TITLE: DOES ENDOTOXIN STIMULATE CELLS BY MIMICKING CERAMIDE

AUTHORS: WRIGHT, SD;KOLESNICK, RN

DISEASE MANAGEMENT TEAM:

AFFILIATIONS: MEM SLOAN KETTERING CANC CTR,SIGNAL TRANSDUCT LAB,NEW YORK,NY 10021.

ABSTRACT: Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.

SOURCE: Immunology Today   YEAR: 1995   VOLUME: 16  ISSUE: 6  PAGES: 297-302

DOCUMENT TYPE: Review Article   DOI: -   LANGUAGE: English