antibodies. This article is a preprint and has not been peer reviewed.
Ben-Arye E, Paller CJ, Lopez AM, White S, Pendleton E (Integrative Medicine), Kienle GS, Samuels N, Abbawaajii N, Balneaves LG.
Support Care Cancer. 2021 Oct;29(10):6155-6165. doi: 10.1007/s00520-021-06205-w. Epub 2021 Apr 14.
Summary: The Society for Integrative Oncology Practice recommendations include recommendations for online practice of manual, acupuncture, movement, mind-body, herbal, and expressive art therapies.
Dilawari A, Rentscher K, Zhai W, Ahles TA (Psychiatry Service), Ahn J, Bethea T, Carroll JE, Cohen H, Graham D, Jim H, McDonald BC, Nakamura Z, Patel S, Root J, Small B, Saykin A, Tometich D, VanDyk K, Mandelblatt J.
Res Sq. 2021 Apr 14;rs.3.rs-416077. doi: 10.21203/rs.3.rs-416077/v1. (Epub ahead of print)
Summary: This article reports on the results of a survey, administered to older breast cancer survivors in 5 U.S. regions, on medical care disruptions (such as interruptions in the ability to see doctors, receive treatment or supportive therapies, or fill prescriptions) during the COVID-19 pandemic and analyzes the patterns discerned from the responses to the survey.
Kalchiem-Dekel O (Medicine), Schwalk AJ, Patel NM, Lin IH (Biostat/Epidemiology), Beattie JA (Medicine), Husta BC (Medicine), Chawla M (Medicine), Sachdeva A, Akulian JA, Musani AI, Argento AC, Lee HJ, Mullon JJ, Desai NR, Hsia DW, Lee RP (Medicine).
ATS Scholar. 2021 Jun;2(2):236-248. doi: 10.34197/ats-scholar.2020-0126OC. Epub 2021 Apr 13.
Summary: The COVID-19 pandemic had an impact not only on patient care but also on medical education. This article describes the challenges faced by such a hands-on area of medical education as interventional pulmonology. The analysis of the challenges and solutions found could be useful for addressing similar situations in the future.
Starr TN, Czudnochowski N, Zatta F, Park YJ, Liu Z, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG (Computational and Systems Biology), Zhang I (Computational and Systems Biology), Dingens AS, Bowen JE, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Tucker H, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota E, Cameroni E, Croll TI, Nix JC, Havenar-Daughton C, Telenti A, Lempp FA, Pizzuto MS, Chodera JD (Computational and Systems Biology), Hebner CM, Whelan SPJ, Virgin HW, Veesler D, Corti D, Bloom JD, Snell G.
bioRxiv. 2021 Apr 8;2021.04.06.438709. doi: 10.1101/2021.04.06.438709.
Summary: The authors characterize the structure of a particular SARS-CoV-2 antibody type to determine features that might be targeted by vaccines and therapeutics in COVID-19 and other diseases. This article is a preprint and has not been peer reviewed.
Emard N (SKI Integrative Medicine), Lynch KA (SKI Psychiatry/Counseling), Liou KT (Integrative Medicine), Atkinson T (Psychiatry Service), Green AK (Medicine), Daly B (Medicine), Trevino K (Psychiatry Service), Mao JJ (Integrative Medicine).
JMIR Cancer. 2021 Apr 7. doi: 10.2196/27384.
Summary: This preprint reports on a study of 30 cancer patients who participated in a virtual mind-body program during the COVID-19 pandemic to determine the program's impact on the patients’ psychosocial well-being. It demonstrated the program's potential for addressing behavioral, psychological, and social challenges faced by cancer patients.
Frank MO, Blachere NE, Parveen S, Hacisuleyman E, Fak J, Luna JM, Michailidis E, Wright S, Stark P, Campbell A, Foo A, Sakmar TP, Huffman V, Bergh M, Goldfarb A, Mansisidor A, Patriotis AL, Palmquist KH, Poulton N, Leicher R, Vargas CDM, Duba I, Hurley A, Colagreco J, Pagane N, Orange DE, Mora K, Rakeman JL, Fowler RC, Fernandes H, Lamendola-Essel MF (SKI Medicine), Didkovsky N, Silvera L, Masci J, Allen M, Rice CM, Darnell RB.
medRxiv. 2021 Apr 6. doi: 10.1101/2021.04.03.21254873.
Summary: The authors developed a saliva test for SARS CoV-2 using a self-collection kit. Its use aided the safe reopening of a child care center. This article is a preprint and has not been peer reviewed.
Chablani SV, Sabra MM (Medicine).
J Endocr Soc. 2021 Apr;5(6):bvab059. doi: 10.1210/jendso/bvab059.
Summary: A survey of nine MSK endocrinologists and endocrine surgeons shows that while physicians were overall satisfied with providing care via telemedicine, work can be done to improve technical, communication, and insurance barriers.
Tkacik PT, Dahlberg JL, Johnson JE, Hoth JJ, Szer RA, Hellman SE (Medical Physics).
PLoS One. 2021 Apr 5;16(4):e0249586. doi: 10.1371/journal.pone.0249586.
Summary: A study of the size and quantity of aerosolized particles resulting from surgery. The authors developed a method for measuring the airborne particles in an operating room setting.
Khawaja F, Chemaly RF, Dadwal S, Pergam S, Wingard J, Auletta J, El Boghdadly Z, Abidi M, Waghmare A, Shahid Z, Pabinger-Fasching I, Michaels L, Hill J, Hohl T (Medicine), Kamboj M (Medicine), Papanicolaou G (Medicine), Boeckh M.
ASTCT. 2021 Apr 1. url: https://www.astct.org/viewdocument/ash-astct-covid-19-vaccination-for-1. (Epub only)
Summary: This document presents the American Society for Transplantation and Cellular Therapy and the American Society of Hematology (ASTCT/ASH) answers to the frequently asked questions on COVID-19 vaccine use in patients undergoing hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR) T-cell therapy. The overall recommendation (as of the time of publication in April 2021) for these patients is to get vaccinated due to the proven efficacy and safety of the COVID-19 vaccines currently approved under Emergency Use Authorization in the US (Moderna, Pfizer & BioNTech and J&J). "All current guidance and responses are based on opinions of the ASTCT/ASH COVID-19 Vaccine expert panel. This document will be updated periodically when new data becomes available."
Burnett GW, Zhou G, Fried EA, Shah RS (Anesthesiology), Park C, Katz D.
Korean J Anesthesiol. 2021 Apr;74(2):158-164. doi: 10.4097/kja.20511. Epub 2020 Nov 17.
Summary: This paper reports on a randomized study of forty-four anesthesiology trainees and faculty who completed a simulated anesthetic case in order to determine if a preoperative educational visual aid led to improved decontamination practices during their use of an aerosol box (which was developed to minimize viral exposure during aerosolizing procedures during the COVID-19 pandemic).
Kim D, Hanna MG (Pathology), Vanderbilt C (Pathology), Sirintrapun SJ (Pathology).
Acta Med Acad. 2021 Apr;50(1):136-142. doi: 10.5644/ama2006-124.331.
Summary: This review details the development and structure of the pathology informatics rotation during Covid-19.
Rosa WE (SKI Psychiatry/Counseling), Dahlin C, Battista V, Finlayson CS (Nursing), Wisniewski RE (Ld - Advanced Practice Providers), Greer K, Ferrell BR.
Clin J Oncol Nurs. 2021 Apr;25(2):119-125. doi: 10.1188/21.CJON.119-125.
Summary: This article describes the need that emerged during the COVID-19 pandemic for oncology nurses to acquire palliative care skills to be better equipped for meeting the needs of patients with cancer. The article supports and advocates for incorporating primary palliative care education into the oncology nursing practice.
Fernandes DA, Araújo Filho JAB (Radiology), de Jesus AR.
Rev Esp Enferm Dig. 2021 Mar 25. doi: 10.17235/reed.2021.7964/2021. (Epub ahead of print)
Summary: With this case report, the authors would like to make health care workers aware of rare thromboembolic events as another possible complication of COVID-19.
Sobrado LF, Nahas CSR, Marques CFS, de Castro Cotti GC, Imperiale AR, Averbach P, de Meira Júnior JD, Horvat N (Radiology), Ribeiro-Júnior U, Cecconello I, Nahas SC.
Clinics (Sao Paulo). 2021 Mar 24;76:e2507. doi: 10.6061/clinics/2021/e2507.
Summary: The study was conducted by a group of researchers from Brazil to evaluate the safety of performing elective surgery for colorectal cancer and Inflammatory Bowel Disease at the time of the COVID-19 pandemic. This retrospective study evaluated the outcomes of elective laparascopic, open, and robotic colorectal surgeries performed at a single tertiary oncological hospital between March 10 and September 9, 2020. The study established that elective colorectal surgeries could be safely performed during the pandemic but preoperative screening for SARS-CoV-2 should be done to decrease the risk of in-hospital cross infection.
Blackler L (Physician in Chief), Scharf AE (Physician in Chief), Masciale JN (Quality of Care Initiative), Lynch KA (Psychiatry/Counseling), Riches JC (Medicine), Matsoukas K (Information Systems), Colletti M (Ld - Advanced Practice Providers), Wall L (Nursing), Chawla S (Anesthesiology), Coyle N (Neurology), Alici Y (Psychiatry Service), Guest R (Human Resources), Voigt LP (Anesthesiology).
Res Sq. 2021 Mar 24:rs.3.rs-268807. doi: 10.21203/rs.3.rs-268807/v1. (Epub ahead of print)
Summary: In this paper, the authors report the results of a survey sent to Memorial Sloan Kettering workers (clinical and non-clinical) in June 2020 during a COVID-19 peak. In addition, they outline suggestions in the case of a new surge or in the event of another public health crisis.
Delgado J, Siow S, de Groot J, McLane B, Hedlin M (Medicine).
J Med Ethics. 2021 Jun;47(6):374-382. doi: 10.1136/medethics-2020-106764. Epub 2021 Mar 24.
Summary: This article explores the increased potential for moral distress in healthcare professionals during the COVID-19 pandemic. It introduces the new term 'collective moral resilience' to help conceptualize the impact of group settings on addressing potential moral distress experienced by healthcare professionals during trying and challenging times, such as the COVID-19 pandemic.
Halley MC, Mathews KS, Diamond LC (Psychiatry Service), Linos E, Sarkar U, Mangurian C, Sabry H, Goyal MK, Olazo K, Miller EG, Jagsi R, Linos E.
J Womens Health (Larchmt). 2021 Apr;30(4):514-524. doi: 10.1089/jwh.2020.8964. Epub 2021 Mar 23.
Summary: This study reports on the results of an online survey administered to the Physician Moms Group (PMG) and PMG COVID-19 Subgroup on Facebook, to understand their work-related and home life concerns during the COVID-19 pandemic. The survey results demonstrated that the concerns of physicians varied somewhat depending on their work settings (e.g. frontline vs non-frontline physicians) and family situation (e.g., children of certain ages). The expressed concerns were related to the following themes: Community and Government Support, Personal Health and Safety, Organizational Communication and Relationships, Family Health and Safety, Patient Care and Safety Financial/Job Security, Parenting/Homeschooling, Work/Life Balance, Access to Childcare, and Spouse/Partner Relationships.
Desai A, Gainor JF, Hegde A, Schram AM (Medicine), Curigliano G, Pal S, Liu SV, Halmos B, Groisberg R, Grande E, Dragovich T, Matrana M, Agarwal N, Chawla S, Kato S, Morgan G, Kasi PM, Solomon B, Loong HH, Park H, Choueiri TK, Subbiah IM, Pemmaraju N, Subbiah V.
Nat Rev Clin Oncol. 2021 May;18(5):313-319. doi: 10.1038/s41571-021-00487-z. Epub 2021 Mar 15.
Summary: With this paper, the authors seek to give guidance on COVID-19 vaccination for patients enrolled or about to get enrolled in oncologic clinical trials. They conclude that COVID-19 vaccination should be standard of care for those patients with some rare exceptions where it would appear not to serve the patient's best interest.
Rosa WE (SKI Psychiatry/Counseling), Pandey S (Nursing), Epstein AS (Medicine), Connor SR, Nelson JE (Medicine).
Palliat Support Care. 2021 Mar 15:1-5. doi: 10.1017/S1478951521000237. (Epub ahead of print)
Summary: In this article, the authors report Memorial Sloan Kettering Cancer Center's experience on hosting the United States World Hospice and Palliative Care Day (WHPCD) Celebration. Two hundred seventy participants from at least 16 countries joined the virtual event on October 10, 2020.
Matos LL, Forster CHQ, Marta GN, Castro Junior G, Ridge JA, Hirata D, Miranda-Filho A, Hosny A, Sanabria A, Gregoire V, Patel SG (Surgery), Fagan JJ, D'Cruz AK, Licitra L, Mehanna H, Hao SP, Psyrri A, Porceddu S, Galloway TJ, Golusinski W, Lee NY (Radiation Oncology), Shiguemori EH, Matieli JE, Shiguemori APAC, Diamantino LR, Schiaveto LF, Leão L, Castro AF, Carvalho AL, Kowalski LP.
Cancer Causes Control. 2021 May;32(5):459-471. doi: 10.1007/s10552-021-01411-7. Epub 2021 Mar 11.
Summary: The authors used a model of head and neck squamous cell carcinoma progression to estimate the increased mortality burden of the pandemic on cancer patients. This preprint has not been peer reviewed.
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Babady NE (Laboratory Medicine).
J Clin Virol. 2021 May;138:104790. doi: 10.1016/j.jcv.2021.104790. Epub 2021 Mar 10.
Summary: This meeting abstract reports on the results of a study (that used a pool of 8 samples) evaluating sample pooling for SARS-CoV-2 testing. It was found to be a viable option worth investigating further.
Kutner A (Medicine), Love D (Medicine), Markova A (Medicine), Rossi A (Medicine), Lee E (Medicine), Nehal K (Medicine), Lacouture M (Medicine), Rotemberg V (Medicine).
J Digit Imaging. 2021 Apr;34(2):284-289. doi: 10.1007/s10278-021-00425-6. Epub 2021 Mar 10.
Summary: This experience report details the teledermatology consultations at MSKCC and how this can impact future improvements to the service.
Hussain K, Marghoob AA (Medicine), Patel NP.
Dermatol Pract Concept. 2021 Mar 8;11(2):e2021069. doi: 10.5826/dpc.1102a69.
Summary: This article describes the evolution of teledermoscopy and how clinicians need to use the technique to its full potential to provide both static and dynamic clues.
Adelhoefer S, Berning P, Solomon SB (Radiology), Maybody M (Radiology), Whelton SP, Blaha MJ, Dzaye O.
Cancer Causes Control. 2021 Jun;32(6):577-585. doi: 10.1007/s10552-021-01409-1. Epub 2021 Mar 8.
Summary: This study describes the decrease in cancer-related searches during the Covid-19 pandemic, beginning in March 2020. This decline mirrors the decline in cancer diagnoses during the same time frame.
Szenes V (Nursing), Bright R (Nursing), Diotallevi D (Nursing), Melendez G (Nursing), Martinez C (Ld - Advanced Practice Providers), Zakak N, (Ld - Advanced Practice Providers), Killinger J (Pediatrics), Gilheeney S (Pediatrics), Roberts SS (Pediatrics), Kamboj M (Medicine), Bender JG (Pediatrics), Kung AL (Pediatrics), Boulad F (Pediatrics).
J Pediatr Oncol Nurs. May-Jun 2021;38(3):176-184. doi: 10.1177/1043454221992301. Epub 2021 Mar 8.
Summary: This paper describes a model developed by MSK Kids during the COVID-19 pandemic for planning continued preparedness that will anticipate "the need to develop plans for the screening, testing, and treating of patients, as well as specific mitigation plans."
Mislang AR, Soto-Perez-de-Celis E, Russo C, Colloca G, Williams GR, O'Hanlon S, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrió RG, Stauder R, Jaklitsch M, Cairo C, Gil LA Jr, Sattar S, Kantilal K, Loh KP, Lichtman SM (Medicine), Brain E, Wildiers H, Kanesvaran R, Battisti NML.
J Geriatr Oncol. 2021 Jun;12(5):848-850. doi: 10.1016/j.jgo.2021.03.003. Epub 2021 Mar 5.
Summary: The International Society of Geriatric Oncology (SIOG) offers Covid-19 vaccination rollout guidelines to prioritize higher risk older patients with cancer.
Park KU, Gregory M, Bazan J, Lustberg M, Rosenberg S, Blinder V (Psychiatry), Sharma P, Pusztai L, Shen C, Partridge A, Thompson A.
Breast Cancer Res Treat.2021 Jul;188(1):249-258. doi: 10.1007/s10549-021-06153-3. Epub 2021 Mar 2.
Summary: This study explored the pandemic-related changes in the practice patterns of medical oncologists, radiation oncologists, and surgeons with regards to their use of neoadjuvant endocrine therapy (NET) for early stage breast cancer. Physicians were surveyed during the initial phase of the pandemic, in May-June2020, when NET was being recommended as an option that made possible the safe deferral of surgery.
Rosa WE (SKI Psychiatry/Counseling), Ferrell BR, Mazanec P.
J Contin Educ Nurs. 2021 Mar 1;52(3):130-135. doi: 10.3928/00220124-20210216-07.
Summary: The authors use the framework of the National Consensus Project Clinical Practice Guidelines for Quality Palliative Care to explore ways to improve nurse education about palliative care.
Zyskind I, Rosenberg AZ, Zimmerman J, Naiditch H, Glatt AE, Pinter A, Theel ES, Joyner MJ, Hill DA, Lieberman MR, Bigajer E, Stok D (Pediatrics), Frank E, Silverberg JI.
JAMA Netw Open. 2021 Mar 1;4(3):e212816. doi: 10.1001/jamanetworkopen.2021.2816.
Summary: This article describes how in culturally bound communities, outbreaks can occur outside of geographic areas, especially during holiday seasons. This study found an increase in outbreaks related to social events during Purim in Orthodox Jewish communities in five different states.
Jee J (Graduate Staff), Stonestrom AJ (Graduate Staff), Devlin S (Biostat/Epidemiology), Nguyentran T (Ld - Advanced Practice Providers), Wills B (Graduate Staff), Narendra V (Graduate Staff), Foote MB (Graduate Staff), Lumish M (Graduate Staff), Vardhana S (Medicine), Pastores SM (Anesthesiology), Korde N (Medicine), Patel D (Medicine), Horwitz S (Medicine), Scordo M (Medicine), Daniyan A (Medicine).
Sci Rep. 2021 Mar 1;11(1):4814. doi: 10.1038/s41598-021-84137-5.
Summary: This study provides a retrospective analysis investigating the effects of oncologic immunomodulatory agents on 820 adult cancer patients (inpatient or outpatient) seen at MSK who were diagnosed with COVID-19 between March 8, 2020 and June 2, 2020.
Friedman DN (Pediatrics), Blackler L (Ethics), Alici Y (Psychiatry Service), Scharf AE (Ethics), Chin M (Psychiatry), Chawla S (Anesthesiology), James MC (Psychiatry), Voigt LP (Anesthesiology).
JCO Oncol Pract. 2021 Mar;17(3):e369-e376. doi: 10.1200/OP.20.00440. Epub 2020 Aug 27
Summary: Treating cancer patients in the time of COVID-19, often in the presence of both cancer and COVID-19 diagnosis, inevitably triggers situations that may raise ethical issues. Clinical ethics consultations in a hospital setting is an instrument aimed at addressing ethical issues that occur in the course of patient care and which concerns clinicians, patients and/or patients' families. This article reviewed Memorial Sloan Kettering Cancer Center clinical ethics consultations that took place in the early and most difficult months of the COVID-19 pandemic, when totally new challenges faced society as a whole, and cancer care in particular.
Wu A (Radiation Oncology), Plodkowski A (Radiology), Ginsberg M (Radiology), Shin J (Surgery), Laplant Q (Radiation Oncology), Shepherd A (Radiation Oncology), Shaverdian N (Radiation Oncology), Ng V (Graduate Staff), Yue Y (Radiation Oncology), Gilbo P (Radiation Oncology), Gelblum D (Radiation Oncology), Braunstein L (Radiation Oncology), Gomez D (Radiation Oncology), Rimner A (Radiation Oncology).
J Thorac Oncol 2021 Mar; 16(3 Suppl.)S252. doi: 10.1016/j.jtho.2021.01.362.
Summary: A review of 414 computed tomography simulation scans performed on 400 radiotherapy patients between March 1, 2020 and April 13, 2020, with authors noting that these scans obtained for radiation treatment planning can be reviewed for signs of COVID-19 pneumonia.
Lauria T (Nursing), Chow K (Nursing), Polskin L (Nursing), Giles C (Physician Assistant), Holland J (Nursing), Majeed J (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):19. doi: 10.1188/21.ONF.E1.
Summary: A description of the patient experience with remote COVID-19 symptom monitoring as implemented by Memorial Sloan Kettering Cancer Center's COVID Cohort Monitoring Team.
Rogers R (Nursing), Singh N (Nursing), Dolan B (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):42. doi: 10.1188/21.ONF.E2.
Summary: A description of the creation of the "Support RN" role within the intensive care unit to help transition step-down nurses to critical care nursing during the COVID-19 pandemic.
Ruby J (Nursing), Noon B (Nursing), Carmody C (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):25. doi: 10.1188/21.ONF.E1.
Summary: A description of a clinical practice change to include manual proning as a standard practice with COVID-19 patients who were mechanically ventilated.
Sales R (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):34. doi: 10.1188/21.ONF.E2.
Summary: A description of how the COVID-19 pandemic impacted the second cohort of a two cohort, non-randomized study to treat patients with oropharyngeal carcinoma and how oncology nurse navigators and oncology nurses responded.
Kim SJ (Nursing), Shahrokni A (Medicine), Korc-Grodzicki B (Medicine), Litchfield H (Medicine), Malling C (Psychiatry), Fessele K (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):26-27. doi: 10.1188/21.ONF.E3.
Summary: A retrospective review of 70 cancer patients over the age of 75 admitted between March 1, 2020 and May 31, 2020 who tested positive for COVID-19 within 72 hours of admission.
Hole A (Nursing), Houlihan N (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):51. doi: 10.1188/21.ONF.E2.
Summary: A description of the experience of standardizing acute and ongoing care for cancer patients during a COVID-19 surge.
Cerulli J (Ld - Advanced Practice Providers), Haviland K (Ld - Advanced Practice Providers).
Oncol Nurs Forum. 2021 Mar;48(2):5-6. doi: 10.1188/21.ONF.E2.
Summary: A description of a COVID-19 pandemic surge plan to meet the needs of cancer patients who were at an increased risk for infection during hospitalization.
Chu S (Nursing).
Oncol Nurs Forum. 2021 Mar;48(2):64. doi: 10.1188/21.ONF.E2.
Summary: An outline of nursing care strategies for critically ill oncology patients during the COVID-19-related surge in intensive care unit patient volume.
Chahar C (Graduate Staff), Choudhary L, Ahuja R, Sreeram K, Choudhary A.
Mod Pathol. 2021 Mar;34(Suppl. 2):325-326. doi: 10.1038/s41379-021-00756-3.
Summary: Results of an electronic survey of 118 pathology trainees to identify how the COVID-19 pandemic impacted their education and training.
Bhanot U (Research Facilities), Kombak FE (Collaborative Research Centers - PIC Directed), Ray-Kirton J (Pathology), Taylor-Mason F (Pathology), Tanaka A (SKI Pathology), Xiaoqing S (Research Facilities), Silber J (Pathology), Roehrl M (Pathology).
Mod Pathol. 2021 Mar;34(Suppl. 2):933. doi: 10.1038/s41379-021-00765-2.
Summary: A description of the experience of the Precision Pathology Center at Memorial Sloan Kettering Cancer Center adopting digital and remote pathology solutions during the COVID-19 pandemic.
Chahar C (Graduate Staff), Choudhary L, Ahuja R, Sreeram K, Choudhary A.
Lab Invest. 2021 Mar;101(Suppl. 1):325-326. doi: 10.1038/s41374-021-00554-0.
Summary: Results of an electronic survey of 118 pathology trainees to identify how the COVID-19 pandemic impacted their education and training.
Bhanot U (Research Facilities), Kombak FE (Collaborative Research Centers - PIC Directed), Ray-Kirton J (Pathology), Taylor-Mason F (Pathology), Tanaka A (SKI Pathology), Xiaoqing S (Research Facilities), Silber J (Pathology), Roehrl M (Pathology).
Lab Invest. 2021 Mar;101(Suppl. 1):933. doi: 10.1038/s41374-021-00563-z.
Summary: A description of the experience of the Precision Pathology Center at Memorial Sloan Kettering Cancer Center adopting digital and remote pathology solutions during the COVID-19 pandemic.
Breitbart W (Psychiatry Service).
Palliat Support Care. 2021 Feb;19(1):1-2. doi: 10.1017/S1478951521000043. (Epub ahead of print)
Summary: This editorial by William Breitbart reflects on the power of reading obituries and thus touching the life stories of those for whom the obituries were written. He highlights the story behind one of the COVID-19 era obituries, that of a Holocaust survivor whose childhood was marred by the tragedy of the genocide of Jews during the Second World War.
Su C, Zhang Y, Flory JH (Medicine), Weiner MG, Kaushal R, Schenck EJ, Wang F.
medRxiv. 2021 Feb 28. doi: https://doi.org/10.1101/2021.02.28.21252645.
Summary: This retrospective study analyzed "14418 COVID-19 patients in five major medical centers in New York City (NYC), between March 1 and June 12, 2020," using machine learning and routinely collected clinical data. The goal of the study was to "derive and validate COVID-19 subphenotypes to assess temporal patterns of these subphenotypes during the pandemic course and examine their interaction with social determinants of health (SDoH)."
Becker AS (Fellow), Perez-Johnston R (Radiology), Chikarmane SA, Chen MM, El Homsi M (Radiology), Feigin KN (Radiology), Gallagher KM (Radiology), Hanna EY, Hicks M, Ilica AT (Fellow), Mayer EL, Shinagare AB, Yeh R (Radiology), Mayerhoefer ME (Radiology), Hricak H (Radiology), Vargas HA (Radiology).
Radiology. 2021 Aug;300(2):E323-E327. doi: 10.1148/radiol.2021210436. Epub 2021 Feb 24.
Summary: People may experience swollen lymph nodes as a side effect of receiving a COVID vaccine. The authors recommend scheduling routine cancer imaging screenings either before vaccination or six weeks after. Patients should not delay getting either the vaccine or clinically urgent imaging.
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehr MH (Pathology).
bioRxiv. 2021 Feb 22. doi: 10.1101/2021.02.21.432171.
Summary: This preprint describes the identification of an autoantigen atlas from human lung epithelium-like A549 cells. The authors hope to understand better the autoimmune diseases caused by COVID-19.
Knight V, Askar MZ, Ntrivalas E (Laboratory Medicine), Nandiwada SL, Peterson LK, Tebo AE, Kadkhoda K, Schmitz JL, Naides SJ, Snyder MR, Sadighi Akha AA.
J Immunol Methods. 2021 May;492:112994. doi: 10.1016/j.jim.2021.112994. Epub 2021 Feb 21.
Summary: A summary of research presented at the virtual conference. MSK's Dr. Susan Prockop spoke about methods for improving transplant outcomes, and Dr. Evangelos Ntrivalas discussed flow cytometry.
Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K (Chemical Biology Program), Li D (Chemical Biology Program), Liu J, Smil D, Luo M (Chemical Biology Program), Jin J, Fish PV, Brown PJ, Vedadi M.
bioRxiv. 2021 Feb 19. doi: 10.1101/2021.02.19.424337.
Summary: In this preprint, the authors present their work on non-structural protein (nsp) 14 to help with developing anti-viral therapeutics against COVID-19.
Urakawa S, Hirashita T, Momose K, Nishimura M (Medicine), Nakajima K, Milsom JW.
Endosc Int Open. 2021 Mar; 9(3):E443-E449. doi: 10.1055/a-1336-2766. Epub 2021 Feb 19.
Summary: The authors make recommendations for endoscopic procedures based on their research into the amount of gas leakage that occurs from a range of devices and use cases.
Abramson Cancer Center at the University of Pennsylvania, American Association for Cancer Research, American Brain Tumor Association, American Cancer Society Cancer Action Network Inc., American Liver Foundation, American Radium Society, American Society for Radiation Oncology, American Society of Hematology, ArmorUp for Life, Association for Clinical Oncology, Association of American Cancer Institutes, Ben & Catherine Ivy Foundation, Blue Hat Foundation, Boston University - Boston Medical Center Cancer Center, Breast Cancer Research Foundation, CancerCare, Cancer Center at Brown University, Cancer Center at Illinois, Cancer Forum of the American Public Health Association, Cancer Support Community, Cardinal Bernardin Cancer Center Stritch School of Medicine Loyola University Chicago, Case Comprehensive Cancer Center at Case Western Reserve University, Chao Family Comprehensive Cancer Center at The University of California Irvine, Children’s Cancer Cause, Cholangiocarcinoma Foundation, Chris Draft Family Foundation, City of Hope, Cleveland Clinic Taussig Cancer Institute, Cold Spring Harbor Laboratory Cancer Center, Colorectal Cancer Alliance, Columbia University Herbert Irving Comprehensive Cancer Center, Community Oncology Alliance, Cure Breast Cancer Foundation, Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, Dana-Farber Cancer Institute, Deadliest Cancers Coalition, Debbie’s Dream Foundation, Duke Cancer Institute, ECAN Esophageal Cancer Action Network, ESMO, EVAN Foundation, FORCE: Facing Our Risk of Cancer Empowered, Fox Chase Cancer Center, Fred & Pamela Buffett Cancer Center at the University of Nebraska Medical Center, Fred Hutchinson Cancer Research Center, Friends of Cancer Research, Global Liver Institute, Georgetown Lombardi Comprehensive Cancer Center, Georgia Cancer Center, GI Cancers Alliance, GO2 Foundation for Lung Cancer, Head and Neck Cancer Alliance, Hope for Stomach Cancer, Huntsman Cancer Institute at The University of Utah, Imerman Angels, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, International Association for the Study of Lung Cancer, International Waldenstrom’s Macroglobulinemia Foundation, Jackson Laboratory, Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, Lazarex Cancer Foundation, Leukemia & Lymphoma Society, Livestrong, Living Beyond Breast Cancer, Loma Linda University Cancer Center, Lung Cancer Action Network, Lung Cancer Research Foundation, LUNGevity, Masonic Cancer Center, University of Minnesota, Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, Melanoma Research Foundation, Memorial Sloan Kettering Cancer Center, Men’s Health Network, Mesothelioma Applied Research Foundation, METAvivor Research and Support, Moffitt Cancer Center, Multiple Myeloma Research Foundation, MUSC Hollings Cancer Center, National Brain Tumor Society, National Cancer Registrars Association, National Comprehensive Cancer Network, National Pancreas Foundation, Norris Cotton Cancer Center at Dartmouth, Oncology Nursing Society, Ovarian Cancer Research Alliance, Penn State Cancer Institute, Raymond Foundation, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Roswell Park Comprehensive Cancer Center, Rutgers Cancer Institute of New Jersey, Sanford Burnham Prebys Medical Discovery Institute, Sarcoma Foundation of America, Shepherd Foundation, Sidney Kimmel Cancer Center at Thomas Jefferson University, Society for Immunotherapy of Cancer (SITC), Society of Surgical Oncology, St. Baldrick’s Foundation, Stand Up To Cancer, Stanford Cancer Institute, Stephenson Cancer Center at The University of Oklahoma, Students Supporting Brain Tumor Research, Stupid Cancer Inc., Susan G. Komen, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, The Advocates for Collaborative Education, The Alliance of Dedicated Cancer Centers, The Mark Foundation for Cancer Research, The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove, Research Institute, The Salk Institute, The University of Kansas Cancer Center, Tigerlily Foundation, Triage Cancer, UC Davis Comprehensive Cancer Center, UC San Diego Moores Cancer Center, UCLA Health Jonsson Comprehensive Cancer Center, UCSF Helen Diller Family Comprehensive Cancer Center, UNC Lineberger Comprehensive Cancer Center, Unite for HER, University of Arizona Cancer Center, University of Chicago Medicine Comprehensive Cancer Center, University of Cincinnati Cancer Center, University of Iowa Holden Comprehensive Cancer Center, University of Michigan Rogel Cancer Center, University of New Mexico Comprehensive Cancer Center, University of Puerto Rico Comprehensive Cancer Center, University of Rochester Wilmot Cancer Institute, University of Vermont Cancer Center, UPMC Hillman Cancer Center, USC Norris Comprehensive Cancer Center, UT Southwestern Simmons Cancer Center, V Foundation for Cancer Research, VCU Medical Center, Winship Cancer Institute of Emory University, Yale Cancer Center, ZERO – The End of Prostate Cancer.
AACR. 2021 Feb 17. https://www.aacr.org/professionals/policy-and-advocacy/aacr-and-the-biden-administration/prioritizing-covid19-vaccines-for-cancer-patients/. (Epub ahead of print)
Summary: This letter published on the American Association for Cancer Research website was sent in February 2021 to President Biden "to underscore the urgency of prioritizing access to a COVID-19 vaccine for patients with active cancer and survivors of cancer."
Desai AV (Medicine), Michael CL (Health Informatics), Kuperman GJ (Health Informatics), Jordan G (Information Systems), Mittelstaedt H (Information Systems), Epstein AS (Medicine), Connor M (Hospital Administration), Villar RPB (Nursing), Bernal C (Medicine), Kramer D (Ld - Advanced Practice Providers), Davis ME (Nursing), Chen Y (Health Informatics), Malisse C (Medicine), Markose G (Nursing), Nelson JE (Medicine).
J Med Internet Res. 2021 Feb;23(2):e21615. doi: 10.2196/21615.
Summary: This article describes a unique approach at Memorial Sloan Kettering Cancer Center to making each patient's personal values visible to and readily accessible by their care providers. MSKCC incorporated the information about each patient's personal health-related values derived from the nurse-led discussions with patients into the electronic health record (an electronic version of a patient chart) creating a special Patient Values tab where this information is stored. In this way health care providers at MSKCC have individual patient's values, goals, and preferences at their fingertips, so that they can take these preferences into consideration when caring for their patients. It is an example of real steps taken by a health care institution to put the patient values principle into practice.
Spinato G, Gaudioso P, Boscolo Rizzo P, Fabbris C, Menegaldo A, Mularoni F, Singh B (Surgery), Maniaci A, Cocuzza S, Frezza D.
Acta Biomed. 2021 Feb 16;92(1):e2021105. doi: 10.23750/abm.v92i1.11281.
Summary: This review presents ways for Otolaryngologists to decrease their risks when caring for Covid-19 patients, such as preventative measures and fewer invasive procedures.
Mendoza RP, Fyke W, Daniel D, Gabutan E, Das B, Bajaj H, Easy M, Vasileva A, Colbourn R, Alawad M, Dehghani A, Lin B, Emechebe D, Patel P, Jabbar A, Nikolov DB (SKI Structural Biology), Giovaniello D, Kang S, Tatem L, Bromberg K, Augenbraun M, Premsrirut P, Libien J, Norin AJ.
Hum Immunol. 2021 Apr;82(4):255-263. doi: 10.1016/j.humimm.2021.02.007. Epub 2021 Feb 16.
Summary: A description of the process and outcomes of the convalescent plasma program at University Hospital Brooklyn from April to June 2020.
Nawas MT (Fellow), Shah GL (Medicine), Feldman DR (Medicine), Ruiz JD (Medicine), Robilotti EV (Medicine), Aslam AA (Infection Control), Dundas M (Infection Control), Kamboj M (Medicine), Barker JN (Medicine), Cho C (Medicine), Chung DJ (Medicine), Dahi PB (Medicine), Giralt SA (Medicine), Gyurkocza B (Medicine), Lahoud OB (Medicine), Landau HJ (Medicine), Lin RJ (Medicine), Mailankody S (Medicine), Palomba ML (Medicine), Papadopoulos EB (Medicine), Politikos I (Medicine), Ponce DM (Medicine), Sauter CS (Medicine), Shaffer BC (Medicine), Scordo M (Medicine), van den Brink MRM (Medicine), Perales MA (Medicine), Tamari R (Medicine).
Transplant Cell Ther. May;27(5):438.e1-438.e6. doi: 10.1016/j.jtct.2021.02.011. Epub 2021 Feb 14.
Summary: The study at Memorial Sloan Kettering Cancer Center evaluated the impact of delays in scheduling hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy caused by the COVID-19 pandemic and found that for patients with high-risk disease treament, delay could be devastating and should be avoided as much as possible.
Li F, Han M, Dai P, Xu W, He J, Tao X, Wu Y, Tong X, Xia X, Guo W, Zhou Y, Li Y, Zhu Y, Zhang X, Liu Z, Aji R, Cai X, Li Y, Qu D, Chen Y (Medicine), Jiang S, Wang Q, Ji H, Xie Y, Sun Y, Lu L, Gao D.
Nat Commun. 2021 Feb 8;12:866. doi: 10.1038/s41467-021-21171-x.
Summary: This study evaluated an existing drug, enzalutamide, for possible repurposing as an anti-COVID-19 agent. This thoroughly designed study concludes that this drug cannot be used for COVID-19 treatment, contrary to some previous studies that suggested such possibility.
Di Gioacchino A, Šulc P, Komarova AV, Greenbaum BD (Biostat/Epidemiology), Monasson R, Cocco S.
Mol Biol Evol. 2021 Jun;38(6):2428-2445. doi: 10.1093/molbev/msab036. Epub 2021 Feb 8.
Summary: To better understand how COVID-19 can induce acute respiratory syndrome in some patients, the authors conducted a genomic study using a model.
Hlubocky FJ, Symington BE, McFarland DC (Fellow), Gallagher CM, Dragnev KH, Burke JM, Lee RT, El-Jawahri A, Popp B, Rosenberg AR, Thompson MA, Dizon DS, Srivastava P, Patel MI, Kamal AH, Daugherty CK, Back AL, Dokucu ME, Shanafelt TD.
JCO Oncol Pract. 2021 Jul;17(7):365-374. doi: 10.1200/OP.20.00937. Epub 2021 Feb 8.
Summary: In this editorial, the authors describe how COVID-19 has impacted oncologists and offer recommendations to prevent or reduce the associated burdens.
Banerjee SC (Psychiatry Service), Staley JM (Psychiatry Service), Howell F (Psychiatry Service), Malling C (SKI Psychiatry/Counseling), Moreno A (Psychiatry Service), Kotsen C (Psychiatry Service), Parikh D (Radiation Oncology), Parker PA (Psychiatry Service).
J Cancer Educ. 2021 Feb 5;1-6. doi: 10.1007/s13187-021-01959-7. (Epub ahead of print)
Summary: With this guide (Comskil TeleOnc), the authors offer strategies to provide the best cancer patient care possible during tele-oncology visits.
Thompson MA, Henderson JP, Shah PK, Rubinstein SM, Joyner MJ, Choueiri TK, Flora DB, Griffiths EA, Gulati AP, Hwang C, Koshkin VS, Papadopoulos EB (Medicine), Robilotti EV (Medicine), Su CT, Wulff-Burchfield EM, Xie Z, Yu PP, Mishra S, Senefeld JW, Shah DP, Warner JL.
medRxiv. 2021 Feb 5;21250953; doi: https://doi.org/10.1101/2021.02.05.21250953.
Summary: A retrospective cohort study of 966 patients with a hematologic malignancy who also have a COVID-19 diagnosis. Of this cohort, 143 (14.8%) received convalescent plasma and were found to have higher 30-day mortality rates than the control group. This preprint has not been peer reviewed.
Mitchell B (Psychosocial Support), Sarfati D (Psychosocial Support), Stewart M (Psychosocial Support).
Clin Soc Work J. 2021 Feb 4;1-8. doi: 10.1007/s10615-021-00788-x. (Epub ahead of print)
Summary: The COVID-19 pandemic affected both clinical practice and education. This article describes how clinical education for students in social work adjusted to the COVID-19 pandemic, and specifically, how an educational program for oncology social work interns from the graduate school was redesigned for remote/virtual learning.
Ikemura K, Bellin E, Yagi Y (Pathology), Billett H, Saada M, Simone K, Stahl L, Szymanski J, Goldstein DY, Reyes Gil M.
J Med Internet Res. 2021 Feb;23(2):e23458. doi: 10.2196/23458.
Summary: This research study looked at automated machine learning to create algorithms to predict a patient's chances of surviving Covid-19 infection, looking at a variety of variables including vital signs, comorbidities, and biomarkers.
Linos E, Halley MC, Sarkar U, Mangurian C, Sabry H, Olazo K, Mathews KS, Diamond L (Psychiatry Service), Goyal MK, Linos E, Jagsi R.
Am J Psychiatry. 2021 Feb 1;178(2):203-204. doi: 10.1176/appi.ajp.2020.20071014.
Summary: After surveying the "Physician Moms Group" on Facebook, the authors note in this letter to the editor that anxiety among physician mothers is significantly higher during the pandemic than during normal times.
Cazeau N (Nursing).
Clin J Oncol Nurs. 2021 Feb 1;25(1):56-60. doi: 10.1188/21.CJON.56-60.
Summary: This paper reviews the communication models and technologies that can be used to enhance interprofessional communication among teams, with a particular focus on the unique challenges presented by the COVID-19 pandemic.
Park KU, Gregory ME, Lustberg MB, Bazan JG, Shen C, Rosenberg SM, Blinder VS (Psychiatry Service), Sharma P, Pusztai L, Partridge AH, Thompson A.
Cancer Res.. 2021 Feb;81(4 Suppl.). doi: 10.1158/1538-7445.SABCS20-SS2-05.
Summary: Results of a survey of 114 healthcare providers to evaluate patterns of care in early stage estrogen receptor positive breast cancer during the first months of the COVID-19 pandemic.
Conforti C, Lallas A, Argenziano G, Dianzani C, Di Meo N, Giuffrida R, Kittler H, Malvehy J, Marghoob AA (Dermatology Service), Soyer HP, Zalaudek I.
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021153. doi: 10.5826/dpc.1101a153.
Summary: A survey of 678 dermatologists in 52 countries found a decrease in the number of working days and skin cancer diagnoses, and an increase in telemedicine visits, during the pandemic.
Pagano A (Radiology), Finkelstein M, Overbey J, Steinberger S, Ellison T, Manna S, Toussie D, Cedillo M, Jacobi A, Gupta YS, Bernheim A, Chung M, Eber C, Fayad ZA, Concepcion J.
Chest. 2021 Jul;160(1):238-248. doi: 10.1016/j.chest.2021.01.053. Epub 2021 Jan 29.
Summary: This study looked at whether chest radiography can be used as an exclusionary test for adverse outcomes in patients with suspected Covid-19.
Wang JY, Zhang W, Roehrl MW, Roehrl VB, Roehrl MH (Pathology).
bioRxiv. 2021 Jan 24. doi: 10.1101/2021.01.24.427965.
Summary: This preprint describes a COVID autoantigen atlas developed using proteins from human fetal lung fibroblast HFL11 cells. This autoantigenome information contributes to a detailed molecular map that can be used to investigate neurological and autoimmune manifestations of COVID-19.
Laszkowska M (Medicine), Kim J, Faye AS, Joelson AM, Ingram M, Truong H, Silver ER, May B, Greendyke WG, Zucker J, Lebwohl B, Hur C, Freedberg DE.
Dig Dis Sci. 2021 Dec;66(12):4398-4405. doi: 10.1007/s10620-020-06760-y. Epub 2021 Jan 22.
Summary: In this study, 4973 hospitalized adult patients at two institutions were tested for COVID-19 and for gastrointestinal infections (from March 11 through April 28, 2020) in order to estimate the prevalence of co-infection with enteric pathogens of COVID-19 positive patients.
Montano M, Victor AR, Griffin DK, Duong T, Bolduc N, Farmer A, Garg V (Graduate Student), Hadjantonakis AK, Barnes FL, Zouves CG, Greene WC, Viotti M.
bioRxiv. 2021 Jan 21. doi: 10.1101/2021.01.21.427501.
Summary: This preprint investigates whether human pre-implantation embryos can be infected by SARS-CoV-2, something which is relevant to "natural human conceptions and assisted reproductive technologies during and after the COVID-19 pandemic."
Park RW, Jeon H, You SC, Kang SY, Seo SI, Warner JL, Belenkaya R (Health Informatics).
JMIR Med Inform. 2021 Apr 6;9(4):e25035. doi: 10.2196/25035. Epub 2021 Jan 20.
Summary: In this preprint, the authors present a technique to generate chemotherapy episodes to make data more discoverable so researchers can compare treatments for patients with cancer.
Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, Dandoy C, Gauthier J, Gowda L, Perales MA (Medicine), Seropian S, Shaw BE, Tuschl EE, Zeidan AM, Riches ML, Shah GL (Medicine).
Lancet Haematol. 2021 Mar;8(3):e185-e193. doi: 10.1016/S2352-3026(20)30429-4. Epub 2021 Jan 19.
Summary: This study analyzes data collected across multiple institutions by the Center for International Blood and Marrow Transplant Research (CIBMTR) using a special form created to capture COVID-19-related data on HSCT recipients between March 27, 2020 and Aug 12, 2020. The authors reported a "30 day survival from COVID-19 of only approximately 70%" in this patient group.
Thomson EC, Rosen LE, Shepherd JG, Spreafico R, da Silva Filipe A, Wojcechowskyj JA, Davis C, Piccoli L, Pascall DJ, Dillen J, Lytras S, Czudnochowski N, Shah R, Meury M, Jesudason N, De Marco A, Li K, Bassi J, O'Toole A, Pinto D, Colquhoun RM, Culap K, Jackson B, Zatta F, Rambaut A, Jaconi S, Sreenu VB, Nix J, Zhang I (Graduate Studies), Jarrett RF, Glass WG (Computational and Systems Biology Program), Beltramello M, Nomikou K, Pizzuto M, Tong L, Cameroni E, Croll TI, Johnson N, Di Iulio J, Wickenhagen A, Ceschi A, Harbison AM, Mair D, Ferrari P, Smollett K, Sallusto F, Carmichael S, Garzoni C, Nichols J, Galli M, Hughes J, Riva A, Ho A, Schiuma M, Semple MG, Openshaw PJM, Fadda E, Baillie JK, Chodera JD (Computational and Systems Biology Program), The ISARIC4C Investigators, the COVID-19 Genomics UK (COG-UK) consortium, Rihn SJ, Lycett SJ, Virgin HW, Telenti A, Corti D, Robertson DL, Snell G.
Cell. 2021 Mar 4;184(5):1171-1187.e20. doi: 10.1016/j.cell.2021.01.037. Epub 2021 Jan 28.
Summary: This research article demonstrates how the Covid-19 mutation N439K has resistance to several of the monoclonal antibody treatments being used and reduces the activity of some the immune responses from persons who have recovered from Covid-19 infection. This research shows why ongoing molecular surveillance is necessary as vaccines and treatments are being developed.
Horvat N (Radiology), Alves Pinto PV, Araujo-Filho JAB (Radiology), Santos JMMM, Dias AB, Miranda JA, de Oliveira CV, Barbosa CS, Morais TC, AN Assuncao Jr, Nomura CH, Cavalcante Viana PC.
Eur J Radiol Open. 2021;8:100326. doi: 10.1016/j.ejro.2021.100326. Epub 2021 Jan 18.
Summary: In this retrospective study, the authors studied abdominal imaging in 81 COVID-positive patients to study intestinal abnormalities and clinical outcomes.
Remsik J (Human Oncology and Pathogenesis Program), Wilcox JA (Graduate Staff), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Human Oncology and Pathogenesis Program), Avila EK (Neurology), Santomasso B (Neurology), Boire A (Human Oncology and Pathogenesis Program).
Cancer Cell. 2021 Feb 8;39(2):276-283.e3. doi: 10.1016/j.ccell.2021.01.007. Epub 2021 Jan 16.
Summary: This research article details how cancer patients with Covid who exhibit neurological symptoms weeks after acute infection have increased inflammatory cytokines in the cerebrospinal fluid, which lead to long term neurological dysfunction. Their findings suggest that anti-inflammatory treatments should be used to manage neurological symptoms in Covid patients.
Yerram P (Pharmacy), Thackray J (Pharmacy), Modelevsky LR (Pharmacy), Land JD (Pharmacy), Reiss SN (Pharmacy), Spatz KH (Pharmacy), Levoir AC (Pharmacy), Pak TK (Pharmacy), Dao PH (Pharmacy), Buege MJ (Pharmacy), DeRespiris LM (Pharmacy), Lau C (Pharmacy), Orozco JS (Pharmacy), Boparai M (Pharmacy), Koranteng LA (Pharmacy), Reichert KE (Pharmacy), Yan SQ (Pharmacy), Daukshus NP (Pharmacy), Mathew S (Pharmacy), Buie LW (Pharmacy), Tizon RF (Pharmacy), Freeswick S (Hospital Administration), Liu D (Pharmacy), Harnicar S (Pharmacy).
J Oncol Pharm Pract. 2021 Mar;27(2):389-394. doi: 10.1177/1078155220987625. Epub 2021 Jan 17.
Summary: MSK restructured its pharmacy services at the height of the pandemic in New York City, deploying six pharmacists to COVID-19 inpatient services for three months and using telemedicine technologies to allow those in outpatient settings to minimize on-site contact.
Mullangi S (Graduate Staff), Agrawal M, Schulman K.
JAMA Intern Med. 2021 Mar 1;181(3):307-308. doi:10.1001/jamainternmed.2020.8710. Epub Jan 13.
Summary: This article highlights the need to adapt state licensure requirements for physicians to the new practice patterns that emerged during the pandemic. For example, the rise of telemedicine during the pandemic allowed physicians to care for patients located in different states. This change in practice calls for adjustments to the physician licesure state laws.
Flores M, Dayan I, Roth H, Zhong A, Harouni A, Gentili A, Abidin A, Liu A, Costa A, Wood B, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan C, Xu D, Wu D, Huang E, Kitamura F, Lacey G, de Antônio Corradi GC, Shin HH (Radiology), Obinata H, Ren H, Crane J, Tetreault J, Guan J, Garrett J, Park JG, Dreyer K, Juluru K (Radiology), Kersten K, Rockenbach MABC, Linguraru M, Haider M, AbdelMaseeh M, Rieke N, Damasceno P, Cruz e Silva PM, Wang P, Xu S, Kawano S, Sriswasdi S, Park SY, Grist T, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon F, Gilbert F, Kaggie J, Li Q, Quraini A, Feng A, Priest A, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Diez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess C, Compas C, Bhatia D, Oermann E, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Keshava Murthy KN (Radiology), Fu LC, de Mendonca MRF, Fralick M, Kang MK, Adil M, Gangai N (Radiology), Vateekul P, Elnajjar P (Radiology), Hickman S, Majumdar S, McLeod S, Reed S, Graf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, de Lima Lavor V, Rakvongthai Y, Lee YR, Wen Y.
Res Sq. 2021 Jan 8;rs.3.rs-126892. doi: 10.21203/rs.3.rs-126892/v1. (Epub ahead of print)
Summary: Twenty institutions collaborated to train an artificial intelligence model to predict COVID patient oxygen requirements. This preprint has not yet been peer reviewed.
Müller C, Obermann W, Karl N, Wendel HG (Cancer Biology and Genetics), Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J.
Antiviral Res. 2021 Feb;186:105012. doi: 10.1016/j.antiviral.2021.105012. Epub 2021 Jan 7.
Summary: Researchers found that a synthetic rocaglate molecule had antiviral effects against SARS-CoV-2 in human bronchial cells.
Ganesh K (Molecular Pharmacology Program), Patel J, Orlova VV, Gifford C, Elias S, Vaughan A.
Cell Stem Cell. 2021 Jan 7;28(1):17-19. doi: 10.1016/j.stem.2020.12.014.
Summary: Six early-career researchers share how their experience of the COVID-19 pandemic has impacted their lab work and research.
Sarfaty M (Graduate Staff), Feldman DR (Medicine), Morris MJ (Medicine), Motzer RJ (Medicine), Rathkopf DE (Medicine), Regazzi AM (Medicine), Iyer G (Medicine), Voss MH (Medicine), Bajorin DF (Medicine), Rosenberg JE (Medicine).
Clin Genitourin Cancer. 2021 Jun;19(3):e178-e183. doi: 10.1016/j.clgc.2020.12.002. Epub 2021 Jan 7.
Summary: The COVID-19 pandemic affected cancer care across all cancer types, including genitourinary cancers. This article reports the results of a survey sent to experts involved in the management of genitourinary cancers in Europe and North America. The survey was intended to collect information about the changes in practice patterns that occurred as a result of the pandemic. The results of the study will inform the genitourinary oncologist community about the effects of the pandemic in their field.
Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H, Aguirre-Ghiso JA, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB (Medicine), Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G..
Clin Cancer Res. 2021 May 15;27(10):2678-2697. doi: 10.1158/1078-0432.CCR-20-4092. Epub 2021 Jan 7.
Summary: This article is a Melanoma Research Foundation (MRF) report on the current progress and future directions for melanoma research, as well as prevention, diagnosis and management of melanoma.
Harschnitz O (Developmental Biology), Studer L (Developmental Biology).
Nat Rev Immunol. 2021 Jul;21(7):441-453. doi: 10.1038/s41577-020-00474-y. Epub 2021 Jan 4.
Summary: In this review, the authors describe how human pluripotent stem cell technology can help understand viral infections of the human central nervous system.
Shaverdian N (Radiation Oncology), Gillespie EF (Radiation Oncology), Cha E (Graduate Staff), Kim SY (Psychiatry Service), Benvengo S (Radiation Oncology), Chino F (Radiation Oncology), Kang JJ (Radiation Oncology), Li Y (Psychiatry Service), Atkinson TM (Psychiatry Service), Lee N (Radiation Oncology), Washington CM (Hospital Administration), Cahlon O (Physician in Chief), Gomez DR (Radiation Oncology).
J Natl Compr Canc Netw. 2021 Jan 4;19(10):1174-1180. doi: 10.6004/jnccn.2020.7687. Epub 2021 Jan 4
Summary: This study, conducted at Memorial Sloan Kettering Cancer Center, compared patient satisfaction with office visits in Radiation Oncology practice before the pandemic with telemedicine consultations during the pandemic (specifically, the first half of 2020). Patient preferences for office and telemedicine consulations and identified predictors of patient preferences for either of these types of visits were assessed.
Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I (Surgery), Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar S, Vidya R, Bhangu AA, on behalf of the COVIDSurg Collaborative (Brown L (Graduate Staff) in group).
J Clin Oncol. 2021 Jan 1;39(1):66-78. doi: 10.1200/JCO.20.01933. Epub 2020 Oct 6.
Summary: This study analyzes pulmonary complication rates in elective cancer surgeries conducted in multiple centers internationally during the pandemic. Those centers were following surgical pathways.
Babady NE (Laboratory Medicine), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti EV (Medicine), Aslam A (Infection Control), Diver M (Nursing), Sokoli D (Hospital Administration), Mason G (BAIC), Shah MK (Medicine), Korenstein D (Medicine), Kamboj M (Medicine).
J Mol Diagn. 2021 Jan;23(1):3-9. doi: 10.1016/j.jmoldx.2020.10.018. Epub 2020 Nov 17.
Summary: Testing for SARS-CoV-2 is an essential tool in the fight against the current pandemic. Swabs, such as oropharyngeal swabs (OPSs) and especially nasopharyngeal swabs (NPSs), are the most common specimen collection methods recommended for SARS but because of a few downsides there is a need for adding more testing methods. This study investigated the reliability of two other methods, self-collected oral rinses (ORs) and oropharyngeal saliva, as alternative sample types for the detection of SARS-CoV-2. The study found that oropharyngeal saliva could be an acceptable alternative.
Generali D, Bosio G, Malberti F, Cuzzoli A, Testa S, Romanini L, Fioravanti A, Morandini A, Pianta L, Giannotti G, Viola EM, Pier-Franceschi MG, Foramitti M, Tira RA, Zangrandi I, Chiodelli G, Machiavelli A, Cappelletti MR, Giossi A, De Giuli V, Costanzi C, Campana C, Bernocchi O, Sirico M, Zoncada A, Molteni A, Venturini S, Giudici F, Scaltriti M (Pathology), Pan A.
Int J Infect Dis. 2021 Mar;104:433-440. doi: 10.1016/j.ijid.2020.12.073. Epub 2020 Dec 29.
Summary: This study evaluated the efficacy and safety of the drug canakinumab in patients with moderate COVID-19-related pneumonia. The drug showed promise in decreasing the need for invasive mechanical ventilation in prevention of clinical deterioration of patients with COVID-19 pneumonia, leading to earlier hospital discharge and better prognosis.
Nelson BA, Lapen K (Graduate Staff), Schultz O, Nangachiveettil J, Braunstein SE, Fernandez C, Fields EC, Gunther JR, Jeans E, Jimenez RB, Kharofa JR, Laucis A, Yechieli RL, Gillespie EF, Golden DW.
Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):315-321. doi: 10.1016/j.ijrobp.2020.12.026. Epub 2020 Dec 26.
Summary: This report shares the advantages and limits of conducting the 2020 ROECSG symposium virtually because of the pandemic. The authors' discussion will help with planning future scientific meetings.
Schmidt AH, Buk D, Bernas SN, Mengling T, Neujahr E, van den Brink MRM (Medicine).
Am J Hematol. 2021 Mar 1;96(3):E91-E92. doi: 10.1002/ajh.26081. Epub 2020 Dec 24.
Summary: In this letter to the editor, the authors discuss cryopreservation of stem cell products from unrelated donors which has been used as a way to overcome the challenges associated with the Covid-19 pandemic but which also presents some challenges of its own, as often these products end up at risk of not being used for various reasons explained by the authors.
Jimenez-Kurlander L (Fellow), Antal Z (Pediatrics), DeRosa A (Pediatrics), Diotallevi D (Pediatrics), Pottenger E (Pediatrics), Wilson N (Pediatrics), Corcoran S (Medicine), Boulad F (Pediatrics), Friedman DN (Pediatrics).
Pediatr Blood Cancer. 2021 Mar;68(3):e28857. doi: 10.1002/pbc.28857. Epub 2020 Dec 23.
Summary: In this paper, the authors analyzed COVID-19 infections among pediatric survivors of childhood cancer followed at Memorial Sloan Kettering Cancer Center and concluded from their preliminary data that "childhood cancer survivors appear to be at relatively low risk for COVID-19 complications."
Madhusoodhan PP, Pierro J, Musante J, Kothari P (Pediatrics), Gampel B, Appel B, Levy A, Tal A, Hogan L, Sharma A, Feinberg S, Kahn A, Pinchinat A, Bhatla T, Glasser CL, Satwani P, Raetz EA, Onel K, Carroll WL.
Pediatr Blood Cancer. 2021 Mar;68(3):e28843. doi: 10.1002/pbc.28843. Epub 2020 Dec 18.
Summary: In this 13-institution, multicenter, retrospective study, 578 pediatric oncology patients were tested for COVID-19, with 98 found to be positive, 73 of which were symptomatic. Their clinical and laboratory information was collected and analyzed, from which it was concluded that although COVID-related morbidity and mortality were low in pediatric oncology patients overall, they were higher than in the general pediatric population, with some subgroups more at risk for severe COVID disease.
Prockop SE (Pediatrics).
Blood. 2020 Dec 17; 136(25):2847-2848. doi: https://doi.org/10.1182/blood.2020009408.
Summary: This is a comment about an article published in Blood by Keller and colleagues. "Keller MD, Harris KM, Jensen-Wachspress MA, et al. SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein. Blood. 2020;136(25):2905-2917."
Hoffmann HH, Sànchez-Rivera FJ (Cancer Biology and Genetics), Schneider WM, Luna JM, Soto-Feliciano YM, Ashbrook AW, Le Pen J, Leal AA, Ricardo-Lax I, Michailidis E, Hao Y, Stenzel AF, Peace A, Zuber J, Allis CD, Lowe SW (Cancer Biology and Genetics), MacDonald MR, Poirier JT, Rice CM.
Cell Host Microbe. 2021 Feb 10;29(2):267-280.e5. doi: 10.1016/j.chom.2020.12.009. Epub 2020 Dec 16.
Summary: In this article, the authors identified SARS-CoV-2 host proteins. They organized their results in a library to help develop possible COVID-19 drug treatments.
Anderson MR, Bach PB (Health Policy & Outcomes), Baldwin MR.
Pharmacoecon Open. 2021 Mar;5(1):129-131. doi: 10.1007/s41669-020-00243-6. Epub 2020 Dec 14.
Summary: This study questions whether the 33% higher price of remdesivir charged to U.S. hospitals is justified. The price is based on the company's clinical trial finding that remdesivir reduces LOS by 4 days, however, in the cohort study reported in this research letter, "the median LOS was markedly shorter than the equivalent endpoint in the ACTT-1 trial (7 vs. 15 days)". This finding led the researchers to conclude that "36% could have their LOS potentially prolonged to complete therapy."
Oh JH (Medical Physics), Tannenbaum A, Deasy JO (Medical Physics).
BMC Med Genomics. 2020 Dec 11;13(1):186. doi: 10.1186/s12920-020-00839-1.
Summary: This study re-analyzed data, originally collected for a genome-wide association study (GWAS) of Italian and Spanish participants by an international consortium group, using gene ontology analysis and protein-protein interaction analysis, to determine which biological processes were most implicated in respiratory failure in COVID-19 patients.
Schneider WM, Luna JM, Hoffmann HH, Sànchez-Rivera FJ (Cancer Biology and Genetics), Leal AA, Ashbrook AW, Le Pen J, Ricardo-Lax I, Michailidis E, Peace A, Stenzel AF, Lowe SW (Cancer Biology and Genetics), MacDonald MR, Rice CM, Poirier JT.
Cell. 2021 Jan 7;184(1):120-132.e14. doi: 10.1016/j.cell.2020.12.006. Epub 2020 Dec 9.
Summary: This article reports on a study into the cellular level of processes associated with SARS-CoV-2 and other coronavirus infections. It contributes to the knowledge base of the biology of coronavirus infections.
Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A (Epidemiology and Biostatistics), Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Xu KH, Raabe MJ, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD (Epidemiology and Biostatistics), Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V.
Nat Commun. 2020 Dec 9;11:6319. doi: 10.1038/s41467-020-20139-7.
Summary: This analysis of 24 autopsy lung samples of patients who died of COVID supports two disease phases: one with high viral RNA and one with low or undetectable viral RNA. The authors believe these to be distinct disease phases rather than different forms of the disease.
Lara OD, Smith MJ, Wang Y, O'Cearbhaill R (Medicine), Blank SV, Kolev V, Carr C, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Jee J, Fehniger J, Lee YC, Isani S, Liu M, Wright JD, Pothuri B.
Cancer. 2021 Apr 1;127(7):1057-1067. doi: 10.1002/cncr.33335. Epub 2020 Dec 9.
Summary: A retrospective, observational cohort study of 193 patients with gynecologic cancer and COVID-19 infection at eight New York City-area hospital systems, where Black patients had disproportionate rates of hospitalization and death than non-Black patients.
Patel VG, Zhong X, Shah NJ (Medicine), Martina LP, Hawley J, Lin E, Gartrell BA, Febles VRA, Wise DR, Qin Q, Mellgard G, Nauseef JT, Green D, Vlachostergios PJ, Kwon D, Huang FW, Liaw BCH, Tagawa ST, Morris MJ (Medicine), Oh WK.
J Clin Oncol. 2021 Jan 20; 39(6 Suppl.): 41. doi: 10.1200/JCO.2021.39.6_suppl.41.
Summary: This ASCO meeting abstract presents the negative findings of a retrospective cohort study of 465 prostate cancer patients who were evaluated for SARS-COV-2 viral detection by PCR to determine whether the use of androgen deprivation therapy by patients prior to COVID-19 diagnosis offered protection against severe COVID illness.
Pennell NA, Dillmon M, Levit LA, Moushey EA, Alva AS, Blau S, Cannon TL, Dickson NR, Diehn M, Gonen M (Biostatistics & Epidemiology), Gonzalez MM, Hensold JO, Hinyard LJ, King T, Lindsey SC, Magnuson A, Marron J, McAneny BL, McDonnell TM, Mileham KF, Nasso SF, Nowakowski GS, Oettel KR, Patel MI, Patt DA, Perlmutter J, Pickard TA, Rodriguez G, Rosenberg AR, Russo B, Szczepanek C, Smith CB, Srivastava P, Teplinsky E, Thota R, Traina TA, Zon R, Bourbeau B, Bruinooge SS, Foster S, Grubbs S, Hagerty K, Hurley P, Kamin D, Phillips J, Schenkel C, Schilsky RL, Burris HA 3rd.
J Clin Oncol. 2021 Jan 10;39(2):155-169. doi: 10.1200/JCO.20.02953. Epub 2020 Dec 8.
Summary: This article reports on the new recommendations from the American Society of Clinical Oncology (ASCO), the world's leading professional organization for physicians who care for people with cancer. The new recommendations are based on evaluation of the COVID-19 pandemic experience and are aimed at improved patient access to high quality cancer research and cancer care delivery going forward.
Auger J, Fletcher L, Frankowiak S, Grills G, Lemas MV, Mische S, Monteiro M, Peláez F, Tabarini D (General & Administration), Vinard A, White AN.
Cytometry A. 2021 Jan;99(1):19-21. doi: 10.1002/cyto.a.24263. Epub 2020 Dec 2.
Summary: This paper provides the perspectives and lessons learned of administrators of biomedical shared resource laboratories/research core facilities on a range of issues that have affected their facilities and operations during the COVID-19 pandemic. They provide guidance on business continuity planning and explain the importance of strong core contingency plans.
COVIDSurg Collaborative (Brown L (Graduate Staff), Ganly I (Surgery) in group).
Br J Surg. 2021 Jan;108(1):88-96. doi: 10.1093/bjs/znaa051.
Summary: An international cohort study of 8,784 adult patients undergoing elective cancer surgery to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications.
Wong K (Graduate Staff), Lazo K (Graduate Staff), Mogilevskaya Y (Graduate Staff), Tan M (Medicine), Feinstein MB (Medicine).
Am J Respir Crit Care Med. 2021; 203:A3812. doi: 10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A3812.
Summary: A retrospective study of 1,770 cancer patients who tested positive for COVID-19 between March 2020 and May 2020 at Memorial Sloan Kettering Cancer Center, with authors noting results suggest short-term mortality among patients receiving immunotherapy may be higher than those receiving chemotherapy alone.
Wood WA, Neuberg DS, Thompson JC, Tallman MS (Medicine), Sekeres MA, Sehn LH, Anderson KC, Goldberg AD (Medicine), Pennell NA, Niemeyer CM, Tucker E, Hewitt K, Plovnick RM, Hicks LK.
Blood Adv. 2020 Dec 8;4(23):5966-5975. doi: 10.1182/bloodadvances.2020003170.
Summary: This article refers to a global public tool, ASH Research Collaborative (ASH RC) COVID-19 Registry, created to compile the data on COVID-19 in patients with leukemia and other blood cancers. The article describes the outcomes and the patterns of coronavirus disease progression as discerned from this data.
Simone CB 2nd (Radiation Oncology).
Oncology Times. 2020 Dec 5;42(23):1,6,9. doi: 10.1097/01.COT.0000724652.36050.46.
Summary: This article describes the success of the New York Proton Center in adjusting to working during the COVID-19 pandemic and the steps taken for the resumption of research activities, such as clinical trials, in preparation for the postpandemic reality.
Tee MW, Stewart C, Aliessa S (Medicine), Polansky M, Shah K, Petukhova T, Rossi A (Medicine), Lipner SR, Minkis K.
J Am Acad Dermatol. 2021 Apr;84(4):1094-1096. doi: 10.1016/j.jaad.2020.12.003. Epub 2020 Dec 5.
Summary: A letter to the editor presenting COVID safety measures taken during surgery at Weill Cornell Dermatology.
Castillo P, Boulad F (Pediatrics), Bhatia M, Arnold S, Lipton J, Wang W, Farrar J, Black V, Bennett C, Shimamura A, Kurre P, Vlachos A.
Authorea. 2020 Dec 2. doi: 10.22541/au.160689244.41003643/v1.
Summary: A survey of 29 institutions identified only four pediatric patients with bone marrow failure (BMF) who tested positive for COVID, or 0.3% of the total surveyed BMF patient population. All four patients had mild disease. This preprint has not been peer reviewed.
Matos LL, Forster CHQ, Marta GN, Castro G Jr, Ridge JA, Hirata D, Miranda-Filho A, Hosni A, Sanabria A, Gregoire V, Patel SG (Surgery), Fagan JJ, D'Cruz AK, Licitra L, Mehanna H, Hao SP, Psyrri A, Porceddu S, Galloway TJ, Golusinski W, Lee NY (Radiation Oncology), Shiguemori EH, Matieli JE, Shiguemori APAC, Diamantino LR, Schiaveto LF, Leão L, Castro AF, Carvalho AL, Kowalski LP.
ResearchSquare. 2020 Dec 2. doi: 10.21203/rs.3.rs-119756/v1.
Summary: The authors used a model of head and neck squamous cell carcinoma progression to estimate the increased mortality burden of the pandemic on cancer patients. This preprint has not been peer reviewed.
Mahadev S, Aroniadis OC, Barraza LH, Agarunov E, Smith MS, Goodman AJ, Benias PC, Buscaglia JM, Gross SA, Kasmin F, Cohen J, Carr-Locke DL, Greenwald D, Mendelsohn R (Medicine), Sethi A, Gonda TA, (on behalf of NYSGE research committee).
Endosc Int Open. 2020 Dec;8(12): E1865-E1871. doi: 10.1055/a-1264-7599. Epub 2020 Nov 27.
Summary: A survey of 11 endoscopy units in the New York area found an overall pandemic-related decline in procedural volume and a general agreement of which situations indicated urgent endoscopic procedures during the pandemic. The 11 units reported notably different pre-procedural COVID testing policies.
Aydillo T, Gonzalez-Reiche AS, Aslam S, van de Guchte A, Khan Z, Obla A, Dutta J, van Bakel H, Aberg J, García-Sastre A, Shah G (Medicine), Hohl T (Medicine), Papanicolaou G (Medicine), Perales MA (Medicine), Sepkowitz K (Physician in Chief), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
N Engl J Med. 2020 Dec 24;383(26):2586-2588. doi: 10.1056/NEJMc2031670. Epub 2020 Dec 1.
Summary: Cell cultures from 20 immunocompromised patients with Covid-19 found that stem cell transplant or CAR-T cell therapy recipients can shed SARS-CoV-2 virus for at least two months.
Thomas J, Rossi AM (Medicine).
Cutis. 2020 Dec;106(6):E4-E8. doi: 10.12788/cutis.0146.
Summary: These recommendations for dermatologists recommend following National Comprehensive Cancer Network and European Society for Medical Oncology guidelines to reduce COVID transmission risk while treating skin cancer patients.
Breitbart W (Psychiatry Service).
Palliat Support Care. 2020 Dec;18(6):634-635. doi: 10.1017/S1478951520001364.
Summary: In this letter, the author shares his opinion on trust in the time of the COVID-19 pandemic. He states how crucial it is for the healthcare workforce to "recognize that trust needs to be restored."
Mullangi S (Graduate Fellow), Diamond R, Patel KK.
Am J Manag Care. 2020 Dec;26(12):499-500. doi: 10.37765/ajmc.2020.88497.
Summary: This article reflects on the tensions that Covid-19 brought about between physicians and administrators and ways in which solutions can be found to remedy them. The three key points are transparancy in leadership, leadership to make sustainable investments in the community, and financial alignment between administrators and the front line workers.
Pillarsetty N (Radiology), Carter LM (SKI Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2020 Dec;61(12):1720-1723. doi: 10.2967/jnumed.120.249748. Epub 2020 Jul 17.
Summary: Researchers used a human antibody that binds to SARS-CoV-2 in a proof of concept study, concluding that molecularly targeting the virus is a potential therapeutic approach.
Sundar SS, Leung E, Khan T, Glasbey J, Abu-Rustum N (Surgery), Chiva LM, Fagotti A, Fujiwara K, Ghebre R, Gultekin M, Konney T, Ng J, Pareja R, Seenivasagam RK, Sehouli J, Shylasree T, Bhangu A, Fotopoulou C, Covidsurg Cancer Collaborators.
Int J Gynecol Cancer. 2020 Dec;30 (Suppl 4): A123-A124. doi: 10.1136/ijgc-2020-ESGO.218.
Summary: This multi-center study looks at the impact of COVID on gynecological cancer surgery. As described in this conference abstract, surgical delays and change in type of surgery occurred relatively frequently, while COVID-related adverse surgical outcomes were low.
Glincher R (Pediatrics), Cheung NK (Pediatrics), Kasper C (Pediatrics), Scoppetuolo LA (Pediatrics), Modak S (Pediatrics).
Pediatr Blood Cancer. 2020 Dec;67 (Suppl 4): S116. doi: 10.1002/pbc.28742.
Summary: A conference abstract about remotely monitoring blood pressure post-immunotherapy during the pandemic in order to detect the potential onset of adverse treatment effects.
Gampel B, Troullioud Lucas A (Graduate Fellow), Broglie L, Gartrell-Corrado R, Lee M, Levine J, Orjuela-Grimm M, Satwani P, Glade Bender J (Pediatrics), Roberts S (Pediatrics).
Pediatr Blood Cancer. 2020 Dec;67 (Suppl 4): S36. doi: 10.1002/pbc.28742.
Summary: This conference abstract describes 19 hematology, oncology and hematopoietic cell transplant pediatric patients who tested positive for COVID. Most had mild symptoms similar to children without cancer.
Taghvaei A, Georgiou TT, Norton L (Office of the Pres & CEO), Tannenbaum A.
Sci Rep. 2020 Nov 30;10:20882. doi: 10.1038/s41598-020-77849-7.
Summary: The authors recommend a change to epidemiological models to better represent transmission dynamics.
Bolton KL, Koh Y, Foote MB (Graduate Fellow), Im H, Jee J (Graduate Fellow), Sun CH, Safonov A (Medicine), Ptashkin R (Pathology), Moon JH, Lee JY, Jung J, Kang CK, Song KH, Choe PG, Park WB, Kim HB, Oh MD, Song H, Kim S, Patel M (Collaborative Research Centers), Derkach A (Biostat/Epidemiology), Gedvilaite E (Pathology), Tkachuk KA (Medicine), Braunstein LZ (Radiation Oncology), Gao T (Collaborative Research Centers), Papaemmanuil E (Biostat/Epidemiology), Babady E (Laboratory Medicine), Pessin MS (Laboratory Medicine), Kamboj M (Medicine), Diaz LA Jr (Medicine), Ladanyi M (Pathology), Rauth MJ, Natarajan P, Machiela MJ, Awadalla P, Joseph V (Medicine), Offit K (Medicine), Norton L (Office of the Pres & CEO), Berger MF (Pathology), Levine RL (Human Oncology & Pathogenesis), Kim SE, Kim NJ, Zehir A (Pathology).
medRxiv. 2020 Nov 27. doi: 10.1101/2020.11.25.20233163v1.
Summary: A study of 515 patients from Memorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia found that patients with clonal hematopoiesis were more likely to have severe COVID infections, along with an increased risk of other infections. This preprint has not been peer reviewed.
Müller C, Obermann W, Karl N, Wendel HG (Cancer Biology and Genetics), Taroncher-Oldenburg G, Pleschka S, Hartmann RK, Grünweller A, Ziebuhr J.
bioRxiv. 2020 Nov 24. doi: 10.1101/2020.11.24.389627.
Summary: Researchers found that a synthetic rocaglate molecule had antiviral effects against SARS-CoV-2 in human bronchial cells. This preprint has not been peer reviewed.
Bergstrom KL, Brander TE, Breen KE (Medicine), Naik H.
Am J Med Genet C Semin Med Genet. 2021 Mar;187(1):28-36. doi: 10.1002/ajmg.c.31855. Epub 2020 Nov 23.
Summary: In this study conducted in New York State, the authors anonymously surveyed 165 genetic counselors to assess the impact of the Covid-19 pandemic on their services. The article highlights the rapid shift to telegenetics and future recommendations, such as implementing a hybrid model.
Fu W, Chen Y, Wang K, Hettinghouse A, Hu W (Human Oncology & Pathogenesis Program), Wang JQ, Lei ZN, Chen ZS, Stapleford KA, Liu CJ.
Protein Cell. 2021 Jul;12(7):586-591. doi: 10.1007/s13238-020-00803-w. Epub 2020 Nov 18..
Summary: In this letter to the editor, the authors present how they developed an Elisa assay and identified from the assay three FDA-approved drugs that may help with treating Covid-19.
Ortega P, Martínez G, Diamond L (Psychiatry Service).
J Health Care Poor Underserved. 2020 Nov;31(4):1530-1535. doi: 10.1353/hpu.2020.0114.
Summary:In this commentary, the authors highlight three critical steps to implement during and beyond the pandemic to decrease linguistic minority communities' health disparities.
Babady NE (Laboratory Medicine), McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti EV (Medicine), Aslam A (Infection Control), Diver M (Nursing), Sokoli D (Hospital Administration), Mason G (BAIC), Shah MK (Medicine), Korenstein D (Medicine), Kamboj M (Medicine).
J Mol Diagn. 2021 Jan;23(1):3-9. doi: 10.1016/j.jmoldx.2020.10.018. 2020 Nov 17.
Summary: Between April and May 2020, the researchers compared COVID screening methods in MSK employees who were either showing symptoms or who had known disease exposure. They found SARS-CoV-2 detection from posterior oropharyngeal saliva, but not from oral rinses or mouthwashes, equivalent to detection from nasopharyngeal swabs.
Fenelus M (Laboratory Medicine), Graham T (Laboratory Medicine), Golden R (Laboratory Medicine), Bautista JL (Laboratory Medicine), So RJ (Laboratory Medicine), Plante N (Laboratory Medicine), Peerschke EIB (Laboratory Medicine).
J Clin Pathol. 2021 Mar;74(3):202-204. doi: 10.1136/jclinpath-2020-207114. Epub 2020 Nov 16.
Summary: This study determined if and how a streamlined system of only testing absolute neutrophil counts (ANC), instead of full blood counts, helped to decrease patient wait times, staffing, and resources in patients undergoing chemotherapy.
Siddiq MM, Chan AT (Medicine), Miorin L, Yadaw AS, Beaumont KG, Kehrer T, White KM, Cupic A, Tolentino RE, Hu B, Stern AD, Tavassoly I, Hansen J, Martinez P, Dubois N, Schaniel C, Iyengar-Kapuganti R, Kukar N, Giustino G, Sud K, Nirenberg S, Kovatch P, Goldfarb J, Croft L, McLaughlin MA, Argulian E, Lerakis S, Narula J, García-Sastre A, Iyengar R.
medRxiv. 2020 Nov 13. doi: 10.1101/2020.11.10.20229294.
Summary: In this preprint, a publication not yet peer-reviewed, the authors use clinical data from patients and results from experiences conducted in the lab to study how Covid-19 might affect the heart.
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Negretti NM, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Vanderbilt COVID-19 Consortium Cohort, Human Cell Atlas Biological Network (Pe'er D (Computational and Systems Biology Program) in group), Kropski JA, Sucre JMS.
J Clin Invest. 2021 Jan 4;131(1):e140766. doi: 10.1172/JCI140766. Epub 2020 Nov 12.
Summary: The authors researched whether genes involved in a person's susceptibility to SARS-COV-2 change their expression during development, and if this might impact the growing seriousness of COVID-19 over the age span.
Baldassarre LA, Yang EH, Cheng RK, DeCara JM, Dent S, Liu JE (Medicine), Rudski LG, Storm JB, Thavendiranathan P, Barac A, Zaha VG, Bucciarelli-Ducci C, Ellahham S, Deswal A, Lenneman C, Villarraga HR, Blaes AH, Ismail-Khan R, Ky B, Leja MJ, Scherrer-Crosbie M.
J Natl Cancer Inst. 2021 May 4;113(5):513-522. doi: 10.1093/jnci/djaa177.
Summary: A consensus statement on cardiovascular care for cardio-oncology patients during the pandemic.
Daniels K (Research Facilities), Conway A, Gardner R (Research Facilities), Martinez L, Price KM, Schneider S, Sheridan R, Srivastava J, Thornton S.
Cytometry A. 2021 Jan;99(1):42-50. doi: 10.1002/cyto.a.24262. Epub 2020 Nov 18.
Summary: This article describes challenges to personnel training experienced by Shared Resource Laboratories (SRLs), which are technologically advanced research laboratory facilities at academic and research institutions, during the COVID-19 epidemic, and provides an overview of remote training platforms used.
Lara O, Smith M, Wang Y, O'Cearbhaill R (Medicine), Blank S, Knisely A, McEachron J, Gabor L, Chapman-Davis E, Jee J (Graduate Fellow), Isani S, Liu M, Wright J, Pothuri B.
Int J Gynecol Cancer. 2020 Nov 1;30(Supp. 3):A54. doi: 10.1136/ijgc-2020-ESGO.96.
Summary: Data from 8 New York-area hospital systems showed that Black patients with gynecologic cancer and COVID-19 were more likely to require hospitalization than non-Black patients.
Smith M, Lara O, O'Cearbhaill R (Medicine), Sutter M, Knisely A, McEachron J, Gabor L, Carr C, Blank S, Prasad-Hayes M, Frey M, Jee J (Graduate Fellow), Fehniger J, Lee YC, Isani S, Wright J, Pothuri B.
Int J Gynecol Cancer. 2020 Nov 1;30(Supp. 3):A120. doi: 10.1136/ijgc-2020-IGCS.253.
Summary: An evaluation of 86 patients with a history of gynecologic cancer who were hospitalized with COVID-19, with authors noting that inflammatory markers (ferritin and C-reactive protein) in these patients are associated with COVID-19 severity and can be used as prognostic markers.
Schaff L (Neurology), Lobbous M, Bozza A (Neurology), Carlow D, Nabors L, Grommes C (Neurology).
Neuro Oncol. 2020 Nov 1;22(Suppl. 2):ii25–ii26. doi: 10.1093/neuonc/noaa215.105.
Summary: This meeting abstract reports on the results of a small study (seven treaments administered to three patients) investigating the feasibility of using glucarpidase to make outpatient high dose methotrexate administration to CNS lymphoma patients possible during the COVID-19 pandemic.
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S37. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which eighty-seven paired NPS and saliva samples were collected) looking into the feasibility of using saliva as an alternative for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR) in order to overcome the lack of availability of nasopharyngeal swabs (NPS). Saliva was found to be an acceptable alternative sample for SARS-CoV-2 RNA detection by RT-PCR.
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S37-S38. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which 98 paired oral rinse and NPS samples were collected) looking into the feasibility of using oral rinse as an alternative for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR) in order to overcome the lack of availability of nasopharyngeal swabs. Oral rinses were not found to be a suitable alternative to nasopharyngeal swabs.
McMillen T (Laboratory Medicine), Jani K (Laboratory Medicine), Viale A (Collaborative Research Centers), Robilotti E (Medicine), Aslam A (Infection Control), Sokoli D (Hospital Administration), Mason G (BAIC), Shah M (Medicine), Korenstein D (Medicine), Kamboj M (Medicine), Babady E (Laboratory Medicine).
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S39. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on the results of a study (during which a total of 100 paired saliva and orophrayngeal swabs (OPS) samples were collected) looking into the feasibility of using saliva versus OPS for COVID-19 testing (SARS-CoV-2 RNA detection by RT-PCR). Saliva was found to be superior to oropharyngeal swabs for detection of SARS-CoV-2 RNA.
Desai N, Ting D, Neyaz A, Szabolcs A, Shih A, Chen J, Thapar V, Nieman L, Solovyov A (Biostat/Epidemiology), Mehta A, Lieb D, Kulkarni A, Jaicks C, Pinto C, Monroe R, Danaher P, Gong J, Juric D, Chebib I, Greenbaum B (Biostat/Epidemiology), Rivera M, Hacohen N, Sholl L, Stone J, Ting D, Deshpande V.
J Mol Diagn. 2020 Nov 1;22(Suppl. 11): S33-S34. doi: 10.1016/S1525-1578(20)30513-4.
Summary: This meeting abstract reports on a study (of 89 pulmonary and extrapulmonary samples from 24 COVID-19 autopsies) that attempted to investigate the relationship between SARS-CoV-2 lung infection and the severity of pulmonary disease.
Breitbart WS (Psychiatry Service).
Palliat Support Care. Oct;18(5):511-512. doi: 10.1017/S1478951520001145. Epub 2020 Nov 9.
Summary: In this editorial, the author reflects on what we can learn from death during the COVID-19 pandemic, hoping that it taught us that "passing love along is what we were born to do."
The COVID Moonshot Consortium (Bruce Macdonald H (Computational and Systems Biology Program), Chodera J (Computational and Systems Biology Program), Rufa D (Graduate Studies), Wittmann M (Computational and Systems Biology Program), Boby ML (Graduate Studies), Glass WG (Computational and Systems Biology Program) in group.)
bioRxiv. 2020 Oct 30. doi: 10.1101/2020.10.29.339317.
Summary: A team of international scientists is working to develop antiviral drugs for COVID-19. They report on their methodologies for determining the structures of compounds in this preprint.
Kurlander L (Pediatrics), Antal Z (Pediatrics), DeRosa A (Pediatrics), Diotallevi D (Pediatrics), Pottenger E (Pediatrics), Wilson N (Pediatrics), Corcoran S (Medicine), Boulad F (Pediatrics), Novetsky Friedman D (Pediatrics).
Authorea. 2020 Oct 29. doi: 10.22541/au.160396932.21022667/v1.
Summary: In this brief report, the authors did a retrospective study to determine the impact of COVID-19 infections on 321 childhood cancer survivors seen at Memorial Sloan Kettering between May 5 and September 10, 2020. Based on preliminary results, they report that pediatric survivors don't seem to be at high risk for COVID-19 complications.
Aslam A (Infection Control), Singh J (Infection Control), Robilotti E (Medicine), Chow K (Epidemiology Infectious Disease), Bist T (Medicine), Reidy-Lagunes D (Medicine), Shah M (Medicine), Korenstein D (Medicine), Babady NE (Laboratory Medicine), Kamboj M (Medicine).
Clin Infect Dis. 2021 Nov 2;73(9):e3013-e3018. doi: 10.1093/cid/ciaa1607.
Summary: From a study conducted at MSKCC, this paper gives guidance on conducting pre-procedural COVID-19 testing. The article also highlights how critical personal protective equipment are in procedural settings.
Szabolcs M, Sauter JL (Pathology), Frosina D (Pathology), Geronimo JA (Pathology), Hernandez E (Pathology), Selbs E, Rapkiewicz AV, Rekhtman N (Pathology), Baine MK (Graduate Fellow), Jäger E, Travis WD (Pathology), Jungbluth AA (Pathology).
Appl Immunohistochem Mol Morphol. 2021 Jan;29(1):5-12. doi: 10.1097/PAI.0000000000000878. Epub 2020 Oct 20.
Summary: SARS-CoV2 is known to cause severe pulmonary disease but may also involve other organs, making the proper assessment of virus-related pathomorphologic changes in specimens valuable for better understanding COVID-19 disease. This study investigated the usefulness of commercially available monoclonal antibodies for detecting viral antigens in standard archival pathological specimens.
Burnett GW, Shah A, Fried EA, Shah R (Anesthesiology), Lai CY, Levin M.
Simul Healthc. 2021 Feb;16(1):78-79. doi: 10.1097/SIH.0000000000000523. Epub 2020 Oct 20.
Summary: This brief report describes the work carried out by the Mount Sinai Department of Anesthesiology's Human Emulation, Education and Evaluation Lab for Patient Safety and Professional Study (HELPS) at the height of the COVID-19 pandemic in NYC. The authors make a strong case for the value of using the safe environment of simulation for testing devices and protocols before use on patients, especially during unprecedented emergency situations.
Kung AL (Pediatrics), Mauguen A (Biostat/Epidemiology), Boulad F [Pediatrics].
JAMA Oncol. 2020 Dec;6(12):1980. doi: 10.1001/jamaoncol.2020.4767. Epub 2020 Oct 15.
Summary: In this reply, authors addressed concerns raised in a commentary regarding their recent Research Letter. One concern was related to the different types of pediatric cancer being pathophysiologically different, and another was related to observed sex differences.
Ikemura K, Goldstein DY, Szymanski J, Bellin E, Stahl L, Yagi Y (Pathology), Saada M, Simone K, Gil MR.
medRxiv. 2020 Oct 14. doi: 10.1101/2020.10.12.20211086.
Summary: This pre-print article describes a novel use of automated machine learning to predict patient survival and mortality from COVID-19. The authors were also able to identify the most important biomarkers correlated with mortality.
Magro CM, Mulvey J (Graduate Fellow), Kubiak J, Mikhail S, Suster D, Crowson AN, Laurence J, Nuovo G.
Ann Diagn Pathol. 2021 Feb;50:151645. doi: 10.1016/j.anndiagpath.2020.151645. Epub 2020 Oct 13.
Summary: This article contibutes to the knowledge of mechanisms causing a severe course of COVID-19 infection and lays the foundation for creating new therapies targeting those mechanisms.
Magro C, Mulvey JJ (Graduate Fellow), Laurence J, Seshan S, Crowson AN, Dannenberg AJ, Salvatore S, Harp J, Nuovo GJ.
Hum Pathol. 2020 Dec;106:106-116. doi: 10.1016/j.humpath.2020.10.002. Epub 2020 Oct 12.
Summary: This study, conducted on 23 patients with COVID-19, investigated the possible complement activation of cutaneous and subcutaneous microvessels and SARS-CoV-2 docked protein within the endothelium.
Park ER, Chiles C, Cinciripini PM, Foley KL, Fucito LM, Haas JS, Joseph AM, Ostroff JS (Psychiatry Service), Rigotti NA, Shelley DR, Taylor KL, Zeliadt SB, Toll BA; Smoking Cessation at Lung Examination (SCALE) Research Group.
Cancer. 2021 Feb 1;127(3):334-338. doi: 10.1002/cncr.33227. Epub 2020 Oct 13.
Summary: This commentary describes the history and barriers of telehealth and how the COVID-19 pandemic impacted telehealth and its use in clinical research.
Rocco N, Montagna G (Graduate Staff), Di Micco R, Benson J, Criscitiello C, Chen L, Di Pace B, Colmenarejo AJE, Harder Y, Karakatsanis A, Maglia A, Mele M, Nafissi N, Ferreira PS, Taher W, Tejerina A, Vinci A, Nava M, Catanuto G.
Oncologist. 2021 Jan;26(1):e66-e77. doi: 10.1002/onco.13560. Epub 2020 Oct 21.
Summary: This paper reports on the findings of a panel of 12 breast surgeons and a Web-based poll created to investigate the changes in surgical practice due to the COVID-19 pandemic among breast surgeons from several countries worldwide.
Paice JA, Wholihan D, Dahlin C, Rosa WE (SKI Psychiatry/Counseling), Mazanec P, Long CO, Thaxton C, Greer K.
J Hosp Palliat Nurs. 2021 Feb;23(1):6-8. doi: 10.1097/NJH.0000000000000709. Epub 2020 Oct 12.
Summary: This article highlights the important role and scope of palliative nursing and how essential to care the palliative nurse is in the COVID-19 era.
Oberg CL, Beattie JA (Medicine), Folch EE.
Chest Physician. 2020 Oct 11;15(10):34-36.
Summary: A discussion of the use of bronchoscopy, tracheostomy, and other aerosol-generating procedures for asymptomatic, symptomatic, and critically ill COVID patients.
Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP (Graduate Studies), Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD (Computational and Systems Biology Program), Bowman GR.
bioRxiv. 2020 Oct 7. doi: 10.1101/2020.06.27.175430.
Summary: This preprint describes how citizen scientists worldwide simulated protein folding to contribute to the understanding of SARS-CoV-2 and potential COVID treatments.
Elsayes KM, Marks RM, Kamel S, Towbin AJ, Kielar AZ, Patel P, Chernyak V, Fowler KJ, Nassar S, Soliman MA, Kamaya A, Mendiratta-Lala M, Borhani AA, Fetzer DT, Fung AW, Do RKG (Radiology), Bashir MR, Lee J, Consul N, Olmsted R, Kambadakone A, Taouli B, Furlan A, Sirlin CB, Hsieh P.
Acad Radiol. 2021 Jan;28(1):119-127. doi: 10.1016/j.acra.2020.10.001. Epub 2020 Oct 6.
Summary: In the time of the COVID-19 pandemic, conferences and workshops have had to switch from in-person to online. This article reports on the successes and challenges of an online Online Liver Imaging Course (OLIC).
Trama A, Proto C, Whisenant JG, Torri V, Cortellini A, Michielin O, Barlesi F, Dingemans AC, Van Meerbeeck J, Pancaldi V, Mazieres J, Soo RA, Leighl NB, Peters S, Wakelee H, Horn L, Hellmann M (Medicine), Wong SK, Garassino MC, Baena J.
Cancer Cell.2020 Nov 9;38(5):602-604. doi: 10.1016/j.ccell.2020.10.002. Epub 2020 Oct 5
Summary: This commentary details how a global collaboration for data collection within the Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) was instrumental in providing decision-making in thoracic cancer. The limits of the registry are also discussed.
BrintzenhofeSzoc K, Krok-Schoen JI, Pisegna JL, MacKenzie AR, Canin B, Plotkin E, Boehmer LM, Shahrokni A (Medicine).
J Geriatr Oncol. 2021 Mar;12(2):196-205. doi: 10.1016/j.jgo.2020.09.028. Epub 2020 Oct 5.
Summary: This study looks at the attitudes and barriers toward the care of older adults with cancer during Covid-19.
Rosa WE (SKI Psychiatry/Counseling), Fitzgerald M, Davis S, Farley JE, Khanyola J, Kwong J, Moreland PJ, Rogers M, Sibanda B, Turale S.
Int Nurs Rev. 2020 Dec;67(4):554-559. doi: 10.1111/inr.12632. Epub 2020 Oct 2.
Summary: This paper makes a case for why Nurse Practitioners (NPs) are currently under-utilized across the globe and argues that their capacities/skills should be better leveraged at all levels and that - especially in the face of a global pandemic - nurse practitioner scopes of practice should be expanded across nations.
Miller RC, Tsai CJ (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):491-495. doi: 10.1016/j.ijrobp.2020.06.048. Epub 2020 Sep 2.
Summary: This communication piece discusses how the Covid-19 pandemic and subsequent need to quickly disseminate scientific literature across the globe impacted scholarly communication and publishing.
Cazeau N (Ld - Advanced Practice Providers).
Clin J Oncol Nurs. 2020 Oct 1;24(5):472-474. doi: 10.1188/20.CJON.472-474.
Summary: This article discusses the importance of assessing and managing the psychological distress of cancer inpatients receiving treatment, particularly during the COVID-19 pandemic, when social isolation may be exacerbated by visitation restrictions.
Sheridan L (Neurology).
Rehabil Oncol. 2020 Oct;38(4):141-142. doi: 10.1097/01.REO.0000000000000234.
Summary: Laura Sheridan, PT, DPT, CLT, the president of the Academy of Oncologic Physical Therapy, shares her perspective on how community and support of one another has been an important constant throughout the COVID-19 pandemic and will continue to be so in the rapidly changing healthcare landscape.
Tan KS (Biostat/Epidemiology).
Clin Trials. 2020 Oct;17(5):505-506. doi: 10.1177/1740774520946026. Epub 2020 Aug 20.
Summary: In this article, the author highlights the importance of adapting statistical methods to analyze survival in Covid-19 clinical trials.
Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N (Radiation Oncology), Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS.
Radiother Oncol. 2020 Oct;151:314-321. doi: 10.1016/j.radonc.2020.04.019. Epub 2020 Jul 27.
Summary: Joint recommendations from the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) offer guidance for radiation oncologists treating head and neck cancer (HNC) on how to proceed with radiation procedures during the COVID-19 pandemic.
Diaz-Salazar C (Immunology), Sun JC (Immunology).
Curr Opin Virol. 2020 Oct;44:97-111. doi: 10.1016/j.coviro.2020.07.003.
Summary: This article describes how natural killer (NK) cells play a critical role in the early anti-viral response of nearly all emerging viruses, including Covid-19.
Oh JH (Medical Physics), Tannenbaum A, Deasy JO (Medical Physics).
medRxiv. 2020 Sep 30. doi: 10.1101/2020.09.29.20204289.
Summary: This preprint re-analyzed data, originally collected for a genome-wide association study (GWAS) of Italian and Spanish participants by an international consortium group, using gene ontology analysis and protein-protein interaction analysis to determine which biological processes were most implicated in respiratory failure in COVID-19 patients.
Das JP (Radiology), Yeh R (Radiology), Schöder H (Radiology).
Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):794-799. doi: 10.1007/s00259-020-05043-y. Epub 2020 Sep 22.
Summary: This paper describes a study that included 33 patients and investigated the utility of using Q-SPECT/CT as an "imaging modality for diagnosing PE in COVID-19 patients with a medium to high probability of PE."
Krok-Schoen JL, Pisegna JL, BrintzenhofeSzoc K, MacKenzie AR, Canin B, Plotkin E, Boehmer LM, Shahrokni A (Medicine).
J Geriatr Oncol. 2021 Mar;12(2):190-195. doi: 10.1016/j.jgo.2020.09.021. Epub 2020 Sep 18.
Summary: This article examines the experiences and challenges of healthcare providers to care for older adults with cancer during Covid-19.
Remsik J (Human Oncology and Pathogenesis Program), Wilcox JA (Graduate Fellow), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Pathology), Avila EK (Neurology), Santomasso B (Neurology), Boire A (Neurology).
medRxiv. 2020 Sept 18. doi: 10.1101/2020.09.15.20195511.
Summary: This preprint (not yet confirmed by peer-review) reports on the "first series to demonstrate an increase in pro-inflammatory CSF cytokines" in cancer patients with moderate and severe COVID-19 infections "who subsequently developed moderate to severe neurologic symptoms" in the weeks following respiratory illness, suggesting that "neurologic toxicity associated with COVID-19 is biochemically similar to CAR T cell neurotoxicity."
Rao PN, Jotwani R, Joshi J, Gulati A (Anesthesiology), Mehta N.
Pain Manag. 2020 Nov;10(6):353-358. doi: 10.2217/pmt-2020-0063. Epub 2020 Sep 18.
Summary: This commentary explores what remote opioid management by pain management providers looks like in the time of the COVID-19 pandemic and the considerations that should be made "in an attempt to further mitigate risks of both COVID-19 exposure and opioid misuse."
Rebeiz T, Lim-Hing K, Khazanehdari S, Rebeiz K (Radiology).
Cureus. 2020 Sep 15;12(9):e10469. doi: 10.7759/cureus.10469.
Summary: This case report describes a febrile patient without respiratory symptoms who presented to the emergency department due to isolated behavioral disturbances and was diagnosed with COVID-19 encephalitis after evaluation.
Ghebrehiwet B, Peerschke EI (Laboratory Medicine).
J Clin Invest. 2020 Nov 2;130(11):5674-5676. doi: 10.1172/JCI142780. Epub 2020 Sept 14.
Summary: A commentary on an article identifying factors behind a circulatory immune process that can be brought on by COVID-19.
Li Y, Wu J, Wang S, Li X, Zhou J, Huang B, Luo D, Cao Q, Chen Y, Chen S, Ma L, Peng L, Pan H, Travis WD (Pathology), Nie X.
Histopathology. 2021 Mar;78(4):542-555. doi: 10.1111/his.14249. Epub 2020 Nov 11.
Summary: An autopsy study of COVID-19 patients to determine the clinical course related to and patterns of damaged lung tissue.
Makkar P (Graduate Fellow), Pastores SM (Anesthesiology).
Respirology. 2020 Nov;25(11):1133-1135. doi: 10.1111/resp.13941. Epub 2020 Sept 14.
Summary: This commentary describes the various respiratory management strategies for Covid-19 patients with acute respiratory distress syndrome (ARDS).
Li F, Han M, Dai P, Xu W, He J, Tao X, Wu Y, Tong X, Xia X, Guo W, Zhou Y, Li Y, Zhu Y, Zhang X, Liu Z, Aji R, Cai X, Li Y, Qu D, Chen Y (Medicine), Jiang S, Wang Q, Ji H, Xie Y, Sun Y, Lu L, Gao D.
bioRxiv. 2020 Sept 12. doi: 10.1101/2020.09.11.293035.
Summary: The authors assess whether the prostate cancer drug enzalutamide could be used to treat COVID-19 patients. Use in a mouse model found inconclusive results. This is a preprint and has not yet been peer reviewed.
Lenihan D, Carver J, Porter C, Liu JE (Medicine), Dent S, Thavendiranathan P, Mitchell JD, Nohria A, Fradley MG, Pusic I, Stockerl-Goldstein K, Blaes A, Lyon AR, Ganatra S, López-Fernández T, O'Quinn R, Minotti G, Szmit S, Cardinale D, Alvarez-Cardona J, Curigliano G, Neilan TG, Herrmann J.
CA Cancer J Clin.2020 Nov;70(6):480-504. doi: 10.3322/caac.21635. Epub 2020 Sep 10.
Summary: This review provides an overview of the implications of Covid-19 on cardio-oncology and outlines modifications such as a shift towards using cardiac biomarkers and focused CV imaging to minimize risk of Covid-19 infection without impacting the care of CVD in patients being treated for cancer.
Matuschek C, Fischer JC, Combs SE, Fietkau R, Corradini S, Zänker K, Bölke E, Djiepmo-Njanang FJ, Tamaskovics B, Fischer JE, Stuschke M, Pöttgen C, Förster R, Zwahlen DR, Papachristofilou A, Ganswindt U, Pelka R, Schneider EM, Feldt T, Jensen BEO, Häussinger D, Knoefel WT, Kindgen-Milles D, Pedoto A (Anesthesiology), Grebe O, van Griensven M, Budach W, Haussmann J.
Strahlenther Onkol. 2020 Dec;196(12):1068-1079. doi: 10.1007/s00066-020-01681-1. Epub 2020 Sep 10.
Summary: The authors analyzed 106 responses to a survey sent to radiation oncology institutions in Germany, Austria, and Switzerland. Cancer treatments, often on modified schedules, continued with the implementation of additional safety measures.
Trevino KM (Psychiatry Service), Raghunathan N (Medicine), Latte-Naor S (Integrative Medicine), Polubriaginof FCG (Health Informatics), Jensen C (Chief Digital Officer and Head of Technology), Atkinson TM (Psychiatry Service), Emard N (Integrative Medicine), Seluzicki CM (Integrative Medicine), Ostroff JS (Psychiatry Service), Mao JJ (Integrative Medicine).
Support Care Cancer. 2021 Feb;29(2):543-546. doi: 10.1007/s00520-020-05740-2. Epub 2020 Sep 9.
Summary: This article describes the rapid deployment of remotely delivered mind-body therapies and services to patients with cancer. The study found high utilization and satisfaction with the virtual services.
Shah GL (Medicine), DeWolf S (Graduate Fellow), Lee YJ (Medicine), Tamari R (Medicine), Dahi PB (Medicine), Lavery JA (Biostat/Epidemiology), Ruiz J (Medicine), Devlin SM (Biostat/Epidemiology), Cho C (Medicine), Peled JU (Medicine), Politikos I (Medicine), Scordo M (Medicine), Babady NE (Laboratory Medicine), Jain T (Graduate Fellow), Vardhana S (Medicine), Daniyan AF (Medicine), Sauter CS (Medicine), Barker JN (Medicine), Giralt SA (Medicine), Goss C (Laboratory Medicine), Maslak P (Laboratory Medicine), Hohl TM (Medicine), Kamboj M (Medicine), Ramanathan L (Laboratory Medicine), van den Brink MR (Medicine), Papadopoulos E (Medicine), Papanicolaou G (Medicine), Perales MA (Medicine).
J Clin Invest. 2020 Dec 1:130(12):6656-6667. doi: 10.1172/JCI141777. Epub 2020 Sep 8.
Summary: In this study, the authors report favorable clinical outcomes for COVID-19-positive patients who received cellular therapies (Allo, Auto, or CAR T therapy). Their research will help other transplant centers with decision-making.
Zhang Z, Ojutiku O, Mango VL (Radiology).
J Am Coll Radiol. 2021 Jan;18(1 Pt A):71-74. doi: 10.1016/j.jacr.2020.09.027. Epub 2020 Sep 7.
Summary: This case study qualitatively analyzed all posts on the COVID-19 forum on breastcancer.org to identify patient concerns in response to COVID-19.
White JR, Foote MB (Graduate Fellow), Jee J (Graduate Fellow), Argilés G (SKI Medicine), Wan JCM (SKI Medicine), Diaz LA Jr (Medicine).
medRxiv. 2020 Sep 3. doi: 10.1101/2020.09.02.20186783.
Summary: This preprint reports on a data evaluation effort at Memorial Sloan Kettering Cancer Center to find possible therapeutic agents for preventing COVID-19 infection. The statistical analysis study identified two classes of therapeutic agents that have a potential to play a preventative role by affecting ACE2, our gene associated with SARS-CoV-2 infection.
Griffiths EA, Alwan LM, Bachiashvili K, Brown A, Cool R, Curtin P, Geyer MB (Medicine), Gojo I, Kallam A, Kidwai WZ, Kloth DD, Kraut EH, Lyman GH, Mukherjee S, Perez LE, Rosovsky RP, Roy V, Rugo HS, Vasu S, Wadleigh M, Westervelt P, Becker PS.
J Natl Compr Canc Netw. 2020 Sep 1;1-4. doi: 10.6004/jnccn.2020.7610.
Summary: Hematopoietic cell growth factors are agents known to support proliferation and differentiation of blood cells. They are used in cancer care in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes. As with other cancer-related therapeutics the use of these agents in the time of the COVID-19 pandemic needed adjustments. This article reports on the National Comprehensive Cancer Network (NCCN) recommendations for adjustments in the use of these agents in the time of the COVID-19 pandemic, to ensure optimal care in the face of multiple new factors the pandemic brought in.
Araujo-Filho JAB (SKI Radiology), Sawamura MVY, Teixeira FB, Apanavicius A, Costa AN.
Einstein (Sao Paulo). 2020 Oct 2;18:eCE5974. doi: 10.31744/einstein_journal/2020CE5974.
Summary: This letter to the editor describes using chest CT imaging for long- term prognosis and follow-up of Covid-19.
Kamran SC, Yerramilli D (Radiation Oncology), Vapiwala N.
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):472-474. doi: 10.1016/j.ijrobp.2020.05.055. Epub 2020 Sep 2.
Summary: This opinion piece discusses diversity in the context of how the Covid-19 pandemic may shape how and whom enters into radiation oncology residency in the coming years.
Zhang H, Cha EE (Graduate Student), Lynch K (Psychiatry/Counseling), Cahlon O (Radiation Oncology), Gomez DR (Radiation Oncology), Shaverdian N (Radiation Oncology), Gillespie EF (Radiation Oncology).
Int J Radiat Oncol Biol Phys. 2020 Oct 1;108(2):421-429. doi: 10.1016/j.ijrobp.2020.07.007. Epub 2020 Sep 2.
Summary: This study looks at the views of radiation oncologists on telemedicine at MSKCC. The study found that for the most part physicians found telemedicine to be a positive experience and the focus should be on increasing access to care for patients limited by location and financial constraints.
Smith M, Lara OD, O'Cearbhaill R (Medicine), Knisely A, McEachron J, Gabor L, Carr C, Blank S, Prasad-Hayes M, Frey M, Jee J (Graduate Fellow), Fehniger J, Wang Y, Lee YC, Isani S, Wright JD, Pothuri B.
Gynecol Oncol.2020 Dec;159(3):618-622. doi: 10.1016/j.ygyno.2020.09.036. Epub 2020 Sep 25.
Summary: This article assessed a variety of inflammatory markers to see if any were predictive of COVID-19 in gynecological cancer patients. They found that ferritin, procalcitonin, and CRP may have prognostic value, as well as elevated white blood cell count, lactate, and creatinine at admission, whereas D-dimers were not found to be predictive of severe COVID-19 infection.
Guterman EL, Braunstein LZ (Radiation Oncology).
J Hosp Med. 2020 Oct;15(10):634-636. doi: 10.12788/jhm.3491. Epub 2020 Sept 23.
Summary: This perspective piece details the advantages and disadvantages of preprints in the context of the speed of COVID-19 literature being produced and provides recommendations for improving the preprint server system.
Goldberg-Stein S, Fink A, Paroder V (Radiology), Kobi M, Yee J, Chernyak V.
Abdom Radiol (NY). 2020 Sep;45(9):2613-2623. doi: 10.1007/s00261-020-02669-2.
Summary: According to this study, 57% of Covid-19-positive patients yielded positive findings on CT scans of the abdomen and pelvis. The hope is that this study will better be able to reveal why some Covid-19 patients experience abdominal symptoms and some do not.
Baena Espinar J, Torri V, Whisenant J, Hirsch FR, Rogado J, de Castro Carpeño J, Halmos B, Ceresoli GL, Gomez Rueda A, Tiseo M, Felip E, Majem Tarruella M, Monnet I, Tapan U, Wakelee H, Huang LC, Garassino MC, Peters S, Horn L, Hellmann M (Medicine).
Ann Oncol. 2020 Sept;31(Suppl 4):S1204-S1205. doi: 10.1016/j.annonc.2020.08.2316.
Summary: This abstract describes a global consortium of outcomes of COVID-19 infection in thoracic malignancies. It identified COVID-19 risk factors for increased mortality in these patients, such as age, smoking status, cancer stage, and need for steroids.
Luo J (Graduate Fellow), Rizvi H (Collaborative Research Centers), Preeshagul IR (Medicine), Egger JV (Collaborative Research Centers), Hoyos D (Biostat/Epidemiology), Bandlamudi C (Collaborative Research Centers), Donoghue MTA (Collaborative Research Centers), Luksza M, Greenbaum BD (Biostat/Epidemiology), Wolchok JD (Human Oncology & Pathogenesis Program), Kris MG (Medicine), Hellmann MD (Medicine).
Clin Cancer Res. 2020 Sep;26(18 Suppl.). doi: 10.1158/1557-3265.COVID-19-IA04.
Summary: While it became clear that cancer patients with COVID-19 were especially vulnerable to a severe course of COVID-19, it raised questions as to whether these vulnerabilities were related predominantly to patient characteristics or to cancer and cancer treatments. The research on specific treatment for lung cancer established that patient-related characteristics influence the severity of COVID-19 rather than cancer treatment. This conclusion will be instrumental for optimal decision making on treatment of these patients.
Belenkaya R (Health Informatics), Watson A (Health Informatics), Bethusamy S (Health Informatics), Patel M (Health Informatics), Sandler T (Health Informatics), Schwartz J (Health Informatics), Park J (Health Informatics), Dobbins M (Health Informatics), Maloy M (Health Informatics), Lam M (Health Informatics), Bahadur N (Health Informatics), Philip J (Health Informatics).
Clin Cancer Res. 2020 Sep;26(18 Suppl.). doi: 10.1158/1557-3265.COVID-19-PO-061.
Summary: The research data on Covid-19 in cancer patients generated during the pandemic is abundant and complex and it is recorded in multiple institutional and cross-institutional registries. It became a challenge to technically reconcile Covid-19 and cancer research registries built on different standards. To address the need, MSKCC created a framework for ensuring compatibility of Covid-19 and cancer research registries.
Galindo-Vázquez O, Ramírez-Orozco M, Costas-Muñiz R (Psychiatry Service), Mendoza-Contreras LA, Calderillo-Ruíz G, Meneses-García A.
Gac Med Mex. 2020;156(4):298-305. doi: 10.24875/GMM.20000266.
Summary: This article studied the impact of COVID-19 on anxiety, depression, and self-care behaviors. The results were analyzed from online surveys answered by 1508 participants.
Kamboj M (Medicine), Pessin M (Laboratory Medicine), Barber T (Surgery), The COVID19 Subcommittee of the O.R. Executive Committee at Memorial Sloan Kettering, (Ardizzone L (Anesthesiology), Drebin J (Surgery), Fischer G (Anesthesiology), Jewell E (Surgery), Laudone V (Surgery), Levine M (Hospital Administration), Linder J (Hospital Administration), Simon B (Josie Robertson Surgery Center), Stromblad C (Strategy and Innovation), Tabar V (Neurosurgery), Weiser M (Surgery), Yee SJ (Nursing) in group).
Ann Surg. 2020 Sep 1;272(3):e243. doi: 10.1097/SLA.0000000000004101.
Summary: This commentary describes a protocol for preoperative assessment of patients for Covid-19 to minimize risk of conducting surgery on Covid-positive patients.
Roeker LE (Medicine), Knorr DA (Medicine), Pessin MS (Laboratory Medicine), Ramanathan LV (Laboratory Medicine), Thompson MC (Graduate Fellow), Leslie LA, Zelenetz AD (Medicine), Mato AR (Medicine).
Leukemia. 2020 Nov;34(11):3047-3049. doi: 10.1038/s41375-020-01030-2. Epub 2020 Aug 27.
Summary: This letter to the editor describes decreased antibody and immune response in immunocompromised patients with CLL, with implications in vaccine success rates in these patients.
Esfahani SA, Lee A (Graduate Fellow), Hu JY, Kelly M, Magudia K, Everett C, Szabunio M, Ackerman S, Spalluto LB.
Clin Imaging. 2020 Dec;68:291-294. doi: 10.1016/j.clinimag.2020.08.016. Epub 2020 Aug 28.
Summary: This article details the challenges of women in radiology due to the Covid-19 pandemic and subsequent changes to work/life needs.
Alboraie M, Piscoya A, Tran QT, Mendelsohn RB (Medicine), Butt AS, Lenz L, Alavinejad P, Emara MH, Samlani Z, Altonbary A, Monged A, Lemmers A, Sudovykh I, Ho DQD, Ghazanfar S, Kamau E, Iqbal S, Tan DMY, Liao WC, Vignesh S; "The Global Endo-COVID working group".
Arab J Gastroenterol. 2020 Sep;21(3):156-161. doi: 10.1016/j.ajg.2020.08.008. Epub 2020 Aug 26.
Summary: A survey of 163 endoscopists in 48 countries found significant COVID-related declines in endoscopic procedures and a need to improve training on the use of personal protective equipment.
Elnadoury O, Beattie J (Medicine), Lubinsky AS.
J Aerosol Med Pulm Drug Deliv. 2020 Dec;33(6):357-360. doi: 10.1089/jamp.2020.1636. Epub 2020 Aug 25.
Summary: This case report describes how to deliver continuous and intermittent nebulizer treatment without interruption in patients infected with SARS-CoV2 using two Aerogen vibratory mesh nebulizers.
Navlakha S, Morjaria S (Medicine), Perez-Johnston R (Radiology), Zhang A, Taur Y (Medicine).
medRxiv. 2020 Aug 23. 20179838; doi: https://doi.org/10.1101/2020.08.23.20179838.
Summary: This preprint describes the creation and use of an artificial intelligence tool for predicting COVID-19 severity in cancer patients at Memorial Sloan Kettering Cancer Center.
Rosa WE (SKI Psychiatry/Counseling), Finlayson CS (Nursing), Ferrell BR.
Cancer Nurs. 2020 Nov/Dec;43(6):431-432. doi: 10.1097/NCC.0000000000000886. Epub 2020 Aug 19.
Summary: This editorial highlights the amplified role of cancer nurses as primary palliative care agents in the unprecedented time of COVID-19. The authors note their inestimable value as "educational resources to support the delivery of primary palliative care."
Algado-Sellés N, Gras-Valentí P, Chico-Sánchez P, Mora-Muriel JG, Soler-Molina VM, Hernández-Maldonado M, Lameiras-Azevedo AS, Jiménez-Sepúlveda NJ, Gómez-Sotero IL, Villanueva-Ruiz CO, Barrenengoa-Sañudo J, Fuster-Pérez M, Cánovas-Javega S, Cerezo-Milan P, Monerris-Palmer M, Esclapez A, Cartagena-Llopis L, García-Rivera C, Martínez-Tornero I, Nadal-Morante V, Merino-Lucas E, Rodriguez-Diaz JC, Vidal-Catala I, Llorens-Soriano P, San Inocencio D, Gil-Carbonell J, Montiel-Higuero I, Sánchez-Vela P (Human Oncology and Pathogenesis Program), Sánchez-Payá J.
Am J Prev Med. 2020 Dec;59(6):e221-e229. doi: 10.1016/j.amepre.2020.07.014. Epub 2020 Aug 18.
Summary: An observational study of 3,900 healthcare personnel in a Spanish health department who showed symptoms or were in contact with a COVID-19 patient between March 2, 2020 and April 19, 2020.
Gany F (Psychiatry Service), Mirpuri S (Psychiatry Service), Kim SY (Psychiatry Service), Narang B (Psychiatry Service), Ramirez J (Psychiatry Service), Roberts-Eversley N (Psychiatry Service), Ocampo A (Psychiatry Service), Aragones A (Psychiatry Service), Leng J (Psychiatry Service).
J Community Health. 2020 Dec;45(6):1098-1110. doi: 10.1007/s10900-020-00903-y. Epub 2020 Aug 17.
Summary: Results of a survey of 422 taxi and for-hire vehicle drivers in the New York City metropolitan area to examine health and financial planning behaviors, including the impact of COVID-19.
Morjaria S (Medicine), Zhang AW, Kaltsas A (Medicine), Parameswaran R (Medicine), Patel D (Quality of Care Initiative), Zhou W (Operation Excellence), Predmore J (Ld - Advanced Practice Providers), Perez-Johnston R (Radiology), Jee J (Graduate Fellow), Perales MA (Medicine), Daniyan AF (Medicine), Taur Y (Medicine), Mailankody S (Medicine).
medRxiv. 2020 Aug 15. doi: 10.1101/2020.08.13.20174565.
Summary: The study looked at hospitalized cancer patients with neutropenia (a condition that commonly affects cancer patients and is treated with recombinant human granulocyte colony-stimulating factor, G-CSF, filgrastim) who also had COVID-19 infection. The retrospective study found that neutropenia did not affect the course of COVID-19 infection in such patients but CSF administration did. The authors recommended exercising caution and weighing risks vs benefits of SCF treatment of neutropenic patients with COVID-19 infection. This preprint has not been peer reviewed.
Jee J (Graduate Fellow), Foote MB (Graduate Fellow), Lumish M (Graduate Fellow), Stonestrom AJ (Graduate Fellow), Wills B (Graduate Fellow), Narendra V (Graduate Fellow), Avutu V (Graduate Fellow), Murciano-Goroff YR (Graduate Fellow), Chan JE (Medicine), Derkach A (Biostat/Epidemology), Philip J (Health Informatics), Belenkaya R (Health Informatics), Kerpelev M (Information Systems), Maloy M (Health Informatics), Watson A (Health Informatics), Fong C (Collaborative Research Centers), Janjigian Y (Medicine), Diaz LA Jr (Medicine), Bolton KL (Medicine), Pessin MS (Laboratory Medicine).
J Clin Oncol. 2020 Oct 20;38(30):3538-3546. doi: 10.1200/JCO.20.01307. Epub 2020 Aug 14.
Summary: In this retrospective study, the authors analyzed the influence of receiving anti-cancer treatments and other cancer-related features on the severity of COVID-19.
Reidy-Lagunes D (Medicine), Saltz LB (Medicine), Postow M (Medicine), Scordo M (Medicine), Moskowitz A (Medicine), Tew W (Medicine), Zamarin D (Medicine), Redelman-Sidi G (Medicine).
J Natl Cancer Inst. 2021 Jul;113(7):820-822. doi: 10.1093/jnci/djaa111. Epub 2020 Aug 14.
Summary: This article reports guidelines for COVID-19 patients receiving anti-cancer treatment (chemotherapy, targeted therapy, or immunotherapy). An MSK task force wrote those guidelines and hopes it will be useful to oncologists in other institutions.
McBride SM (Radiation Oncology), Bundick K (Radiation Oncology), Hubbeling H (Graduate Staff), Freret M (Graduate Staff), Modlin LA (Graduate Staff), Kamboj M (Medicine), Cahlon O (Radiation Oncology), Gomez DA (Radiation Oncology).
medRxiv. 2020 Aug 14. doi: 10.1101/2020.08.11.20172551.
Summary: The study reported on the efforts by the Memorial Sloan Kettering Cancer Center for reducing interruptions in radiation therapy during the COVID-19 pandemic. The Department of Radiation Oncology implemented PCR testing of outpatients coming for treatment along with antibody testing later into the pandemic. These departmental efforts, combined with following the statewide pandemic fighting policies, helped prevent interruptions in radiotherapy treatment that could have jeopardized the treatment's efficacy during the pandemic. This preprint has not been peer reviewed.
Matuschek C, Moll F, Fangerau H, Fischer JC, Zänker K, van Griensven M, Schneider M, Kindgen-Milles D, Knoefel WT, Lichtenberg A, Tamaskovics B, Djiepmo-Njanang FJ, Budach W, Corradini S, Häussinger D, Feldt T, Jensen B, Pelka R, Orth K, Peiper M, Grebe O, Maas K, Gerber PA, Pedoto A (Anesthesiology), Bölke E, Haussmann J.
Eur J Med Res. 2020 Aug 12;25(1):32. doi: 10.1186/s40001-020-00430-5.
Summary: This review of available literature found that wearing face masks that cover the nose and mouth are effective at interrupting airborne infections in the community. This review highlights the protectiveness of certain types of face masks in defined risk groups as well as their risks.
Anderson MR, Bach PB (Center for Health Policy and Outcomes), Baldwin MR.
medRxiv. 2020 Aug 12. doi: 10.1101/2020.08.10.20171637.
Summary: The retrospective study looked at the impact of the drug Remdesivir (that received emergency use authorization for treatment of severe COVID-19) on the length of stay of inpatients with severe COVID-19 infection and found that, contrary to the expectations, the use of Remdesivir did not reduce the length of stay in the studied population. This preprint has not been peer reviewed.
Jee J (Graduate Fellow), Stonestrom AJ (Graduate Fellow), Devlin S (Biostat/Epidemiology), Nguyentran T (Ld - Advanced Practice Providers), Wills B (Graduate Staff), Narendra V (Graduate Fellow), Foote MB (Graduate Staff), Lumish M (Graduate Staff), Vardhana S (Medicine), Pastores SM (Anesthesiology), Korde N (Medicine), Patel D (Medicine), Horwitz S (Medicine), Scordo M (Medicine), Daniyan A (Medicine).
medRxiv. 2020 Aug 12. doi: 10.1101/2020.08.11.20145458.
Summary: This preprint provides a retrospective investigation of the effects of oncologic immunomodulatory agents on the 820 cancer patients diagnosed with SARS-CoV-2 at Memorial Sloan Kettering Cancer Center up to June 2, 2020.
de Almeida JR, Noel CW, Forner D, Zhang H, Nichols AC, Cohen MA (Surgery), Wong RJ (Surgery), McMullen C, Graboyes EM, Divi V, Shuman AG, Rosko AJ, Lewis CM, Hanna EY, Myers J, Paleri V, Miles B, Genden E, Eskander A, Enepekides DJ, Higgins KM, Brown D, Chepeha DB, Witterick IJ, Gullane PJ, Irish JC, Monteiro E, Goldstein DP, Gilbert R.
Cancer. 2020 Nov 15;126(22):4895-4904. doi: 10.1002/cncr.33114. Epub 2020 Aug 11.
Summary: This study defines an algorithm to fairly and consistently triage head and neck cancer patients that require surgery.
Laurence J, Mulvey JJ (Graduate Fellow), Seshadri M, Racanelli A, Harp J, Schenck EJ, Zappetti D, Horn EM, Magro CM.
Clin Immunol. 2020 Oct;219:108555. doi: 10.1016/j.clim.2020.108555. Epub 2020 Aug 6.
Summary: This article reports on the effects of the administration of the anti-C5 monoclonal antibody eculizumab to three critically ill COVID-19 patients who had failed to respond to multiple other interventions, including steroids, remdesivir, and tociluzimab.
Nabhan C, Choueiri TK, Mato AR (Medicine).
JAMA Oncol. 2020 Sep;6(9):1327-1329. doi: 10.1001/jamaoncol.2020.3142. Epub 2020 Aug 6.
Summary: This viewpoint article details how Covid-19 has caused a significant change to how clinical trials are conducted, including telemedicine and virtual support for trial participants, laboratory tests and procedures done in clinics not affiliated with the trial, the speed of recruitment into trials, and the focus on patient-reported outcomes. These are all changes that can shape how clinical trials are conducted in a post-Covid world to improve access to and impact of clinical trials.
Talaulikar D, Advani RH, Branagan AR, Buske C, Dimopoulos MA, D'Sa S, Kersten MJ, Leblond V, Minnema MC, Owen RG, Palomba ML (Medicine), Tedeschi A, Trotman J, Varettoni M, Vos JM, Treon SP, Kastritis E, Castillo JJ.
HemaSphere. 2020 Aug; 4(4): e433. doi: 10.1097/HS9.0000000000000433.
Summary: The International Workshop on Waldenström Macroglobulinemia (IWWM) Treatment Recommendations Panel provides answers to help guide patient therapy during the pandemic.
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Hackett A, Koval M, Guttentag SH, Blackwell TS, Vanderbilt COVID-19 Consortium Cohort, Webber SA, Banovich NE, Kropski JA, Sucre JMS, HCA Lung Biological Network.
medRxiv. 2020 Aug 3. doi: 10.1101/2020.05.22.111187.
Summary: In this preprint, researchers use a mouse model of SARS-COV-2 to determine how lung development impacts disease susceptibility.
Moreno CC, Yee J, Ahmed FS, Barish MA, Brewington C, Dachman AH, Gollub MJ (Radiology), Kim DH, McFarland E, Pickhardt PJ, Reddy S, Zalis M, Chang KJ.
Abdom Radiol (NY). 2021 Feb;46(2):486-490. doi: 10.1007/s00261-020-02674-5. Epub 2020 Aug 3.
Summary: The favorable procedural profile of CT colonography (CTC) for colorectal cancer screening is described in this paper as it may be a reasonable alternative to optical colonoscopy during the COVID-19 pandemic.
Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A (Biostat/Epidemiology), Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD (Biostat/Epidemiology), Hacohen N, Lagana SM, Rivera MN, Sholl, LM, Stone JR, Ting DT, Deshpande V.
medRxiv. 2020 Aug 2. doi: 10.1101/2020.07.30.20165241.
Summary: This preprint contributes to the knowledge of the pathology of pulmonary disease associated with Covid-19 infection.
Akula SM, Abrams SL, Steelman LS, Candido S, Libra M, Lerpiriyapong K (Research Facilities), Cocco L, Ramazzotti G, Ratti S, Follo MY, Martelli AM, Blalock WL, Piazzi M, Montalto G, Cervello M, Notarbartolo M, Basecke J, McCubrey JA.
Adv Biol Regul. 2020 Aug;77:100739. doi: 10.1016/j.jbior.2020.100739.
Summary: This article provides a summary of the impact of COVID-19 on patients with different types of cancer and their treatments, as well as, the potential repurposing of various drugs/agents to minimize or treat COVID-19 disease.
Rocco G (Surgery).
J Thorac Cardiovasc Surg. 2020 Aug;160(2):594-595. doi: 10.1016/j.jtcvs.2020.03.130. Epub 2020 Apr 10.
Summary: This commentary by MSK thoracic surgeon Dr. Gaetano Rocco discusses how early reports of the pandemic from China and Italy should inform surgical care in New York, the new epicenter of COVID at the time of publication.
Rossi D, Shadman M, Condoluci A, Brown JR, Byrd JC, Gaidano G, Hallek M, Hillmen, P, Mato A (Medicine), Montserrat E, Ghia P.
HemaSphere. 2020 Aug; 4(4): e432. doi: 10.1097/HS9.0000000000000432.
Summary: Cancer patients with Covid-19 are especially vulnerable to infection and their treatment during the pandemic has to be reviewed and revised in that new light. This article provides expert opinion, based on literature review, on treatment adjustments needed for patients with Chronic Lymphocytic Leukemia at the time of the pandemic.
Diamond LC (Psychiatry), Jacobs EA, Karliner L.
Patient Educ Couns.2020 Aug;103(8):1451-1452. doi: 10.1016/j.pec.2020.05.028.
Summary: This editorial highlights the health care disparities experienced disproportionately by populations who are limited English proficient (LEP), exacerbated during the COVID-19 pandemic. It outlines steps for more clear communication that can be taken to provide equitable care to LEP populations and help contain the spread of COVID-19.
Lara OD, O'Cearbhaill RE (Medicine), Smith MJ, Sutter ME, Knisely A, McEachron J, Gabor LR, Jee J, Fehniger JE, Lee YC, Isani SS, Wright JD, Pothuri B.
Cancer. 2020 Oct 1;126(19):4294-4303. doi: 10.1002/cncr.33084. Epub 2020 Jul 30.
Summary: Cancer patients that also have COVID-19 may be affected by this infection in a different way than the general population. The interplay between Covid-19 infection and various cancer treatments is an important factor in patients' severity of infection, its complications, and survival. This article reports a study which compiled data on patients with gynecologic cancers in multiple NYC hospitals. The study found that the immunotherapy treatments negatively affect the infection severity and patient survival while cancer chemotherapy and surgery don't. These findings inform treatment decisions that also allow for continuing chemotherapy and surgery. Further evaluation of immunotherapy for cancer patients with Covid-19 is needed and caution should be exercised during the pandemic.
Chams N, Chams S, Badran R, Shams A, Araji A (Radiology), Raad M, Mukhopadhyay S, Stroberg E, Duval EJ, Barton LM, Hajj Hussein I.
Front Public Health. 2020 Jul 29;8:383. doi: 10.3389/fpubh.2020.00383.
Summary: This is a comprehensive review of what we have learned about the novel coronavirus and the infection it causes (up to July 2020, the time of this article's publication). It covers the whole spectrum of COVID-19 including timeline, origins, how the virus is transmitted, epidemiology, clinical symptoms, disease course and complications, treatments that emerged, etc.
Waghmare A, Abidi MZ, Boeckh M, Chemaly RF, Dadwal S, El Boghdadly Z, Kamboj M (Medicine), Papanicolaou GA (Medicine), Pergam SA, Shahid Z.
Biol Blood Marrow Transplant. 2020 Nov;26(11):1983-1994. doi: 10.1016/j.bbmt.2020.07.027. Epub 2020 Jul 28.
Summary: Guidelines for the diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplantation and cellular therapy recipients, produced using available data and the expert opinion of the American Society for Transplantation and Cellular Therapy Infectious Diseases Special Interest Group members.
Algwaiz G, Aljurf M, Koh M, Horowitz MM, Ljungman P, Weisdorf D, Saber W, Kodera Y, Szer J, Jawdat D, Wood WA, Brazauskas R, Lehmann L, Pasquini MC, Seber A, Lu PH, Atsuta Y, Riches M, Perales MA (Medicine), Worel N, Okamoto S, Srivastava A, Chemaly RF, Cordonnier C, Dandoy CE, Wingard JR, Kharfan-Dabaja MA, Hamadani M, Majhail NS, Waghmare AA, Chao N, Kröger N, Shaw B, Mohty M, Niederwieser D, Greinix H, Hashmi SK; WBMT and the CIBMTR Health Services and International Studies Committee.
Biol Blood Marrow Transplant. 2020 Dec;26(12):2181-2189. doi: 10.1016/j.bbmt.2020.07.021. Epub 2020 Jul 24.
Summary: The Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee collaborated to write these worldwide guidelines on Hematopoietic Cell Transplantation in the times of COVID-19.
Magro C, Mulvey JJ (Laboratory Medicine), Laurence J, Sanders S, Crowson N, Grossman M, Harp J, Nuovo G.
Br J Dermatol. 2021 Jan;184(1):141-150. doi: 10.1111/bjd.19415. Epub 2020 Jul 22.
Summary: The authors compare two skin manifestations of COVID, one that arises in mild disease and one in severe illness, and the distinct immune responses behind them.
Schultz L, Link MP, Rheingold S, Hawkins DS, Dome JS, Wickiser J, Kung AL (Pediatrics), Henderson TO, Aftandilian C.
Pediatr Blood Cancer. 2020 Nov;67(11):e28411. doi: 10.1002/pbc.28411. Epub 2020 Jul 19.
Summary: This letter to the editor details physician recommendations from six academic pediatric hematology/oncology programs for caring for immunocompromised pediatric patients who are at higher risk of infection.
Mato AR (Medicine), Roeker LE (Medicine), Lamanna N, Allan J, Leslie LA, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs RW, Ahn IE, Pu JJ, Isaac K, Barr PM, Ujjani C, Geyer MB (Medicine), Berman E, Zelenetz AD (Medicine), Malakhov N, Furman RR, Koropsak M, Bailey N, Hansson L, Perini GF, Ma S, Ryan CE, Wiestner A, Portell CA, Shadman M, Chong EA, Brander DM, Sundaram S, Seddon AN, Seymour E, Patel M, Martinez-Calle N, Munir T, Walewska R, Broom A, Walter HS, El-Sharkawi D, Parry H, Wilson MR, Patten PE, Hernández-Rivas JÂ, Miras F, Fernàndez Escalada N, Ghione P (Graduate Fellow), Nabhan C, Lebowitz S (Outpatient Operations), Bhavsar EB, López-Jiménez J, Naya D, Garcia-Marco JA, Skånland SS, Cordoba R, Eyre TA.
Blood. 2020 Sep 3;136(10):1134-1143. doi: 10.1182/blood.2020006965. Epub 2020 Jul 20.
Summary: This study of nearly 200 chronic lymphocytic leukemia patients with symptomatic COVID infections found that patients requiring hospitalization had high mortality rates.
Levine RL (Human Oncology & Pathogenesis).
Sci Adv. 2020 Sep 10;6(37):eabd7487. doi: 10.1126/sciadv.abd7487. Epub 2020 Jul 17.
Summary: Dr. Ross Levine delineates the challenges COVID-19 has brought to cancer care and research in this editorial.
Pillarsetty N (Radiology), Carter L (Medical Physics), Lewis JS (Radiology), Reiner T (Radiology).
J Nucl Med. 2020 Dec;61(12):1720-1723. doi: 10.2967/jnumed.120.249748. Epub 2020 Jul 17.
Summary: In this article, the authors explore using radiotherapy developed for cancer therapy as a potential co-treatment for COVID-19.
Battisti NML, Mislang AR, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrió RG, Stauder R, Soto-Perez-de-Celis E, Jaklitsch M, Williams GR, O'Hanlon S, Alam M, Cairo C, Colloca G, Gil LA Jr, Sattar S, Kantilal K, Russo C, Lichtman SM (Medicine), Brain E, Kanesvaran R, Wildiers H.
J Geriatr Oncol. 2020 Nov;11(8):1190-1198. doi: 10.1016/j.jgo.2020.07.008. Epub 2020 Jul 16
Summary: In this article, experts from the International Society of Geriatric Oncology (SIOG) wrote cancer care recommendations for older patients during a pandemic.
Majeed J (Ld-Advanced Practice Providers), Garcia J (Nursing), Holland J (Nursing), Daly B (Medicine), Robson ME (Medicine), Reidy-Lagunes D (Medicine).
Harvard Business Review 2020 Jul 16.
Summary: This article reports on the successes and challenges of an MSKCC program that remotely monitors cancer patients who test positive to Covid-19. The program involves five digital platforms.
Mukherjee D, Kumar R (Molecular Biology), Ray U.
ChemRxiv. 2020 Jul 15. doi: 10.1101/2020.07.30.20165241.
Summary: This preprint identifies five drugs approved for other diseases that bind to both COVID-19 and Dengue virus.
Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A (Radiation Oncology), Rodrigues GB, Schild SE, Senan S, Simone CB II (Radiation Oncology), Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D.
Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):631-640. doi: 10.1016/j.ijrobp.2020.05.012.
Summary: : A consensus statement of 32 experts in lung cancer recommend adhering to guidelines for recommended practice. For patients positive for Covid-19 it's recommended to postpone or interrupt radiation therapy. In a severe pandemic scenario, patients should be triaged based on a variety of factors.
Rusch VW (Surgery), Wexner SD, in collaboration with the American College of Surgeons COVID-19 Communications Committee, Board of Regents, and Officers.
J Am Coll Surg. 2020 Oct;231(4):490-496. doi: 10.1016/j.jamcollsurg.2020.06.020. Epub 2020 Jul 14.
Summary: This article describes the efforts made by the American College of Surgeons and its multiple divisions to support medical professionals in addressing the challenges presented by the COVID-19 pandemic. These efforts also included support to cancer programs by creating guidelines on managing cancer patients during the pandemic.
Begg CB (Biostat/Epidemiology), Gonen M (Biostat/Epidemiology), Heitjan DF.
Clin Trials. 2020 Oct;17(5):465-466. doi: 10.1177/1740774520940230. Epub 2020 Jul 10.
Summary: This editorial highlights three articles published in volume 17, issue 5, of the journal "Clinical Trials," dedicated to the important aspects of experimental research in a pandemic such as COVID-19. The articles highlighted by the editors provide an overview of the health care response to the COVID-19 pandemic in a historical perspective, discuss what COVID-19 clinical trials should focus on, and discuss the suitability of traditional clinical research design during special situations such as the COVID-19 pandemic.
Elmunzer BJ, Spitzer RL, Foster LD, Merchant AA, Howard EF, Patel VA, West MK, Qayad E, Nustas R, Zakaria A, Piper MS, Taylor JR, Jaza L, Forbes N, Chau M, Lara LF, Papachristou GI, Volk ML, Hilson LG, Zhou S, Kushnir VM, Lenyo AM, McLeod CG, Amin S, Kuftinec GN, Yadav D, Fox C, Kolb JM, Pawa S, Pawa R, Canakis A, Huang C, Jamil LH, Aneese AM, Glamour BK, Smith ZL, Hanley KA, Wood J, Patel HK, Shah JN, Agarunov E, Sethi A, Evan L. Fogel EL, McNulty G, Haseeb A, Trieu JA, Dixon RE, Yang JY, Mendelsohn RB (Medicine), Calo D (Medicine), Aroniadis OC, LaComb JF, Scheiman JM, Sauer BG, Dang DT, Piraka CR, Shah ED, Pohl H, Tierney WM, Mitchell S, Condon A, Lenhart A, Dua KS, Kanagala VS, Kamal A, Singh VK, Pinto-Sanchez MI, Hutchinson JM, Kwon RS, Korsnes SJ, Singh H, Solati Z, Deshpande AR, Rockey DC, Alford TB, Durkalski V, the North American Alliance for the Study of Digestive Manifestations of COVID-19.
medRxiv. 2020 Jul 9. doi: 10.1101/2020.07.07.20143024.
Summary: This preprint compiles evidence on the presence and severity of gastrointestinal problems in patients with COVID-19.
Kotsen C (Psychiatry Service), Dilip D (Psychiatry Service), Carter-Harris L (Psychiatry Service), O'Brien M (Psychiatry Service), Witlock CW (Psychiatry Service), de Leon-Sanchez S (Psychiatry Service), Ostroff JS (Psychiatry Service).
Telemed J E Health.2021 Jan;27(1):20-29. doi: 10.1089/tmj.2020.0194. Epub 2020 Jul 9.
Summary: This article describes Memorial Sloan Kettering Cancer Center's successful transitioning from in-person smoking cessation counseling, to telehealth treatment for tobacco dependent cancer patients during COVID-19 pandemic.
Kang JJ (Radiation Oncology), Wong RJ (Surgery), Sherman EJ (Medicine), Rybkin A (Radiation Oncology), McBride SM (Radiation Oncology), Riaz N (Radiation Oncology), Tsai CJ (Radiation Oncology), Yu Y (Radiation Oncology), Chen L (Radiation Oncology), Zakeri K (Radiation Oncology), Gelblum DY (Radiation Oncology), Gillespie EF (Radiation Oncology), Cohen MA (Surgery), Cracchiolo JR (Surgery), Ganly I (Surgery), Patel S (Surgery), Singh B (Surgery), Boyle JO (Surgery), Roman BR (Surgery), Morris LG (Surgery), Shaha AR (Surgery), Dunn LA (Medicine), Ho AL (Medicine), Fetten JV (Medicine), Shah JP (Surgery), Pfister DG (Medicine), Lee NY (Radiation Oncology).
Cancer. 2020 Sep 15;126(18):4092-4104. doi: 10.1002/cncr.33031. Epub 2020 Jul 8.
Summary: MSK's treatment for head and neck cancer during the COVID pandemic followed the best available evidence while expanding telemedicine utilization.
Sauter JL (Pathology), Baine MK (Graduate Fellow), Butnor KJ, Buonocore DJ (Pathology), Chang JC (Pathology), Jungbluth AA (Pathology), Szabolcs MJ, Morjaria S (Medicine), Mount SL, Rekhtman N (Pathology), Selbs E, Sheng ZM, Xiao Y, Kleiner DE, Pittaluga S, Taubenberger JK, Rapkiewicz AV, Travis WD (Pathology).
Histopathology. 2020 Dec;77(6):915-925. doi: 10.1111/his.14201. Epub 2020 Jul 2.
Summary: This article describes post-mortem pathology findings from patients who died of Covid-19 pneumonia, including the wide spectrum of progression from rapid to prolonged disease course.
Almassi N (Graduate Fellow), Mulhall JP (Surgery), Funt SA (Medicine), Sheinfeld J (Surgery).
BJU Int. 2020 Sep;126(3):333-335. doi: 10.1111/bju.15157. Epub 2020 Aug 18.
Summary: A case report of a patient whose surgery was postponed due to a positive COVID screening test and the disease management considerations that followed.
Chodera J (Computational and Systems Biology Program), Lee AA, London N, von Delft F.
Nat Chem. 2020 Jul;12(7):581. doi: 10.1038/s41557-020-0496-2. Epub 2020 Jun 18.
Summary: This letter to the editor describes the creation of Moonshot COVID, an international consortium of scientists being funded through charity grants and crowdfunding to quickly and easily develop antiviral drugs to treat Covid-19 disease.
Wilcox JA (Neurology), Remsik J (Human Oncology and Pathogenesis Program), Babady NE (Laboratory Medicine), McMillen TA (Laboratory Medicine), Vachha BA (Radiology), Halpern NA (Anesthesiology), Dhawan V (Anesthesiology), Rosenblum M (Pathology), Iacobuzio-Donahue CA (Pathology), Avila E (Neurology), Sontomasso B (Neurology), Boire A (Neurology).
Cancer Res. 2020 Jul 1; 81(13 Suppl.). doi: 10.1158/1538-7445.AM2021-703.
Summary: A prospective evaluation of 18 cancer patients with confirmed SARS-CoV-2 infection and subsequent neurologic manifestations, with authors noting that findings suggest a potential role for anti-inflammatory treatments with these patients.
Chen GH (Medical Physics), Hellman S (Anesthesiology), Irie T (Anesthesiology), Downey RJ (Surgery), Fischer GW (Anesthesiology).
Br J Anaesth. 2020 Oct;125(4):e366-e368. doi: 10.1016/j.bja.2020.06.043. Epub 2020 June 30.
Summary: A serious complication of COVID-19 infection is acute respiratory distress syndrome and ventilators are used to address this condition. The high number of such cases at the time of the pandemic caused ventilator shortages which were sometimes solved by providing a single ventilator to more than one patient at the same time, presenting several challenges. This article reports on finding a technical solution to these challenges.
Wang E, Tsai CJ (Radiation Oncology), Miller RC.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):523-524. doi: 10.1016/j.adro.2020.06.015. Epub 2020 Jun 29.
Summary: This article serves as an introduction to a special issue of the Society for Radiation Oncology's Advances in Radiation Oncology. It describes the evolution of topics and manuscript submissions as the practice of radiation oncology around the world has been impacted in response to the COVID-19 pandemic.
Gampel B, Troullioud Lucas AG (Graduate Fellow), Broglie L, Gartrell-Corrado RD, Lee MT, Levine J, Orjuela-Grimm M, Satwani P, Glade-Bender J (Pediatrics), Roberts SS (Pediatrics).
Pediatr Blood Cancer. 2020 Sep; 67(9): e28420. doi: 10.1002/pbc.28420. Epub 2020 Jun 26.
Summary: This letter to the editor describes the experience of two pediatric oncology departments in NYC (MSK and NYP) with Covid-19, including demographics and clinical characteristics of patients tested, and the clinical characteristics and impacts of the patients who tested positive.
Iuga AC, Marboe CC, Yilmaz MM, Lefkowitch JH, Gauran C (Anesthesiology), Lagana SM.
Arch Pathol Lab Med. 2020 Oct;144(10):1159-1160. doi: 10.5858/arpa.2020-0248-LE. Epub 2020 Jun 24.
Summary: This article reports on the "pathological findings in the adrenal glands of the first five post-mortem examinations of patients with COVID-19 diagnosed on clinical grounds with confirmatory real-time polymerase chain reaction testing of nasopharyngeal swab." The authors consider the potential role of adrenal function in the pathogenesis of COVID-19 disease.
Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Mead PA (Medicine), Rolling T (SKI Medicine), Perez-Johnston R (Radiology), Bernardes M (Graduate Fellow), Bogler Y (Graduate Fellow), Caldararo M (Graduate Fellow), Figueroa CJ (Medicine), Glickman MS (Immunology), Joanow A (Ld - Advanced Practice Providers), Kaltsas A (Medicine), Lee YJ (Medicine), Lucca A (Emp Health & Wellness), Mariano A (Ld - Advanced Practice Providers), Morjaria S (Medicine), Nawar T (Graduate Fellow), Papanicolaou GA (Medicine), Predmore J (Ld - Advanced Practice Providers), Redelman-Sidi G (Medicine), Schmidt E (Ld - Advanced Practice Providers), Seo SK (Medicine), Sepkowitz K (Physician in Chief), Shah MK (Medicine), Wolchok JD (Human Oncology & Pathogenesis Pgm), Hohl TM (Medicine), Taur Y (Medicine), Kamboj M (Medicine).
Nat Med. 2020 Aug;26(8):1218-1223. doi: 10.1038/s41591-020-0979-0. Epub Jun 24.
Summary: This article adds to the characterization of COVID-19 in patients with cancer as it reports the most extensive single-institution experience in patients with cancer from the epicenter of the US outbreak, describing outcomes on COVID-19-associated respiratory compromise and including a full 30-d follow-up for reporting primary study outcomes and death rates.
Sarpatwari A, Kaltenboeck A (Biostat/Epidemiology), Kesselheim AS.
JAMA. 2020 Jul 28;324(4):331-332. doi: 10.1001/jama.2020.11932. Epub 2020 Jun 24
Summary: This editorial expresses concerns about the emergency-use authorization of remdesivir for COVID: a lack of robust monitoring of drug safety and effectiveness and pricing issues.
Rosa WE, Ferrell BR, Applebaum AJ (Psychiatry Service).
Palliat Support Care. 2020 Aug;18(4):376-378. doi: 10.1017/S1478951520000462. Epub 2020 Jun 23
Summary: This editorial article delineates the types of mental suffering brought on by COVID and discusses how palliative care practices can inform responses to these challenges.
Lichtenthal WG (Psychiatry Service), Roberts KE (SKI Psychiatry/Counseling), Prigerson HG.
Ann Intern Med. 2020 Nov 17;173(10):833-835. doi: 10.7326/M20-2526. Epub 2020 Jun 23.
Summary: In the challenging time of COVID-19, the article gives physicians direction to assess the need for a mental health provider referral for bereaved family members. The authors also offer guidance to communicate condolences.
Bodei L (Radiology), Bergsland EK, de Herder WK, Ferone D, Hicks RJ, Hope TA, Kunikowska JA, Pavel M, Reidy-Lagunes DL (Medicine), Siveke J, Strosberg JR, Dittmer U, Herrmann K.
J Nucl Med. 2020 Aug;61(8):1094-1095. doi: 10.2967/jnumed.120.249136. Epub 2020 Jun 23
Summary: The authors discuss the risk factors for COVID-19 severity with regard to peptide receptor radionuclide therapy (PRRT), providing suggestions for monitoring the association of PRRT and COVID-19, as well as, clinical recommendations.
Paffenholz P, Peine A, Hellmich M, Paffenholz SV (GSK Graduate Student), Martin L, Luedde M, Haverkamp M, Roderburg C, Marx G, Heidenreich A, Trautwein C, Luedde T, Loosen SH.
Emerg Microbes Infect. 2020 Dec;9(1):1590-1599. doi: 10.1080/22221751.2020.1785951. Epub 2020 Jun 23.
Summary: This article reports the results of an online survey addressed to medical professionals in Germany to measure the COVID-19 pandemic impact. The results outline differences between subgroups, such as ambulatory centers versus university hospitals.
Hanna MG (Pathology), Reuter VE (Pathology), Ardon O (Pathology), Kim D, Sirintrapun SJ (Pathology), Schüffler PJ (Collaborative Research Centers), Busam KJ (Pathology), Sauter JL (Pathology), Brogi E (Pathology), Tan LK (Pathology), Xu B (Pathology), Bale T (Pathology), Agaram NP (Pathology), Tang LH (Pathology), Ellenson LH (Pathology), Philip J (Health Informatics), Corsale L (Pathology), Stamelos E (Pathology), Friedlander MA (Regulatory Affairs), Ntiamoah P (Pathology), Labasin M (Pathology), England C (Hospital Administration), Klimstra DS (Pathology), Hameed M (Pathology).
Mod Pathol. 2020 Nov;33(11):2115-2127. doi: 10.1038/s41379-020-0601-5. Epub 2020 Jun 22.
Summary: This randomized, prospective study is the first validation of a digital pathology system from a remote non-CLIA (Clinical Laboratory Improvement Amendments) certified facility. Researchers found a major concordance rate of 100% comparing remote review and reporting of whole slide images to conventional microscopy.
Paganelli G, Bodei L (Radiology), Modlin I.
Eur J Nucl Med Mol Imaging. 2020 Sep;47(10):2223-2226. doi: 10.1007/s00259-020-04904-w. Epub 2020 Jun 20.
Summary: This Editorial article is an emotional appeal to the Oncologist, Radiologist and Endocrinologist communities to compare the process of Peptide Receptor RadioTherapy (PRRT) acceptance and implementation with the deficiencies of COVID-19 pandemic response and to make PRRT implementation process efficient based on lessons learned from the COVID-19 pandemic.
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW (Developmental Biology), Harschnitz O (Developmental Biology), Redmond D, Houghton S, Liu C, Naji A, Ciceri G (Developmental Biology), Guttikonda S (Graduate Studies), Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L (Developmental Biology), Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S.
Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. doi: 10.1016/j.stem.2020.06.015. Epub 2020 Jun 19.
Summary: The article presents a platform of cell and organoid derivatives from human pluripotent stem cells (hPSCs) to study tissue tropism. The authors underline that models are needed to understand how human cells respond to SARS-CoV-2 infection.
Moskowitz CS (Biostat/Epidemiology), Panageas KS (Biostat/Epidemiology).
JAMA Oncol. 2020 Sep;6(9):1326-1327. doi: 10.1001/jamaoncol.2020.2370 Epub 2020 Jun 18.
Summary: In this viewpoint, the authors discuss best practices for clinical trials reporting and design. They also advise adapting designs when developing a new clinical trial.
Hellman S (Medical Physics), Chen GH (Anesthesiology), Irie T (Anesthesiology).
Br J Anaesth. 2020 Sep;125(3):e296-e299. doi: 10.1016/j.bja.2020.06.017. Epub 2020 Jun 18.
Summary: This letter to the editor describes a tool developed by the authors to filter droplets and aerosols during aerosol-generating procedures.
Nolte FS, Babady NE (Laboratory Medicine), Buchan BW, Capraro GA, Graf EH, Leber AL, McElvania E, Yao JDC.
J Mol Diagn. 2020 Aug;22(8):968-974. doi: 10.1016/j.jmoldx.2020.06.003. Epub 2020 Jun 18.
Summary: In the era of pandemics, including Covid-19, laboratories are crucial as laboratory results make a foundation for subsequent care. Yet laboratories are facing many challenges in such times including regulatory, logistical, and supply-chain challenges. This article outlines the ways clinical laboratories addressed these challenges and offers recommendations for conducting laboratory work during the current pandemic.
Zeidan AM, Boddu PC, Patnaik MM, Bewersdorf JP, Stahl M (Graduate Fellow), Rampal RK (Medicine), Shallis R, Steensma DP, Savona MR, Sekeres MA, Roboz GJ, DeAngelo DJ, Schuh AC, Padron E, Zeidner JF, Walter RB, Onida F, Fathi A, DeZern A, Hobbs G, Stein EM (Medicine), Vyas P, Wei AH, Bowen DT, Montesinos P, Griffiths EA, Verma AK, Keyzner A, Bar-Natan M, Navada SC, Kremyanskaya M, Goldberg AD (Medicine), Al-Kali A, Heaney ML, Nazha A, Salman H, Luger S, Pratz KW, Konig H, Komrokji R, Deininger M, Cirici BX, Bhatt VR, Silverman LR, Erba HP, Fenaux P, Platzbecker U, Santini V, Wang ES, Tallman MS (Medicine), Stone RM, Mascarenhas J.
Lancet Haematol. 2020 Aug;7(8):e601-e612. doi: 10.1016/S2352-3026(20)30205-2. Epub 2020 Jun 18.
Summary: This article presents recommendations from a group of international experts from major cancer institutions and academic medical centers in the U.S.A., Europe, and Australia on different aspects of managing patients with hematological cancers adjusted for specific circumstances of the Covid-19 pandemic.
Mullangi S, Schleicher SM, Aviki EM (Surgery).
JCO Oncol Pract. 2020 Nov; 16(11):718-719. doi: 10.1200/OP.20.00336. Epub 2020 Jun 17.
Summary: Cancer centers had to adapt their care delivery models because of COVID-19. The authors describe three changes that they hope will stay: Eliminate Low-Value Care, Offer Patient-Centered Substitutes, and Justify Start-Up Costs for Technology Adoption.
Rosa WE, Anderson E, Applebaum AJ (Psychiatry Service), Ferrell BR, Kestenbaum A, Nelson JE (Medicine).
J Palliat Med. 2020 Oct;23(10):1290-1291. doi: 10.1089/jpm.2020.0306. Epub 2020 Jun 16.
Summary: This letter to the editor discusses how Covid-19 gives an opportunity to push all healthcare workers to support palliative care and deliver palliative care in a unified framework.
Luo J (GME Medicine), Rizvi H (Collaborative Research Centers), Preeshagul IR (Medicine), Egger JV (Collaborative Research Centers), Hoyos D (Biostat/Epidemiology), Bandlamudi C (Collaborative Research Centers), McCarthy CG (Collaborative Research Centers), Falcon CJ (Collaborative Research Centers), Schoenfeld AJ (Medicine), Arbour KC (Medicine), Chaft JE (Medicine), Daly RM (Medicine), Drilon A (Medicine), Eng J (Medicine), Iqbal A (Medicine), Lai WV (Medicine), Li BT (Medicine), Lito P (Medicine), Namakydoust A (Medicine), Ng K (Medicine), Offin M (Medicine), Paik PK (Medicine), Riely GJ (Medicine), Rudin CM (Medicine), Yu HA (Medicine), Zauderer MG (Medicine), Donoghue MTA, Luksza M, Greenbaum BD (Biostat/Epidemiology), Kris MG (Medicine), Hellmann MD (Medicine).
Ann Oncol. 2020 Oct;31(10):1386-1396. doi:10.1016/j.annonc.2020.06.007. Epub 2020 Jun 17.
Summary: While the current pandemic demonstrated an increased severity of Covid-19 infection course in lung cancer patients, the study reported in this article established that this severity is a result of patient characteristics and behaviors that were the risk factors for lung cancer (e.g., smoking status and chronic obstructive pulmonary disease) rather than cancer itself.
Maio M, Hamid O, Larkin J, Covre A, Altomonte M, Calabrò L, Vardhana SA (Medicine), Robert C, Ibrahim R, Anichini A, Wolchok JD (Human Oncology & Pathogenesis Program), Di Giacomo AM.
Clin Cancer Res. 2020 Aug 15;26(16):4201-4205. doi: 10.1158/1078-0432.CCR-20-1657.2020. Epub 2020 Jun 15.
Summary: The authors recommend continuing with immune checkpoint inhibitor immunotherapy during the pandemic and adhering to strict COVID screening practices for these patients.
Hultcrantz M (Medicine), Richter J, Rosenbaum C, Patel D (Medicine), Smith E (Medicine), Korde N (Medicine), Lu S (Medicine), Mailankody S (Medicine), Shah U (Medicine), Lesokhin A (Medicine), Hassoun H (Medicine), Tan C (Medicine), Maura F (Medicine), Derkacs A (Biostat/Epidemiology), Diamond B (Medicine), Rossi A, Pearse RN, Madduri D, Chari A, Kaminetsky D, Braunstein M, Gordillo C, Davies F, Jagannath S, Niesvizky R, Lentzsch S, Morgan G, Landgren O (Medicine).
medRxiv. 2020 Jun 11. doi: 10.1016/j.jgo.2020.04.010.
Summary: Researchers studied a cohort of patients with multiple myeloma and related diseases at five large New York City institutions. Risk factors for more severe COVID symptoms tracked with those documented in the general population. The authors make recommendations for cancer treatment and COVID risk reduction during the pandemic.
Brissot E, Labopin M, Baron F, Bazarbachi A4, Bug G, Ciceri F, Esteve J, Giebel S, Gilleece MH, Gorin NC, Lanza F, Peric Z, Ruggeri A, Sanz J, Savani BN, Schmid C, Shouval R (Graduate Fellow), Spyridonidis A, Versluis J, Nagler A, Mohty M.
Bone Marrow Transplant. 2021 Mar;56(3):532-535. doi: 10.1038/s41409-020-0970-x. Epub 2020 Jun 11.
Summary: These working group guidelines recommend in-hospital practices to reduce COVID infection among patients with leukemia, along with best practices for screening, treatment, and clinical trial participation.
Williams BJ, Fraggetta F, Hanna MG (Pathology), Huang R, Lennerz J, Salgado R, Sirintrapun SJ (Pathology), Pantanowitz L, Parwani A, Zarella M, Treanor DE.
J Pathol Inform. 2020 Jun 9;11:15. doi: 10.4103/jpi.jpi_29_20.
Summary: This editorial emphasizes the importance of Digital Pathology, and its advantages over classic laboratory techniques, highlighted by the COVID-19 pandemic.
Bates DDB (Radiology), Vintonyak A (Radiology), Mohabir R (Radiology), Mahmood U (Medical Physics), Soto P (Radiology), Groeger JS (Medicine), Ginsberg MS (Radiology), Gollub MJ (Radiology).
Emerg Radiol.2020 Dec;27(6):597-600. doi: 10.1007/s10140-020-01801-5. Epub 2020 Jun 9
Summary: This article describes how MSK's urgent care used a portable CT scanner to get chest images of patients for evaluation of Covid-19.
Avasthi P, Neill US (General & Administration), Pollack Porter KM, Weeraratna AT.
Nat Med. 2020 Jul;26(7):1003-1004. doi: 10.1038/s41591-020-0943-z. Epub 2020 Jun 8.
Summary: Challenges to research scientists are great during the pandemic, and even greater for those trying to get their foot in the door as junior researchers. This commentary urges funders to extend grant times and institutions to accommodate and evaluate researchers with pandemic-related challenges at the forefront of the review.
Fader AN, Huh WK, Kesterson J, Pothuri B, Wethington S, Wright JD, Bakkum-Gamez JN, Soliman PT, Sinno AK, Leitao M (Surgery), Martino MA, Karam A, Rossi E, Brown J, Blank S, Burke W, Goff B, Yamada SD, Uppal S, Dowdy SC.
Gynecol Oncol. 2020 Aug;158(2):236-243. doi: 10.1016/j.ygyno.2020.06.001. Epub 2020 Jun 6.
Summary: Society of Gynecologic Oncology recommendations for when to operate and when to delay gynecologic cancer surgery during the COVID pandemic.
Levine RL (Human Oncology & Pathogenesis Program), Rathmell WK.
Nat Rev Cancer. 2020 Jul;20(7):357-358.2020. doi: 10.1038/s41568-020-0279-5. Epub 2020 Jun 5.
Summary: In this commentary, the authors discuss how the COVID-19 pandemic has impacted research, and they lay out initiatives to help early career researchers through a variety of innovations.
Rosa WE, Gray TF, Chow K (Ld-Advanced Practice Providers), Davidson PM, Dionne-Odom JN, Karanja V, Khanyola J, Kpoeh JDN, Lusaka J, Matula ST, Mazanec P, Moreland PJ, Pandey S (Ld - Advanced Practice Providers), de Campos AP, Meghani SH.
J Hosp Palliat Nurs. 2020 Aug;22(4):260-269. doi: 10.1097/NJH.0000000000000665. Epub 2020 Jun 5.
Summary: This article provides recommendations for palliative care nurses and other healthcare providers to ensure that their optimal value is realized and leveraged during Covid-19 and future public health crises.
Shoushtari A (Medicine), Choudhury N (Graduate Fellow).
Oncologist. 2020 Jul;25(7):546-547. doi: 10.1634/theoncologist.2020-0373. Epub 2020 Jun 2.
Summary: This commentary emphasizes the importance of prioritizing the training of the next generation of oncologists even during the COVID-19 pandemic.
Breitbart WS (Psychiatry Service).
Palliative & Supportive Care. 2020 June;18(3):252-253. doi: 10.1017/S1478951520000334.
Summary: In this editorial, Dr. William Breitbart, Chair of the Department of Psychiatry and Behavioral Sciences at MSKCC, reflects on life and death in this unprecedented time of COVID-19.
Baumann BC, MacArthur KM, Brewer JD, Mendenhall WM, Barker CA (Radiation Oncology), Etzkorn JR, Jellinek NJ, Scott JF, Gay HA, Baumann JC, Manian FA, Devlin PM, Michalski JM, Lee NY, Thorstad WL1 Wilson LD, Perez CA, Miller CJ.
Cancer. 2020 Sep 1;126(17):3900-3906. doi: 10.1002/cncr.32969. Epub 2020 Jun 1.
Summary: This commentary describes recommendations for weighing pros and cons of early or delayed interventions for localized skin cancers. For most patients at higher risk of serious Covid-related illness or death, the risk of Covid generally outweighs the benefits of early skin cancer treatment.
LoGiudice SH (Strategy & Innovation), Liebhaber A (Strategy & Innovation), Schöder H (Radiology).
J Nucl Med. 2020 Aug;61(8):1096-1101. doi: 10.2967/jnumed.120.250522. Epub 2020 Jun 1
Summary: In this article, the authors address how healthcare organizations and health systems can approach some of the uncertainties that have arisen due to the COVID-19 pandemic and adjust their planning and strategy development accordingly.
Betts BC, Young, JW (Medicine).
Critical Care Explorations 2020 Jun; 2(6);pe0138. doi: 10.1097/CCE.0000000000000138.
Summary: This commentary details evidence that selecting targeted Il-6 blockades are more effective than broad nonselective blockades at combating cytokine release syndrome. Cytokine release syndrome is a major trigger of Covid-19 mortality.
Chen LL (Ld-Advanced Practice Providers).
J Am Assoc Nurse Pract. 2020 Jun;32(6):416-418. doi: 10.1097/JXX.0000000000000448.
Summary: This perspective article describes training on point-of-care ultrasounds, as they provide a key role in managing critically ill patients in isolation due to Covid-19.
Sciubba DM, Ehresman J, Pennington Z, Lubelski D, Feghali J, Bydon A, Chou D, Elder BD, Elsamadicy AA, Goodwin CR, Goodwin ML, Harrop J, Klineberg E, Laufer I (Neurosurgery), Lo SL, Neuman BJ, Passias PG, Protopsaltis T, Shin JH, Theodore N, Witham TF, Benzel EC.
World Neurosurg. 2020 Aug; 140: e373-e380. doi: 10.1016/j.wneu.2020.05.233. Epub 2020 May 29.
Summary: The authors describe a quantitative urgency scoring system that was generated to guide the triage and prioritizing of spine surgery cases in resource-limited settings, both during the COVID pandemic and post-COVID period.
Ganatra S, Dani SS, Shah S, Asnani A, Neilan TG, Lenihan D, Ky B, Barac A, Hayek SS, Leja M, Herrmann J, Thavendiranathan P, Fradley M, Bang V, Shreyder K, Parikh R, Patel R, Singh A, Brar S, Guha A, Gupta D (Medicine), Mascari P, Patten R, Venesy D, Nohria A, Resnic FS.
Trends Cardiovasc Med. 2020 Aug; 30(6): 315-325. doi: 10.1016/j.tcm.2020.05.004. Epub 2020 May 28.
Summary: From a review of the published literature, the authors provide a list of recommendations for the management of patients with cardiovascular disease in the time of COVID-19.
Perni S, Milligan MG, Saraf A, Vivenzio T, Marques A, Baker MA, Kosak T, Bartlett S, Physic MA, Batchelder MR, McBride S (Radiation Oncology), Bredfeldt J, Cail DW, Kearney MC, Whitehouse C, Orio P, Walsh G, Haas-Kogan DA, Martin NE.
Cancer. 2020 Sep 1;126(17):3896-3899. doi: 10.1002/cncr.32962. Epub 2020 May 28.
Summary: In this commentary, the authors describe the creation and implementation of a multidisciplinary treatment prioritization committee and its ethical and transparent decision-making processes that could be applicable to other oncologic settings.
Goldstein DA, Ratain MJ, Saltz LB. (Medicine).
JAMA Oncol. 2020 Nov;6(11):1694-1695. doi: 10.1001/jamaoncol.2020.2493. Epub 2020 May 27.
Summary: In this viewpoint, the authors present a solution to adjust pembrolizumab dosing regimen to decrease patients' financial burden. This new dosage would also reduce their risk of exposure to COVID-19.
Frigault MJ, Nikiforow S, Mansour M, Hu ZH, Horowitz MM, Riches M, Hematti P, Turtle CJ, Zhang MJ, Perales MA (Medicine), Pasquini MC.
Blood. 2020 Jul 2;136(1):137-139. doi: 10.1182/blood.2020006216. Epub 2020 May 26.
Summary: In this letter, the authors report their findings on the risk of infections following tocilizumab use for chimeric antigen receptor T-cell (CAR-T)-mediated cytokine release syndrome (CRS).
Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ (Radiation Oncology), Koval M, Guttentag SH, Blackwell TS, Vanderbilt COVID-19 Consortium Cohort, Webber SA, Banovich NE, Kropski JA, Sucre JMS, HCA Lung Biological Network.
bioRxiv. 2020 May 22. doi: https://doi.org/10.1101/2020.05.22.111187.
Summary: This preprint (which has not yet been confirmed by peer-review) reports on a mouse research study that looked at how viral entry-factors are regulated differently at different stages of lung development which may explain the biology behind why children appear to be less susceptible to SARS-CoV-2.
Gartrell-Corrado RD, Gampel B, Troullioud Lucas AG (Pediatrics), Broglie L, Lee MT, Levine J, Orjuela-Grimm M, Satwani P, Glade-Bender J (Pediatrics), Roberts SS (Pediatrics).
Lancet. 2020 May 22. doi: 10.2139/ssrn.3582825.
Summary: This paper reports on the effect of COVID-19 disease on pediatric hematology, oncology and hematopoietic stem cell transplant (HCT) patients. The study included 19 out of 174 patients that tested positive for COVID-19, the majority of which were found to have mild disease that did not not require inpatient care.
Yahalom J (Radiation Oncology), Dabaja BS, Ricardi U, Ng A, Mikhaeel NG, Vogelius IR, Illidge TM, Qi S, Wirth A, Specht L.
Blood. 2020 May 21;135(21):1829-1832. doi: 10.1182/blood.2020006028.
Summary: The International Lymphoma Radiation Oncology Group (ILROG) is a recognized international organization of radiation oncologists which produces guidelines for radiation therapy in blood cancers. In this article ILROG presents guidelines for radiation therapy practice adjusted to the complexities caused by the COVID-19 pandemic.
Kushnir VM, Berzin TM, Elmunzer BJ, Mendelsohn RB (Medicine), Patel V, Pawa S, Smith ZL, Keswani RN; North American Alliance for the Study of Digestive Manefestations of COVID-19.
Clin Gastroenterol Hepatol. 2020 Sep;18(10):2287-2294.e1. doi: 10.1016/j.cgh.2020.05.030. Epub 2020 May 21.
Summary: In this study, 123 gastroenterology practices located in North America answered to a survey designed by the authors to identify reactivation barriers and strategies during the COVID-19 pandemic.
Cleary S, D'Angelica M (Surgery), Demartines N, Doyle MB, Kent T, Pawlik TM.
HPB (Oxford). 2020 Aug;22(8):1135-1138. doi: 10.1016/j.hpb.2020.04.019. Epub 2020 May 20.
Summary: This commentary provides a summary of an international webinar help by the leadership of the Americas Hepato-Pancreato-Biliary Association (AHPBA) on lessons learned during the COVID-19 pandemic. A link to the full webinar is available in the commentary.
Krebs S (Radiology), Petkovska I (Radiology), Ho AL (Medicine), Ulaner GA (Radiology).
Clin Nucl Med. 2020 Aug;45(8):654-655. doi: 10.1097/RLU.0000000000003141. Epub 2020 May 19.
Summary: This case report describes a cancer patient in an outpatient setting whose COVID-19 infection diagnosis was made during a cancer imaging procedure which involved imaging of the lungs, along with other body regions. This accidental finding of COVID-19-related pneumonia in a cancer patient without Covid-19 symptoms stresses the necessity to test outpatient cancer patients, even those not displaying COVID symptoms, for the presence of coronavirus during COVID-19 pandemics.
Bergsland EK, Halperin DM, Dillon JS, Dasari NA, Kunz PL, Soares HP, Pryma D, Bodei L (Radiology), Hope T, Soulen MC, Mailman J, Howe JR.
Pancreas. 2020 Jul; 49(6): 723-728. doi: 10.1097/MPA.0000000000001561. Epub 2020 May 19.
Summary: This editorial article presents suggestions from the North American Neuroendocrine Tumor Society (NANETS) on adjustments to the care of patients with neuroendocrine cancers in the time of the COVID-19 pandemic aimed at decreasing risk of infection transmission to patients and health care professionals.
Farley JH, Hines J, Lee NK, Brooks SE, Nair N, Brown CL (Surgery), Doll KM, Sullivan EJ, Chapman-Davis E.
Gynecol Oncol.2020 Jul;158(1):25-31. doi: 10.1016/j.ygyno.2020.05.023. Epub 2020 May 19
Summary: This article is a Clinical Practice Statement by the Society of Gynecologic Oncology (SGO) aimed at striving for greater socioeconomic equality in providing care for patients in the time of the COVID-19 pandemic. The article describes psychological factors of inequality, such as biases, and describes what constitutes socioeconomic disparities in healthcare including those related to income and race, and how they were exacerbated by the COVID-19 pandemic. The challenges and solutions related to cancer care, and gynecologic oncology in particular, are described.
Nawar T (Graduate Fellow), Morjaria S (Medicine), Kaltsas A (Medicine), Patel D (Quality & Safety), Perez-Johnston R (Radiology), Daniyan AF (Medicine), Mailankody S (Medicine), Parameswaran R (Medicine).
Am J Hematol. 2020 Aug;95(8):E210-E213. doi: 10.1002/ajh.25870. Epub 2020 May 17.
Summary: In this Letter to the Editor, the authors express concerns related to administering a Granulocyte-colony stimulating factor (GCSF) which is routinely given to cancer patients for prevention of neutropenia, during the Covid-19 pandemic. The concerns arose from 3 cases of administering GCSF for neutropenia to cancer patients who also had COVID-19. In all probability, this was the first report describing the course of COVID-19 infection in selected cancer patients who received GCSF for neutropenic fever in the United States.
Moon MR, Jones DR (Surgery), Adams DH, Starnes VA.
J Thorac Cardiovasc Surg. 2020 Sep;160(3):737-739. doi: 10.1016/j.jtcvs.2020.05.022. Epub 2020 May 16
Summary: In the time of COVID-19 pandemic many scientific activities were disrupted. This affected the activities of scholarly and professional societies, American Association for Thoracic Surgery (AATS) being one of them. Thus, the Association's 100th Annual Meeting could not be held in a physical setting. However, recognizing the importance of professional exchange between surgeons from 70 countries which would contribute significantly to the advancements in the field, this important forum was modified to be held virtually. The article also briefly outlines the early history of AATS which corresponded to the time of great world catastrophes.
Boulad F (Pediatrics), Kamboj M (Medicine), Bouvier N (SKI Pediatrics), Mauguen A (Biostat/Epidemiology), Kung AL (Pediatrics).
JAMA Oncol. 2020 Sep;6(9):1459-1460. doi: 10.1001/jamaoncol.2020.2028. Epub 2020 May 13.
Summary: In this study, 178 children with cancer showed similar rates of COVID infection and mortality as children in the general population.
Luo J (Graduate Fellow), Rizvi H (Collaborative Research Centers), Egger JV (Collaborative Research Centers), Preeshagul IR (Medicine), Wolchok JD (Human Oncology & Pathogenesis Program), Hellmann MD (Medicine).
Cancer Discov. Cancer Discov. 2020 Aug;10(8):1121-1128. doi: 10.1158/2159-8290.Cd-20-0596. Epub 2020 May 12.
Summary: The authors found that a small sample of lung cancer patients who had previously received PD-1 blockade immune therapy did not experience statistically significant increased COVID symptom severity, but smoking history did make an impact.
Samson P, Ning MS, Shaverdian N (Radiation Oncology), Shepherd AF (Radiation Oncology), Gomez DR (Radiation Oncology), McGinnis GJ, Nitsch PL, Chmura S, O'Reilly MS, Lee P, Chang JY, Robinson C, Lin SH.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):700-704. doi: 10.1016/j.adro.2020.04.020. Epub 2020 May 11.
Summary: A case series of how COVID-19 presented in three lung cancer patients receiving radiation therapy.
Givi B, Moore MG, Bewley AF, Coffey CS, Cohen MA (Surgery), Hessel AC, Jalisi S, Kang S, Newman JG, Puscas L, Shindo M, Shuman A, Thakkar P, Weed DT, Chalian A.
Head Neck. 2020 Jul;42(7):1411-1417. doi: 10.1002/hed.26252. Epub 2020 May 8.
Summary: In this study, authors surveyed head and neck fellows and accredited program directors to assess the impact of COVID-19 on head and neck surgical training. They conclude that "current trainees appear well-positioned to achieve expertise before entering practice."
Shah UA (Medicine).
JAMA Oncol. 2020 Sep 1;6(9):1330-1331. doi: 10.1001/jamaoncol.2020.1848. Epub 2020 May 7.
Summary: In this opinion piece, an MSK oncologist and cancer survivor who was diagnosed with Hodgkin lymphoma during her fellowship training, reflects on being diagnosed with COVID-19.
Cancio M (Pediatrics), Ciccocioppo R, Rocco PRM, Levine BL, Bronte V, Bollard CM, Weiss D, Boelens JJ (Pediatrics), Hanley PJ.
Cytotherapy. 2020 Sep;22(9):474-481. doi: 10.1016/j.jcyt.2020.04.100. Epub 2020 May 7.
Summary: This article discusses the inflammatory conditions that arise both as a side effect of certain therapies used in oncology (such as cellular therapies and stem cell transplantation), and as a result of Covid-19 infection. The authors suggest that therapeutic approaches used in managing such complications may be applicable in management of Covid-19 patients.
di Gioacchino A, Ŝulc P, Komarova AV, Greenbaum BD (Biostat/Epidemiology), Monasson R, Cocco S.
bioRxiv. 2020 May 06. doi: https://doi.org/10.1101/2020.05.06.074039
Summary: This preprint looks at the genetics of the virus that causes COVID-19, specifically at the rate and drivers of its mutation.
Shaverdian N (Radiation Oncology), Shepherd AF (Radiation Oncology), Rimner A (Radiation Oncology), Wu AJ (Radiation Oncology), Simone CB (Radiation Oncology), Gelblum DY (Radiation Oncology), Gomez DR (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):617-620. doi: 10.1016/j.adro.2020.04.015. Epub 2020 May 5.
Summary: This research letter reports on four patients presenting radiation pneumonitis' symptoms during the time of COVID-19. The authors recommend COVID-19 testing before starting high-dose corticosteroids.
Robilotti EV (Medicine), Babady NE (Laboratory Medicine), Mead PA (Medicine), Rolling T (SKI Medicine), Perez-Johnston R (Radiology), Bernardes M (Graduate Fellow), Bogler Y (Graduate Fellow), Caldararo M (Graduate Fellow), Figueroa CJ (Medicine), Glickman MS (Immunology), Joanow A (Ld - Advanced Practice Providers), Kaltsas A (Medicine), Lee YJ (Medicine), Lucca A (Emp Health & Wellness), Joanow A (Ld - Advanced Practice Providers), Mariano AR (Ld - Advanced Practice Providers), Morjaria S (Medicine), Nawar T (Graduate Fellow), Papanicolaou GA (Medicine), Predmore J (Ld - Advanced Practice Providers), Redelman-Sidi G (Medicine), Schmidt E (Ld - Advanced Practice Providers), Seo SK (Medicine), Sepkowitz K (Physician in Chief), Shah MK (Medicine), Wolchok JD (Human Oncology & Pathogenesis Pgm), Hohl TM (Medicine), Taur Y (Medicine), Kamboj M (Medicine).
medRxiv. 2020 May 04. doi: https://doi.org/10.1101/2020.05.04.20086322.
Summary: This preprint studies outcomes in 423 patients with cancer hospitalized for COVID-related symptoms. It found age (over 65) and immune checkpoint inhibitor therapy to be risk factors for disease severity and hospitalization.
Gras-Valentí P, Mora-Muriel JG, Chico-Sánchez P, Algado-Sellés N, Soler-Molina VM, Hernández-Maldonado M, Sánchez-Vela P (Human Oncology & Pathogenesis Program), et al.
Bull World Health Organ. 4 May 2020. doi: http://dx.doi.org/10.2471/BLT.20.263384.
Summary: This study of healthcare worker exposure to COVID recommends the continuous wearing of surgical masks in both patient and staff areas of the hospital.
Mukhopadhyay S, Booth AL, Calkins SM, Doxtader EE, Fine SW (Pathology), Gardner JM, Gonzalez RS, Mirza KM, Jiang XS.
Arch Pathol Lab Med. 2020 Sep 1;144(9):1027-1036. doi: 10.5858/arpa.2020-0201-ED. Epub 2020 May 4.
Summary: This article is a guide for pathologists and pathologists-in-training. It provides a curated list of online resources for virtual learning, specifically in pathology, with a focus on anatomic pathology.
Czernin J, Fanti S, Meyer PT, Allen-Auerbach M, Hacker M, Sathekge M, Hicks R, Scott AM, Hatazawa J, Yun M, Schöder H (Radiology), Bartenstein P, Herrmann K.
J Nucl Med. 2020 May 01;61(5):626-629. doi: 10.2967/jnumed.120.245738.
Summary: In this editorial, 11 teams from hospitals in Europe, Australia, Africa, and the United States share their experience as well as their strategies to contain the coronavirus from spreading.
Koffman B, Mato A (Medicine), Byrd JC, Danilov A, Hedrick B, Ujjani C, Roeker L (Graduate Fellow), Stephens DM, Davids MS, Pagel JM, Shadman M.
Am J Hematol. 2020 Aug;95(8):E199-E203. doi: 10.1002/ajh.25851. Epub 2020 Apr 30.
Summary: This correspondence reports on the results of a survey of a cohort of chronic lymphocytic leukemia (CLL) experts who were asked "questions about experts' base-line information and their recommendations on isolation, testing and CLL management in patients with CLL and COVID-19".
Vardhana SA (Medicine), Wolchok JD (Human Oncology & Pathogenesis Program).
J Exp Med. 2020 Apr 30;217(6). doi: 10.1084/jem.20200678.
Summary: In this article, the authors "explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity."
Lou E, Beg S, Bergsland E, Eng C, Khorana A, Kopetz , Lubner S, Saltz L (Medicine), Shankara V, Zafar SY.
JCO Oncol Pract.2020 Jul;16(7):383-388. doi: 10.1200/OP.20.00239. Epub 2020 Apr 30
Summary: A group of expert oncologists in the field of GI oncology summarize recommendations for adapting/changing practices in response to the COVID-19 pandemic, and carefully consider the costs versus benefits to patients when modifying treatment and practice.
Chong EA, Roeker L (Graduate Fellow), Shadman M, Davids MS, Schuster SJ, Mato A (Medicine).
Clin Cancer Res. 2020 Jul 15;26(14):3514-3516. doi: 10.1158/1078-0432.CCR-20-1427. Epub 2020 Apr 28.
Summary: The authors discuss the benefits and risks of continuing to treat with BTK inhibitors patients with chronic lymphocytic leukemia (CLL) and B-cell lymphomas who get infected with COVID-19. The pros and cons of BTKi discontinuation for patients are considered.
Redelman-Sidi G (Medicine).
Nat Rev Urol. 2020 Jun 01. doi: 10.1038/s41585-020-0325-9. Epub 2020 Apr 27.
Summary: The author comments on clinical studies that are trying to determine whether BCG vaccination could protect humans against COVID-19 infection. Discussed are data from a non-peer-reviewed publication and the trials in progress, while important questions are considered about how this will impact bladder cancer patients who have been or will be treated with BCG.
Shaha AR (Surgery).
Head Neck. 2020 Jun;42(6):1322-1324. doi: 10.1002/hed.26198. Epub 2020 Apr 27.
Summary: A surgeon shares his clinical observations/philosophy of managing patients with thyroid cancer during the COVID-19 pandemic and describes some issues to be considered in the decision-making process when determining if patients require thyroid surgery urgently or not.
Mulvey JJ (Graduate Fellow), Magro CM, Ma LX, Nuovo GJ, Baergen RN.
Ann Diagn Pathol. 2020 Jun;46:151530. doi: 10.1016/j.anndiagpath.2020.151530. Epub 2020 Apr 25.
Summary: This article reports on the placental pathology of five full-term babies that were delivered from COVID-19 infected patients without significant morbidity or mortality to the mothers or their newborns.
Mahadev S, Aroniadis OS, Barraza L, Agarunov E, Goodman AJ, Benias PC, Buscaglia JM, Gross SA4, Kasmin FE, Cohen JJ, Carr-Locke DL, Greenwald DA, Mendelsohn RB (Medicine), Sethi A, Gonda TA; NYSGE research committee.
Gastrointest Endosc. 2020 Sep;92(3):788-789. doi: 10.1016/j.gie.2020.04.047. Epub 2020 Apr 25.
Summary: Endoscopists from hospitals across the New York metropolitan area report on the results of a survey of 69 endoscopists, administered with the support of the New York Society of Gastroenterological Endoscopy, that collected "information regarding demographics, case volume, personal protective equipment (PPE) use, and endoscopist exposure to COVID-19."
Chaves ALF, Castro AF, Marta GN, Junior GC, Ferris RL, Giglio RE, Golusinski W, Gorphe P, Hosal S, Leemans CR, Magné N, Mehanna H, Mesía R, Netto E, Psyrri A, Sacco AG, Shah JP (Surgery), Simon C, Vermorken JB, Kowalski LP.
Oral Oncol. 2020 Aug;107:104734. doi: 10.1016/j.oraloncology.2020.104734. Epub 2020 Apr 24.
Summary: General guidelines/recommendations meant to assist multidisciplinary teams around the world make diagnosis and treatment decisions for HNSCC patients, while they take into consideration the constraints and epidemiological characteristics of their local situation.
Shah JP (Surgery).
Head Neck. 2020 Jun;42(6):1344-1347. doi: 10.1002/hed.26188. Epub 2020 Apr 25.
Summary: In these trying times of COVID-19, renowned Head and Neck Surgeon, Dr. Jatin Shah, considers the question "how do we conduct our day-to-day activities, and plan to retain our robust education and training programs, to educate and train the next generation of head and neck surgeons?" and discusses "embracing technology and alternative means" to deal with these challenges.
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL; HCA Lung Biological Network (Pe'er D (Computational and Systems Biology Program) in group).
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
Summary: An investigation of how the virus that causes COVID-19 binds to a person's cells, and how genetic expression in cells throughout the body impacts this process and disease transmission.
Aroniadis OC, DiMaio CJ, Dixon RE, Elmunzer BJ, Kolb JM, Mendelsohn RB (Medicine), Singal AG, Ordiah CO, Rockey DC, Spitzer RL, Tierney WM, Wani S, Yadav D.
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1682-1684. doi: 10.1016/j.cgh.2020.04.039. Epub 2020 Apr 22.
Summary: The authors review what is known about the gastrointestinal impact of COVID-19.
Romesser PB (Radiation Oncology), Wu AJ (Radiation Oncology), Cercek A (Medicine), Smith JJ (Surgery), Weiser M (Surgery), Saltz L (Medicine), Garcia-Aguilar J (Surgery), Crane CH (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):687-689. doi: 10.1016/j.adro.2020.04.011. Epub 2020 Apr 22.
Summary: MSK practitioners detail how COVID-19 changed the standard of care for rectal cancer patients at the hospital.
Sethi A, Swaminath A, Latorre M, Behin DS, Jodorkovsky D, Calo D (Medicine), Aroniadis O, Mone A, Mendelsohn RB (Medicine), Sharaiha RZ, Gonda TA, Khanna LG, Bucobo JC, Nagula S, Ho S, Carr-Locke DL, Robbins DH; New York Society for Gastrointestinal Endoscopy (NYSGE).
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1673-1681. doi: 10.1016/j.cgh.2020.04.032. Epub 2020 Apr 21.
Summary: Gastroenterologists from New York City-area hospitals discuss how COVID-19 impacted their practice.
Mohile S, Dumontier C, Mian H, Loh KP, Williams GR, Wildes TM, Boyd K, Ramsdale E, Pyne S, Magnuson A, Tew W (Medicine), Klepin HD, Dale W, Shahrokni A (Medicine).
J Geriatr Oncol. 2020 Jun;10(6):779-782. doi: 10.1016/j.jgo.2020.04.010. Epub 2020 Apr 10.
Summary: Recommendations from the Cancer and Aging Research Group on how to safely treat older patients with cancer.
Wu AJ (Radiation Oncology), Rimner A (Radiation Oncology), Shepherd AF (Radiation Oncology), Gelblum DY (Radiation Oncology), Shaverdian N (Radiation Oncology), Yorke E (Medical Physics), Simone CB (Radiation Oncology), Gomez DR (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):603-607 doi: 10.1016/j.adro.2020.04.008. Epub 2020 Apr 20.
Summary: The article presents MSK's provisional guidelines for providing radiation treatment to patients with lung and other thoracic cancers during the COVID-19 pandemic.
Miles BA, Schiff B, Ganly I (Surgery), Ow T, Cohen E, Genden E, Culliney B, Mehrotra B, Savona S, Wong RJ (Surgery), Haigentz M, Caruana S, Givi B, Patel K, Hu K.
Head Neck. 2020 Jun;42(6):1282-1290. doi: 10.1002/hed.26166. Epub 2020 Apr 17.
Summary: The New York Head and Neck Society provides guidance on performing tracheostomy procedures for patients with COVID-19.
Calvillo-Argüelles O., Abdel-Qadir H, Ky B, Liu JE (Medicine), Lopez-Mattei JC, Amir E, Thavendiranathan P.
JACC CardioOncol. 2020 Jun;2(2):345-349. doi: 10.1016/j.jaccao.2020.04.001. Epub 2020 Apr 16.
Summary: Guidance on when to provide cardiac surveillance imaging to cancer patients and cancer survivors taking anthracyclines and trastuzumab.
Kaltenboeck A (Biostat/Epidemiology), Rajkumar SV.
Mayo Clin Proc. 2020 Jun 01;95(6):1132-1134. doi: Epub 2020 Apr 15.
Summary: The authors recommend that everyone who works at or enters a healthcare organization wear a mask, regardless of patient contact.
Magro C, Mulvey JJ (Graduate Fellow), Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J.
Transl Res. 2020 Jun;220:1-13. doi: 10.1016/j.trsl.2020.04.007. Epub 2020 Apr 15
Summary: The researchers compared the pathology of COVID-19 to the more familiar acute respiratory distress syndrome.
Yeoh CB (Anesthesiology), Lee KJ, Rieth EF (Anesthesiology), Mapes R, Tchoudovskaia A (Anesthesiology), Fischer GW (Anesthesiology), Tollinche LE (Anesthesiology).
Anesthesia & Analgesia 2020 Jul;131(1):16-23. doi: 10.1213/ANE.0000000000004884. Epub 2020 Apr 15.
Summary: This review article looks at how COVID-19 impacts cancer patients and how to proceed with cancer surgeries in light of these considerations.
Walsh CM, Fishman DS, Lerner DG; NASPGHAN Endoscopy and Procedures Committee (Queliza K (Pediatrics) in group).
J Pediatr Gastroenterol Nutr. 2020 Jun;70(6):741-750. doi: 10.1097/MPG.0000000000002750. Epub 2020 Apr 14.
Summary: The North American Society for Pediatric Gastroenterology, Hepatology & Nutrition offers guidance on how to safely offer endoscopy services to children during the pandemic.
Thomson DJ, Palma D, Guckenberger M, Balermpas P, Beitler JJ, Blanchard P, Brizel D, Budach W, Caudell J, Corry J, Corvo R, Evans M, Garden AS, Giralt J, Gregoire V, Harari PM, Harrington K, Hitchcock YJ, Johansen J, Kaanders J, Koyfman S, Langendijk JA, Le QT, Lee N (Radiation Oncology), Margalit D, Mierzwa M, Porceddu S, Soong YL, Sun Y, Thariat J, Waldron J, Yom SS.
Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):618-627. doi: 10.1016/j.ijrobp.2020.04.016. Epub 2020 Apr 14.
Summary: Joint recommendations from the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) offer guidance on how to proceed with radiation procedures during the COVID-19 pandemic.
COVID19 Subcommittee of the O.R. Executive Committee at Memorial Sloan Kettering, Ardizzone L (Anesthesiology), Barber T (Surgery), Drebin J (Surgery), Fischer G (Anesthesiology), Jewell E (Surgery), Laudone V (Surgery), Levine M (Hospital Administration), Linder J (Hospital Administration), Simon B (Josie Robertson Surgery Center), Stromblad C (Strategy and Innovation), Tabar V (Neurosurgery), Weiser M (Surgery), Yee SJ (Nursing).
Ann Surg Oncol. 2020 Jun;27(6):1713-1716. doi: 10.1245/s10434-020-08462-1. Epub 2020 Apr 13.
Summary: This Editorial article describes cancer surgery practice at the time of the Covid-19 pandemic at the Memorial Sloan Kettering Cancer Center. It outlines the challenges faced and the solutions found. The insights from this leading cancer dedicated institution could be helpful for any institution which conducts surgeries in cancer patients.
Bachanova V, Bishop MR, Dahi P (Medicine), Dholaria B, Grupp SA, Hayes-Lattin B, Janakiram M, Maziarz RT, McGuirk JP, Nastoupil LJ, Oluwole OO, Perales MA (Medicine), Porter DL, Riedell PA.
Biol Blood Marrow Transplant. 2020 Jul;26(7):1239-1246. doi: 10.1016/j.bbmt.2020.04.008. Epub 2020 Apr 14.
Summary: Chimeric antigen receptor (CAR) T-cell therapy is currently one of the most promising immune therapies for blood cancers. This article presents consensus recommendations from the CAR T-cell Consortium (a group formed by researchers from 8 U.S. academic institutions), on multiple aspects of using this treatment at the time of the Covid-19 pandemic. The recommendations for institutions which treat patients with CAR T-cell therapy are formatted as questions and answers.
Stopsack KH (SKI Medicine), Mucci LA, Antonarakis ES, Nelson PS, Kantoff PW (Medicine).
Cancer Discov. 2020 Jun;10(6):779-782. doi: 10.1158/2159-8290.CD-20-0451. Epub 2020 Apr 10
Summary: Covid-19 pandemic statistics have shown gender inequality in susceptibility to the coronavirus infection. It appears that men are more susceptible than women. This article discusses the role of a specific gene, involved both in viral infection and cancer processes, which could be a potential culprit in the increased male susceptibility to coronavirus and influenza infections and a potential target for treatments to fight this susceptibility.
Bartlett DL, Howe JR, Chang G, Crago A (Surgery), Hogg M, Karakousis G, Levine E, Maker A, Mamounas E, McGuire K, Merchant N, Shibata D, Sohn V, Solorzano C, Turaga K, White R, Yang A, Yoon S, Society of Surgical Oncology.
Ann Surg Oncol. 2020 Jun;27(6):1717-1720. doi: 10.1245/s10434-020-08461-2. Epub 2020 Apr 8.
Summary: This Editorial article presents the Society of Surgical Oncology's cumulation of expert recommendations on the optimal surgical practice changes in the time of the COVID-19 pandemic. The recommendations are given for surgical management of different types of cancer.
Guckenberger M, Belka C, Bezjak A, Bradley J, Daly ME, DeRuysscher D, Dziadziuszko R, Faivre-Finn C, Flentje M, Gore E, Higgins KA, Iyengar P, Kavanagh BD, Kumar S, Le Pechoux C, Lievens Y, Lindberg K, McDonald F, Ramella S, Rengan R, Ricardi U, Rimner A (Radiation Oncology), Rodrigues GB, Schild SE, Senan S, Simone CB II (Radiation Oncology), Slotman BJ, Stuschke M, Videtic G, Widder J, Yom SS, Palma D.
Radiother Oncol. 2020 May;146:223-229. doi: 10.1016/j.radonc.2020.04.001. Epub 2020 Apr 6.
Summary: A consensus statement of 32 experts in lung cancer recommend adhering to guidelines for recommended practice. For patients positive for Covid-19 it's recommended to postpone or interrupt radiation therapy. In a severe pandemic scenario, patients should be triaged based on a variety of factors.
Chowell G, Chowell D (Human Oncology & Pathogenesis Program), Roosa K, Dhillon R, Srikrishna D.
medRxiv. 2020 April 6. doi:10.1101/2020.04.01.20049981
Summary: This preprint article describes a model in which the pandemic may be controlled through a combination of robust testing, treatment, self-isolation, along with social distancing measures and wearing face masks.
Braunstein LZ (Radiation Oncology), Gillespie EF (Radiation Oncology), Hong L (Medical Physics), Xu A (Radiation Oncology), Bakhoum SF (Radiation Oncology), Cuaron J (Radiation Oncology), Mueller B (Radiation Oncology), Cahlon O (Radiation Oncology), Powell S (Radiation Oncology), Khan AJ (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug; 5(4): 582-588. doi: 10.1016/j.adro.2020.03.013. Epub 2020 Apr 1.
Summary: The MSKCC Breast radiation department advises omitting radiation therapy in favorable subgroups of breast cancer patients and accelerating or abbreviating regimens for others. Hypofractionated approaches are shown to be safe and effective.
Yerramilli D (Radiation Oncology), Xu AJ (Radiation Oncology), Gillespie EF (Radiation Oncology), Shepherd AF (Radiation Oncology), Beal K (Radiation Oncology), Gomez D (Radiation Oncology), Yamada J (Research and Technology Management), Tsai J (Radiation Oncology), Yang J (Radiation Oncology).
Adv Radiat Oncol. 2020 Jul-Aug;5(4):589-594 doi: 10.1016/j.adro.2020.04.001. 2020 Jul-Aug;5(4):589-594. Epub 2020 Apr 1.
Summary: The authors state that abbreviated courses of palliative radiation during the Covid-19 pandemic can best maximize benefits to metastatic cancer patients and reduce risks of viral transmission.
Zaorsky NG, Yu JB, McBride SM (Radiation Oncology), Dess RT, Jackson WC, Mahal BA, Chen R, Choudhury A, Henry A, Syndikus I, Mitin T, Tree A, Kishan AU, Spratt DE.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):659-665. doi: 10.1016/j.adro.2020.03.010 Epub 2020 Apr 1.
Summary: Recommendations from the National Comprehensive Cancer Network risk group for prostate cancer advise a reduction of resources for all stages of prostate cancer. Telemedicine, consultations, and return visits can be delayed one to six months until there are more resources and staff, and treatment can be delayed for low risk until safe, and for unfavorable or high risk neoadjuvant hormone therapy for four to six months.
Villar J, Confalonieri M, Pastores, S (Anesthesiology), Meduri GU.
Crit Care Expl 2020 Apr 1; 2(4):e0111. doi: 10.1097/CCE.0000000000000111.
Summary: Recommendations for corticosteroids for Covid-19-associated acute respiratory distress syndrome. Based on the current lack of strong evidence, the authors advise that it is unethical to deny the administration of corticosteroids to Covid-19 ARDS patients experiencing severe cytokine storm.
Costas-Muniz R (Psychiatry Service), Montana F, Ruda-Santolaria L, Sanchez-Ramirez JC, Torres-Blasco N, Castro EM, Esenarro L, Galindo-Vazquez O, Breitbart WS (Psychiatry Service), Claros M (Psychiatry Service), Narang B (Psychiatry Service), Gany F (Psychiatry Service).
Ann Behav Med. 2020 Apr;55(Suppl. 1):S123. doi: 10.1093/abm/kaab020.
Summary: Results of an online survey of mental health providers offering services to Latino or Hispanic cancer patients in the United States, Latin America, and Spain, specifically their perspective of the concerns and needs of these patients during the COVID-19 pandemic.
Costas-Muniz R (Psychiatry Service), Galindo-Vazquez O, Montana F, Ruda-Santolaria L, Sanchez-Ramirez JC, Torres-Blasco N, Castro EM, Esenarro L, Claros M (Psychiatry Service), Narang B (Psychiatry Service), Breitbart WS (Psychiatry Service), Gany F (Psychiatry Service).
Ann Behav Med. 2020 Apr;55(Suppl. 1):S133. doi: 10.1093/abm/kaab020.
Summary: Results of an online survey of mental health providers offering services to Latino or Hispanic cancer patients in the United States, Latin America, and Spain, specifically their professional background, clinical productivity, and delivery of mental health services during the COVID-19 pandemic.
Kiviniemi MT, Hay JL (Psychiatry Service), Waters EA, Orom HA.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S547. doi: 10.1093/abm/kaab020.
Summary: This abstract from the 2021 Annals of Behavioral Medicine meeting reports on a survey of 410 American adults on the perception of their own risk versus the risk to other people.
Waters EA, Peters E, Kiviniemi MT, Tuman M (SKI Psychiatry/Counseling), Hay JL (Psychiatry Service), Orom HA.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S547. doi: 10.1093/abm/kaab020.
Summary: This abstract from the 2021 Annals of Behavioral Medicine meeting introduces the symposium's risk perception research presenters and their topics.
Orom HA, Waters EA, Hay JL (Psychiatry Service), Tuman M (SKI Psychiatry/Counseling), Kiviniemi MT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S548. doi: 10.1093/abm/kaab020.
Summary: This conference abstract discusses the results of a survey on COVID-19 beliefs and prevention completed by a representative sample of the U.S. adults in June 2020. The respondents' breakdown by race, and the impact of different racial groups attitudes towards COVID-19 prevention on the course of the pandemic, is discussed.
Tuman M (SKI Psychiatry/Counseling), Hay JL (Psychiatry Service), Schofield E (Psychiatry Service), Orom HA, Waters EA, Kiviniemi MT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S548. doi: 10.1093/abm/kaab020.
Summary: This conference abstract reports on the results of a survey on COVID-19 risk perception completed by a sample of U.S. adults in June 2021. The research was aimed at establishing whether any correlation existed between beliefs prioritizing hierarchical social order, and individualism (beliefs prioritizing autonomy) and perception of infectious disease risks.
Rowland JH, Goyal N, Applebaum AJ (Psychiatry Service), Coons HLT.
Ann Behav Med. 2021 Apr;55(Suppl. 1):S596. doi: 10.1093/abm/kaab020.
Summary: This conference abstract describes the agenda for a clinical expert discussion panel on the unique challenges that faced cancer patients, caregivers and cancer care providers, as well as lessons learned and innovative modifications to providing care that can be incorporated into post-pandemic practice and improve future cancer care delivery.
Givi B, Schiff BA, Chinn SB, Clayburgh D, Iyer NG, Jalisi S, Moore MG, Nathan CA, Orloff LA, O'Neill JP, Parker N, Zender C, Morris LGT (Surgery), Davies L.
JAMA Otolaryngol Head Neck Surg. 2020 Jun 01;146(6):579-584. doi: 10.1001/jamaoto.2020.0780. Epub 2020 Mar 31.
Summary: This report identifies safety recommendations for clinicians performing head and neck procedures and surgeries during the Covid-19 pandemic.
Araujo-Filho JAB (SKI Radiology), Sawamura MVY, Costa AN, Cerri GG, Nomura CH.
J Bras Pneumol. 2020 Mar 27;46(2):e20200114. doi: 10.36416/1806-3756/e20200114
Summary: This letter describes that CT scans should not be used to diagnose asymptomatic Covid-19 patients, but can be considered in hospitalized or symptomatic cases of potential Covid-19 pneumonia, but that Covid-19 diagnostic tests should always be used to confirm a positive Covid-19 diagnosis.
Patel R, Babady E (Laboratory Medicine), Theel ES, Storch GA, Pinsky BA, St George K, Smith TC, Bertuzzi S.
mBio. 2020 Mar 26;11(2). doi: 10.1128/mBio.00722-20
Summary: A report describing the use and value of the two types of Covid-19 tests, viral RNA tests and serology tests, and how to leverage these tests to address the pandemic.
Halpern NA (Anesthesiology), Tan KS (Biost/Epidemiology), SCCM Ventilator Taskforce.
SCCM. 2020 Mar 25.
Summary: This blog post describes the availability of critical care resources in the US in order to care for the surge in Covid-19 patients.
Chen YL, Hsu FM, Tsai CJ (Radiation Oncology), Cheng JCH.
Adv Radiat Oncol. 2020 Jul-Aug;5(4):534-537. doi: 10.1016/j.adro.2020.03.005. Epub 2020 Mar 17.
Summary: This opinion piece details the steps that Taiwan has taken to provide uninterrupted radiation oncology services throughout the Covid-19 pandemic.
Sungnak W, Huang Ni, Becavin C, Berg M, HCLA Lung Biological Network (Pe'er D (Computational and Systems Biology Program) in group).
arXiv.org. 2020 Mar 13. arXiv:2003.06122 [q-bio.CB].
Summary: This preprint article describes how the expression of genes that are coronavirus receptors are found in large amounts in the nasal passages. This could explain why nasal respiratory transmission is so significant.
Waghmare A, Boeckh M, Chemaly RF, Dadwal SS, Papanicolaou GA (Medicine), Pergam S.
American Society for Transplantation and Cellular Therapy (ASTCT) 2020 March 9. Version 1.1.
Summary: This document is intended as a guide for diagnosis and management of COVID-19 in adult and pediatric hematopoietic cell transplant (HCT) and cellular therapy patients. It does not cover specific infection prevention policies and procedures.
Jethava YS, Fonseca R, Landgren O (Laboratory Medicine).
Leuk Res Rep. 2020; 14: 100212. doi: 10.1111/bjd.19415.
Summary: The authors recommend best practices for caring for multiple myeloma patients during the COVID pandemic.